nizatidine-3385 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the nizatidine-3385 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
AIM1L absent in melanoma 1-like
AK1 adenylate kinase 1
AKR1C4 aldo-keto reductase family 1, member C4
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ARSD arylsulfatase D
ATG10 autophagy related 10
B9D1 B9 protein domain 1
BARX2 BARX homeobox 2
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BMP8B bone morphogenetic protein 8b
BMX BMX non-receptor tyrosine kinase
C1QTNF1 C1q and tumor necrosis factor related protein 1
C2 complement component 2
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CDH8 cadherin 8, type 2
CEP41 centrosomal protein 41kDa
CES3 carboxylesterase 3
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CPN2 carboxypeptidase N, polypeptide 2
CPQ carboxypeptidase Q
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DGCR8 DGCR8 microprocessor complex subunit
DOC2A double C2-like domains, alpha
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
ECE1 endothelin converting enzyme 1
EDN1 endothelin 1
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2
ELAVL3 ELAV like neuron-specific RNA binding protein 3
EMC3 ER membrane protein complex subunit 3
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1
ERCC2 excision repair cross-complementation group 2
FABP6 fatty acid binding protein 6, ileal
FBXO4 F-box protein 4
FGF6 fibroblast growth factor 6
FHL1 four and a half LIM domains 1
FRMD1 FERM domain containing 1
FUT2 fucosyltransferase 2 (secretor status included)
GPER1 G protein-coupled estrogen receptor 1
HCRP1 hepatocellular carcinoma-related HCRP1
HNRNPM heterogeneous nuclear ribonucleoprotein M
HOXD11 homeobox D11
HSF4 heat shock transcription factor 4
ICAM2 intercellular adhesion molecule 2
IGLJ3 immunoglobulin lambda joining 3
IL1B interleukin 1, beta
IL22 interleukin 22
IRF4 interferon regulatory factor 4
ITGB5 integrin, beta 5
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
LATS1 large tumor suppressor kinase 1
LINC00652 long intergenic non-protein coding RNA 652
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MYOF myoferlin
N4BP2L1 NEDD4 binding protein 2-like 1
NEFL neurofilament, light polypeptide
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR6A1 nuclear receptor subfamily 6, group A, member 1
NUDT7 nudix (nucleoside diphosphate linked moiety X)-type motif 7
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OVGP1 oviductal glycoprotein 1, 120kDa
PAX9 paired box 9
PCDH17 protocadherin 17
PCDHA9 protocadherin alpha 9
PCDHGA8 protocadherin gamma subfamily A, 8
PCNXL2 pecanex-like 2 (Drosophila)
PDE4C phosphodiesterase 4C, cAMP-specific
PHC3 polyhomeotic homolog 3 (Drosophila)
PKD1 polycystic kidney disease 1 (autosomal dominant)
PKNOX1 PBX/knotted 1 homeobox 1
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PRKG2 protein kinase, cGMP-dependent, type II
PTCRA pre T-cell antigen receptor alpha
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB40C RAB40C, member RAS oncogene family
RAB6B RAB6B, member RAS oncogene family
SALL1 spalt-like transcription factor 1
SCLY selenocysteine lyase
SENP7 SUMO1/sentrin specific peptidase 7
SERHL2 serine hydrolase-like 2
SH3GL3 SH3-domain GRB2-like 3
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPON1 spondin 1, extracellular matrix protein
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SSTR5 somatostatin receptor 5
STAT4 signal transducer and activator of transcription 4
TAGLN3 transgelin 3
TBX6 T-box 6
TP53I11 tumor protein p53 inducible protein 11
TREM2 triggering receptor expressed on myeloid cells 2
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae)
TXNRD2 thioredoxin reductase 2
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
ZNF286A zinc finger protein 286A
ZNF518A zinc finger protein 518A
ZNF695 zinc finger protein 695

decreased expression

Symbol Name
ABI3BP ABI family, member 3 (NESH) binding protein
ADAP2 ArfGAP with dual PH domains 2
ADTRP androgen-dependent TFPI-regulating protein
ATAT1 alpha tubulin acetyltransferase 1
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
B9D2 B9 protein domain 2
C10ORF95 chromosome 10 open reading frame 95
C1ORF54 chromosome 1 open reading frame 54
C1QB complement component 1, q subcomponent, B chain
C9ORF9 chromosome 9 open reading frame 9
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CARD8 caspase recruitment domain family, member 8
CBX8 chromobox homolog 8
CD82 CD82 molecule
CDK20 cyclin-dependent kinase 20
CGA glycoprotein hormones, alpha polypeptide
CLCN6 chloride channel, voltage-sensitive 6
COPZ2 coatomer protein complex, subunit zeta 2
CPEB3 cytoplasmic polyadenylation element binding protein 3
DBF4B DBF4 zinc finger B
DBR1 debranching RNA lariats 1
DEAF1 DEAF1 transcription factor
DVL1 dishevelled segment polarity protein 1
EDAR ectodysplasin A receptor
EMID1 EMI domain containing 1
FAM186A family with sequence similarity 186, member A
FSCN1 fascin actin-bundling protein 1
FSCN3 fascin actin-bundling protein 3, testicular
GLDC glycine dehydrogenase (decarboxylating)
GNL1 guanine nucleotide binding protein-like 1
GPR21 G protein-coupled receptor 21
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H4D histone cluster 1, H4d
HOXC11 homeobox C11
HOXC5 homeobox C5
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCTD7 potassium channel tetramerization domain containing 7
KDM8 lysine (K)-specific demethylase 8
KIAA0319L KIAA0319-like
KRT24 keratin 24, type I
LAIR2 leukocyte-associated immunoglobulin-like receptor 2
LARP6 La ribonucleoprotein domain family, member 6
LINC00341 long intergenic non-protein coding RNA 341
LMTK2 lemur tyrosine kinase 2
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MICALL2 MICAL-like 2
MON1B MON1 secretory trafficking family member B
MUC3A mucin 3A, cell surface associated
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NACA2 nascent polypeptide-associated complex alpha subunit 2
NPM3 nucleophosmin/nucleoplasmin 3
NRGN neurogranin (protein kinase C substrate, RC3)
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PALM paralemmin
PARD6A par-6 family cell polarity regulator alpha
PDE8B phosphodiesterase 8B
PGM1 phosphoglucomutase 1
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
PLEKHS1 pleckstrin homology domain containing, family S member 1
PLXNB3 plexin B3
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
POLM polymerase (DNA directed), mu
PPT2 palmitoyl-protein thioesterase 2
PRAMEF11 PRAME family member 11
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PTDSS2 phosphatidylserine synthase 2
RAB3A RAB3A, member RAS oncogene family
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAB40AL RAB40A, member RAS oncogene family-like
RHBG Rh family, B glycoprotein (gene/pseudogene)
RND1 Rho family GTPase 1
RPL10L ribosomal protein L10-like
SAV1 salvador family WW domain containing protein 1
SAYSD1 SAYSVFN motif domain containing 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SLPI secretory leukocyte peptidase inhibitor
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SUN2 Sad1 and UNC84 domain containing 2
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TEX40 testis expressed 40
TLR5 toll-like receptor 5
TMEM209 transmembrane protein 209
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18
TPCN1 two pore segment channel 1
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TSGA10 testis specific, 10
TUBA3C tubulin, alpha 3c
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VIPR1 vasoactive intestinal peptide receptor 1
WDR78 WD repeat domain 78
XYLT1 xylosyltransferase I
ZNF136 zinc finger protein 136
ZNF639 zinc finger protein 639