nifurtimox-6608 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the nifurtimox-6608 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A1CF APOBEC1 complementation factor
ADH6 alcohol dehydrogenase 6 (class V)
AIM2 absent in melanoma 2
AKR1C2 aldo-keto reductase family 1, member C2
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
ATXN2L ataxin 2-like
BET1L Bet1 golgi vesicular membrane trafficking protein-like
BTF3P11 basic transcription factor 3 pseudogene 11
BTG2 BTG family, member 2
C1ORF54 chromosome 1 open reading frame 54
CD6 CD6 molecule
CD7 CD7 molecule
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CNKSR2 connector enhancer of kinase suppressor of Ras 2
COL4A6 collagen, type IV, alpha 6
CPN2 carboxypeptidase N, polypeptide 2
CST4 cystatin S
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DHODH dihydroorotate dehydrogenase (quinone)
DICER1 dicer 1, ribonuclease type III
DSG3 desmoglein 3
EPHA7 EPH receptor A7
FAM46C family with sequence similarity 46, member C
FBXO31 F-box protein 31
FLT1 fms-related tyrosine kinase 1
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
HIST1H2BM histone cluster 1, H2bm
HLA-DOB major histocompatibility complex, class II, DO beta
HMG20B high mobility group 20B
HSF1 heat shock transcription factor 1
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
IL17RB interleukin 17 receptor B
IL1R2 interleukin 1 receptor, type II
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
ITGB8 integrin, beta 8
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KALRN kalirin, RhoGEF kinase
KDM6B lysine (K)-specific demethylase 6B
KIAA1109 KIAA1109
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1
MAG myelin associated glycoprotein
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MEP1B meprin A, beta
MUC5B mucin 5B, oligomeric mucus/gel-forming
NEBL nebulette
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
NPR1 natriuretic peptide receptor 1
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
NPY neuropeptide Y
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRF1 nuclear respiratory factor 1
OR1D2 olfactory receptor, family 1, subfamily D, member 2
PBOV1 prostate and breast cancer overexpressed 1
PCDHA5 protocadherin alpha 5
PCDHA9 protocadherin alpha 9
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PKNOX1 PBX/knotted 1 homeobox 1
PLAC4 placenta-specific 4
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
PRKCA protein kinase C, alpha
PRPH peripherin
PRR5L proline rich 5 like
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
PTPN21 protein tyrosine phosphatase, non-receptor type 21
REEP2 receptor accessory protein 2
RGS5 regulator of G-protein signaling 5
RNASEH2B ribonuclease H2, subunit B
RNGTT RNA guanylyltransferase and 5'-phosphatase
SERHL2 serine hydrolase-like 2
SLC4A5 solute carrier family 4 (sodium bicarbonate cotransporter), member 5
SMC1A structural maintenance of chromosomes 1A
SMCP sperm mitochondria-associated cysteine-rich protein
SOS2 son of sevenless homolog 2 (Drosophila)
SPRED2 sprouty-related, EVH1 domain containing 2
STAB2 stabilin 2
STK38 serine/threonine kinase 38
STS steroid sulfatase (microsomal), isozyme S
TAAR3 trace amine associated receptor 3 (gene/pseudogene)
TBX5 T-box 5
TCF3 transcription factor 3
TMEM206 transmembrane protein 206
TMOD1 tropomodulin 1
TNN tenascin N
TRIO trio Rho guanine nucleotide exchange factor
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C
VIPR2 vasoactive intestinal peptide receptor 2
XAF1 XIAP associated factor 1
XDH xanthine dehydrogenase
YBX2 Y box binding protein 2
ZNF236 zinc finger protein 236
ZNF407 zinc finger protein 407
ZNF518A zinc finger protein 518A

decreased expression

Symbol Name
ACAD10 acyl-CoA dehydrogenase family, member 10
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALS2CL ALS2 C-terminal like
ANGPTL4 angiopoietin-like 4
ANKFY1 ankyrin repeat and FYVE domain containing 1
APOLD1 apolipoprotein L domain containing 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARMCX4 armadillo repeat containing, X-linked 4
ARRB2 arrestin, beta 2
BAHD1 bromo adjacent homology domain containing 1
C11ORF30 chromosome 11 open reading frame 30
C19ORF40 chromosome 19 open reading frame 40
C7ORF43 chromosome 7 open reading frame 43
CAPN15 calpain 15
CAPN5 calpain 5
CD79B CD79b molecule, immunoglobulin-associated beta
CHMP1A charged multivesicular body protein 1A
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CPPED1 calcineurin-like phosphoesterase domain containing 1
CUZD1 CUB and zona pellucida-like domains 1
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DBF4B DBF4 zinc finger B
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DMTN dematin actin binding protein
DNAH17 dynein, axonemal, heavy chain 17
EGLN2 egl-9 family hypoxia-inducible factor 2
ELP6 elongator acetyltransferase complex subunit 6
ERAL1 Era-like 12S mitochondrial rRNA chaperone 1
EVPL envoplakin
FAM53B family with sequence similarity 53, member B
FAM86C1 family with sequence similarity 86, member C1
FBRS fibrosin
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FNTB farnesyltransferase, CAAX box, beta
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GSTCD glutathione S-transferase, C-terminal domain containing
HIST1H2AK histone cluster 1, H2ak
HYI hydroxypyruvate isomerase (putative)
INO80D INO80 complex subunit D
KRT8P12 keratin 8 pseudogene 12
LAMC3 laminin, gamma 3
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LRP5L low density lipoprotein receptor-related protein 5-like
LYPD3 LY6/PLAUR domain containing 3
LYRM9 LYR motif containing 9
MB myoglobin
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MOSPD3 motile sperm domain containing 3
MRPL44 mitochondrial ribosomal protein L44
MT1HL1 metallothionein 1H-like 1
NAG18 NAG18 mRNA
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
ONECUT2 one cut homeobox 2
OSR2 odd-skipped related transciption factor 2
PAIP2B poly(A) binding protein interacting protein 2B
PC pyruvate carboxylase
PDZD2 PDZ domain containing 2
PDZK1 PDZ domain containing 1
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
POLL polymerase (DNA directed), lambda
RNF39 ring finger protein 39
RPGRIP1L RPGRIP1-like
RPP25 ribonuclease P/MRP 25kDa subunit
RUNX1-IT1 RUNX1 intronic transcript 1
RWDD2A RWD domain containing 2A
SAYSD1 SAYSVFN motif domain containing 1
SCN10A sodium channel, voltage gated, type X alpha subunit
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SRD5A3 steroid 5 alpha-reductase 3
STARD3 StAR-related lipid transfer (START) domain containing 3
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
THRAP3 thyroid hormone receptor associated protein 3
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM212 transmembrane protein 212
TOLLIP toll interacting protein
TPCN1 two pore segment channel 1
TRIM21 tripartite motif containing 21
TRIM62 tripartite motif containing 62
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TUBA3C tubulin, alpha 3c
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
VNN1 vanin 1
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
XYLT2 xylosyltransferase II
YIPF1 Yip1 domain family, member 1
YOD1 YOD1 deubiquitinase
ZC3H12A zinc finger CCCH-type containing 12A
ZFHX3 zinc finger homeobox 3
ZNF276 zinc finger protein 276
ZNF510 zinc finger protein 510
ZNF528 zinc finger protein 528