nitrofurantoin-2341 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the nitrofurantoin-2341 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACRV1 acrosomal vesicle protein 1
APOM apolipoprotein M
ARRB1 arrestin, beta 1
ATP10B ATPase, class V, type 10B
ATP9A ATPase, class II, type 9A
C21ORF2 chromosome 21 open reading frame 2
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CD70 CD70 molecule
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3
CLSTN2 calsyntenin 2
CNN1 calponin 1, basic, smooth muscle
CNR2 cannabinoid receptor 2 (macrophage)
COL10A1 collagen, type X, alpha 1
DAPK2 death-associated protein kinase 2
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DNASE2 deoxyribonuclease II, lysosomal
DOK5 docking protein 5
DRD2 dopamine receptor D2
ELK1 ELK1, member of ETS oncogene family
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
EXPH5 exophilin 5
FAM188A family with sequence similarity 188, member A
FN1 fibronectin 1
FOXN2 forkhead box N2
FRMD1 FERM domain containing 1
GATA2 GATA binding protein 2
GIMAP5 GTPase, IMAP family member 5
GK glycerol kinase
GOSR2 golgi SNAP receptor complex member 2
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent)
HIST1H2AM histone cluster 1, H2am
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HSPA2 heat shock 70kDa protein 2
ICOSLG inducible T-cell co-stimulator ligand
IGFBP3 insulin-like growth factor binding protein 3
IL12RB1 interleukin 12 receptor, beta 1
KDM4B lysine (K)-specific demethylase 4B
KHK ketohexokinase (fructokinase)
KIAA1211L KIAA1211-like
KIF5A kinesin family member 5A
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
LIMD2 LIM domain containing 2
LOC257152 uncharacterized LOC257152
LTB lymphotoxin beta (TNF superfamily, member 3)
MLH3 mutL homolog 3
MRPS12 mitochondrial ribosomal protein S12
MT3 metallothionein 3
MTAP methylthioadenosine phosphorylase
MTSS1L metastasis suppressor 1-like
MVK mevalonate kinase
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYOZ1 myozenin 1
NEURL1 neuralized E3 ubiquitin protein ligase 1
NF1 neurofibromin 1
NINJ2 ninjurin 2
NPIPB3 nuclear pore complex interacting protein family, member B3
NRP1 neuropilin 1
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
PDE12 phosphodiesterase 12
PEX5L peroxisomal biogenesis factor 5-like
PHC3 polyhomeotic homolog 3 (Drosophila)
PLAC1 placenta-specific 1
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAD50 RAD50 homolog (S. cerevisiae)
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RNF19B ring finger protein 19B
RPH3A rabphilin 3A
RPL10 ribosomal protein L10
SIRT4 sirtuin 4
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLCO1A2 solute carrier organic anion transporter family, member 1A2
SOCS2 suppressor of cytokine signaling 2
SORBS2 sorbin and SH3 domain containing 2
SULT4A1 sulfotransferase family 4A, member 1
SYNGR1 synaptogyrin 1
SYT5 synaptotagmin V
TAPBP TAP binding protein (tapasin)
TNNT1 troponin T type 1 (skeletal, slow)
TPSD1 tryptase delta 1
TPST1 tyrosylprotein sulfotransferase 1
TRMT1 tRNA methyltransferase 1 homolog (S. cerevisiae)
TRO trophinin
TTN titin
ULK1 unc-51 like autophagy activating kinase 1
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VASH2 vasohibin 2
WDR78 WD repeat domain 78
WFDC2 WAP four-disulfide core domain 2
WSB1 WD repeat and SOCS box containing 1
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
YOD1 YOD1 deubiquitinase
ZNF510 zinc finger protein 510

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ADGRE5 adhesion G protein-coupled receptor E5
APOBR apolipoprotein B receptor
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
BAHCC1 BAH domain and coiled-coil containing 1
BCL2A1 BCL2-related protein A1
BCL2L2 BCL2-like 2
BPI bactericidal/permeability-increasing protein
BRMS1 breast cancer metastasis suppressor 1
C3 complement component 3
CASP7 caspase 7, apoptosis-related cysteine peptidase
CDA cytidine deaminase
CEP85 centrosomal protein 85kDa
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
CPPED1 calcineurin-like phosphoesterase domain containing 1
CSAD cysteine sulfinic acid decarboxylase
CSF1R colony stimulating factor 1 receptor
CXCR2 chemokine (C-X-C motif) receptor 2
CYSLTR1 cysteinyl leukotriene receptor 1
DAAM1 dishevelled associated activator of morphogenesis 1
DDHD2 DDHD domain containing 2
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DPY19L2P2 DPY19L2 pseudogene 2
DSE dermatan sulfate epimerase
EDC3 enhancer of mRNA decapping 3
EDEM2 ER degradation enhancer, mannosidase alpha-like 2
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative)
EXD2 exonuclease 3'-5' domain containing 2
F8 coagulation factor VIII, procoagulant component
FAM134B family with sequence similarity 134, member B
FHIT fragile histidine triad
GAB2 GRB2-associated binding protein 2
GALNS galactosamine (N-acetyl)-6-sulfatase
GDI1 GDP dissociation inhibitor 1
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPATCH3 G patch domain containing 3
GPS1 G protein pathway suppressor 1
GSTA4 glutathione S-transferase alpha 4
GTF2H2B general transcription factor IIH, polypeptide 2B (pseudogene)
HIST1H2AJ histone cluster 1, H2aj
IFT81 intraflagellar transport 81
KDM5C lysine (K)-specific demethylase 5C
KLF1 Kruppel-like factor 1 (erythroid)
KLF13 Kruppel-like factor 13
KLHL21 kelch-like family member 21
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
MAPK3 mitogen-activated protein kinase 3
MKLN1 muskelin 1, intracellular mediator containing kelch motifs
MTRF1 mitochondrial translational release factor 1
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NBEAL2 neurobeachin-like 2
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NPM3 nucleophosmin/nucleoplasmin 3
NT5M 5',3'-nucleotidase, mitochondrial
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PDZD8 PDZ domain containing 8
PEX13 peroxisomal biogenesis factor 13
PGM3 phosphoglucomutase 3
PLEKHO2 pleckstrin homology domain containing, family O member 2
PPARG peroxisome proliferator-activated receptor gamma
PWAR5 Prader Willi/Angelman region RNA 5
QTRT1 queuine tRNA-ribosyltransferase 1
RARS arginyl-tRNA synthetase
RHOC ras homolog family member C
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
S1PR4 sphingosine-1-phosphate receptor 4
SETD8 SET domain containing (lysine methyltransferase) 8
SLC35E3 solute carrier family 35, member E3
SMA4 glucuronidase, beta pseudogene
SNRPN small nuclear ribonucleoprotein polypeptide N
SP140L SP140 nuclear body protein-like
SRBD1 S1 RNA binding domain 1
STARD8 StAR-related lipid transfer (START) domain containing 8
SYNJ2BP synaptojanin 2 binding protein
THEM6 thioesterase superfamily member 6
TOMM34 translocase of outer mitochondrial membrane 34
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRAPPC13 trafficking protein particle complex 13
TRIM16 tripartite motif containing 16
TRIM68 tripartite motif containing 68
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TUBA3C tubulin, alpha 3c
TUBGCP5 tubulin, gamma complex associated protein 5
UFSP2 UFM1-specific peptidase 2
URGCP upregulator of cell proliferation
USF2 upstream transcription factor 2, c-fos interacting
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
WDR19 WD repeat domain 19
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
ZC3H12A zinc finger CCCH-type containing 12A
ZDHHC13 zinc finger, DHHC-type containing 13
ZNF16 zinc finger protein 16
ZNF222 zinc finger protein 222
ZNF280D zinc finger protein 280D
ZNF480 zinc finger protein 480
ZNF580 zinc finger protein 580