nephrotic syndrome Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description Xref MGI. (Human Disease Ontology, DOID_1184)
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Genes

326 genes co-occuring with the disease nephrotic syndrome in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
NPHS1 nephrosis 1, congenital, Finnish type (nephrin) 2.73203
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin) 2.66337
ALB albumin 2.51681
LYZ lysozyme 2.01112
CD2AP CD2-associated protein 1.94078
CD79A CD79a molecule, immunoglobulin-associated alpha 1.9066
ACTN4 actinin, alpha 4 1.84863
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 1.65475
WT1 Wilms tumor 1 1.6516
KIRREL kin of IRRE like (Drosophila) 1.65115
ACE angiotensin I converting enzyme 1.60949
PLCE1 phospholipase C, epsilon 1 1.58537
SYNPO synaptopodin 1.57067
APOB apolipoprotein B 1.39302
TRPC6 transient receptor potential cation channel, subfamily C, member 6 1.38254
POMC proopiomelanocortin 1.33981
PLA2R1 phospholipase A2 receptor 1, 180kDa 1.32803
NPPA natriuretic peptide A 1.32192
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 1.31799
REN renin 1.30969
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) 1.30357
CMIP c-Maf inducing protein 1.22952
LPA lipoprotein, Lp(a) 1.17464
TF transferrin 1.12572
MYO1E myosin IE 1.10343
B2M beta-2-microglobulin 1.10258
FBXL20 F-box and leucine-rich repeat protein 20 1.08454
PROS1 protein S (alpha) 1.07992
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase 1.07446
ADCK4 aarF domain containing kinase 4 1.069
STOM stomatin 1.06228
CABIN1 calcineurin binding protein 1 1.04041
LPL lipoprotein lipase 1.02482
FN1 fibronectin 1 1.01469
APOE apolipoprotein E 1.00921
LCAT lecithin-cholesterol acyltransferase 0.997814
AQP2 aquaporin 2 (collecting duct) 0.99697
INF2 inverted formin, FH2 and WH2 domain containing 0.996127
PTPRO protein tyrosine phosphatase, receptor type, O 0.986007
PLG plasminogen 0.954525
APOA1 apolipoprotein A-I 0.951604
COQ6 coenzyme Q6 monooxygenase 0.9238
F12 coagulation factor XII (Hageman factor) 0.922149
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.908965
TNS2 tensin 2 0.907731
KIRREL3 kin of IRRE like 3 (Drosophila) 0.900335
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 0.899514
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 0.898282
F9 coagulation factor IX 0.89623
C3 complement component 3 0.881882
MPV17 MpV17 mitochondrial inner membrane protein 0.874919
LRP2 low density lipoprotein receptor-related protein 2 0.868368
F2 coagulation factor II (thrombin) 0.862637
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.855677
RARA retinoic acid receptor, alpha 0.855268
TGFB1 transforming growth factor, beta 1 0.825768
AVP arginine vasopressin 0.823718
SDC2 syndecan 2 0.820847
PLA2G1B phospholipase A2, group IB (pancreas) 0.814693
IL2RA interleukin 2 receptor, alpha 0.803616
VEGFA vascular endothelial growth factor A 0.801154
GNS glucosamine (N-acetyl)-6-sulfatase 0.782298
SAA1 serum amyloid A1 0.77575
TJP1 tight junction protein 1 0.756564
F3 coagulation factor III (thromboplastin, tissue factor) 0.75005
LMX1B LIM homeobox transcription factor 1, beta 0.749237
APOA2 apolipoprotein A-II 0.746798
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B 0.745172
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 0.741923
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.740299
CD4 CD4 molecule 0.739894
KIRREL2 kin of IRRE like 2 (Drosophila) 0.734622
GC group-specific component (vitamin D binding protein) 0.734217
IL13 interleukin 13 0.726524
CD19 CD19 molecule 0.721673
F8 coagulation factor VIII, procoagulant component 0.716425
ANGPTL4 angiopoietin-like 4 0.711587
ZHX3 zinc fingers and homeoboxes 3 0.705547
TREH trehalase (brush-border membrane glycoprotein) 0.703536
PTH parathyroid hormone 0.701124
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 0.6791
HPX hemopexin 0.661594
ALPPL2 alkaline phosphatase, placental-like 2 0.660008
ALPP alkaline phosphatase, placental 0.659611
ALPL alkaline phosphatase, liver/bone/kidney 0.658818
F5 coagulation factor V (proaccelerin, labile factor) 0.656046
IL2 interleukin 2 0.63907
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 0.636708
GZF1 GDNF-inducible zinc finger protein 1 0.633956
LAMA5 laminin, alpha 5 0.63042
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.625711
PIGN phosphatidylinositol glycan anchor biosynthesis, class N 0.616703
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.59952
CD68 CD68 molecule 0.577716
CD80 CD80 molecule 0.572662
SOD2 superoxide dismutase 2, mitochondrial 0.570718
CTXN1 cortexin 1 0.569163
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 0.560616
CYCS cytochrome c, somatic 0.559839
IL36A interleukin 36, alpha 0.557509
IQGAP1 IQ motif containing GTPase activating protein 1 0.545481
GCA grancalcin, EF-hand calcium binding protein 0.529222
COX5A cytochrome c oxidase subunit Va 0.52536
PPOX protoporphyrinogen oxidase 0.52536
GPX1 glutathione peroxidase 1 0.522659
PLAT plasminogen activator, tissue 0.522659
SCNN1B sodium channel, non voltage gated 1 beta subunit 0.522273
GPX5 glutathione peroxidase 5 0.514571
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 0.513417
SAA2 serum amyloid A2 0.512264
GPX4 glutathione peroxidase 4 0.511496
CRP C-reactive protein, pentraxin-related 0.508424
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 0.503058
HP haptoglobin 0.501144
AFM afamin 0.498085
MGP matrix Gla protein 0.497321
HPR haptoglobin-related protein 0.495029
IGSF5 immunoglobulin superfamily, member 5 0.485505
AQP3 aquaporin 3 (Gill blood group) 0.485125
PTPRU protein tyrosine phosphatase, receptor type, U 0.482844
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 0.480945
CORIN corin, serine peptidase 0.46655
VWF von Willebrand factor 0.464283
CAT catalase 0.463905
ZHX1 zinc fingers and homeoboxes 1 0.463149
INS insulin 0.461261
APOL1 apolipoprotein L, 1 0.460129
SEBOX SEBOX homeobox 0.458996
CFP complement factor properdin 0.457864
COQ4 coenzyme Q4 0.455224
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 0.454093
TNF tumor necrosis factor 0.454093
SYNJ1 synaptojanin 1 0.449194
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.448064
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 0.447311
SOCS4 suppressor of cytokine signaling 4 0.444676
IGLV1-51 immunoglobulin lambda variable 1-51 0.443923
TTR transthyretin 0.443547
LCN2 lipocalin 2 0.442042
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) 0.43753
HLA-A major histocompatibility complex, class I, A 0.435275
IFNA1 interferon, alpha 1 0.430017
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 0.42589
IL4 interleukin 4 0.42364
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 0.418394
IGF1 insulin-like growth factor 1 (somatomedin C) 0.417644
MIR192 microRNA 192 0.417644
MME membrane metallo-endopeptidase 0.410535
KLKB1 kallikrein B, plasma (Fletcher factor) 1 0.409787
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 0.40904
APOC3 apolipoprotein C-III 0.404931
SNX16 sorting nexin 16 0.404557
TBX1 T-box 1 0.402692
SCO1 SCO1 cytochrome c oxidase assembly protein 0.40008
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 0.397843
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 0.395235
DDN dendrin 0.392257
AFP alpha-fetoprotein 0.388538
SH3GL2 SH3-domain GRB2-like 2 0.388166
CST3 cystatin C 0.387423
MEFV Mediterranean fever 0.386679
NARS asparaginyl-tRNA synthetase 0.385193
THBD thrombomodulin 0.384079
LCA10 lung carcinoma-associated 10 0.383708
IL18 interleukin 18 0.382966
AMOTL1 angiomotin like 1 0.382594
HBE1 hemoglobin, epsilon 1 0.370368
COQ9 coenzyme Q9 0.36704
PBX4 pre-B-cell leukemia homeobox 4 0.360395
F7 coagulation factor VII (serum prothrombin conversion accelerator) 0.359657
RORC RAR-related orphan receptor C 0.35892
SREBF2 sterol regulatory element binding transcription factor 2 0.355604
PAX2 paired box 2 0.355235
PLAU plasminogen activator, urokinase 0.353763
COL4A4 collagen, type IV, alpha 4 0.351923
SPP1 secreted phosphoprotein 1 0.351187
CD44 CD44 molecule (Indian blood group) 0.350084
NEIL1 nei endonuclease VIII-like 1 (E. coli) 0.348246
CP ceruloplasmin (ferroxidase) 0.344941
DNAH8 dynein, axonemal, heavy chain 8 0.334681
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.333949
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 0.333218
MPO myeloperoxidase 0.330295
MN1 meningioma (disrupted in balanced translocation) 1 0.32774
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.32701
GP1BA glycoprotein Ib (platelet), alpha polypeptide 0.326646
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.324094
SGK1 serum/glucocorticoid regulated kinase 1 0.32373
ADIPOQ adiponectin, C1Q and collagen domain containing 0.323365
GSTK1 glutathione S-transferase kappa 1 0.318272
CCL2 chemokine (C-C motif) ligand 2 0.317909
COQ7 coenzyme Q7 homolog, ubiquinone (yeast) 0.317545
PITPNB phosphatidylinositol transfer protein, beta 0.317545
IGFBP3 insulin-like growth factor binding protein 3 0.317182
SH3GL3 SH3-domain GRB2-like 3 0.315366
IGHA1 immunoglobulin heavy constant alpha 1 0.305948
CD3G CD3g molecule, gamma (CD3-TCR complex) 0.303059
EDA ectodysplasin A 0.302337
AMBP alpha-1-microglobulin/bikunin precursor 0.301976
SDK1 sidekick cell adhesion molecule 1 0.301615
PF4 platelet factor 4 0.300894
DNM2 dynamin 2 0.300533
PIGC phosphatidylinositol glycan anchor biosynthesis, class C 0.295132
HAVCR1 hepatitis A virus cellular receptor 1 0.294413
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.293694
LDLR low density lipoprotein receptor 0.289744
RAF1 Raf-1 proto-oncogene, serine/threonine kinase 0.289744
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 0.289027
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.287235
AGTR1 angiotensin II receptor, type 1 0.284013
PRSS8 protease, serine, 8 0.282582
CLNS1A chloride channel, nucleotide-sensitive, 1A 0.28151
CETP cholesteryl ester transfer protein, plasma 0.277584
SCARB1 scavenger receptor class B, member 1 0.273308
GLCCI1 glucocorticoid induced 1 0.269398
IL1B interleukin 1, beta 0.267977
BCAT2 branched chain amino-acid transaminase 2, mitochondrial 0.267622
EZR ezrin 0.267267
MYH9 myosin, heavy chain 9, non-muscle 0.267267
FTH1 ferritin, heavy polypeptide 1 0.266913
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.265494
NFRKB nuclear factor related to kappaB binding protein 0.264431
STS steroid sulfatase (microsomal), isozyme S 0.261952
GUSB glucuronidase, beta 0.261952
CFB complement factor B 0.257711
COL4A5 collagen, type IV, alpha 5 0.256299
PDXP pyridoxal (pyridoxine, vitamin B6) phosphatase 0.253831
FOXP3 forkhead box P3 0.24996
ITSN2 intersectin 2 0.245747
IFNA2 interferon, alpha 2 0.244345
APOC2 apolipoprotein C-II 0.238403
THEM5 thioesterase superfamily member 5 0.238403
AHSG alpha-2-HS-glycoprotein 0.23666
CFH complement factor H 0.235616
CXCL8 chemokine (C-X-C motif) ligand 8 0.231795
IL6 interleukin 6 0.227297
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.227297
POU6F2 POU class 6 homeobox 2 0.225573
WEE1 WEE1 G2 checkpoint kinase 0.225229
DGCR6 DiGeorge syndrome critical region gene 6 0.223853
HRG histidine-rich glycoprotein 0.222822
TNC tenascin C 0.22145
BGLAP bone gamma-carboxyglutamate (gla) protein 0.210589
DCAF7 DDB1 and CUL4 associated factor 7 0.209248
HPSE heparanase 0.205916
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 0.204593
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.204263
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.203933
PCNA proliferating cell nuclear antigen 0.202618
NPPC natriuretic peptide C 0.200656
NSDHL NAD(P) dependent steroid dehydrogenase-like 0.199356
PRTN3 proteinase 3 0.198386
TRPV5 transient receptor potential cation channel, subfamily V, member 5 0.197099
PRKD2 protein kinase D2 0.196779
COG2 component of oligomeric golgi complex 2 0.195501
CANX calnexin 0.195501
FTL ferritin, light polypeptide 0.191408
GSN gelsolin 0.190476
NEBL nebulette 0.189859
ALG10 ALG10, alpha-1,2-glucosyltransferase 0.189244
KIF27 kinesin family member 27 0.187113
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 0.183248
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 0.182086
AMPD2 adenosine monophosphate deaminase 2 0.180084
KNG1 kininogen 1 0.177029
BCHE butyrylcholinesterase 0.177029
PKD2 polycystic kidney disease 2 (autosomal dominant) 0.176215
ACTB actin, beta 0.174881
LAMB1 laminin, beta 1 0.173571
DNM3 dynamin 3 0.173314
AFF2 AF4/FMR2 family, member 2 0.172544
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 0.171286
TIMP1 TIMP metallopeptidase inhibitor 1 0.171286
FRAT1 frequently rearranged in advanced T-cell lymphomas 1 0.170544
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.170054
HAND1 heart and neural crest derivatives expressed 1 0.167915
FMN1 formin 1 0.167452
SOAT2 sterol O-acyltransferase 2 0.166768
WTIP Wilms tumor 1 interacting protein 0.165655
CFI complement factor I 0.163317
LVRN laeverin 0.162109
IFNB1 interferon, beta 1, fibroblast 0.161523
MGAM maltase-glucoamylase 0.160948
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.160574
LEP leptin 0.159302
ZNF266 zinc finger protein 266 0.158605
MX2 MX dynamin-like GTPase 2 0.145285
ARHGEF19 Rho guanine nucleotide exchange factor (GEF) 19 0.144817
EFNB1 ephrin-B1 0.144771
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase 0.144316
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.144311
UBC ubiquitin C 0.144176
NID1 nidogen 1 0.144165
RPS27A ribosomal protein S27a 0.144109
GPC5 glypican 5 0.143893
ETV4 ets variant 4 0.14374
UBB ubiquitin B 0.14373
CA10 carbonic anhydrase X 0.143202
SPTBN1 spectrin, beta, non-erythrocytic 1 0.143125
MOGS mannosyl-oligosaccharide glucosidase 0.142989
CD14 CD14 molecule 0.142966
ILK integrin-linked kinase 0.142952
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.142915
COL5A1 collagen, type V, alpha 1 0.14242
RRM1 ribonucleotide reductase M1 0.142353
LIG3 ligase III, DNA, ATP-dependent 0.142187
APLP1 amyloid beta (A4) precursor-like protein 1 0.142085
FAT1 FAT atypical cadherin 1 0.141255
MX1 MX dynamin-like GTPase 1 0.140936
LAMC2 laminin, gamma 2 0.140822
PSAP prosaposin 0.140747
PAEP progestagen-associated endometrial protein 0.140325
TREX1 three prime repair exonuclease 1 0.140288
TRPC3 transient receptor potential cation channel, subfamily C, member 3 0.140232
IL10 interleukin 10 0.140003
SLC26A3 solute carrier family 26 (anion exchanger), member 3 0.139629
CD151 CD151 molecule (Raph blood group) 0.139619
ARRB2 arrestin, beta 2 0.139262
HMGA2 high mobility group AT-hook 2 0.138917
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.138688
CD276 CD276 molecule 0.13823
CTNND1 catenin (cadherin-associated protein), delta 1 0.137988
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.135098
LAMB2 laminin, beta 2 (laminin S) 0.135058
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 0.135018
IGF2R insulin-like growth factor 2 receptor 0.134559