nizatidine-3047 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

192 genes differentially expressed following the nizatidine-3047 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD6 abhydrolase domain containing 6
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ACSBG1 acyl-CoA synthetase bubblegum family member 1
ACSF2 acyl-CoA synthetase family member 2
ADAM30 ADAM metallopeptidase domain 30
ADRB1 adrenoceptor beta 1
ALOX5 arachidonate 5-lipoxygenase
ANGEL2 angel homolog 2 (Drosophila)
APOA4 apolipoprotein A-IV
ATXN3L ataxin 3-like
BMP6 bone morphogenetic protein 6
C11ORF16 chromosome 11 open reading frame 16
CASR calcium-sensing receptor
CCDC181 coiled-coil domain containing 181
CD59 CD59 molecule, complement regulatory protein
COL1A2 collagen, type I, alpha 2
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
DAGLA diacylglycerol lipase, alpha
DCHS2 dachsous cadherin-related 2
DCLK2 doublecortin-like kinase 2
DGKE diacylglycerol kinase, epsilon 64kDa
EBF2 early B-cell factor 2
EGR4 early growth response 4
EYA3 EYA transcriptional coactivator and phosphatase 3
FAIM2 Fas apoptotic inhibitory molecule 2
FAM189A1 family with sequence similarity 189, member A1
FLT3LG fms-related tyrosine kinase 3 ligand
FUBP1 far upstream element (FUSE) binding protein 1
G0S2 G0/G1 switch 2
GIPR gastric inhibitory polypeptide receptor
GK3P glycerol kinase 3 pseudogene
GNAT1 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1
GPR20 G protein-coupled receptor 20
GRIA3 glutamate receptor, ionotropic, AMPA 3
GZMM granzyme M (lymphocyte met-ase 1)
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-F major histocompatibility complex, class I, F
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
IDS iduronate 2-sulfatase
IGL immunoglobulin lambda locus
IL1R2 interleukin 1 receptor, type II
IL4 interleukin 4
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KLC2 kinesin light chain 2
KRT18 keratin 18, type I
LCAT lecithin-cholesterol acyltransferase
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LOC730101 uncharacterized LOC730101
LRRTM4 leucine rich repeat transmembrane neuronal 4
MARC1 mitochondrial amidoxime reducing component 1
MAU2 MAU2 sister chromatid cohesion factor
MTL5 metallothionein-like 5, testis-specific (tesmin)
MYH7 myosin, heavy chain 7, cardiac muscle, beta
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NPR1 natriuretic peptide receptor 1
NR2E3 nuclear receptor subfamily 2, group E, member 3
NRG1 neuregulin 1
ONECUT2 one cut homeobox 2
OPCML opioid binding protein/cell adhesion molecule-like
PARD6A par-6 family cell polarity regulator alpha
PAX8 paired box 8
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLXDC1 plexin domain containing 1
PMP2 peripheral myelin protein 2
POMT2 protein-O-mannosyltransferase 2
PRO2964 uncharacterized protein PRO2964
PYGB phosphorylase, glycogen; brain
RARA retinoic acid receptor, alpha
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RDH5 retinol dehydrogenase 5 (11-cis/9-cis)
RGS6 regulator of G-protein signaling 6
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
RPS2P45 ribosomal protein S2 pseudogene 45
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SHANK2 SH3 and multiple ankyrin repeat domains 2
SLC12A8 solute carrier family 12, member 8
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SRPX2 sushi-repeat containing protein, X-linked 2
TACR1 tachykinin receptor 1
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TCL6 T-cell leukemia/lymphoma 6 (non-protein coding)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TEX11 testis expressed 11
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TRIM3 tripartite motif containing 3
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
USP29 ubiquitin specific peptidase 29
ZFHX3 zinc finger homeobox 3
ZNF165 zinc finger protein 165

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ADGRB1 adhesion G protein-coupled receptor B1
AFF4 AF4/FMR2 family, member 4
AMPH amphiphysin
ANO2 anoctamin 2, calcium activated chloride channel
AP1B1 adaptor-related protein complex 1, beta 1 subunit
ARR3 arrestin 3, retinal (X-arrestin)
ATG10 autophagy related 10
BCAP29 B-cell receptor-associated protein 29
C1QB complement component 1, q subcomponent, B chain
C4BPA complement component 4 binding protein, alpha
C8A complement component 8, alpha polypeptide
CCDC71 coiled-coil domain containing 71
CD79B CD79b molecule, immunoglobulin-associated beta
CDY1 chromodomain protein, Y-linked, 1
CELP carboxyl ester lipase pseudogene
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CNGB3 cyclic nucleotide gated channel beta 3
CNPY4 canopy FGF signaling regulator 4
CNR2 cannabinoid receptor 2 (macrophage)
COL15A1 collagen, type XV, alpha 1
DHRS9 dehydrogenase/reductase (SDR family) member 9
ELAVL3 ELAV like neuron-specific RNA binding protein 3
EXOSC1 exosome component 1
FAAH fatty acid amide hydrolase
FAM114A1 family with sequence similarity 114, member A1
FGF6 fibroblast growth factor 6
GATA4 GATA binding protein 4
GPC3 glypican 3
GPR19 G protein-coupled receptor 19
HDAC7 histone deacetylase 7
HIST1H1B histone cluster 1, H1b
HIST1H2BC histone cluster 1, H2bc
HIST1H4E histone cluster 1, H4e
HOXD10 homeobox D10
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
IBSP integrin-binding sialoprotein
IFT140 intraflagellar transport 140
IL22 interleukin 22
JPH3 junctophilin 3
KIAA0408 KIAA0408
KLRG1 killer cell lectin-like receptor subfamily G, member 1
LENEP lens epithelial protein
LIMD2 LIM domain containing 2
LOC257152 uncharacterized LOC257152
LOC57399 uncharacterized gastric protein ZA52P
LRRC6 leucine rich repeat containing 6
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MDM4 MDM4, p53 regulator
MNX1 motor neuron and pancreas homeobox 1
MUC6 mucin 6, oligomeric mucus/gel-forming
MYO15A myosin XVA
NABP1 nucleic acid binding protein 1
NNAT neuronatin
OCM2 oncomodulin 2
PADI2 peptidyl arginine deiminase, type II
PARP16 poly (ADP-ribose) polymerase family, member 16
PHKG1 phosphorylase kinase, gamma 1 (muscle)
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLD2 phospholipase D2
PROX1 prospero homeobox 1
PRSS12 protease, serine, 12 (neurotrypsin, motopsin)
PTCD1 pentatricopeptide repeat domain 1
QSER1 glutamine and serine rich 1
RAB33A RAB33A, member RAS oncogene family
RAB3D RAB3D, member RAS oncogene family
RANBP17 RAN binding protein 17
RASAL2 RAS protein activator like 2
RCAN3 RCAN family member 3
RFPL1S RFPL1 antisense RNA 1
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RHOB ras homolog family member B
SCAMP5 secretory carrier membrane protein 5
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SGCE sarcoglycan, epsilon
SH3BGR SH3 domain binding glutamate-rich protein
SH3PXD2A SH3 and PX domains 2A
SLAMF7 SLAM family member 7
SPATA2L spermatogenesis associated 2-like
SPHK1 sphingosine kinase 1
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STARD13 StAR-related lipid transfer (START) domain containing 13
SYNJ2BP synaptojanin 2 binding protein
TAGLN transgelin
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TRIM49 tripartite motif containing 49
TRPV6 transient receptor potential cation channel, subfamily V, member 6
YPEL1 yippee-like 1 (Drosophila)
ZFP37 ZFP37 zinc finger protein
ZNF219 zinc finger protein 219
ZNF428 zinc finger protein 428
ZNF480 zinc finger protein 480
ZNF749 zinc finger protein 749