neuroendocrine cell Gene Set

Dataset TISSUES Text-mining Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description Neuroendocrine cells are cells that receive neuronal input (neurotransmitters released by nerve cells) and, as a consequence of this input, release message molecules (hormones) to the blood. An example of a neuroendocrine cell is the cell of the adrenal medulla which releases adrenalin to the blood. The major center of neuroendocrine integration in the body is found in the hypothalamus and the pituitary gland. Here hypothalamic neurosecretory cells release factors to the blood. (BRENDA Tissue and Enzyme Source Ontology, BTO_0002691)
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Genes

368 proteins co-occuring with the tissue neuroendocrine cell in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

Symbol Name Standardized Value
CHGA chromogranin A 3.24054
GAST gastrin 3.05286
HDC histidine decarboxylase 2.44566
SST somatostatin 2.16126
SYP synaptophysin 2.15437
GRP gastrin-releasing peptide 2.08509
ENO2 enolase 2 (gamma, neuronal) 2.08456
SCG2 secretogranin II 1.86307
CALCA calcitonin-related polypeptide alpha 1.85482
NPS neuropeptide S 1.83682
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 1.80615
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 1.80564
CHGB chromogranin B 1.78084
CGB7 chorionic gonadotropin, beta polypeptide 7 1.74127
CGB chorionic gonadotropin, beta polypeptide 1.74027
CGB8 chorionic gonadotropin, beta polypeptide 8 1.73877
CGB5 chorionic gonadotropin, beta polypeptide 5 1.73678
CCKBR cholecystokinin B receptor 1.694
RAB3A RAB3A, member RAS oncogene family 1.66457
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 1.65057
MEN1 multiple endocrine neoplasia I 1.60564
NSF N-ethylmaleimide-sensitive factor 1.54632
CCK cholecystokinin 1.51285
SCG3 secretogranin III 1.51
PCSK2 proprotein convertase subtilisin/kexin type 2 1.47055
RPH3A rabphilin 3A 1.42922
SCG5 secretogranin V 1.39513
ASCL1 achaete-scute family bHLH transcription factor 1 1.391
CPE carboxypeptidase E 1.36632
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 1.32687
POMC proopiomelanocortin 1.28322
STX1A syntaxin 1A (brain) 1.27964
PTPRN protein tyrosine phosphatase, receptor type, N 1.27561
PCSK1 proprotein convertase subtilisin/kexin type 1 1.25547
SCGN secretagogin, EF-hand calcium binding protein 1.25503
PPY pancreatic polypeptide 1.23182
GHRL ghrelin/obestatin prepropeptide 1.22692
SNAP23 synaptosomal-associated protein, 23kDa 1.2109
STXBP1 syntaxin binding protein 1 1.1758
SYT1 synaptotagmin I 1.16781
RESP18 regulated endocrine-specific protein 18 1.15229
GCG glucagon 1.14875
HRH2 histamine receptor H2 1.12571
RAB3B RAB3B, member RAS oncogene family 1.11553
VGF VGF nerve growth factor inducible 1.10579
PYY peptide YY 1.09783
RTN1 reticulon 1 1.07353
NTS neurotensin 1.07044
CADPS Ca++-dependent secretion activator 1.06074
FURIN furin (paired basic amino acid cleaving enzyme) 1.0339
NPY neuropeptide Y 1.02513
PAM peptidylglycine alpha-amidating monooxygenase 1.02118
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 1.01943
INS insulin 1.00763
JAKMIP2 janus kinase and microtubule interacting protein 2 1.00327
UNC13B unc-13 homolog B (C. elegans) 0.98282
NKX2-1 NK2 homeobox 1 0.974583
DNAH8 dynein, axonemal, heavy chain 8 0.971119
TGOLN2 trans-golgi network protein 2 0.959449
VIP vasoactive intestinal peptide 0.924194
SIM1 single-minded family bHLH transcription factor 1 0.915215
GAL galanin/GMAP prepropeptide 0.913507
NGF nerve growth factor (beta polypeptide) 0.91308
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor 0.898595
NCS1 neuronal calcium sensor 1 0.895195
ARF6 ADP-ribosylation factor 6 0.89477
STC1 stanniocalcin 1 0.87782
KLK3 kallikrein-related peptidase 3 0.876129
VAMP4 vesicle-associated membrane protein 4 0.863048
CRH corticotropin releasing hormone 0.863048
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1) 0.859258
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) 0.850005
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.843706
TAC1 tachykinin, precursor 1 0.842447
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.842027
CREM cAMP responsive element modulator 0.828197
NEUROD1 neuronal differentiation 1 0.824849
NCAM1 neural cell adhesion molecule 1 0.818994
SSTR2 somatostatin receptor 2 0.809386
CCKAR cholecystokinin A receptor 0.806882
AR androgen receptor 0.797708
PENK proenkephalin 0.797708
STX6 syntaxin 6 0.796041
GRPR gastrin-releasing peptide receptor 0.791044
RAB18 RAB18, member RAS oncogene family 0.790212
B3GAT1 beta-1,3-glucuronyltransferase 1 0.787299
KRT20 keratin 20, type I 0.782725
KIDINS220 kinase D-interacting substrate, 220kDa 0.781063
OTP orthopedia homeobox 0.766539
PTHLH parathyroid hormone-like hormone 0.759914
RAB27A RAB27A, member RAS oncogene family 0.757845
RAB3C RAB3C, member RAS oncogene family 0.75495
TPH1 tryptophan hydroxylase 1 0.749166
TH tyrosine hydroxylase 0.74834
MYO5A myosin VA (heavy chain 12, myoxin) 0.734735
TP53 tumor protein p53 0.7335
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 0.731854
SYNPR synaptoporin 0.728975
CREB1 cAMP responsive element binding protein 1 0.726507
SYTL4 synaptotagmin-like 4 0.70968
PLCH1 phospholipase C, eta 1 0.706812
RAB3D RAB3D, member RAS oncogene family 0.706402
PLD1 phospholipase D1, phosphatidylcholine-specific 0.699444
REEP2 receptor accessory protein 2 0.684327
GHRH growth hormone releasing hormone 0.6721
SSTR1 somatostatin receptor 1 0.6721
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 0.663149
SRRM4 serine/arginine repetitive matrix 4 0.663149
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 0.660304
NGEF neuronal guanine nucleotide exchange factor 0.657054
CAPS2 calcyphosine 2 0.6534
SYT4 synaptotagmin IV 0.652589
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 0.651777
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 0.6461
S100A3 S100 calcium binding protein A3 0.642858
NEUROG3 neurogenin 3 0.635976
TRH thyrotropin-releasing hormone 0.632335
PCSK6 proprotein convertase subtilisin/kexin type 6 0.629101
FOS FBJ murine osteosarcoma viral oncogene homolog 0.625061
KRT7 keratin 7, type II 0.612958
SYT7 synaptotagmin VII 0.610943
STX7 syntaxin 7 0.604904
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 0.601283
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) 0.584823
HMGN2P46 high mobility group nucleosomal binding domain 2 pseudogene 46 0.580417
PTPRD protein tyrosine phosphatase, receptor type, D 0.576015
VAMP3 vesicle-associated membrane protein 3 0.574816
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.573616
POU3F2 POU class 3 homeobox 2 0.564035
CHMP3 charged multivesicular body protein 3 0.559652
REG4 regenerating islet-derived family, member 4 0.559652
SYT3 synaptotagmin III 0.554478
CYB561 cytochrome b561 0.546533
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.538604
ZDHHC2 zinc finger, DHHC-type containing 2 0.538209
POFUT1 protein O-fucosyltransferase 1 0.537812
SYPL1 synaptophysin-like 1 0.537021
ARFIP2 ADP-ribosylation factor interacting protein 2 0.53346
INSM2 insulinoma-associated 2 0.531879
BRS3 bombesin-like receptor 3 0.531089
SCFD1 sec1 family domain containing 1 0.527928
EXPH5 exophilin 5 0.516497
PTH parathyroid hormone 0.511384
PDYN prodynorphin 0.510992
INSRR insulin receptor-related receptor 0.509027
ISL1 ISL LIM homeobox 1 0.506279
CARTPT CART prepropeptide 0.506279
ITSN1 intersectin 1 (SH3 domain protein) 0.505887
FOXM1 forkhead box M1 0.503141
BHLHA15 basic helix-loop-helix family, member a15 0.50079
REST RE1-silencing transcription factor 0.489838
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 0.487496
CGA glycoprotein hormones, alpha polypeptide 0.487106
ANXA2 annexin A2 0.487106
TFF2 trefoil factor 2 0.486326
GFI1 growth factor independent 1 transcription repressor 0.482817
INSM1 insulinoma-associated 1 0.482038
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.476979
RET ret proto-oncogene 0.466111
MME membrane metallo-endopeptidase 0.458373
INTS1 integrator complex subunit 1 0.454898
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.444884
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.444499
P3H2 prolyl 3-hydroxylase 2 0.444115
DUSP1 dual specificity phosphatase 1 0.442194
HRH3 histamine receptor H3 0.435672
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.435289
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.434906
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 0.43414
MIA2 melanoma inhibitory activity 2 0.432991
DEAF1 DEAF1 transcription factor 0.431077
CDC42 cell division cycle 42 0.428783
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1 0.424963
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase 0.416576
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.409351
AMPH amphiphysin 0.406315
SYT9 synaptotagmin IX 0.402523
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.398735
SYTL5 synaptotagmin-like 5 0.398735
RTN4 reticulon 4 0.397222
ZNF23 zinc finger protein 23 0.394197
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor 0.390421
CALB1 calbindin 1, 28kDa 0.390044
MTA1 metastasis associated 1 0.387404
AVP arginine vasopressin 0.384766
TFRC transferrin receptor 0.38439
WASL Wiskott-Aldrich syndrome-like 0.382884
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 0.379875
SCN1B sodium channel, voltage gated, type I beta subunit 0.378748
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha 0.377245
SYT5 synaptotagmin V 0.376494
NOTCH1 notch 1 0.375368
ITSN2 intersectin 2 0.374993
PSCA prostate stem cell antigen 0.372743
FGGY FGGY carbohydrate kinase domain containing 0.369747
DYNLRB1 dynein, light chain, roadblock-type 1 0.363766
VAMP8 vesicle-associated membrane protein 8 0.363393
UNC13A unc-13 homolog A (C. elegans) 0.362646
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 0.361901
STX4 syntaxin 4 0.359664
CST3 cystatin C 0.35743
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D 0.356686
RAP2B RAP2B, member of RAS oncogene family 0.350001
NRXN1 neurexin 1 0.34963
RAB1B RAB1B, member RAS oncogene family 0.34963
GPHB5 glycoprotein hormone beta 5 0.348889
GSDMB gasdermin B 0.347408
SCAMP1 secretory carrier membrane protein 1 0.347408
SAR1A secretion associated, Ras related GTPase 1A 0.347038
ARF3 ADP-ribosylation factor 3 0.345188
NAP1L1 nucleosome assembly protein 1-like 1 0.342233
SYNGR2 synaptogyrin 2 0.341495
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 0.334498
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 0.333396
SCN3B sodium channel, voltage gated, type III beta subunit 0.333028
NTF3 neurotrophin 3 0.33046
CDX2 caudal type homeobox 2 0.329361
SV2A synaptic vesicle glycoprotein 2A 0.328994
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 0.328262
YME1L1 YME1-like 1 ATPase 0.326798
HES1 hes family bHLH transcription factor 1 0.32497
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 0.32497
GHSR growth hormone secretagogue receptor 0.324605
PPIC peptidylprolyl isomerase C (cyclophilin C) 0.323947
NDUFA12 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 0.32205
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein 0.317315
ACPP acid phosphatase, prostate 0.316588
NMBR neuromedin B receptor 0.315498
VIM vimentin 0.314409
PI4KB phosphatidylinositol 4-kinase, catalytic, beta 0.306083
MKI67 marker of proliferation Ki-67 0.305361
CD44 CD44 molecule (Indian blood group) 0.303919
ADORA2B adenosine A2b receptor 0.303919
SYN1 synapsin I 0.302478
SIM2 single-minded family bHLH transcription factor 2 0.302478
PGLS 6-phosphogluconolactonase 0.301758
RCVRN recoverin 0.301039
BDNF brain-derived neurotrophic factor 0.298883
NPAS1 neuronal PAS domain protein 1 0.297447
APOPT1 apoptogenic 1, mitochondrial 0.297089
PACS1 phosphofurin acidic cluster sorting protein 1 0.29673
SCN11A sodium channel, voltage gated, type XI alpha subunit 0.29673
RAB5A RAB5A, member RAS oncogene family 0.296372
TMEM127 transmembrane protein 127 0.296013
SDF4 stromal cell derived factor 4 0.293151
PTPRB protein tyrosine phosphatase, receptor type, B 0.290295
PHOX2A paired-like homeobox 2a 0.290295
MLN motilin 0.289226
GOLGA4 golgin A4 0.28887
ADGRL2 adhesion G protein-coupled receptor L2 0.284607
REEP1 receptor accessory protein 1 0.275444
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.270561
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 0.266069
CUL4B cullin 4B 0.265381
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 0.262304
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 0.262304
ADM adrenomedullin 0.261284
REM2 RAS (RAD and GEM)-like GTP binding 2 0.260267
GSDMA gasdermin A 0.259929
PDCD2 programmed cell death 2 0.259254
GATA5 GATA binding protein 5 0.257572
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4 0.2557
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.255234
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 0.254239
GIF gastric intrinsic factor (vitamin B synthesis) 0.253578
MSI2 musashi RNA-binding protein 2 0.252919
NFASC neurofascin 0.251934
STMN3 stathmin-like 3 0.251934
CAPRIN2 caprin family member 2 0.251934
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) 0.249329
JUN jun proto-oncogene 0.248683
SV2C synaptic vesicle glycoprotein 2C 0.247079
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 0.245491
RXFP4 relaxin/insulin-like family peptide receptor 4 0.245491
VIPR1 vasoactive intestinal peptide receptor 1 0.242054
UBN1 ubinuclein 1 0.240826
PROM1 prominin 1 0.240216
CXCR2 chemokine (C-X-C motif) receptor 2 0.239007
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit 0.23781
STX3 syntaxin 3 0.234302
GPHA2 glycoprotein hormone alpha 2 0.233731
TYRL tyrosinase-like (pseudogene) 0.232881
TNF tumor necrosis factor 0.232599
ENO3 enolase 3 (beta, muscle) 0.231482
GIP gastric inhibitory polypeptide 0.231206
PRL prolactin 0.23011
IL1B interleukin 1, beta 0.22797
CYTH2 cytohesin 2 0.227186
GPC5 glypican 5 0.2259
DEFB105B defensin, beta 105B 0.2259
KRT5 keratin 5, type II 0.224893
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.223906
LUM lumican 0.221521
GALR1 galanin receptor 1 0.220604
CST2 cystatin SA 0.220604
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.219928
ERG v-ets avian erythroblastosis virus E26 oncogene homolog 0.219047
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) 0.21883
RGS12 regulator of G-protein signaling 12 0.218613
TG thyroglobulin 0.215341
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 0.215341
TINAG tubulointerstitial nephritis antigen 0.214954
FLII flightless I homolog (Drosophila) 0.214017
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.213112
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.213112
ADGRG4 adhesion G protein-coupled receptor G4 0.199776
ALG9 ALG9, alpha-1,2-mannosyltransferase 0.198287
SAMD8 sterile alpha motif domain containing 8 0.196615
IFNA1 interferon, alpha 1 0.196234
OR51E1 olfactory receptor, family 51, subfamily E, member 1 0.196124
CSN1S1 casein alpha s1 0.196008
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 0.192954
NKX2-3 NK2 homeobox 3 0.192826
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.192728
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 0.192266
STMN1 stathmin 1 0.189116
APLP2 amyloid beta (A4) precursor-like protein 2 0.188232
MSH3 mutS homolog 3 0.187708
CRYGD crystallin, gamma D 0.18657
CLCN3 chloride channel, voltage-sensitive 3 0.186179
CALR calreticulin 0.186156
RCC1 regulator of chromosome condensation 1 0.186145
ALCAM activated leukocyte cell adhesion molecule 0.185632
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.185184
STMN2 stathmin 2 0.184562
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 0.183768
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 0.183529
CXCL14 chemokine (C-X-C motif) ligand 14 0.182934
CISH cytokine inducible SH2-containing protein 0.182403
TRPM8 transient receptor potential cation channel, subfamily M, member 8 0.179652
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.179225
DNM3 dynamin 3 0.178926
NMU neuromedin U 0.178866
IGF1R insulin-like growth factor 1 receptor 0.177148
GRIA2 glutamate receptor, ionotropic, AMPA 2 0.177056
TMSB4X thymosin beta 4, X-linked 0.176802
MAP2K1 mitogen-activated protein kinase kinase 1 0.176231
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 0.175256
GLP1R glucagon-like peptide 1 receptor 0.175153
PNMA2 paraneoplastic Ma antigen 2 0.174942
HCRT hypocretin (orexin) neuropeptide precursor 0.173252
IGF1 insulin-like growth factor 1 (somatomedin C) 0.173104
PSENEN presenilin enhancer gamma secretase subunit 0.172867
CLDN4 claudin 4 0.172596
NR0B1 nuclear receptor subfamily 0, group B, member 1 0.171726
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 0.17071
ZFP36L1 ZFP36 ring finger protein-like 1 0.169387
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.168577
CREBBP CREB binding protein 0.168463
MAPK1 mitogen-activated protein kinase 1 0.168236
CXCR1 chemokine (C-X-C motif) receptor 1 0.16722
CCND3 cyclin D3 0.166735
LAMP1 lysosomal-associated membrane protein 1 0.165125
IFNL2 interferon, lambda 2 0.164367
HBEGF heparin-binding EGF-like growth factor 0.164275
GRM1 glutamate receptor, metabotropic 1 0.163015
TSC2 tuberous sclerosis 2 0.161338
HRH1 histamine receptor H1 0.161287
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.161287
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 0.160982
HAL histidine ammonia-lyase 0.16093
VCL vinculin 0.160459
ANGPT2 angiopoietin 2 0.159606
RHOQ ras homolog family member Q 0.15884
MECOM MDS1 and EVI1 complex locus 0.158729
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.157768
KLF10 Kruppel-like factor 10 0.157015
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.156363