nipecotic acid-5999 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the nipecotic acid-5999 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAMDC adipogenesis associated, Mth938 domain containing
ADCY2 adenylate cyclase 2 (brain)
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
AMPH amphiphysin
AOX1 aldehyde oxidase 1
BCL2L10 BCL2-like 10 (apoptosis facilitator)
C11ORF1 chromosome 11 open reading frame 1
C21ORF2 chromosome 21 open reading frame 2
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CASR calcium-sensing receptor
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CD22 CD22 molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CD53 CD53 molecule
CD58 CD58 molecule
CDH10 cadherin 10, type 2 (T2-cadherin)
CDRT1 CMT1A duplicated region transcript 1
CEP164 centrosomal protein 164kDa
CNPY4 canopy FGF signaling regulator 4
COPG2IT1 COPG2 imprinted transcript 1 (non-protein coding)
CRMP1 collapsin response mediator protein 1
CXORF21 chromosome X open reading frame 21
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DMBT1 deleted in malignant brain tumors 1
DOCK9 dedicator of cytokinesis 9
DOK4 docking protein 4
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
EDNRA endothelin receptor type A
EGFR epidermal growth factor receptor
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EPHB2 EPH receptor B2
EXOSC1 exosome component 1
FN1 fibronectin 1
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPATCH4 G patch domain containing 4
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
HBEGF heparin-binding EGF-like growth factor
HBS1L HBS1-like translational GTPase
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2
HOXC5 homeobox C5
IAPP islet amyloid polypeptide
ING2 inhibitor of growth family, member 2
IRS2 insulin receptor substrate 2
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KCNIP1 Kv channel interacting protein 1
KCNIP2 Kv channel interacting protein 2
LGALS2 lectin, galactoside-binding, soluble, 2
LOC644450 uncharacterized LOC644450
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MLXIP MLX interacting protein
MST1L macrophage stimulating 1-like
MX1 MX dynamin-like GTPase 1
MYOZ1 myozenin 1
N4BP3 NEDD4 binding protein 3
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NMT2 N-myristoyltransferase 2
NRF1 nuclear respiratory factor 1
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDLIM5 PDZ and LIM domain 5
PEX3 peroxisomal biogenesis factor 3
PLAU plasminogen activator, urokinase
PML promyelocytic leukemia
PPP1R3A protein phosphatase 1, regulatory subunit 3A
PRDM2 PR domain containing 2, with ZNF domain
PRKCI protein kinase C, iota
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RPL35A ribosomal protein L35a
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SFRP5 secreted frizzled-related protein 5
SH3BP2 SH3-domain binding protein 2
SIPA1 signal-induced proliferation-associated 1
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
SOCS7 suppressor of cytokine signaling 7
SSTR2 somatostatin receptor 2
STOM stomatin
STS steroid sulfatase (microsomal), isozyme S
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TBXA2R thromboxane A2 receptor
TLR8 toll-like receptor 8
TM4SF1 transmembrane 4 L six family member 1
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TRIM10 tripartite motif containing 10
TTC38 tetratricopeptide repeat domain 38
UBE3A ubiquitin protein ligase E3A
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VPS9D1 VPS9 domain containing 1
WLS wntless Wnt ligand secretion mediator
ZER1 zyg-11 related, cell cycle regulator
ZNF507 zinc finger protein 507

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACSL4 acyl-CoA synthetase long-chain family member 4
AMH anti-Mullerian hormone
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARRB1 arrestin, beta 1
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATP7B ATPase, Cu++ transporting, beta polypeptide
BCAS1 breast carcinoma amplified sequence 1
BPGM 2,3-bisphosphoglycerate mutase
C14ORF93 chromosome 14 open reading frame 93
C17ORF70 chromosome 17 open reading frame 70
C5AR2 complement component 5a receptor 2
CBX8 chromobox homolog 8
CCDC25 coiled-coil domain containing 25
CCDC9 coiled-coil domain containing 9
CD82 CD82 molecule
CDON cell adhesion associated, oncogene regulated
CFD complement factor D (adipsin)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHRM3 cholinergic receptor, muscarinic 3
CIC capicua transcriptional repressor
CIDEB cell death-inducing DFFA-like effector b
CINP cyclin-dependent kinase 2 interacting protein
CNN2 calponin 2
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13
EFNA3 ephrin-A3
FAM118A family with sequence similarity 118, member A
FBXO22 F-box protein 22
GFPT2 glutamine-fructose-6-phosphate transaminase 2
HINFP histone H4 transcription factor
HIRA histone cell cycle regulator
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
ISG15 ISG15 ubiquitin-like modifier
ITPKB inositol-trisphosphate 3-kinase B
JMJD4 jumonji domain containing 4
KIAA0319L KIAA0319-like
KIF16B kinesin family member 16B
KLF11 Kruppel-like factor 11
LMNB1 lamin B1
LRP5L low density lipoprotein receptor-related protein 5-like
LRRC23 leucine rich repeat containing 23
LRRC37A2 leucine rich repeat containing 37, member A2
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAN2C1 mannosidase, alpha, class 2C, member 1
MANBA mannosidase, beta A, lysosomal
MAP1S microtubule-associated protein 1S
MBOAT2 membrane bound O-acyltransferase domain containing 2
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MSL3 male-specific lethal 3 homolog (Drosophila)
MTERF1 mitochondrial transcription termination factor 1
NDE1 nudE neurodevelopment protein 1
NPFFR1 neuropeptide FF receptor 1
NUPL2 nucleoporin like 2
OSMR oncostatin M receptor
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PCDHA5 protocadherin alpha 5
PDE8B phosphodiesterase 8B
PHC1 polyhomeotic homolog 1 (Drosophila)
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLEKHA6 pleckstrin homology domain containing, family A member 6
POLI polymerase (DNA directed) iota
PRMT7 protein arginine methyltransferase 7
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
RBL1 retinoblastoma-like 1
RNF31 ring finger protein 31
RPGR retinitis pigmentosa GTPase regulator
SCN1B sodium channel, voltage gated, type I beta subunit
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC35F5 solute carrier family 35, member F5
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SND1-IT1 SND1 intronic transcript 1
SPRYD7 SPRY domain containing 7
TBC1D17 TBC1 domain family, member 17
THBS3 thrombospondin 3
TMEM121 transmembrane protein 121
TRAPPC13 trafficking protein particle complex 13
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae)
TTBK2 tau tubulin kinase 2
TTC30A tetratricopeptide repeat domain 30A
TUBA3C tubulin, alpha 3c
ULBP2 UL16 binding protein 2
UNC119 unc-119 homolog (C. elegans)
USP20 ubiquitin specific peptidase 20
XK X-linked Kx blood group
ZNF134 zinc finger protein 134
ZNF136 zinc finger protein 136
ZNF205 zinc finger protein 205
ZNF227 zinc finger protein 227
ZNF329 zinc finger protein 329
ZNF365 zinc finger protein 365
ZNF606 zinc finger protein 606
ZNF778 zinc finger protein 778
ZNF862 zinc finger protein 862