newborn respiratory distress syndrome Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A respiratory failure that is characterized by deficiency of the surfactant coating the inner surface of the lungs, by failure of the lungs to expand and contract properly during breathing with resulting collapse, and by the accumulation of a protein-containing film lining the alveoli and their ducts. (Human Disease Ontology, DOID_12716)
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Genes

204 genes co-occuring with the disease newborn respiratory distress syndrome in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
SFTPB surfactant protein B 2.35769
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 1.93139
SFTPC surfactant protein C 1.83863
TTN titin 1.75732
SFTPA1 surfactant protein A1 1.6368
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 1.61486
PROS2P protein S (beta) pseudogene 1.35768
CHPT1 choline phosphotransferase 1 1.21565
C9ORF3 chromosome 9 open reading frame 3 1.20093
TRH thyrotropin-releasing hormone 1.13374
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 1.13332
ALB albumin 1.11309
LPCAT1 lysophosphatidylcholine acyltransferase 1 1.04083
PCYT1B phosphate cytidylyltransferase 1, choline, beta 1.0071
NKX2-1 NK2 homeobox 1 0.998236
INS insulin 0.988114
OR7E87P olfactory receptor, family 7, subfamily E, member 87 pseudogene 0.961634
TEF thyrotrophic embryonic factor 0.95745
SFTPD surfactant protein D 0.942027
GLS2 glutaminase 2 (liver, mitochondrial) 0.939119
LSR lipolysis stimulated lipoprotein receptor 0.936629
GPR162 G protein-coupled receptor 162 0.91308
PLG plasminogen 0.912668
RAB9A RAB9A, member RAS oncogene family 0.91061
SOD2 superoxide dismutase 2, mitochondrial 0.891718
SFTA3 surfactant associated 3 0.857724
FTSJ1 FtsJ RNA methyltransferase homolog 1 (E. coli) 0.841344
SFTPA2 surfactant protein A2 0.841344
CXCL8 chemokine (C-X-C motif) ligand 8 0.833148
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 0.830279
PLA2G1B phospholipase A2, group IB (pancreas) 0.815514
FOXA2 forkhead box A2 0.805667
LPCAT3 lysophosphatidylcholine acyltransferase 3 0.805257
IL6 interleukin 6 0.787213
PLA2G10 phospholipase A2, group X 0.77207
GRP gastrin-releasing peptide 0.76431
PHF5A PHD finger protein 5A 0.759008
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.737865
IL1B interleukin 1, beta 0.724907
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.724502
TNF tumor necrosis factor 0.715618
NPPA natriuretic peptide A 0.711183
OXTR oxytocin receptor 0.691094
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria 0.690293
GSX2 GS homeobox 2 0.682294
AP2M1 adaptor-related protein complex 2, mu 1 subunit 0.667152
F2 coagulation factor II (thrombin) 0.664372
C5AR1 complement component 5a receptor 1 0.660008
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 0.65565
CRP C-reactive protein, pentraxin-related 0.654858
FN1 fibronectin 1 0.647743
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.641039
SCNN1G sodium channel, non voltage gated 1 gamma subunit 0.640645
KLHL20 kelch-like family member 20 0.637889
F3 coagulation factor III (thromboplastin, tissue factor) 0.637495
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 0.635135
SAP18 Sin3A-associated protein, 18kDa 0.634742
ELANE elastase, neutrophil expressed 0.612401
CEPT1 choline/ethanolamine phosphotransferase 1 0.607323
CPVL carboxypeptidase, vitellogenic-like 0.588612
KLHL17 kelch-like family member 17 0.584719
EDN1 endothelin 1 0.573828
CAT catalase 0.573439
IPO13 importin 13 0.536183
ISX intestine-specific homeobox 0.534635
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 0.533088
INPP5J inositol polyphosphate-5-phosphatase J 0.528835
DNM1 dynamin 1 0.525746
GPX5 glutathione peroxidase 5 0.51919
GPX4 glutathione peroxidase 4 0.51611
KLKB1 kallikrein B, plasma (Fletcher factor) 1 0.514571
S100A12 S100 calcium binding protein A12 0.514571
CDH8 cadherin 8, type 2 0.509192
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.508424
GPX1 glutathione peroxidase 1 0.500379
APEH acylaminoacyl-peptide hydrolase 0.499614
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 0.498085
NPSR1 neuropeptide S receptor 1 0.491597
CHKA choline kinase alpha 0.487788
FGFR4 fibroblast growth factor receptor 4 0.478289
PLAT plasminogen activator, tissue 0.472604
TAF8 TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa 0.469954
IL10 interleukin 10 0.456355
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.450324
PGF placental growth factor 0.447687
PRRC2A proline-rich coiled-coil 2A 0.446182
CP ceruloplasmin (ferroxidase) 0.443547
SELL selectin L 0.437154
MMP8 matrix metallopeptidase 8 0.429642
MPO myeloperoxidase 0.425139
TADA3 transcriptional adaptor 3 0.425139
ACE angiotensin I converting enzyme 0.421765
EMX1 empty spiracles homeobox 1 0.421016
POMC proopiomelanocortin 0.416521
GCSH glycine cleavage system protein H (aminomethyl carrier) 0.414276
SLC38A4 solute carrier family 38, member 4 0.407545
PER2 period circadian clock 2 0.395608
DSPP dentin sialophosphoprotein 0.393746
IL1A interleukin 1, alpha 0.385565
PFDN4 prefoldin subunit 4 0.380739
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 0.378143
INSM1 insulinoma-associated 1 0.377402
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.37555
PRAMEF6 PRAME family member 6 0.372958
ITM2B integral membrane protein 2B 0.371107
MLN motilin 0.369997
ZSCAN1 zinc finger and SCAN domain containing 1 0.369258
CALCA calcitonin-related polypeptide alpha 0.365193
F5 coagulation factor V (proaccelerin, labile factor) 0.365193
HOXB8 homeobox B8 0.360026
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15 0.359289
DLX1 distal-less homeobox 1 0.354499
FLT1 fms-related tyrosine kinase 1 0.348981
LECT1 leukocyte cell derived chemotaxin 1 0.344574
MMP9 matrix metallopeptidase 9 0.343473
FGF10 fibroblast growth factor 10 0.340173
MMP2 matrix metallopeptidase 2 0.337242
PER1 period circadian clock 1 0.336144
CCDC34 coiled-coil domain containing 34 0.334315
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 0.32993
MGAM maltase-glucoamylase 0.328105
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.326646
EPGN epithelial mitogen 0.324458
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.312464
PRL prolactin 0.311739
CSH2 chorionic somatomammotropin hormone 2 0.31029
STK10 serine/threonine kinase 10 0.306672
SULT4A1 sulfotransferase family 4A, member 1 0.301976
LRRC38 leucine rich repeat containing 38 0.299452
HOXA4 homeobox A4 0.297651
VEGFA vascular endothelial growth factor A 0.294413
ASIC2 acid sensing (proton gated) ion channel 2 0.294053
F7 coagulation factor VII (serum prothrombin conversion accelerator) 0.290821
MZF1 myeloid zinc finger 1 0.288668
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 0.287952
GCLC glutamate-cysteine ligase, catalytic subunit 0.285086
ERAS ES cell expressed Ras 0.279367
MLX MLX, MAX dimerization protein 0.273308
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 0.269398
A1BG alpha-1-B glycoprotein 0.26514
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 0.264785
GPANK1 G patch domain and ankyrin repeats 1 0.264785
ATP7B ATPase, Cu++ transporting, beta polypeptide 0.264431
C6ORF25 chromosome 6 open reading frame 25 0.26266
KLHL2 kelch-like family member 2 0.259124
INSIG1 insulin induced gene 1 0.256299
RICTOR RPTOR independent companion of MTOR, complex 2 0.250663
GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2 0.250311
GUSB glucuronidase, beta 0.249608
OLIG1 oligodendrocyte transcription factor 1 0.248203
PHF12 PHD finger protein 12 0.243645
OR10K2 olfactory receptor, family 10, subfamily K, member 2 0.237706
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.234573
NPAT nuclear protein, ataxia-telangiectasia locus 0.233183
DSP desmoplakin 0.232142
SLC25A18 solute carrier family 25 (glutamate carrier), member 18 0.230409
AVP arginine vasopressin 0.230409
ADCY9 adenylate cyclase 9 0.230063
IL18RAP interleukin 18 receptor accessory protein 0.228333
INSIG2 insulin induced gene 2 0.228333
CCL3 chemokine (C-C motif) ligand 3 0.226952
KDR kinase insert domain receptor 0.226262
PEX10 peroxisomal biogenesis factor 10 0.22454
TNNT2 troponin T type 2 (cardiac) 0.218715
ICAM1 intercellular adhesion molecule 1 0.218034
THBD thrombomodulin 0.216672
ALPPL2 alkaline phosphatase, placental-like 2 0.215653
ALPP alkaline phosphatase, placental 0.214975
ALPL alkaline phosphatase, liver/bone/kidney 0.214636
PPAN peter pan homolog (Drosophila) 0.211597
CHAD chondroadherin 0.207578
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 0.207245
TIMP1 TIMP metallopeptidase inhibitor 1 0.200006
IL18R1 interleukin 18 receptor 1 0.198064
NTS neurotensin 0.196139
APITD1 apoptosis-inducing, TAF9-like domain 1 0.194232
IGLV5-52 immunoglobulin lambda variable 5-52 0.193915
OR4F29 olfactory receptor, family 4, subfamily F, member 29 0.190786
PLCH2 phospholipase C, eta 2 0.189244
SCO2 SCO2 cytochrome c oxidase assembly protein 0.189244
CFB complement factor B 0.188938
ICT1 immature colon carcinoma transcript 1 0.188326
CKAP2 cytoskeleton associated protein 2 0.187113
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 0.185016
TGFB1 transforming growth factor, beta 1 0.18472
MFRP membrane frizzled-related protein 0.182375
CUTA cutA divalent cation tolerance homolog (E. coli) 0.181222
PRSS1 protease, serine, 1 (trypsin 1) 0.179802
RAB3D RAB3D, member RAS oncogene family 0.178682
SSB Sjogren syndrome antigen B (autoantigen La) 0.177029
TF transferrin 0.173057
COX5A cytochrome c oxidase subunit Va 0.170544
ESAM endothelial cell adhesion molecule 0.168381
FGF7 fibroblast growth factor 7 0.166319
LNPEP leucyl/cystinyl aminopeptidase 0.166095
MMP1 matrix metallopeptidase 1 0.165217
CCL22 chemokine (C-C motif) ligand 22 0.163938
B2M beta-2-microglobulin 0.162908
POLL polymerase (DNA directed), lambda 0.161912
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.161716
EGLN2 egl-9 family hypoxia-inducible factor 2 0.161331
AREG amphiregulin 0.160948
HOXA5 homeobox A5 0.159124
CRH corticotropin releasing hormone 0.157765