nitrofurantoin-2303 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the nitrofurantoin-2303 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
AHNAK2 AHNAK nucleoprotein 2
AKAP6 A kinase (PRKA) anchor protein 6
AP2S1 adaptor-related protein complex 2, sigma 1 subunit
APC adenomatous polyposis coli
ATAD5 ATPase family, AAA domain containing 5
ATP10A ATPase, class V, type 10A
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BEX1 brain expressed, X-linked 1
BTF3P11 basic transcription factor 3 pseudogene 11
C17ORF59 chromosome 17 open reading frame 59
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CAV2 caveolin 2
CAV3 caveolin 3
CD248 CD248 molecule, endosialin
CD58 CD58 molecule
CD82 CD82 molecule
CD86 CD86 molecule
CDC25A cell division cycle 25A
CDK6 cyclin-dependent kinase 6
CEP41 centrosomal protein 41kDa
CFLAR CASP8 and FADD-like apoptosis regulator
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric)
COL1A1 collagen, type I, alpha 1
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
DGAT1 diacylglycerol O-acyltransferase 1
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
DOK4 docking protein 4
EFNB3 ephrin-B3
ESR1 estrogen receptor 1
EYA4 EYA transcriptional coactivator and phosphatase 4
FHL1 four and a half LIM domains 1
GSTTP1 glutathione S-transferase theta pseudogene 1
GYG2 glycogenin 2
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
ICA1 islet cell autoantigen 1, 69kDa
IFI35 interferon-induced protein 35
IL23A interleukin 23, alpha subunit p19
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLRD1 killer cell lectin-like receptor subfamily D, member 1
KREMEN2 kringle containing transmembrane protein 2
LAMP1 lysosomal-associated membrane protein 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPT microtubule-associated protein tau
MEF2D myocyte enhancer factor 2D
MIER2 mesoderm induction early response 1, family member 2
MLXIP MLX interacting protein
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NAT6 N-acetyltransferase 6 (GCN5-related)
NCAN neurocan
NOX5 NADPH oxidase, EF-hand calcium binding domain 5
NPR3 natriuretic peptide receptor 3
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR6A1 nuclear receptor subfamily 6, group A, member 1
NRF1 nuclear respiratory factor 1
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
NXPE3 neurexophilin and PC-esterase domain family, member 3
OXCT2 3-oxoacid CoA transferase 2
PAPPA2 pappalysin 2
PARVA parvin, alpha
PCLO piccolo presynaptic cytomatrix protein
POLM polymerase (DNA directed), mu
POMT2 protein-O-mannosyltransferase 2
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PQLC2 PQ loop repeat containing 2
PRAME preferentially expressed antigen in melanoma
PRSS3 protease, serine, 3
PTHLH parathyroid hormone-like hormone
PTRF polymerase I and transcript release factor
RAB11B RAB11B, member RAS oncogene family
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAD54L2 RAD54-like 2 (S. cerevisiae)
RB1 retinoblastoma 1
RBFA ribosome binding factor A (putative)
RPS3A ribosomal protein S3A
RUNX1 runt-related transcription factor 1
S100A2 S100 calcium binding protein A2
SBNO2 strawberry notch homolog 2 (Drosophila)
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SLC45A2 solute carrier family 45, member 2
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1
SLC7A4 solute carrier family 7, member 4
SNCG synuclein, gamma (breast cancer-specific protein 1)
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
STAC SH3 and cysteine rich domain
THBD thrombomodulin
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM212 transmembrane protein 212
TPM2 tropomyosin 2 (beta)
TRIM29 tripartite motif containing 29
UPK1B uroplakin 1B
VPS13B vacuolar protein sorting 13 homolog B (yeast)
WNT1 wingless-type MMTV integration site family, member 1
XYLT1 xylosyltransferase I
ZFP64 ZFP64 zinc finger protein
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ADM adrenomedullin
ALPK1 alpha-kinase 1
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
C11ORF68 chromosome 11 open reading frame 68
C17ORF70 chromosome 17 open reading frame 70
C1ORF105 chromosome 1 open reading frame 105
C5AR2 complement component 5a receptor 2
C7ORF43 chromosome 7 open reading frame 43
CALCOCO1 calcium binding and coiled-coil domain 1
CAPN15 calpain 15
CBX8 chromobox homolog 8
CCDC186 coiled-coil domain containing 186
CDK3 cyclin-dependent kinase 3
CENPC centromere protein C
CHKB choline kinase beta
CIDEC cell death-inducing DFFA-like effector c
CLCN6 chloride channel, voltage-sensitive 6
CLDN15 claudin 15
CPPED1 calcineurin-like phosphoesterase domain containing 1
CUL9 cullin 9
CXORF56 chromosome X open reading frame 56
DEFA4 defensin, alpha 4, corticostatin
DOCK4 dedicator of cytokinesis 4
DOK2 docking protein 2, 56kDa
DPY19L1P1 DPY19L1 pseudogene 1
EHMT1 euchromatic histone-lysine N-methyltransferase 1
ERCC4 excision repair cross-complementation group 4
ERMAP erythroblast membrane-associated protein (Scianna blood group)
ERN2 endoplasmic reticulum to nucleus signaling 2
EXD3 exonuclease 3'-5' domain containing 3
FAM131A family with sequence similarity 131, member A
FKBP14 FK506 binding protein 14, 22 kDa
FOXC1 forkhead box C1
FPGS folylpolyglutamate synthase
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GINS4 GINS complex subunit 4 (Sld5 homolog)
GLS2 glutaminase 2 (liver, mitochondrial)
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GRB7 growth factor receptor-bound protein 7
GSTM5 glutathione S-transferase mu 5
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H1E histone cluster 1, H1e
HIST1H2BJ histone cluster 1, H2bj
HPS6 Hermansky-Pudlak syndrome 6
HYI hydroxypyruvate isomerase (putative)
IPO8 importin 8
IRF2BP1 interferon regulatory factor 2 binding protein 1
KCNK5 potassium channel, two pore domain subfamily K, member 5
KIF13A kinesin family member 13A
KIFC1 kinesin family member C1
KLHL25 kelch-like family member 25
LHX1 LIM homeobox 1
LIN7B lin-7 homolog B (C. elegans)
MEFV Mediterranean fever
MNX1 motor neuron and pancreas homeobox 1
NHEJ1 nonhomologous end-joining factor 1
NMU neuromedin U
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OSMR oncostatin M receptor
PAIP2B poly(A) binding protein interacting protein 2B
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLEKHO2 pleckstrin homology domain containing, family O member 2
PMP22 peripheral myelin protein 22
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PTDSS2 phosphatidylserine synthase 2
PTPRS protein tyrosine phosphatase, receptor type, S
RLN1 relaxin 1
RNF122 ring finger protein 122
RPAP1 RNA polymerase II associated protein 1
RPL23AP32 ribosomal protein L23a pseudogene 32
SAYSD1 SAYSVFN motif domain containing 1
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SMTN smoothelin
SNHG20 small nucleolar RNA host gene 20
SPINK5 serine peptidase inhibitor, Kazal type 5
STAB2 stabilin 2
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TBKBP1 TBK1 binding protein 1
TET3 tet methylcytosine dioxygenase 3
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TTC30A tetratricopeptide repeat domain 30A
VASH2 vasohibin 2
WDR76 WD repeat domain 76
XK X-linked Kx blood group
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZC3H12A zinc finger CCCH-type containing 12A
ZNF480 zinc finger protein 480
ZNF652 zinc finger protein 652
ZNF696 zinc finger protein 696
ZNF770 zinc finger protein 770