nisoxetine-6496 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the nisoxetine-6496 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ACO2 aconitase 2, mitochondrial
ACPP acid phosphatase, prostate
ALDOB aldolase B, fructose-bisphosphate
APOC4 apolipoprotein C-IV
BGN biglycan
C10ORF95 chromosome 10 open reading frame 95
CA5BP1 carbonic anhydrase VB pseudogene 1
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CAMK1 calcium/calmodulin-dependent protein kinase I
CD14 CD14 molecule
CDADC1 cytidine and dCMP deaminase domain containing 1
CIB2 calcium and integrin binding family member 2
CNOT4 CCR4-NOT transcription complex, subunit 4
DENND5B DENN/MADD domain containing 5B
DLEC1 deleted in lung and esophageal cancer 1
DLG5 discs, large homolog 5 (Drosophila)
DMP1 dentin matrix acidic phosphoprotein 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DOK4 docking protein 4
DSG3 desmoglein 3
DVL3 dishevelled segment polarity protein 3
EDNRA endothelin receptor type A
ELOVL5 ELOVL fatty acid elongase 5
EPHA1 EPH receptor A1
ETV5 ets variant 5
FABP3 fatty acid binding protein 3, muscle and heart
FABP7 fatty acid binding protein 7, brain
FAM134B family with sequence similarity 134, member B
FBLN1 fibulin 1
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FPR1 formyl peptide receptor 1
FRS2 fibroblast growth factor receptor substrate 2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GID4 GID complex subunit 4
GJA8 gap junction protein, alpha 8, 50kDa
GK glycerol kinase
GNRHR gonadotropin-releasing hormone receptor
GPR37L1 G protein-coupled receptor 37 like 1
HCRP1 hepatocellular carcinoma-related HCRP1
HMHB1 histocompatibility (minor) HB-1
HP1BP3 heterochromatin protein 1, binding protein 3
HR hair growth associated
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL11 interleukin 11
INO80B INO80 complex subunit B
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
KATNB1 katanin p80 (WD repeat containing) subunit B 1
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KIF25 kinesin family member 25
LAMA4 laminin, alpha 4
LONRF3 LON peptidase N-terminal domain and ring finger 3
LOX lysyl oxidase
MAN2A2 mannosidase, alpha, class 2A, member 2
MBD2 methyl-CpG binding domain protein 2
MTMR8 myotubularin related protein 8
MUC6 mucin 6, oligomeric mucus/gel-forming
MVK mevalonate kinase
NEUROD1 neuronal differentiation 1
OR12D3 olfactory receptor, family 12, subfamily D, member 3
PARD3 par-3 family cell polarity regulator
PDE4DIP phosphodiesterase 4D interacting protein
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PEG10 paternally expressed 10
PPP5C protein phosphatase 5, catalytic subunit
PTPRU protein tyrosine phosphatase, receptor type, U
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RCAN1 regulator of calcineurin 1
RGS14 regulator of G-protein signaling 14
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
RUSC2 RUN and SH3 domain containing 2
SAMD9 sterile alpha motif domain containing 9
SIRT4 sirtuin 4
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SMAD3 SMAD family member 3
STK3 serine/threonine kinase 3
STX7 syntaxin 7
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
TAPBP TAP binding protein (tapasin)
TBC1D19 TBC1 domain family, member 19
TBCD tubulin folding cofactor D
TCP10L t-complex 10-like
TLR8 toll-like receptor 8
TONSL tonsoku-like, DNA repair protein
TPMT thiopurine S-methyltransferase
TRBC1 T cell receptor beta constant 1
TRIM2 tripartite motif containing 2
UNC5B unc-5 homolog B (C. elegans)
UTRN utrophin
VCAN versican
WDR91 WD repeat domain 91
WHSC1 Wolf-Hirschhorn syndrome candidate 1
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF318 zinc finger protein 318

decreased expression

Symbol Name
ADAP2 ArfGAP with dual PH domains 2
ADTRP androgen-dependent TFPI-regulating protein
AGO1 argonaute RISC catalytic component 1
ANKZF1 ankyrin repeat and zinc finger domain containing 1
APLP1 amyloid beta (A4) precursor-like protein 1
BAHD1 bromo adjacent homology domain containing 1
BCAS1 breast carcinoma amplified sequence 1
C16ORF58 chromosome 16 open reading frame 58
C2ORF27A chromosome 2 open reading frame 27A
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CAMKMT calmodulin-lysine N-methyltransferase
CDH10 cadherin 10, type 2 (T2-cadherin)
CDON cell adhesion associated, oncogene regulated
CEL carboxyl ester lipase
CEP85 centrosomal protein 85kDa
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3
CINP cyclin-dependent kinase 2 interacting protein
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DCAF13 DDB1 and CUL4 associated factor 13
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DYSF dysferlin
EDAR ectodysplasin A receptor
EMID1 EMI domain containing 1
ERN2 endoplasmic reticulum to nucleus signaling 2
ERO1L ERO1-like (S. cerevisiae)
FAM120C family with sequence similarity 120C
FGL1 fibrinogen-like 1
GATA4 GATA binding protein 4
GEMIN8 gem (nuclear organelle) associated protein 8
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GRTP1 growth hormone regulated TBC protein 1
GUSBP3 glucuronidase, beta pseudogene 3
HIRA histone cell cycle regulator
HIST1H1B histone cluster 1, H1b
HIST1H2AM histone cluster 1, H2am
HIST1H4A histone cluster 1, H4a
HMOX1 heme oxygenase 1
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2
HYI hydroxypyruvate isomerase (putative)
KLHL25 kelch-like family member 25
LENEP lens epithelial protein
LIME1 Lck interacting transmembrane adaptor 1
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MBTPS2 membrane-bound transcription factor peptidase, site 2
METTL16 methyltransferase like 16
MTHFSD methenyltetrahydrofolate synthetase domain containing
MYO1F myosin IF
NFS1 NFS1 cysteine desulfurase
NPFFR1 neuropeptide FF receptor 1
ONECUT2 one cut homeobox 2
PARP12 poly (ADP-ribose) polymerase family, member 12
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDGFD platelet derived growth factor D
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PECR peroxisomal trans-2-enoyl-CoA reductase
PER3 period circadian clock 3
PHACTR4 phosphatase and actin regulator 4
PLAT plasminogen activator, tissue
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RHBG Rh family, B glycoprotein (gene/pseudogene)
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF126P1 ring finger protein 126 pseudogene 1
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RPL10L ribosomal protein L10-like
RUNDC3B RUN domain containing 3B
SARS2 seryl-tRNA synthetase 2, mitochondrial
SCYL2 SCY1-like 2 (S. cerevisiae)
SECTM1 secreted and transmembrane 1
SH2D4A SH2 domain containing 4A
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
TAGLN transgelin
TDRD7 tudor domain containing 7
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TIGD6 tigger transposable element derived 6
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TTBK2 tau tubulin kinase 2
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
UBXN6 UBX domain protein 6
UNC119 unc-119 homolog (C. elegans)
UNC93B1 unc-93 homolog B1 (C. elegans)
VIM vimentin
ZBED1 zinc finger, BED-type containing 1
ZNF428 zinc finger protein 428
ZNF747 zinc finger protein 747
ZSWIM1 zinc finger, SWIM-type containing 1