nicardipine-6297 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the nicardipine-6297 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAMDC adipogenesis associated, Mth938 domain containing
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ABHD17B abhydrolase domain containing 17B
ACSBG1 acyl-CoA synthetase bubblegum family member 1
AFF3 AF4/FMR2 family, member 3
AGRP agouti related neuropeptide
ARMCX4 armadillo repeat containing, X-linked 4
ATAT1 alpha tubulin acetyltransferase 1
ATP9B ATPase, class II, type 9B
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
B9D1 B9 protein domain 1
C21ORF2 chromosome 21 open reading frame 2
CA9 carbonic anhydrase IX
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CDH8 cadherin 8, type 2
CDK6 cyclin-dependent kinase 6
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CGA glycoprotein hormones, alpha polypeptide
CNPY4 canopy FGF signaling regulator 4
CSF1 colony stimulating factor 1 (macrophage)
CTNS cystinosin, lysosomal cystine transporter
DMBT1 deleted in malignant brain tumors 1
DPY19L1 dpy-19-like 1 (C. elegans)
DTX2P1-UPK3BP1-PMS2P11 DTX2P1-UPK3BP1-PMS2P11 readthrough transcribed pseudogene
EHF ets homologous factor
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2
FBXO22 F-box protein 22
FLT1 fms-related tyrosine kinase 1
GLS2 glutaminase 2 (liver, mitochondrial)
GRM1 glutamate receptor, metabotropic 1
GSTCD glutathione S-transferase, C-terminal domain containing
HIST1H4B histone cluster 1, H4b
HOXC5 homeobox C5
ICOSLG inducible T-cell co-stimulator ligand
IMPG2 interphotoreceptor matrix proteoglycan 2
IRAK4 interleukin-1 receptor-associated kinase 4
ITPK1 inositol-tetrakisphosphate 1-kinase
KANK1 KN motif and ankyrin repeat domains 1
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KERA keratocan
KHSRP KH-type splicing regulatory protein
KIF21B kinesin family member 21B
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KLHL1 kelch-like family member 1
KRT2 keratin 2, type II
KRT6B keratin 6B, type II
LMBR1L limb development membrane protein 1-like
LOC81691 exonuclease NEF-sp
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MEOX2 mesenchyme homeobox 2
MFGE8 milk fat globule-EGF factor 8 protein
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
MFSD6 major facilitator superfamily domain containing 6
MTA2 metastasis associated 1 family, member 2
MVP major vault protein
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NME5 NME/NM23 family member 5
NPFFR1 neuropeptide FF receptor 1
NUMA1 nuclear mitotic apparatus protein 1
PAX2 paired box 2
PDE4DIP phosphodiesterase 4D interacting protein
PGPEP1 pyroglutamyl-peptidase I
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PML promyelocytic leukemia
POU2F2 POU class 2 homeobox 2
PPIAL4A peptidylprolyl isomerase A (cyclophilin A)-like 4A
PRODH2 proline dehydrogenase (oxidase) 2
PTBP3 polypyrimidine tract binding protein 3
PTCH1 patched 1
PTGIS prostaglandin I2 (prostacyclin) synthase
RANGAP1 Ran GTPase activating protein 1
SCN11A sodium channel, voltage gated, type XI alpha subunit
SCN8A sodium channel, voltage gated, type VIII alpha subunit
SETD8 SET domain containing (lysine methyltransferase) 8
SIRPA signal-regulatory protein alpha
SIRT5 sirtuin 5
SIX2 SIX homeobox 2
SORBS1 sorbin and SH3 domain containing 1
SPTBN1 spectrin, beta, non-erythrocytic 1
SSX3 synovial sarcoma, X breakpoint 3
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STS steroid sulfatase (microsomal), isozyme S
STX2 syntaxin 2
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
THEMIS2 thymocyte selection associated family member 2
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TRIM14 tripartite motif containing 14
TRIM29 tripartite motif containing 29
TTLL3 tubulin tyrosine ligase-like family member 3
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VAV3 vav 3 guanine nucleotide exchange factor
VNN2 vanin 2
WAPAL wings apart-like homolog (Drosophila)
WDR1 WD repeat domain 1
WDR76 WD repeat domain 76
WSB1 WD repeat and SOCS box containing 1

decreased expression

Symbol Name
ABCA11P ATP-binding cassette, sub-family A (ABC1), member 11, pseudogene
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
ACAD8 acyl-CoA dehydrogenase family, member 8
ANKRD40 ankyrin repeat domain 40
AUH AU RNA binding protein/enoyl-CoA hydratase
BBS7 Bardet-Biedl syndrome 7
BEX1 brain expressed, X-linked 1
C6ORF47 chromosome 6 open reading frame 47
CASD1 CAS1 domain containing 1
CCDC176 coiled-coil domain containing 176
CENPQ centromere protein Q
CHPF chondroitin polymerizing factor
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
COQ6 coenzyme Q6 monooxygenase
CTSO cathepsin O
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DENND4A DENN/MADD domain containing 4A
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DIXDC1 DIX domain containing 1
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
ERN2 endoplasmic reticulum to nucleus signaling 2
FA2H fatty acid 2-hydroxylase
FAM102A family with sequence similarity 102, member A
FAM169A family with sequence similarity 169, member A
FANCF Fanconi anemia, complementation group F
FBXL2 F-box and leucine-rich repeat protein 2
FLCN folliculin
FPGS folylpolyglutamate synthase
GAL3ST4 galactose-3-O-sulfotransferase 4
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GLTSCR1 glioma tumor suppressor candidate region gene 1
GMIP GEM interacting protein
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GSR glutathione reductase
HDAC5 histone deacetylase 5
HOXC4 homeobox C4
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGSF3 immunoglobulin superfamily, member 3
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
IRF9 interferon regulatory factor 9
KDM4D lysine (K)-specific demethylase 4D
KDM5C lysine (K)-specific demethylase 5C
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
MAGEA3 melanoma antigen family A3
MANEA mannosidase, endo-alpha
MBTD1 mbt domain containing 1
MCRS1 microspherule protein 1
MED15 mediator complex subunit 15
MEIS1 Meis homeobox 1
MFSD12 major facilitator superfamily domain containing 12
MSL2 male-specific lethal 2 homolog (Drosophila)
MTG1 mitochondrial ribosome-associated GTPase 1
NDE1 nudE neurodevelopment protein 1
NLRX1 NLR family member X1
PCBP4 poly(rC) binding protein 4
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PLCD1 phospholipase C, delta 1
PLEKHO2 pleckstrin homology domain containing, family O member 2
POLH polymerase (DNA directed), eta
PROSER1 proline and serine rich 1
QTRT1 queuine tRNA-ribosyltransferase 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB5B RAB5B, member RAS oncogene family
RPUSD2 RNA pseudouridylate synthase domain containing 2
SCAI suppressor of cancer cell invasion
SCN1B sodium channel, voltage gated, type I beta subunit
SCRN3 secernin 3
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SLC12A9 solute carrier family 12, member 9
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2
SLITRK5 SLIT and NTRK-like family, member 5
SREBF1 sterol regulatory element binding transcription factor 1
STBD1 starch binding domain 1
TBC1D31 TBC1 domain family, member 31
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast)
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM156 transmembrane protein 156
TMEM62 transmembrane protein 62
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSPAN8 tetraspanin 8
TUBA3C tubulin, alpha 3c
ULK1 unc-51 like autophagy activating kinase 1
URGCP upregulator of cell proliferation
USB1 U6 snRNA biogenesis 1
VASH2 vasohibin 2
WBP1L WW domain binding protein 1-like
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZBTB10 zinc finger and BTB domain containing 10
ZMAT3 zinc finger, matrin-type 3
ZNF280D zinc finger protein 280D
ZNF675 zinc finger protein 675
ZNF747 zinc finger protein 747
ZNF767P zinc finger family member 767, pseudogene
ZSCAN16 zinc finger and SCAN domain containing 16