nitrofurantoin-3674 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the nitrofurantoin-3674 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACAN aggrecan
ACSBG2 acyl-CoA synthetase bubblegum family member 2
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADGRB2 adhesion G protein-coupled receptor B2
AIF1 allograft inflammatory factor 1
AIM2 absent in melanoma 2
ANGPTL2 angiopoietin-like 2
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
BTN2A3P butyrophilin, subfamily 2, member A3, pseudogene
C1ORF95 chromosome 1 open reading frame 95
CAPN10 calpain 10
CAPZB capping protein (actin filament) muscle Z-line, beta
CAT catalase
CAV3 caveolin 3
CCDC132 coiled-coil domain containing 132
CCDC64 coiled-coil domain containing 64
CDRT1 CMT1A duplicated region transcript 1
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CHST4 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
COL14A1 collagen, type XIV, alpha 1
CSDC2 cold shock domain containing C2, RNA binding
CST2 cystatin SA
CTSS cathepsin S
CYP2A7 cytochrome P450, family 2, subfamily A, polypeptide 7
CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18
CYTH3 cytohesin 3
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EGR1 early growth response 1
ELAVL4 ELAV like neuron-specific RNA binding protein 4
ERC2-IT1 ERC2 intronic transcript 1
EXOSC2 exosome component 2
GPR6 G protein-coupled receptor 6
GRK5 G protein-coupled receptor kinase 5
HIST1H2AK histone cluster 1, H2ak
HLA-DOA major histocompatibility complex, class II, DO alpha
HOXD1 homeobox D1
IL15 interleukin 15
INADL InaD-like (Drosophila)
ITGA7 integrin, alpha 7
KRT32 keratin 32, type I
LEPR leptin receptor
MAP2K5 mitogen-activated protein kinase kinase 5
MAP2K7 mitogen-activated protein kinase kinase 7
MMP11 matrix metallopeptidase 11
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MYCNOS MYCN opposite strand
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle
MYOZ3 myozenin 3
NCLN nicalin
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NME5 NME/NM23 family member 5
NPIPB15 nuclear pore complex interacting protein family, member B15
NPY4R neuropeptide Y receptor Y4
ORAI3 ORAI calcium release-activated calcium modulator 3
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLXNB1 plexin B1
PML promyelocytic leukemia
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
RAD23B RAD23 homolog B (S. cerevisiae)
RAG1 recombination activating gene 1
RBM12B-AS1 RBM12B antisense RNA 1
RFX2 regulatory factor X, 2 (influences HLA class II expression)
RIF1 replication timing regulatory factor 1
RUNX1 runt-related transcription factor 1
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLC45A2 solute carrier family 45, member 2
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLCO1A2 solute carrier organic anion transporter family, member 1A2
SLIT3 slit homolog 3 (Drosophila)
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5)
SOX2 SRY (sex determining region Y)-box 2
STAG3 stromal antigen 3
STRN striatin, calmodulin binding protein
SULT4A1 sulfotransferase family 4A, member 1
TBL1Y transducin (beta)-like 1, Y-linked
TBX5 T-box 5
TFR2 transferrin receptor 2
TMEM63A transmembrane protein 63A
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
TP63 tumor protein p63
TSPAN2 tetraspanin 2
TTLL3 tubulin tyrosine ligase-like family member 3
UBR2 ubiquitin protein ligase E3 component n-recognin 2
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
YY2 YY2 transcription factor
ZHX3 zinc fingers and homeoboxes 3
ZNF235 zinc finger protein 235
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ADGRE2 adhesion G protein-coupled receptor E2
ADGRL2 adhesion G protein-coupled receptor L2
ALPK3 alpha-kinase 3
ANP32A-IT1 ANP32A intronic transcript 1
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ATAD5 ATPase family, AAA domain containing 5
BDKRB1 bradykinin receptor B1
BGLAP bone gamma-carboxyglutamate (gla) protein
C5ORF45 chromosome 5 open reading frame 45
C8ORF44 chromosome 8 open reading frame 44
CA11 carbonic anhydrase XI
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CBX8 chromobox homolog 8
CCDC121 coiled-coil domain containing 121
CCDC85C coiled-coil domain containing 85C
CD101 CD101 molecule
CD68 CD68 molecule
CDK6 cyclin-dependent kinase 6
CHKB choline kinase beta
CLTCL1 clathrin, heavy chain-like 1
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
COPG2IT1 COPG2 imprinted transcript 1 (non-protein coding)
CRY2 cryptochrome circadian clock 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
DAPK3 death-associated protein kinase 3
DEAF1 DEAF1 transcription factor
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DSCAM Down syndrome cell adhesion molecule
DUSP9 dual specificity phosphatase 9
ENOX1 ecto-NOX disulfide-thiol exchanger 1
ERO1LB ERO1-like beta (S. cerevisiae)
EXOSC1 exosome component 1
FBRS fibrosin
FBXL7 F-box and leucine-rich repeat protein 7
FOXC1 forkhead box C1
GAL3ST4 galactose-3-O-sulfotransferase 4
GAS8 growth arrest-specific 8
GDAP1 ganglioside induced differentiation associated protein 1
GJC1 gap junction protein, gamma 1, 45kDa
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GPR3 G protein-coupled receptor 3
HDAC9 histone deacetylase 9
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IL22 interleukin 22
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1
KIAA0355 KIAA0355
KIAA0754 KIAA0754
LEFTY1 left-right determination factor 1
LIMD2 LIM domain containing 2
LIME1 Lck interacting transmembrane adaptor 1
LOC100127972 uncharacterized LOC100127972
LOC157562 uncharacterized LOC157562
MCC mutated in colorectal cancers
MEFV Mediterranean fever
MMP3 matrix metallopeptidase 3
MRPL41 mitochondrial ribosomal protein L41
MXD3 MAX dimerization protein 3
NACA2 nascent polypeptide-associated complex alpha subunit 2
NEK11 NIMA-related kinase 11
NHEJ1 nonhomologous end-joining factor 1
NT5C 5', 3'-nucleotidase, cytosolic
ODF2 outer dense fiber of sperm tails 2
OSGIN1 oxidative stress induced growth inhibitor 1
PADI1 peptidyl arginine deiminase, type I
PCBP4 poly(rC) binding protein 4
PCDH17 protocadherin 17
PCOLCE procollagen C-endopeptidase enhancer
PGP phosphoglycolate phosphatase
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PODXL2 podocalyxin-like 2
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
ROM1 retinal outer segment membrane protein 1
SH2D4A SH2 domain containing 4A
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SMO smoothened, frizzled class receptor
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SPTBN2 spectrin, beta, non-erythrocytic 2
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TAOK1 TAO kinase 1
TM6SF1 transmembrane 6 superfamily member 1
TMEM183A transmembrane protein 183A
TNS4 tensin 4
UNC93B1 unc-93 homolog B1 (C. elegans)
USB1 U6 snRNA biogenesis 1
USP20 ubiquitin specific peptidase 20
USP27X ubiquitin specific peptidase 27, X-linked
VGF VGF nerve growth factor inducible
VN1R1 vomeronasal 1 receptor 1
WDR25 WD repeat domain 25
WFDC2 WAP four-disulfide core domain 2
WT1-AS WT1 antisense RNA
ZFHX2 zinc finger homeobox 2
ZFHX3 zinc finger homeobox 3
ZNF112 zinc finger protein 112
ZNF74 zinc finger protein 74