nervous system benign neoplasm Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description An organ system benign neoplasm that is located_in the central nervous system or located_in the peripheral nervous system. (Human Disease Ontology, DOID_0060115)
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Genes

369 genes co-occuring with the disease nervous system benign neoplasm in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
NF2 neurofibromin 2 (merlin) 3.11127
NF1 neurofibromin 1 1.94924
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 1.83591
CD34 CD34 molecule 1.61396
ENO2 enolase 2 (gamma, neuronal) 1.60234
B3GAT1 beta-1,3-glucuronyltransferase 1 1.33196
GFAP glial fibrillary acidic protein 1.23126
CLDN1 claudin 1 1.13459
CRLF1 cytokine receptor-like factor 1 1.12825
CLDN7 claudin 7 1.1194
SYP synaptophysin 1.10594
NGFR nerve growth factor receptor 1.08412
NCMAP noncompact myelin associated protein 1.04924
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 1.04588
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 1.02945
NGF nerve growth factor (beta polypeptide) 1.01891
OLIG2 oligodendrocyte lineage transcription factor 2 0.974642
ARHGAP28 Rho GTPase activating protein 28 0.954943
RET ret proto-oncogene 0.942443
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.925039
MLANA melan-A 0.902389
TAC1 tachykinin, precursor 1 0.890488
CALCA calcitonin-related polypeptide alpha 0.878605
PEX5L peroxisomal biogenesis factor 5-like 0.875738
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.855268
FKBP4 FK506 binding protein 4, 59kDa 0.840525
PCNA proliferating cell nuclear antigen 0.820847
FAM131B family with sequence similarity 131, member B 0.805257
TP53 tumor protein p53 0.783936
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.774114
CNTF ciliary neurotrophic factor 0.772479
MBP myelin basic protein 0.769618
KRT83 keratin 83, type II 0.760231
RIMS3 regulating synaptic membrane exocytosis 3 0.698313
CD68 CD68 molecule 0.684692
ASMTL acetylserotonin O-methyltransferase-like 0.660008
ANO1 anoctamin 1, calcium activated chloride channel 0.652089
NFIC nuclear factor I/C (CCAAT-binding transcription factor) 0.643797
GDNF glial cell derived neurotrophic factor 0.643009
SOX10 SRY (sex determining region Y)-box 10 0.642221
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.641433
GLTSCR1 glioma tumor suppressor candidate region gene 1 0.620617
KIAA1549 KIAA1549 0.618268
KRT84 keratin 84, type II 0.618268
ADGRL4 adhesion G protein-coupled receptor L4 0.617877
POU3F1 POU class 3 homeobox 1 0.611229
CRYBB2 crystallin, beta B2 0.610448
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.60264
ERBB3 erb-b2 receptor tyrosine kinase 3 0.6003
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 0.59952
COQ6 coenzyme Q6 monooxygenase 0.58939
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 0.584719
NPY neuropeptide Y 0.579272
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.578883
NCOA1 nuclear receptor coactivator 1 0.574605
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 0.569941
MYT1 myelin transcription factor 1 0.569163
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 0.563335
CST7 cystatin F (leukocystatin) 0.560616
CALD1 caldesmon 1 0.553239
FN1 fibronectin 1 0.545868
EGFL6 EGF-like-domain, multiple 6 0.545481
FOLH1B folate hydrolase 1B 0.545093
SLC26A11 solute carrier family 26 (anion exchanger), member 11 0.544705
SLC4A9 solute carrier family 4, sodium bicarbonate cotransporter, member 9 0.539667
NES nestin 0.534248
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2) 0.531928
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F 0.526518
ERBB2 erb-b2 receptor tyrosine kinase 2 0.523816
NOTCH1 notch 1 0.517265
MB myoglobin 0.508424
CALB2 calbindin 2 0.501527
FNTA farnesyltransferase, CAAX box, alpha 0.500761
FAM107A family with sequence similarity 107, member A 0.496939
HIF3A hypoxia inducible factor 3, alpha subunit 0.495029
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4 0.493503
PDE8A phosphodiesterase 8A 0.492359
MITF microphthalmia-associated transcription factor 0.48893
NRG1 neuregulin 1 0.453716
ARMC10 armadillo repeat containing 10 0.453339
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 0.452585
CDC42 cell division cycle 42 0.448441
PGM1 phosphoglucomutase 1 0.439034
AQP6 aquaporin 6, kidney specific 0.43753
LMO3 LIM domain only 3 (rhombotin-like 2) 0.436026
TGFB1 transforming growth factor, beta 1 0.434148
PTEN phosphatase and tensin homolog 0.419517
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.418768
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.41727
SCN10A sodium channel, voltage gated, type X alpha subunit 0.413527
FAT3 FAT atypical cadherin 3 0.406425
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 0.403811
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.402692
RICTOR RPTOR independent companion of MTOR, complex 2 0.400826
RAD54B RAD54 homolog B (S. cerevisiae) 0.400453
NCAM1 neural cell adhesion molecule 1 0.390025
TYR tyrosinase 0.389281
HBA1 hemoglobin, alpha 1 0.381481
PROS1 protein S (alpha) 0.380368
EGFR epidermal growth factor receptor 0.379626
EZR ezrin 0.379626
BDNF brain-derived neurotrophic factor 0.377402
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal 0.373698
GAP43 growth associated protein 43 0.372587
CTSC cathepsin C 0.366671
DSP desmoplakin 0.364454
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit 0.361502
KRT7 keratin 7, type II 0.360764
HBA2 hemoglobin, alpha 2 0.360026
SNX9 sorting nexin 9 0.357077
ZHX2 zinc fingers and homeoboxes 2 0.354868
MSH4 mutS homolog 4 0.354131
MOCS2 molybdenum cofactor synthesis 2 0.352659
SNN stannin 0.351555
FGF2 fibroblast growth factor 2 (basic) 0.344207
PGR progesterone receptor 0.34384
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.339806
PDPN podoplanin 0.33651
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.335046
CCND1 cyclin D1 0.334315
F8 coagulation factor VIII, procoagulant component 0.333583
NRG2 neuregulin 2 0.331756
CDKN2A cyclin-dependent kinase inhibitor 2A 0.320817
MLPH melanophilin 0.319363
TRPV1 transient receptor potential cation channel, subfamily V, member 1 0.316456
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 0.316092
TPM1 tropomyosin 1 (alpha) 0.315366
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 0.305587
MVP major vault protein 0.299452
PRNT prion protein (testis specific) 0.298011
FSCN1 fascin actin-bundling protein 1 0.296931
CHGA chromogranin A 0.294772
NEFM neurofilament, medium polypeptide 0.294053
SST somatostatin 0.293694
IGKV1D-42 immunoglobulin kappa variable 1D-42 (non-functional) 0.289744
PRKACB protein kinase, cAMP-dependent, catalytic, beta 0.289744
TNK2 tyrosine kinase, non-receptor, 2 0.286877
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein 0.28616
CASC5 cancer susceptibility candidate 5 0.283655
LYZ lysozyme 0.281868
SIK1 salt-inducible kinase 1 0.281153
PDE9A phosphodiesterase 9A 0.27687
CHL1 cell adhesion molecule L1-like 0.275445
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.272953
IFT122 intraflagellar transport 122 0.268332
PKN1 protein kinase N1 0.267977
NID1 nidogen 1 0.265849
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.264431
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 0.260538
TRPV4 transient receptor potential cation channel, subfamily V, member 4 0.260184
TP73 tumor protein p73 0.257358
CKS2 CDC28 protein kinase regulatory subunit 2 0.25207
ERBB4 erb-b2 receptor tyrosine kinase 4 0.248554
MMP2 matrix metallopeptidase 2 0.24715
RASA1 RAS p21 protein activator (GTPase activating protein) 1 0.241196
BCAN brevican 0.238054
CD44 CD44 molecule (Indian blood group) 0.235268
LGALS3 lectin, galactoside-binding, soluble, 3 0.233878
CAPN1 calpain 1, (mu/I) large subunit 0.233183
S100P S100 calcium binding protein P 0.232489
CD53 CD53 molecule 0.22937
PMEL premelanosome protein 0.227297
BIN2 bridging integrator 2 0.227297
BMP4 bone morphogenetic protein 4 0.223509
FBXO42 F-box protein 42 0.223165
COCH cochlin 0.221793
HAVCR1 hepatitis A virus cellular receptor 1 0.211261
QKI QKI, KH domain containing, RNA binding 0.210589
SCGB2A1 secretoglobin, family 2A, member 1 0.208579
SOX6 SRY (sex determining region Y)-box 6 0.206248
ARTN artemin 0.205254
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.204593
OLIG1 oligodendrocyte transcription factor 1 0.198064
HSD17B1P1 hydroxysteroid (17-beta) dehydrogenase 1 pseudogene 1 0.19582
SCN3A sodium channel, voltage gated, type III alpha subunit 0.194548
NPS neuropeptide S 0.1936
PAX7 paired box 7 0.193285
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2 0.188632
TUBA1A tubulin, alpha 1a 0.18621
TIMP3 TIMP metallopeptidase inhibitor 3 0.177576
EDA ectodysplasin A 0.176485
PER3 period circadian clock 3 0.174617
MEN1 multiple endocrine neoplasia I 0.174354
MUTYH mutY homolog 0.171535
IGF1R insulin-like growth factor 1 receptor 0.171036
CX3CL1 chemokine (C-X3-C motif) ligand 1 0.171036
CHEK2 checkpoint kinase 2 0.170054
NEU2 sialidase 2 (cytosolic sialidase) 0.169812
SCN8A sodium channel, voltage gated, type VIII alpha subunit 0.166768
SLC26A6 solute carrier family 26 (anion exchanger), member 6 0.166319
FGF1 fibroblast growth factor 1 (acidic) 0.166319
BMP2 bone morphogenetic protein 2 0.161912
NT5C2 5'-nucleotidase, cytosolic II 0.160948
PTPRC protein tyrosine phosphatase, receptor type, C 0.160387
C1QBP complement component 1, q subcomponent binding protein 0.159124
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.158266
ENAM enamelin 0.13886
POMC proopiomelanocortin 0.13857
FAR2 fatty acyl CoA reductase 2 0.13752
SP7 Sp7 transcription factor 0.136824
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.136683
PYY peptide YY 0.135187
KRT8 keratin 8, type II 0.134906
PROP1 PROP paired-like homeobox 1 0.134062
PPY pancreatic polypeptide 0.134019
KRT5 keratin 5, type II 0.133946
KRT14 keratin 14, type I 0.132957
AGO2 argonaute RISC catalytic component 2 0.129623
UBE2C ubiquitin-conjugating enzyme E2C 0.128439
POU1F1 POU class 1 homeobox 1 0.127877
MMP20 matrix metallopeptidase 20 0.127865
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 0.127635
AOX1 aldehyde oxidase 1 0.12688
CTSL cathepsin L 0.126469
KRT19 keratin 19, type I 0.126315
FBLN1 fibulin 1 0.126206
PDGFD platelet derived growth factor D 0.125619
CSTA cystatin A (stefin A) 0.125117
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.124429
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.124373
HESX1 HESX homeobox 1 0.124252
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 0.123386
EPCAM epithelial cell adhesion molecule 0.123215
RUNX2 runt-related transcription factor 2 0.122579
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.122295
THEM4 thioesterase superfamily member 4 0.122286
CXCR6 chemokine (C-X-C motif) receptor 6 0.122231
KITLG KIT ligand 0.12187
AVP arginine vasopressin 0.121046
PLAUR plasminogen activator, urokinase receptor 0.120644
SYNPO synaptopodin 0.120198
PDE10A phosphodiesterase 10A 0.119953
IGF1 insulin-like growth factor 1 (somatomedin C) 0.11988
CXCL16 chemokine (C-X-C motif) ligand 16 0.11819
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.117809
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 0.11759
PTTG1 pituitary tumor-transforming 1 0.117578
MN1 meningioma (disrupted in balanced translocation) 1 0.117325
PRL prolactin 0.117325
TRH thyrotropin-releasing hormone 0.116975
TIMP4 TIMP metallopeptidase inhibitor 4 0.116404
ZBTB16 zinc finger and BTB domain containing 16 0.115965
PDYN prodynorphin 0.115744
GPX3 glutathione peroxidase 3 0.115208
MCM6 minichromosome maintenance complex component 6 0.114815
AMELY amelogenin, Y-linked 0.114337
FXYD5 FXYD domain containing ion transport regulator 5 0.113317
MMP11 matrix metallopeptidase 11 0.113102
NTS neurotensin 0.112664
AMELX amelogenin, X-linked 0.11211
LEF1 lymphoid enhancer-binding factor 1 0.111885
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.111442
FECH ferrochelatase 0.111271
SCRT1 scratch family zinc finger 1 0.110807
INS insulin 0.110572
MIR145 microRNA 145 0.109316
GRP gastrin-releasing peptide 0.10881
LEP leptin 0.107697
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 0.107569
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.107201
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 0.106846
GHRL ghrelin/obestatin prepropeptide 0.106436
ADAMDEC1 ADAM-like, decysin 1 0.106255
IGFBP3 insulin-like growth factor binding protein 3 0.105355
CCNH cyclin H 0.105052
MYB v-myb avian myeloblastosis viral oncogene homolog 0.104696
CX3CR1 chemokine (C-X3-C motif) receptor 1 0.104644
DCX doublecortin 0.104281
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 0.104143
GCG glucagon 0.103746
CCK cholecystokinin 0.102934
GHRH growth hormone releasing hormone 0.102934
EPOR erythropoietin receptor 0.102916
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 0.102598
WRN Werner syndrome, RecQ helicase-like 0.10144
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.101221
GSK3B glycogen synthase kinase 3 beta 0.099994
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 0.098274
DNTT DNA nucleotidylexotransferase 0.097378
SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae) 0.097081
MKI67 marker of proliferation Ki-67 0.095906
HCRT hypocretin (orexin) neuropeptide precursor 0.092736
SHH sonic hedgehog 0.09187
IGFBP1 insulin-like growth factor binding protein 1 0.090673
GH1 growth hormone 1 0.089867
DAPK1 death-associated protein kinase 1 0.089454
NCAN neurocan 0.089345
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) 0.088728
MIER1 mesoderm induction early response 1, transcriptional regulator 0.08791
RBP2 retinol binding protein 2, cellular 0.085931
MCAM melanoma cell adhesion molecule 0.08559
GHRHR growth hormone releasing hormone receptor 0.085066
FABP5 fatty acid binding protein 5 (psoriasis-associated) 0.084401
GC group-specific component (vitamin D binding protein) 0.084355
SATB2 SATB homeobox 2 0.081469
CD274 CD274 molecule 0.080831
CTSK cathepsin K 0.079429
SSTR3 somatostatin receptor 3 0.079429
IVL involucrin 0.079429
AQP2 aquaporin 2 (collecting duct) 0.07931
E2F5 E2F transcription factor 5, p130-binding 0.079167
CYS1 cystin 1 0.078761
LATS1 large tumor suppressor kinase 1 0.078088
AHSG alpha-2-HS-glycoprotein 0.077943
GHR growth hormone receptor 0.077389
MDM4 MDM4, p53 regulator 0.076444
CRABP2 cellular retinoic acid binding protein 2 0.076274
CPSF3L cleavage and polyadenylation specific factor 3-like 0.076031
MIR21 microRNA 21 0.075982
NRTN neurturin 0.075715
RPIA ribose 5-phosphate isomerase A 0.075302
CA9 carbonic anhydrase IX 0.074199
COL4A4 collagen, type IV, alpha 4 0.074052
FGA fibrinogen alpha chain 0.07393
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 0.073783
OR10A4 olfactory receptor, family 10, subfamily A, member 4 0.073561
GSTM3 glutathione S-transferase mu 3 (brain) 0.073314
SSTR1 somatostatin receptor 1 0.073166
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.073018
RHOB ras homolog family member B 0.072772
MID2 midline 2 0.072698
AIP aryl hydrocarbon receptor interacting protein 0.072673
SETD1A SET domain containing 1A 0.072476
ALAD aminolevulinate dehydratase 0.072279
AGRP agouti related neuropeptide 0.071957
MMP7 matrix metallopeptidase 7 0.071585
TERT telomerase reverse transcriptase 0.07156
OR10K1 olfactory receptor, family 10, subfamily K, member 1 0.07156
NMT1 N-myristoyltransferase 1 0.071164
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.070866
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.070693
PRRC2A proline-rich coiled-coil 2A 0.07047
VEGFA vascular endothelial growth factor A 0.070096
CD79B CD79b molecule, immunoglobulin-associated beta 0.069946
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase 0.069473
LEPR leptin receptor 0.069274
FASN fatty acid synthase 0.069149
PDE4D phosphodiesterase 4D, cAMP-specific 0.068751
MTAP methylthioadenosine phosphorylase 0.068576
MMP9 matrix metallopeptidase 9 0.068126
AQP3 aquaporin 3 (Gill blood group) 0.068101
WT1 Wilms tumor 1 0.068001
CCNB1 cyclin B1 0.068001
TGFB2 transforming growth factor, beta 2 0.067901
MOG myelin oligodendrocyte glycoprotein 0.067851
NPPC natriuretic peptide C 0.067076
TIMP2 TIMP metallopeptidase inhibitor 2 0.067001
LOX lysyl oxidase 0.0669
CTSS cathepsin S 0.0667
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.066675
TNC tenascin C 0.065673
AQP4 aquaporin 4 0.065095
EDN3 endothelin 3 0.064995
ERCC4 excision repair cross-complementation group 4 0.06497
ATF1 activating transcription factor 1 0.064794
KRT3 keratin 3, type II 0.064518
ANXA5 annexin A5 0.064418
PROM1 prominin 1 0.064192
ALLC allantoicase 0.064192
PRDM2 PR domain containing 2, with ZNF domain 0.064067
CCNA2 cyclin A2 0.064067
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase 0.064042
WDFY2 WD repeat and FYVE domain containing 2 0.064042
ERCC5 excision repair cross-complementation group 5 0.063816
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) 0.063715
UST uronyl-2-sulfotransferase 0.063489
MC4R melanocortin 4 receptor 0.063363
MMP3 matrix metallopeptidase 3 0.063313
FLCN folliculin 0.063238