neoplasm Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A benign or malignant tissue growth resulting from uncontrolled cell proliferation. Benign neoplastic cells resemble normal cells without exhibiting significant cytologic atypia, while malignant cells exhibit overt signs such as dysplastic features, atypical mitotic figures, necrosis, nuclear pleomorphism, and anaplasia. Representative examples of benign neoplasms include papillomas, cystadenomas, and lipomas; malignant neoplasms include carcinomas, sarcomas, lymphomas, and leukemias. (Experimental Factor Ontology, EFO_0000616)
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Genes

224 genes co-occuring with the biological term neoplasm in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADAM12 ADAM metallopeptidase domain 12
ADAM15 ADAM metallopeptidase domain 15
AFP alpha-fetoprotein
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALK anaplastic lymphoma receptor tyrosine kinase
ANGPT2 angiopoietin 2
ANXA2 annexin A2
ASCL1 achaete-scute family bHLH transcription factor 1
ATM ATM serine/threonine kinase
AURKA aurora kinase A
AURKB aurora kinase B
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BCL2 B-cell CLL/lymphoma 2
BCR breakpoint cluster region
BIRC5 baculoviral IAP repeat containing 5
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BSG basigin (Ok blood group)
CALR calreticulin
CCDC28A coiled-coil domain containing 28A
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCND1 cyclin D1
CD24 CD24 molecule
CD4 CD4 molecule
CD5 CD5 molecule
CD82 CD82 molecule
CD99 CD99 molecule
CDC73 cell division cycle 73
CDCP1 CUB domain containing protein 1
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH17 cadherin 17, LI cadherin (liver-intestine)
CDK2 cyclin-dependent kinase 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDX2 caudal type homeobox 2
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEP85L centrosomal protein 85kDa-like
CHD1 chromodomain helicase DNA binding protein 1
CHEK2 checkpoint kinase 2
CHGA chromogranin A
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKMT1A creatine kinase, mitochondrial 1A
CLDN1 claudin 1
CNR1 cannabinoid receptor 1 (brain)
CNR2 cannabinoid receptor 2 (macrophage)
CRP C-reactive protein, pentraxin-related
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DLC1 DLC1 Rho GTPase activating protein
DMKN dermokine
ECM1 extracellular matrix protein 1
EGFR epidermal growth factor receptor
EML4 echinoderm microtubule associated protein like 4
ENG endoglin
ERBB2 erb-b2 receptor tyrosine kinase 2
ESR1 estrogen receptor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F3 coagulation factor III (thromboplastin, tissue factor)
FASN fatty acid synthase
FBLN1 fibulin 1
FGF2 fibroblast growth factor 2 (basic)
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FHIT fragile histidine triad
FIP1L1 factor interacting with PAPOLA and CPSF1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXE1 forkhead box E1
FOXN3 forkhead box N3
FOXP1 forkhead box P1
FOXP3 forkhead box P3
GATA3 GATA binding protein 3
GLI1 GLI family zinc finger 1
GLUL glutamate-ammonia ligase
GNAS GNAS complex locus
GPC3 glypican 3
GRP gastrin-releasing peptide
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HLA-C major histocompatibility complex, class I, C
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HP haptoglobin
HRAS Harvey rat sarcoma viral oncogene homolog
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL1B interleukin 1, beta
IL3RA interleukin 3 receptor, alpha (low affinity)
IL6 interleukin 6
JAK2 Janus kinase 2
JAKMIP2 janus kinase and microtubule interacting protein 2
KANK1 KN motif and ankyrin repeat domains 1
KAT2B K(lysine) acetyltransferase 2B
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KLK10 kallikrein-related peptidase 10
KRT15 keratin 15, type I
KRT19 keratin 19, type I
LAMP1 lysosomal-associated membrane protein 1
LEPQTL1 Leptin, serum levels of
LEPR leptin receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LGI1 leucine-rich, glioma inactivated 1
LMX1A LIM homeobox transcription factor 1, alpha
LOC645468 insulin-like growth factor 2 mRNA binding protein 3 pseudogene
LRP5 low density lipoprotein receptor-related protein 5
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAP2 microtubule-associated protein 2
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MCAM melanoma cell adhesion molecule
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEFV Mediterranean fever
MET MET proto-oncogene, receptor tyrosine kinase
MGAT5B mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B
MIR139 microRNA 139
MIR196A1 microRNA 196a-1
MIR196A2 microRNA 196a-2
MIR223 microRNA 223
MIR26A1 microRNA 26a-1
MIR26B microRNA 26b
MKI67 marker of proliferation Ki-67
MMP1 matrix metallopeptidase 1
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MPL MPL proto-oncogene, thrombopoietin receptor
MPO myeloperoxidase
MSX2 msh homeobox 2
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MUC1 mucin 1, cell surface associated
MUC2 mucin 2, oligomeric mucus/gel-forming
MUC4 mucin 4, cell surface associated
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MUC6 mucin 6, oligomeric mucus/gel-forming
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAPSA napsin A aspartic peptidase
NBN nibrin
NCAM1 neural cell adhesion molecule 1
NDRG1 N-myc downstream regulated 1
NDRG2 NDRG family member 2
NFE2 nuclear factor, erythroid 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NKX2-1 NK2 homeobox 1
NOS2 nitric oxide synthase 2, inducible
NOTCH1 notch 1
NOX1 NADPH oxidase 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NPY neuropeptide Y
NR1H3 nuclear receptor subfamily 1, group H, member 3
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NTS neurotensin
NTSR1 neurotensin receptor 1 (high affinity)
NUDC nudC nuclear distribution protein
NUP98 nucleoporin 98kDa
OCLN occludin
PACRG PARK2 co-regulated
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PARK2 parkin RBR E3 ubiquitin protein ligase
PAX3 paired box 3
PCNA proliferating cell nuclear antigen
PDCD1 programmed cell death 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDCD5 programmed cell death 5
PDGFD platelet derived growth factor D
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PECAM1 platelet/endothelial cell adhesion molecule 1
PGR progesterone receptor
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PKM pyruvate kinase, muscle
PNLIP pancreatic lipase
PODXL podocalyxin-like
POU3F2 POU class 3 homeobox 2
PPARG peroxisome proliferator-activated receptor gamma
PRKCI protein kinase C, iota
PRKCZ protein kinase C, zeta
PRUNE prune exopolyphosphatase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
QSOX1 quiescin Q6 sulfhydryl oxidase 1
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RET ret proto-oncogene
RRM2B ribonucleotide reductase M2 B (TP53 inducible)
S100A1 S100 calcium binding protein A1
SAA1 serum amyloid A1
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SHH sonic hedgehog
SOCS3 suppressor of cytokine signaling 3
SOD2 superoxide dismutase 2, mitochondrial
SOX10 SRY (sex determining region Y)-box 10
SOX9 SRY (sex determining region Y)-box 9
SP1 Sp1 transcription factor
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPP1 secreted phosphoprotein 1
SSTR2 somatostatin receptor 2
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TET2 tet methylcytosine dioxygenase 2
TIMP1 TIMP metallopeptidase inhibitor 1
TJP1 tight junction protein 1
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TP63 tumor protein p63
TSC2 tuberous sclerosis 2
TYRO3 TYRO3 protein tyrosine kinase
VEGFA vascular endothelial growth factor A
VIM vimentin
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3