nomegestrol-6525 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the nomegestrol-6525 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
AGBL2 ATP/GTP binding protein-like 2
AJAP1 adherens junctions associated protein 1
ALDOAP2 aldolase A, fructose-bisphosphate pseudogene 2
ALOX5 arachidonate 5-lipoxygenase
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ARMC4 armadillo repeat containing 4
ATN1 atrophin 1
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
C19ORF73 chromosome 19 open reading frame 73
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CAV2 caveolin 2
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CELA2A chymotrypsin-like elastase family, member 2A
CLCN6 chloride channel, voltage-sensitive 6
CLEC4M C-type lectin domain family 4, member M
CLIC2 chloride intracellular channel 2
COL1A1 collagen, type I, alpha 1
COL6A1 collagen, type VI, alpha 1
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DCX doublecortin
DENND3 DENN/MADD domain containing 3
DGCR5 DiGeorge syndrome critical region gene 5 (non-protein coding)
DOK4 docking protein 4
EDDM3B epididymal protein 3B
EFNA3 ephrin-A3
EPHA1 EPH receptor A1
FADS2 fatty acid desaturase 2
FGF2 fibroblast growth factor 2 (basic)
FLRT2 fibronectin leucine rich transmembrane protein 2
FPR1 formyl peptide receptor 1
GBP1 guanylate binding protein 1, interferon-inducible
GREB1 growth regulation by estrogen in breast cancer 1
GSTCD glutathione S-transferase, C-terminal domain containing
GSTTP1 glutathione S-transferase theta pseudogene 1
GTPBP10 GTP-binding protein 10 (putative)
GYPB glycophorin B (MNS blood group)
HIF3A hypoxia inducible factor 3, alpha subunit
HP haptoglobin
HP1BP3 heterochromatin protein 1, binding protein 3
HYMAI hydatidiform mole associated and imprinted (non-protein coding)
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2
KCNIP1 Kv channel interacting protein 1
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KCTD17 potassium channel tetramerization domain containing 17
KIF25 kinesin family member 25
KLHL22 kelch-like family member 22
KRIT1 KRIT1, ankyrin repeat containing
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LAMA4 laminin, alpha 4
LMF2 lipase maturation factor 2
LOC100131532 uncharacterized LOC100131532
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN2A2 mannosidase, alpha, class 2A, member 2
MAP2K5 mitogen-activated protein kinase kinase 5
MAPK13 mitogen-activated protein kinase 13
MED25 mediator complex subunit 25
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MST1 macrophage stimulating 1
MTMR8 myotubularin related protein 8
MTRF1L mitochondrial translational release factor 1-like
MVD mevalonate (diphospho) decarboxylase
MYBPC3 myosin binding protein C, cardiac
NBR2 neighbor of BRCA1 gene 2 (non-protein coding)
NPAS3 neuronal PAS domain protein 3
NT5E 5'-nucleotidase, ecto (CD73)
OBSL1 obscurin-like 1
OVGP1 oviductal glycoprotein 1, 120kDa
PARD3 par-3 family cell polarity regulator
PDE4C phosphodiesterase 4C, cAMP-specific
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PPP1R2P9 protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 9
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PPP5C protein phosphatase 5, catalytic subunit
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RBP4 retinol binding protein 4, plasma
RELN reelin
RPL18 ribosomal protein L18
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SIX1 SIX homeobox 1
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STS steroid sulfatase (microsomal), isozyme S
TEF thyrotrophic embryonic factor
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast)
TOP3A topoisomerase (DNA) III alpha
WDR59 WD repeat domain 59
WHSC1 Wolf-Hirschhorn syndrome candidate 1
ZBTB48 zinc finger and BTB domain containing 48
ZDHHC8P1 zinc finger, DHHC-type containing 8 pseudogene 1
ZFP64 ZFP64 zinc finger protein
ZNF277 zinc finger protein 277
ZNF506 zinc finger protein 506
ZNF79 zinc finger protein 79

decreased expression

Symbol Name
AATK apoptosis-associated tyrosine kinase
ACYP2 acylphosphatase 2, muscle type
ADGRG2 adhesion G protein-coupled receptor G2
AIDA axin interactor, dorsalization associated
ARHGAP24 Rho GTPase activating protein 24
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ATP10D ATPase, class V, type 10D
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BAHCC1 BAH domain and coiled-coil containing 1
BPGM 2,3-bisphosphoglycerate mutase
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C2ORF27A chromosome 2 open reading frame 27A
CD82 CD82 molecule
CFAP44 cilia and flagella associated protein 44
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DAPK3 death-associated protein kinase 3
DBR1 debranching RNA lariats 1
DCAF17 DDB1 and CUL4 associated factor 17
DDIT3 DNA-damage-inducible transcript 3
DEAF1 DEAF1 transcription factor
ECI2 enoyl-CoA delta isomerase 2
ELP3 elongator acetyltransferase complex subunit 3
EMID1 EMI domain containing 1
ERCC6 excision repair cross-complementation group 6
ERN2 endoplasmic reticulum to nucleus signaling 2
F3 coagulation factor III (thromboplastin, tissue factor)
FBRS fibrosin
FBXO22 F-box protein 22
FBXO31 F-box protein 31
FMO4 flavin containing monooxygenase 4
GALK1 galactokinase 1
GCHFR GTP cyclohydrolase I feedback regulator
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GNG4 guanine nucleotide binding protein (G protein), gamma 4
HIST1H4F histone cluster 1, H4f
IKZF5 IKAROS family zinc finger 5 (Pegasus)
INSIG2 insulin induced gene 2
ITGA10 integrin, alpha 10
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KLHL25 kelch-like family member 25
KLHL28 kelch-like family member 28
LOC729164 hCG1732469
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAGOH2P mago-nashi homolog 2, pseudogene
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MBTPS2 membrane-bound transcription factor peptidase, site 2
MGC12488
MTERF4 mitochondrial transcription termination factor 4
NKX3-2 NK3 homeobox 2
NMU neuromedin U
NR1H3 nuclear receptor subfamily 1, group H, member 3
NUS1P3 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 3
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PDGFD platelet derived growth factor D
PECR peroxisomal trans-2-enoyl-CoA reductase
PEX26 peroxisomal biogenesis factor 26
PODXL2 podocalyxin-like 2
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PRODH proline dehydrogenase (oxidase) 1
PTPN14 protein tyrosine phosphatase, non-receptor type 14
RANBP17 RAN binding protein 17
RANGRF RAN guanine nucleotide release factor
RHBG Rh family, B glycoprotein (gene/pseudogene)
RNF146 ring finger protein 146
S100A9 S100 calcium binding protein A9
SAYSD1 SAYSVFN motif domain containing 1
SCYL2 SCY1-like 2 (S. cerevisiae)
SGPP1 sphingosine-1-phosphate phosphatase 1
SH2B3 SH2B adaptor protein 3
SH2D4A SH2 domain containing 4A
SLC12A9 solute carrier family 12, member 9
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SPINK5 serine peptidase inhibitor, Kazal type 5
STK16 serine/threonine kinase 16
STON1 stonin 1
SYNC syncoilin, intermediate filament protein
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TBX19 T-box 19
TCHH trichohyalin
TCTN1 tectonic family member 1
TCTN2 tectonic family member 2
TDRD1 tudor domain containing 1
TDRD7 tudor domain containing 7
TM6SF1 transmembrane 6 superfamily member 1
TMEM104 transmembrane protein 104
TRAIP TRAF interacting protein
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VAV1 vav 1 guanine nucleotide exchange factor
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
VGF VGF nerve growth factor inducible
ZNF492 zinc finger protein 492
ZNF573 zinc finger protein 573
ZNF862 zinc finger protein 862
ZSCAN31 zinc finger and SCAN domain containing 31