nifurtimox-7328 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the nifurtimox-7328 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACVR1B activin A receptor, type IB
ADAM22 ADAM metallopeptidase domain 22
ADAP1 ArfGAP with dual PH domains 1
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
B9D2 B9 protein domain 2
BBS9 Bardet-Biedl syndrome 9
BICD1 bicaudal D homolog 1 (Drosophila)
BRSK2 BR serine/threonine kinase 2
C11ORF63 chromosome 11 open reading frame 63
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CCDC186 coiled-coil domain containing 186
CDC25C cell division cycle 25C
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1
E2F4 E2F transcription factor 4, p107/p130-binding
EEA1 early endosome antigen 1
EFNA3 ephrin-A3
EGFL7 EGF-like-domain, multiple 7
FADS3 fatty acid desaturase 3
FAM65A family with sequence similarity 65, member A
FGFR4 fibroblast growth factor receptor 4
FST follistatin
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GOLGA2 golgin A2
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
HFE hemochromatosis
HIPK2 homeodomain interacting protein kinase 2
HLA-C major histocompatibility complex, class I, C
HNMT histamine N-methyltransferase
HOXA4 homeobox A4
HOXC5 homeobox C5
IFI35 interferon-induced protein 35
IGFALS insulin-like growth factor binding protein, acid labile subunit
IPP intracisternal A particle-promoted polypeptide
IQCG IQ motif containing G
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1
KCTD17 potassium channel tetramerization domain containing 17
KLK2 kallikrein-related peptidase 2
LOC257152 uncharacterized LOC257152
LPCAT4 lysophosphatidylcholine acyltransferase 4
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K
MAP2K5 mitogen-activated protein kinase kinase 5
MARK4 MAP/microtubule affinity-regulating kinase 4
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MOCS1 molybdenum cofactor synthesis 1
MTA1 metastasis associated 1
MTMR8 myotubularin related protein 8
MYO1B myosin IB
NCAPH2 non-SMC condensin II complex, subunit H2
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
PDK3 pyruvate dehydrogenase kinase, isozyme 3
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLXNA3 plexin A3
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PXN paxillin
RAB11B RAB11B, member RAS oncogene family
RGS12 regulator of G-protein signaling 12
RHOBTB2 Rho-related BTB domain containing 2
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
RUNX1 runt-related transcription factor 1
SASH1 SAM and SH3 domain containing 1
SBF1 SET binding factor 1
SCAPER S-phase cyclin A-associated protein in the ER
SEC24D SEC24 family member D
SENP7 SUMO1/sentrin specific peptidase 7
SH3BP2 SH3-domain binding protein 2
SHANK2 SH3 and multiple ankyrin repeat domains 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SMC1A structural maintenance of chromosomes 1A
SRI sorcin
SSX3 synovial sarcoma, X breakpoint 3
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
STMN1 stathmin 1
TADA3 transcriptional adaptor 3
TET3 tet methylcytosine dioxygenase 3
TIMP3 TIMP metallopeptidase inhibitor 3
TMLHE trimethyllysine hydroxylase, epsilon
TMOD1 tropomodulin 1
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNK1 tyrosine kinase, non-receptor, 1
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TRPV6 transient receptor potential cation channel, subfamily V, member 6
ULK2 unc-51 like autophagy activating kinase 2
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)
USP20 ubiquitin specific peptidase 20
UTRN utrophin
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
ZFHX4 zinc finger homeobox 4
ZNF223 zinc finger protein 223
ZNF224 zinc finger protein 224
ZNF440 zinc finger protein 440
ZNF532 zinc finger protein 532
ZNF74 zinc finger protein 74

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ANXA2P3 annexin A2 pseudogene 3
APH1B APH1B gamma secretase subunit
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
C14ORF93 chromosome 14 open reading frame 93
C16ORF45 chromosome 16 open reading frame 45
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CCDC25 coiled-coil domain containing 25
CENPQ centromere protein Q
CLDN15 claudin 15
CLK3 CDC-like kinase 3
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CUEDC1 CUE domain containing 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DNALI1 dynein, axonemal, light intermediate chain 1
EDC3 enhancer of mRNA decapping 3
ELOVL4 ELOVL fatty acid elongase 4
EXD3 exonuclease 3'-5' domain containing 3
F3 coagulation factor III (thromboplastin, tissue factor)
FANCE Fanconi anemia, complementation group E
FBRS fibrosin
FBXO31 F-box protein 31
FLJ11710 uncharacterized protein FLJ11710
FLJ22184
FRS2 fibroblast growth factor receptor substrate 2
FSCN1 fascin actin-bundling protein 1
GBP2 guanylate binding protein 2, interferon-inducible
GNA12 guanine nucleotide binding protein (G protein) alpha 12
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GPATCH2L G patch domain containing 2-like
HIST1H1D histone cluster 1, H1d
IFI6 interferon, alpha-inducible protein 6
IL4R interleukin 4 receptor
IPO8 importin 8
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
KCTD20 potassium channel tetramerization domain containing 20
LAMA3 laminin, alpha 3
LAMB3 laminin, beta 3
LIN7A lin-7 homolog A (C. elegans)
LINS lines homolog (Drosophila)
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MBTPS2 membrane-bound transcription factor peptidase, site 2
MCC mutated in colorectal cancers
MED4 mediator complex subunit 4
MPG N-methylpurine-DNA glycosylase
MRPL44 mitochondrial ribosomal protein L44
MTERF4 mitochondrial transcription termination factor 4
MTHFSD methenyltetrahydrofolate synthetase domain containing
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
MYO1E myosin IE
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NIPAL2 NIPA-like domain containing 2
NLRX1 NLR family member X1
NRSN2 neurensin 2
NT5DC3 5'-nucleotidase domain containing 3
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
POLR1E polymerase (RNA) I polypeptide E, 53kDa
R3HCC1L R3H domain and coiled-coil containing 1-like
RABEP1 rabaptin, RAB GTPase binding effector protein 1
RPAP2 RNA polymerase II associated protein 2
SDC3 syndecan 3
SETD8 SET domain containing (lysine methyltransferase) 8
SIRT2 sirtuin 2
SKA1 spindle and kinetochore associated complex subunit 1
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SPINK4 serine peptidase inhibitor, Kazal type 4
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STARD13 StAR-related lipid transfer (START) domain containing 13
STARD5 StAR-related lipid transfer (START) domain containing 5
TAOK1 TAO kinase 1
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TCTN2 tectonic family member 2
TMCC2 transmembrane and coiled-coil domain family 2
TMEM183A transmembrane protein 183A
TRAIP TRAF interacting protein
TRIM25 tripartite motif containing 25
TRIM5 tripartite motif containing 5
TSPYL2 TSPY-like 2
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2
WDR76 WD repeat domain 76
WDR91 WD repeat domain 91
ZNF141 zinc finger protein 141
ZNF205 zinc finger protein 205
ZNF428 zinc finger protein 428
ZNF506 zinc finger protein 506
ZNF747 zinc finger protein 747
ZNF767P zinc finger family member 767, pseudogene
ZSCAN31 zinc finger and SCAN domain containing 31