nitrendipine-6304 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the nitrendipine-6304 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
AATK apoptosis-associated tyrosine kinase
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ABI2 abl-interactor 2
ACE2 angiotensin I converting enzyme 2
ACSBG1 acyl-CoA synthetase bubblegum family member 1
ACSL5 acyl-CoA synthetase long-chain family member 5
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADCY9 adenylate cyclase 9
ALAD aminolevulinate dehydratase
ALG12 ALG12, alpha-1,6-mannosyltransferase
AMH anti-Mullerian hormone
ARMCX2 armadillo repeat containing, X-linked 2
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BCL2 B-cell CLL/lymphoma 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BTC betacellulin
C22ORF29 chromosome 22 open reading frame 29
CACFD1 calcium channel flower domain containing 1
CADM1 cell adhesion molecule 1
CALCR calcitonin receptor
CD4 CD4 molecule
CD8B CD8b molecule
CNR2 cannabinoid receptor 2 (macrophage)
DMTN dematin actin binding protein
EFR3B EFR3 homolog B (S. cerevisiae)
EML2 echinoderm microtubule associated protein like 2
ESR1 estrogen receptor 1
FGF5 fibroblast growth factor 5
FRMD1 FERM domain containing 1
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GAL galanin/GMAP prepropeptide
GIF gastric intrinsic factor (vitamin B synthesis)
GM2A GM2 ganglioside activator
GPRIN2 G protein regulated inducer of neurite outgrowth 2
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HMG20B high mobility group 20B
HPS1 Hermansky-Pudlak syndrome 1
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
IL6ST interleukin 6 signal transducer
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KIF1A kinesin family member 1A
KRT33A keratin 33A, type I
LMF1 lipase maturation factor 1
LPCAT4 lysophosphatidylcholine acyltransferase 4
LRRN2 leucine rich repeat neuronal 2
LYPD3 LY6/PLAUR domain containing 3
MAP3K9 mitogen-activated protein kinase kinase kinase 9
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
METTL16 methyltransferase like 16
MFGE8 milk fat globule-EGF factor 8 protein
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
MMP9 matrix metallopeptidase 9
MYL10 myosin, light chain 10, regulatory
NEK9 NIMA-related kinase 9
NNAT neuronatin
NT5M 5',3'-nucleotidase, mitochondrial
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OR10H1 olfactory receptor, family 10, subfamily H, member 1
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OR3A3 olfactory receptor, family 3, subfamily A, member 3
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDGFB platelet-derived growth factor beta polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PHLDB1 pleckstrin homology-like domain, family B, member 1
PICALM phosphatidylinositol binding clathrin assembly protein
PLEKHO1 pleckstrin homology domain containing, family O member 1
PLIN2 perilipin 2
PRDX2 peroxiredoxin 2
PRSS16 protease, serine, 16 (thymus)
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RAB28 RAB28, member RAS oncogene family
RPP25 ribonuclease P/MRP 25kDa subunit
SAMD9 sterile alpha motif domain containing 9
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SNX13 sorting nexin 13
SSX3 synovial sarcoma, X breakpoint 3
STXBP6 syntaxin binding protein 6 (amisyn)
SUSD5 sushi domain containing 5
TAOK2 TAO kinase 2
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TLE2 transducin-like enhancer of split 2
TMEM53 transmembrane protein 53
TMPRSS15 transmembrane protease, serine 15
TOP3A topoisomerase (DNA) III alpha
TPM1 tropomyosin 1 (alpha)
TROVE2 TROVE domain family, member 2
UBA7 ubiquitin-like modifier activating enzyme 7
UGCG UDP-glucose ceramide glucosyltransferase
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZNF292 zinc finger protein 292
ZNF440 zinc finger protein 440
ZNF79 zinc finger protein 79

decreased expression

Symbol Name
ACAD10 acyl-CoA dehydrogenase family, member 10
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
APLP1 amyloid beta (A4) precursor-like protein 1
ARID3B AT rich interactive domain 3B (BRIGHT-like)
BGLAP bone gamma-carboxyglutamate (gla) protein
C11ORF80 chromosome 11 open reading frame 80
C5 complement component 5
CAPN15 calpain 15
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CCS copper chaperone for superoxide dismutase
CDC37L1 cell division cycle 37-like 1
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDIP1 cell death-inducing p53 target 1
CNKSR1 connector enhancer of kinase suppressor of Ras 1
CNTNAP3B contactin associated protein-like 3B
CRYBA2 crystallin, beta A2
CTSK cathepsin K
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
DENND4A DENN/MADD domain containing 4A
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DTX4 deltex 4, E3 ubiquitin ligase
ERN2 endoplasmic reticulum to nucleus signaling 2
FA2H fatty acid 2-hydroxylase
FAM102A family with sequence similarity 102, member A
FAM50B family with sequence similarity 50, member B
FAN1 FANCD2/FANCI-associated nuclease 1
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FCHO1 FCH domain only 1
FEM1C fem-1 homolog c (C. elegans)
FOXN2 forkhead box N2
FSD1 fibronectin type III and SPRY domain containing 1
FUZ fuzzy planar cell polarity protein
GAL3ST4 galactose-3-O-sulfotransferase 4
GAMT guanidinoacetate N-methyltransferase
GDAP1 ganglioside induced differentiation associated protein 1
IDI2-AS1 IDI2 antisense RNA 1
IGFLR1 IGF-like family receptor 1
IGSF3 immunoglobulin superfamily, member 3
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
ITPKC inositol-trisphosphate 3-kinase C
JUNB jun B proto-oncogene
KIF20A kinesin family member 20A
KLHL12 kelch-like family member 12
LRP3 low density lipoprotein receptor-related protein 3
MAMLD1 mastermind-like domain containing 1
MANBA mannosidase, beta A, lysosomal
MN1 meningioma (disrupted in balanced translocation) 1
NMB neuromedin B
NRTN neurturin
NUPR1 nuclear protein, transcriptional regulator, 1
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PARPBP PARP1 binding protein
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PIEZO1 piezo-type mechanosensitive ion channel component 1
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PILRB paired immunoglobin-like type 2 receptor beta
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PNRC1 proline-rich nuclear receptor coactivator 1
PRPH peripherin
PRR7 proline rich 7 (synaptic)
PSKH1 protein serine kinase H1
PTGES2 prostaglandin E synthase 2
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
RAB4B RAB4B, member RAS oncogene family
RASA2 RAS p21 protein activator 2
RBM4B RNA binding motif protein 4B
RPL23AP32 ribosomal protein L23a pseudogene 32
SCPEP1 serine carboxypeptidase 1
SCUBE3 signal peptide, CUB domain, EGF-like 3
SDAD1 SDA1 domain containing 1
SETBP1 SET binding protein 1
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SLC10A3 solute carrier family 10, member 3
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SND1-IT1 SND1 intronic transcript 1
SP140L SP140 nuclear body protein-like
STIM1 stromal interaction molecule 1
STX1A syntaxin 1A (brain)
TAGLN3 transgelin 3
TGFB3 transforming growth factor, beta 3
TGS1 trimethylguanosine synthase 1
THBS3 thrombospondin 3
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TM6SF1 transmembrane 6 superfamily member 1
TNS2 tensin 2
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
ULK1 unc-51 like autophagy activating kinase 1
VWA1 von Willebrand factor A domain containing 1
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial
WDR41 WD repeat domain 41
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZFP36 ZFP36 ring finger protein
ZFP69B ZFP69 zinc finger protein B
ZNF197 zinc finger protein 197
ZNF350 zinc finger protein 350
ZNF385D zinc finger protein 385D
ZNF442 zinc finger protein 442
Funding