niridazole-4621 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the niridazole-4621 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AASS aminoadipate-semialdehyde synthase
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ACAN aggrecan
ADAM8 ADAM metallopeptidase domain 8
AKR1C2 aldo-keto reductase family 1, member C2
ANKRD6 ankyrin repeat domain 6
ARC activity-regulated cytoskeleton-associated protein
ARL2BP ADP-ribosylation factor-like 2 binding protein
BGN biglycan
CA5B carbonic anhydrase VB, mitochondrial
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit
CCDC7 coiled-coil domain containing 7
CDK3 cyclin-dependent kinase 3
CENPO centromere protein O
CREBZF CREB/ATF bZIP transcription factor
DICER1 dicer 1, ribonuclease type III
DOCK5 dedicator of cytokinesis 5
DRP2 dystrophin related protein 2
EDNRA endothelin receptor type A
ENOX2 ecto-NOX disulfide-thiol exchanger 2
ERAP1 endoplasmic reticulum aminopeptidase 1
ESR1 estrogen receptor 1
FAM198B family with sequence similarity 198, member B
FKBP10 FK506 binding protein 10, 65 kDa
FLT3LG fms-related tyrosine kinase 3 ligand
FLT4 fms-related tyrosine kinase 4
GAL3ST4 galactose-3-O-sulfotransferase 4
GNAT1 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GPR45 G protein-coupled receptor 45
GRB7 growth factor receptor-bound protein 7
GRM2 glutamate receptor, metabotropic 2
GUCY1A2 guanylate cyclase 1, soluble, alpha 2
GULP1 GULP, engulfment adaptor PTB domain containing 1
GYG2 glycogenin 2
GZMK granzyme K (granzyme 3; tryptase II)
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4
HIC2 hypermethylated in cancer 2
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DOA major histocompatibility complex, class II, DO alpha
HRASLS HRAS-like suppressor
IL18R1 interleukin 18 receptor 1
IL2 interleukin 2
IMPG1 interphotoreceptor matrix proteoglycan 1
INCENP inner centromere protein antigens 135/155kDa
KIF1C kinesin family member 1C
KIF25-AS1 KIF25 antisense RNA 1
KLHL23 kelch-like family member 23
LPAR4 lysophosphatidic acid receptor 4
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAGEA11 melanoma antigen family A11
MFAP5 microfibrillar associated protein 5
MOCS1 molybdenum cofactor synthesis 1
MST1 macrophage stimulating 1
MUC2 mucin 2, oligomeric mucus/gel-forming
MYF5 myogenic factor 5
NCOA2 nuclear receptor coactivator 2
NIPAL2 NIPA-like domain containing 2
NR0B2 nuclear receptor subfamily 0, group B, member 2
NRG1 neuregulin 1
NUP88 nucleoporin 88kDa
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PAX2 paired box 2
PCDH11Y protocadherin 11 Y-linked
PDE4DIP phosphodiesterase 4D interacting protein
PDGFB platelet-derived growth factor beta polypeptide
PHLDB1 pleckstrin homology-like domain, family B, member 1
PLBD1 phospholipase B domain containing 1
PLEKHO1 pleckstrin homology domain containing, family O member 1
PMFBP1 polyamine modulated factor 1 binding protein 1
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRB1 proline-rich protein BstNI subfamily 1
PRMT2 protein arginine methyltransferase 2
PRO2964 uncharacterized protein PRO2964
PTPRF protein tyrosine phosphatase, receptor type, F
SAMD4A sterile alpha motif domain containing 4A
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium)
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
SPTBN1 spectrin, beta, non-erythrocytic 1
STXBP6 syntaxin binding protein 6 (amisyn)
SYNPO2L synaptopodin 2-like
TAOK1 TAO kinase 1
TLE4 transducin-like enhancer of split 4
TLX3 T-cell leukemia homeobox 3
TMEM144 transmembrane protein 144
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1
TRIM48 tripartite motif containing 48
UCN urocortin
VGF VGF nerve growth factor inducible
VIPR2 vasoactive intestinal peptide receptor 2
WT1 Wilms tumor 1
ZIC3 Zic family member 3
ZNF440 zinc finger protein 440

decreased expression

Symbol Name
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABHD17B abhydrolase domain containing 17B
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ACKR3 atypical chemokine receptor 3
AFAP1 actin filament associated protein 1
AP1AR adaptor-related protein complex 1 associated regulatory protein
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ASTN1 astrotactin 1
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C1ORF105 chromosome 1 open reading frame 105
C1ORF35 chromosome 1 open reading frame 35
C5ORF45 chromosome 5 open reading frame 45
CADPS2 Ca++-dependent secretion activator 2
CBX8 chromobox homolog 8
CISH cytokine inducible SH2-containing protein
CLDN15 claudin 15
CLSPN claspin
CNN2 calponin 2
CNR2 cannabinoid receptor 2 (macrophage)
COL9A3 collagen, type IX, alpha 3
CPNE7 copine VII
CRYBB2P1 crystallin, beta B2 pseudogene 1
DBR1 debranching RNA lariats 1
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
ECE1 endothelin converting enzyme 1
ERCC2 excision repair cross-complementation group 2
ETNK2 ethanolamine kinase 2
EYA3 EYA transcriptional coactivator and phosphatase 3
FAIM Fas apoptotic inhibitory molecule
FAM110B family with sequence similarity 110, member B
FAM114A2 family with sequence similarity 114, member A2
FAM131B family with sequence similarity 131, member B
FAM206A family with sequence similarity 206, member A
FAM50B family with sequence similarity 50, member B
FANCE Fanconi anemia, complementation group E
FAT4 FAT atypical cadherin 4
FBRS fibrosin
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FGGY FGGY carbohydrate kinase domain containing
FILIP1L filamin A interacting protein 1-like
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GLS2 glutaminase 2 (liver, mitochondrial)
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GPR137B G protein-coupled receptor 137B
GSTA3 glutathione S-transferase alpha 3
HIST1H2AL histone cluster 1, H2al
HIST2H2AA3 histone cluster 2, H2aa3
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFNAR1 interferon (alpha, beta and omega) receptor 1
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
KDM8 lysine (K)-specific demethylase 8
KIAA0922 KIAA0922
KRT31 keratin 31, type I
LIG4 ligase IV, DNA, ATP-dependent
LINC00597 long intergenic non-protein coding RNA 597
MED31 mediator complex subunit 31
MFSD6 major facilitator superfamily domain containing 6
MX1 MX dynamin-like GTPase 1
MYLIP myosin regulatory light chain interacting protein
MYLK myosin light chain kinase
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NMB neuromedin B
NSUN6 NOP2/Sun domain family, member 6
NTF3 neurotrophin 3
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13
NXPH4 neurexophilin 4
OLFM4 olfactomedin 4
OSR2 odd-skipped related transciption factor 2
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PDE8B phosphodiesterase 8B
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PMM1 phosphomannomutase 1
PRM2 protamine 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIBC2 RIB43A domain with coiled-coils 2
RWDD3 RWD domain containing 3
SCRN3 secernin 3
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC22A1 solute carrier family 22 (organic cation transporter), member 1
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
STAG3L4 stromal antigen 3-like 4 (pseudogene)
SYNGR3 synaptogyrin 3
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TBC1D8B TBC1 domain family, member 8B (with GRAM domain)
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae)
TSNAXIP1 translin-associated factor X interacting protein 1
UBQLN4 ubiquilin 4
ZNF208 zinc finger protein 208
ZNF227 zinc finger protein 227
ZNF253 zinc finger protein 253
ZNF254 zinc finger protein 254
ZNF286A zinc finger protein 286A
ZNF33B zinc finger protein 33B
ZNF571 zinc finger protein 571