nipecotic acid-3121 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the nipecotic acid-3121 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADRA1A adrenoceptor alpha 1A
AFF4 AF4/FMR2 family, member 4
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
AMPH amphiphysin
ARSE arylsulfatase E (chondrodysplasia punctata 1)
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
ATXN2L ataxin 2-like
BCAS3 breast carcinoma amplified sequence 3
BLZF1 basic leucine zipper nuclear factor 1
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CACNB2 calcium channel, voltage-dependent, beta 2 subunit
CASZ1 castor zinc finger 1
CCL7 chemokine (C-C motif) ligand 7
CD47 CD47 molecule
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3
CHAT choline O-acetyltransferase
CNTNAP2 contactin associated protein-like 2
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CXCL3 chemokine (C-X-C motif) ligand 3
DHRS7 dehydrogenase/reductase (SDR family) member 7
DIRAS3 DIRAS family, GTP-binding RAS-like 3
DKK1 dickkopf WNT signaling pathway inhibitor 1
DMP1 dentin matrix acidic phosphoprotein 1
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)
EXPH5 exophilin 5
EZR ezrin
F12 coagulation factor XII (Hageman factor)
FADS3 fatty acid desaturase 3
FGL1 fibrinogen-like 1
FRMPD1 FERM and PDZ domain containing 1
FXYD2 FXYD domain containing ion transport regulator 2
GADD45G growth arrest and DNA-damage-inducible, gamma
GPR132 G protein-coupled receptor 132
GPR15 G protein-coupled receptor 15
GPR22 G protein-coupled receptor 22
GRSF1 G-rich RNA sequence binding factor 1
HIST1H4E histone cluster 1, H4e
IKZF4 IKAROS family zinc finger 4 (Eos)
IL3RA interleukin 3 receptor, alpha (low affinity)
IRF4 interferon regulatory factor 4
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCNK1 potassium channel, two pore domain subfamily K, member 1
LAMC2 laminin, gamma 2
LEF1 lymphoid enhancer-binding factor 1
LHFPL2 lipoma HMGIC fusion partner-like 2
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYRM9 LYR motif containing 9
MAGEA5 melanoma antigen family A5
MAL mal, T-cell differentiation protein
MAP4 microtubule-associated protein 4
MAP6D1 MAP6 domain containing 1
MLN motilin
MPPE1 metallophosphoesterase 1
MXD1 MAX dimerization protein 1
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NTNG1 netrin G1
OR10H1 olfactory receptor, family 10, subfamily H, member 1
PALLD palladin, cytoskeletal associated protein
PCDH11Y protocadherin 11 Y-linked
PDE4DIP phosphodiesterase 4D interacting protein
PDGFB platelet-derived growth factor beta polypeptide
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PGK1 phosphoglycerate kinase 1
PLAC1 placenta-specific 1
PRKCA protein kinase C, alpha
PTCRA pre T-cell antigen receptor alpha
PTPN12 protein tyrosine phosphatase, non-receptor type 12
QSER1 glutamine and serine rich 1
RCN3 reticulocalbin 3, EF-hand calcium binding domain
RPLP2 ribosomal protein, large, P2
RSU1 Ras suppressor protein 1
RTEL1 regulator of telomere elongation helicase 1
SCAND2P SCAN domain containing 2 pseudogene
SCHIP1 schwannomin interacting protein 1
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SPRR2B small proline-rich protein 2B
SRPK2 SRSF protein kinase 2
SRR serine racemase
STK38 serine/threonine kinase 38
SYT2 synaptotagmin II
TACSTD2 tumor-associated calcium signal transducer 2
TMEM30B transmembrane protein 30B
TNP2 transition protein 2 (during histone to protamine replacement)
TTLL3 tubulin tyrosine ligase-like family member 3
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
WSCD1 WSC domain containing 1
YIPF2 Yip1 domain family, member 2
ZBTB18 zinc finger and BTB domain containing 18
ZC3H7B zinc finger CCCH-type containing 7B
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ACOX2 acyl-CoA oxidase 2, branched chain
AKTIP AKT interacting protein
AMIGO2 adhesion molecule with Ig-like domain 2
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRMS1 breast cancer metastasis suppressor 1
C1QTNF3 C1q and tumor necrosis factor related protein 3
CAMK4 calcium/calmodulin-dependent protein kinase IV
CD3D CD3d molecule, delta (CD3-TCR complex)
CD70 CD70 molecule
CHPF chondroitin polymerizing factor
CLSPN claspin
CORT cortistatin
CSF3R colony stimulating factor 3 receptor (granulocyte)
CTAGE9 CTAGE family, member 9
CTSV cathepsin V
DCAF13 DDB1 and CUL4 associated factor 13
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DFNA5 deafness, autosomal dominant 5
DGKG diacylglycerol kinase, gamma 90kDa
DNMBP dynamin binding protein
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FGF22 fibroblast growth factor 22
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPR19 G protein-coupled receptor 19
GRAMD1B GRAM domain containing 1B
GSTA4 glutathione S-transferase alpha 4
HIRA histone cell cycle regulator
HIST1H1B histone cluster 1, H1b
HIST1H3G histone cluster 1, H3g
HRAS Harvey rat sarcoma viral oncogene homolog
HYAL2 hyaluronoglucosaminidase 2
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV1-44 immunoglobulin lambda variable 1-44
IPO4 importin 4
JAM2 junctional adhesion molecule 2
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KDM5C lysine (K)-specific demethylase 5C
KLHL26 kelch-like family member 26
KLRG1 killer cell lectin-like receptor subfamily G, member 1
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAGEB2 melanoma antigen family B2
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAPK3 mitogen-activated protein kinase 3
MB myoglobin
MFSD6 major facilitator superfamily domain containing 6
MLPH melanophilin
MTMR12 myotubularin related protein 12
NAG18 NAG18 mRNA
NBEAL2 neurobeachin-like 2
NFS1 NFS1 cysteine desulfurase
NPDC1 neural proliferation, differentiation and control, 1
OXTR oxytocin receptor
PCSK7 proprotein convertase subtilisin/kexin type 7
PDE12 phosphodiesterase 12
PHC1 polyhomeotic homolog 1 (Drosophila)
PIEZO1 piezo-type mechanosensitive ion channel component 1
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
POLR1B polymerase (RNA) I polypeptide B, 128kDa
POR P450 (cytochrome) oxidoreductase
PPDPF pancreatic progenitor cell differentiation and proliferation factor
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PRDM1 PR domain containing 1, with ZNF domain
PYGB phosphorylase, glycogen; brain
RNF31 ring finger protein 31
RPL23AP7 ribosomal protein L23a pseudogene 7
RPP25 ribonuclease P/MRP 25kDa subunit
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
RRP1 ribosomal RNA processing 1
SAP30L SAP30-like
SCN10A sodium channel, voltage gated, type X alpha subunit
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae)
SFT2D2 SFT2 domain containing 2
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SMR3A submaxillary gland androgen regulated protein 3A
SP140 SP140 nuclear body protein
SPAG1 sperm associated antigen 1
SPON2 spondin 2, extracellular matrix protein
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STBD1 starch binding domain 1
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae)
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
TESK1 testis-specific kinase 1
TMEM120B transmembrane protein 120B
TMEM134 transmembrane protein 134
TRABD TraB domain containing
TRAF1 TNF receptor-associated factor 1
TUBB2A tubulin, beta 2A class IIa
WDR91 WD repeat domain 91
YOD1 YOD1 deubiquitinase
ZNF215 zinc finger protein 215
ZNF286A zinc finger protein 286A
ZNF580 zinc finger protein 580
ZNF623 zinc finger protein 623
ZNF862 zinc finger protein 862