non-small cell lung carcinoma Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
Description A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma. (Human Disease Ontology, DOID_3908)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:3908
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Genes

296 genes associated with the disease non-small cell lung carcinoma in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
XKR6 XK, Kell blood group complex subunit-related family, member 6 3.34809
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) 2.17224
HYKK hydroxylysine kinase 2.10846
TERT telomerase reverse transcriptase 2.02116
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) 1.50185
IREB2 iron-responsive element binding protein 2 1.46453
TP63 tumor protein p63 1.4332
XXYLT1 xyloside xylosyltransferase 1 1.39396
EIF4E2 eukaryotic translation initiation factor 4E family member 2 1.32598
LOC100507065 uncharacterized LOC100507065 1.31063
FCGBP Fc fragment of IgG binding protein 1.28995
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 1.28906
SAXO1 stabilizer of axonemal microtubules 1 1.28906
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila) 1.2612
NELL1 NEL-like 1 (chicken) 1.25944
CMKLR1 chemerin chemokine-like receptor 1 1.24194
JAZF1 JAZF zinc finger 1 1.2326
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 1.20023
PIEZO2 piezo-type mechanosensitive ion channel component 2 1.19386
TMEM163 transmembrane protein 163 1.17051
SORCS2 sortilin-related VPS10 domain containing receptor 2 1.15334
APOM apolipoprotein M 1.13553
MAP2K4 mitogen-activated protein kinase kinase 4 1.12226
RGS7 regulator of G-protein signaling 7 1.09109
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 1.08866
DSCAM Down syndrome cell adhesion molecule 1.07599
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 1.03332
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 1.02476
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 1.02476
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2 1.02476
USP10 ubiquitin specific peptidase 10 1.02476
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8 1.01535
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein 1.01514
RYR2 ryanodine receptor 2 (cardiac) 1.00558
LAMA1 laminin, alpha 1 1.00407
THSD7B thrombospondin, type I, domain containing 7B 1.00407
KAT2B K(lysine) acetyltransferase 2B 1.00407
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) 1.00407
NCOA2 nuclear receptor coactivator 2 1.00407
LINC00189 long intergenic non-protein coding RNA 189 0.986376
CDH8 cadherin 8, type 2 0.986376
CLPTM1L CLPTM1-like 0.983866
BPTF bromodomain PHD finger transcription factor 0.980528
CDC123 cell division cycle 123 0.973451
NALCN sodium leak channel, non selective 0.971169
DCC DCC netrin 1 receptor 0.971169
SLC35D2 solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2 0.971169
C8ORF34 chromosome 8 open reading frame 34 0.971169
DEC1 deleted in esophageal cancer 1 0.962747
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 0.960778
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.951514
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.947208
CACHD1 cache domain containing 1 0.942098
FAM178B family with sequence similarity 178, member B 0.939181
MSH5 mutS homolog 5 0.937692
OGFRL1 opioid growth factor receptor-like 1 0.932777
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.931899
FRMD8 FERM domain containing 8 0.93103
KIAA1147 KIAA1147 0.923572
C6ORF10 chromosome 6 open reading frame 10 0.923269
PCSK6 proprotein convertase subtilisin/kexin type 6 0.911472
C2 complement component 2 0.91002
IQSEC3 IQ motif and Sec7 domain 3 0.898875
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.896938
CSMD1 CUB and Sushi multiple domains 1 0.890183
TRPM1 transient receptor potential cation channel, subfamily M, member 1 0.885252
CPNE5 copine V 0.885252
FRRS1L ferric-chelate reductase 1-like 0.884624
MAN1B1 mannosidase, alpha, class 1B, member 1 0.88094
LOC146513 uncharacterized LOC146513 0.877977
SHROOM3 shroom family member 3 0.877977
ZMYND15 zinc finger, MYND-type containing 15 0.871229
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 0.86494
TTYH1 tweety family member 1 0.859451
ZNRD1 zinc ribbon domain containing 1 0.859032
LOC100507195 uncharacterized LOC100507195 0.857354
HCG18 HLA complex group 18 (non-protein coding) 0.855621
LOC441601 septin 7 pseudogene 0.854796
ARHGAP24 Rho GTPase activating protein 24 0.852796
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.847563
CFB complement factor B 0.846156
STK19 serine/threonine kinase 19 0.844953
SLC2A7 solute carrier family 2 (facilitated glucose transporter), member 7 0.842929
BTNL2 butyrophilin-like 2 0.84116
PPP1R18 protein phosphatase 1, regulatory subunit 18 0.838861
KDM1A lysine (K)-specific demethylase 1A 0.836459
ALKBH6 alkB, alkylation repair homolog 6 (E. coli) 0.832379
ATP2A3 ATPase, Ca++ transporting, ubiquitous 0.829868
DOCK1 dedicator of cytokinesis 1 0.826025
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1 0.823542
PPEF1 protein phosphatase, EF-hand calcium binding domain 1 0.822323
ZC3H3 zinc finger CCCH-type containing 3 0.820721
CLIP3 CAP-GLY domain containing linker protein 3 0.818753
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.815307
TCEA3 transcription elongation factor A (SII), 3 0.811252
SCARB1 scavenger receptor class B, member 1 0.799531
CREB3L2 cAMP responsive element binding protein 3-like 2 0.79563
DMD dystrophin 0.793221
PTPRO protein tyrosine phosphatase, receptor type, O 0.789217
PAQR5 progestin and adipoQ receptor family member V 0.788564
GPA33 glycoprotein A33 (transmembrane) 0.788239
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.783797
PRKG1 protein kinase, cGMP-dependent, type I 0.78104
AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2 0.780437
NIM1K NIM1 serine/threonine protein kinase 0.780437
SP100 SP100 nuclear antigen 0.778649
RNF39 ring finger protein 39 0.773496
GTSF1 gametocyte specific factor 1 0.769887
RNF168 ring finger protein 168, E3 ubiquitin protein ligase 0.767882
FAM13A family with sequence similarity 13, member A 0.764659
DPH6 diphthamine biosynthesis 6 0.762941
MRPL23 mitochondrial ribosomal protein L23 0.754478
FOXP1 forkhead box P1 0.754478
SGCZ sarcoglycan, zeta 0.749605
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.748359
HS6ST3 heparan sulfate 6-O-sulfotransferase 3 0.743993
HCG9 HLA complex group 9 (non-protein coding) 0.742757
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 0.742757
PPA2 pyrophosphatase (inorganic) 2 0.734059
HELQ helicase, POLQ-like 0.728446
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.720109
DLG2 discs, large homolog 2 (Drosophila) 0.714752
PARK2 parkin RBR E3 ubiquitin protein ligase 0.712959
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 0.712564
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 0.711585
PITPNM3 PITPNM family member 3 0.711001
DOCK5 dedicator of cytokinesis 5 0.708319
CDH23 cadherin-related 23 0.705888
TCF19 transcription factor 19 0.703663
DGKI diacylglycerol kinase, iota 0.70172
TMEM222 transmembrane protein 222 0.701015
CEP128 centrosomal protein 128kDa 0.698242
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.69621
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive) 0.691618
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 0.689868
AADACL3 arylacetamide deacetylase-like 3 0.688615
NPFFR2 neuropeptide FF receptor 2 0.685395
PPME1 protein phosphatase methylesterase 1 0.684644
ARID1A AT rich interactive domain 1A (SWI-like) 0.682862
INSC inscuteable homolog (Drosophila) 0.681111
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 0.678965
LOXHD1 lipoxygenase homology domains 1 0.678682
MARCH1 membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase 0.6784
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.676587
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast) 0.676448
SLIT3 slit homolog 3 (Drosophila) 0.675623
MROH2A maestro heat-like repeat family member 2A 0.675077
RAI1 retinoic acid induced 1 0.674534
MTUS1 microtubule associated tumor suppressor 1 0.67239
ADGRB3 adhesion G protein-coupled receptor B3 0.672258
SASH1 SAM and SH3 domain containing 1 0.669747
ONECUT2 one cut homeobox 2 0.668936
TNXB tenascin XB 0.636552
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 0.635081
PBX1 pre-B-cell leukemia homeobox 1 0.620518
DPCR1 diffuse panbronchiolitis critical region 1 0.615118
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) 0.599314
NOTCH4 notch 4 0.594635
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.56878
KSR2 kinase suppressor of ras 2 0.54076
ZNRD1-AS1 ZNRD1 antisense RNA 1 0.528056
LDB2 LIM domain binding 2 0.517605
TRIM31 tripartite motif containing 31 0.515113
FRMD5 FERM domain containing 5 0.506603
LOC100129636 uncharacterized LOC100129636 0.502085
ZNRF3 zinc and ring finger 3 0.492929
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 0.492786
PRRC2A proline-rich coiled-coil 2A 0.490044
C6ORF15 chromosome 6 open reading frame 15 0.488778
GPANK1 G patch domain and ankyrin repeats 1 0.486614
SEC63 SEC63 homolog (S. cerevisiae) 0.485954
OR12D3 olfactory receptor, family 12, subfamily D, member 3 0.484105
FLOT1 flotillin 1 0.483809
VLDLR very low density lipoprotein receptor 0.483564
M6PR mannose-6-phosphate receptor (cation dependent) 0.483523
PHC1 polyhomeotic homolog 1 (Drosophila) 0.483364
VARS2 valyl-tRNA synthetase 2, mitochondrial 0.482462
EML1 echinoderm microtubule associated protein like 1 0.482181
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 0.481394
TLE2 transducin-like enhancer of split 2 0.480735
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.480572
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae) 0.480022
PDCD6 programmed cell death 6 0.4797
UBR1 ubiquitin protein ligase E3 component n-recognin 1 0.479579
LOC100507424 uncharacterized LOC100507424 0.478271
FKBP11 FK506 binding protein 11, 19 kDa 0.477754
MEOX2 mesenchyme homeobox 2 0.476572
LRRC16A leucine rich repeat containing 16A 0.474861
PGBD1 piggyBac transposable element derived 1 0.474612
DPF3 D4, zinc and double PHD fingers, family 3 0.474177
ZFP57 ZFP57 zinc finger protein 0.472969
C10ORF11 chromosome 10 open reading frame 11 0.471198
PRR16 proline rich 16 0.471097
KLRG1 killer cell lectin-like receptor subfamily G, member 1 0.470308
EGFL8 EGF-like-domain, multiple 8 0.469052
C5 complement component 5 0.468613
PSORS1C1 psoriasis susceptibility 1 candidate 1 0.468017
SH3PXD2B SH3 and PX domains 2B 0.467851
TGM5 transglutaminase 5 0.46525
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.464937
PTPRD protein tyrosine phosphatase, receptor type, D 0.464937
CNTN5 contactin 5 0.464398
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.463561
CHODL chondrolectin 0.461735
HPSE2 heparanase 2 (inactive) 0.460921
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 0.460824
CAMKMT calmodulin-lysine N-methyltransferase 0.460255
SLC13A5 solute carrier family 13 (sodium-dependent citrate transporter), member 5 0.459802
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1 0.459758
PLEKHG4B pleckstrin homology domain containing, family G (with RhoGef domain) member 4B 0.459453
MYH9 myosin, heavy chain 9, non-muscle 0.459367
SLC17A1 solute carrier family 17 (organic anion transporter), member 1 0.459072
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 0.458744
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 0.458308
SRD5A3 steroid 5 alpha-reductase 3 0.458192
TMCO6 transmembrane and coiled-coil domains 6 0.457463
PRC1 protein regulator of cytokinesis 1 0.457099
AMICA1 adhesion molecule, interacts with CXADR antigen 1 0.456965
EHMT2 euchromatic histone-lysine N-methyltransferase 2 0.456965
CA10 carbonic anhydrase X 0.456788
SUN5 Sad1 and UNC84 domain containing 5 0.456484
SGMS1 sphingomyelin synthase 1 0.45606
CAPN12 calpain 12 0.455936
ZBTB16 zinc finger and BTB domain containing 16 0.455853
MEMO1 mediator of cell motility 1 0.45565
MORF4L1 mortality factor 4 like 1 0.455609
LINGO2 leucine rich repeat and Ig domain containing 2 0.455529
PCDH17 protocadherin 17 0.455133
COL19A1 collagen, type XIX, alpha 1 0.454939
LOC100506985 uncharacterized LOC100506985 0.454448
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein) 0.454081
TP53BP1 tumor protein p53 binding protein 1 0.453136
GLDN gliomedin 0.452968
JADE2 jade family PHD finger 2 0.452769
EBF3 early B-cell factor 3 0.452316
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 0.45222
WNK1 WNK lysine deficient protein kinase 1 0.452094
NUCB2 nucleobindin 2 0.452001
AGBL4 ATP/GTP binding protein-like 4 0.452001
ULK2 unc-51 like autophagy activating kinase 2 0.451481
PPARA peroxisome proliferator-activated receptor alpha 0.451391
PSD3 pleckstrin and Sec7 domain containing 3 0.451361
TENM2 teneurin transmembrane protein 2 0.451272
SETBP1 SET binding protein 1 0.451059
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa 0.451024
LOC644662 0.450706
MRPL54 mitochondrial ribosomal protein L54 0.450532
LOC285692 uncharacterized LOC285692 0.450224
ACTN4 actinin, alpha 4 0.449689
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 0.449138
NELFE negative elongation factor complex member E 0.449043
EIF3K eukaryotic translation initiation factor 3, subunit K 0.448605
RYR1 ryanodine receptor 1 (skeletal) 0.448482
ZNF229 zinc finger protein 229 0.448421
LBH limb bud and heart development 0.44794
AMPD3 adenosine monophosphate deaminase 3 0.447272
IP6K2 inositol hexakisphosphate kinase 2 0.447243
SFTPB surfactant protein B 0.445932
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 0.445827
GPR158 G protein-coupled receptor 158 0.445542
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 0.445212
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.444912
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.444814
HCG27 HLA complex group 27 (non-protein coding) 0.444691
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.444522
LRRC4C leucine rich repeat containing 4C 0.444377
CNTN4 contactin 4 0.443905
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.443905
KMT2E lysine (K)-specific methyltransferase 2E 0.443674
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.443447
SORBS3 sorbin and SH3 domain containing 3 0.443267
MCHR2 melanin-concentrating hormone receptor 2 0.443222
BSN bassoon presynaptic cytomatrix protein 0.443133
REM1 RAS (RAD and GEM)-like GTP-binding 1 0.443067
EFR3A EFR3 homolog A (S. cerevisiae) 0.442881
RNF165 ring finger protein 165 0.441584
FMN1 formin 1 0.441563
MIR3135B microRNA 3135b 0.441391
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2 0.441306
ROR1 receptor tyrosine kinase-like orphan receptor 1 0.440805
PCDHA9 protocadherin alpha 9 0.44062
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) 0.440519
LINC00473 long intergenic non-protein coding RNA 473 0.440438
SCAF11 SR-related CTD-associated factor 11 0.440098
TGFB2 transforming growth factor, beta 2 0.44
SECISBP2L SECIS binding protein 2-like 0.439707
HS3ST4 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 0.439553
ZNF287 zinc finger protein 287 0.439325
SH2D4B SH2 domain containing 4B 0.438876
PDGFB platelet-derived growth factor beta polypeptide 0.438821
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.438638
KLHL31 kelch-like family member 31 0.425409
SPACA1 sperm acrosome associated 1 0.422199
WWOX WW domain containing oxidoreductase 0.406898
SPRED1 sprouty-related, EVH1 domain containing 1 0.406898
TSPAN33 tetraspanin 33 0.397817