negative regulation of intracellular signal transduction Gene Set

Dataset GO Biological Process Annotations
Category structural or functional annotations
Type biological process
Description Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction. (Gene Ontology, GO_1902532)
External Link http://amigo.geneontology.org/amigo/term/GO:1902532
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Genes

372 genes participating in the negative regulation of intracellular signal transduction biological process from the curated GO Biological Process Annotations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACKR3 atypical chemokine receptor 3
ADIPOQ adiponectin, C1Q and collagen domain containing
ADRA1A adrenoceptor alpha 1A
AIDA axin interactor, dorsalization associated
AJUBA ajuba LIM protein
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT1S1 AKT1 substrate 1 (proline-rich)
AMBP alpha-1-microglobulin/bikunin precursor
ANKRD26 ankyrin repeat domain 26
APC adenomatous polyposis coli
APOE apolipoprotein E
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
ARHGAP24 Rho GTPase activating protein 24
ARHGAP35 Rho GTPase activating protein 35
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BAG5 BCL2-associated athanogene 5
BANK1 B-cell scaffold protein with ankyrin repeats 1
BCL2 B-cell CLL/lymphoma 2
BCL2A1 BCL2-related protein A1
BCL2L1 BCL2-like 1
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BCL2L12 BCL2-like 12 (proline rich)
BCL2L2 BCL2-like 2
BCL6 B-cell CLL/lymphoma 6
BDKRB2 bradykinin receptor B2
BMP4 bone morphogenetic protein 4
BMP7 bone morphogenetic protein 7
C1QBP complement component 1, q subcomponent binding protein
C1QL4 complement component 1, q subcomponent-like 4
C1QTNF3 C1q and tumor necrosis factor related protein 3
C3ORF33 chromosome 3 open reading frame 33
C9ORF89 chromosome 9 open reading frame 89
CARD8 caspase recruitment domain family, member 8
CASP8 caspase 8, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CAV3 caveolin 3
CBLC Cbl proto-oncogene C, E3 ubiquitin protein ligase
CCAR2 cell cycle and apoptosis regulator 2
CCDC22 coiled-coil domain containing 22
CD300A CD300a molecule
CD44 CD44 molecule (Indian blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC34 cell division cycle 34
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CHP1 calcineurin-like EF-hand protein 1
CIB1 calcium and integrin binding 1 (calmyrin)
CISH cytokine inducible SH2-containing protein
CLU clusterin
CMYA5 cardiomyopathy associated 5
CNKSR3 CNKSR family member 3
CREB3 cAMP responsive element binding protein 3
CREB3L1 cAMP responsive element binding protein 3-like 1
CRHR2 corticotropin releasing hormone receptor 2
CRTC3 CREB regulated transcription coactivator 3
CSK c-src tyrosine kinase
CUL3 cullin 3
CXCL12 chemokine (C-X-C motif) ligand 12
CYLD cylindromatosis (turban tumor syndrome)
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila)
DAB2IP DAB2 interacting protein
DACT1 dishevelled-binding antagonist of beta-catenin 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DEPTOR DEP domain containing MTOR-interacting protein
DGKZ diacylglycerol kinase, zeta
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58
DLC1 DLC1 Rho GTPase activating protein
DLG1 discs, large homolog 1 (Drosophila)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP14 dual specificity phosphatase 14
DUSP16 dual specificity phosphatase 16
DUSP18 dual specificity phosphatase 18
DUSP19 dual specificity phosphatase 19
DUSP2 dual specificity phosphatase 2
DUSP21 dual specificity phosphatase 21
DUSP22 dual specificity phosphatase 22
DUSP26 dual specificity phosphatase 26 (putative)
DUSP3 dual specificity phosphatase 3
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
DUSP8 dual specificity phosphatase 8
DUSP9 dual specificity phosphatase 9
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
ELL3 elongation factor RNA polymerase II-like 3
EPHA2 EPH receptor A2
EPO erythropoietin
ESR1 estrogen receptor 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAF1 Fas (TNFRSF6) associated factor 1
FBP1 fructose-1,6-bisphosphatase 1
FBXW11 F-box and WD repeat domain containing 11
FIGNL1 fidgetin-like 1
FKTN fukutin
FLCN folliculin
FNIP1 folliculin interacting protein 1
FOXM1 forkhead box M1
FOXO1 forkhead box O1
G2E3 G2/M-phase specific E3 ubiquitin protein ligase
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
GBA glucosidase, beta, acid
GCG glucagon
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPS1 G protein pathway suppressor 1
GPS2 G protein pathway suppressor 2
GPX1 glutathione peroxidase 1
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
GSTP1 glutathione S-transferase pi 1
HDAC2 histone deacetylase 2
HDAC3 histone deacetylase 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIPK3 homeodomain interacting protein kinase 3
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HSPB1 heat shock 27kDa protein 1
HTRA2 HtrA serine peptidase 2
HYAL2 hyaluronoglucosaminidase 2
HYOU1 hypoxia up-regulated 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL10 interleukin 10
IL1B interleukin 1, beta
IL1RL1 interleukin 1 receptor-like 1
ING2 inhibitor of growth family, member 2
INPP5K inositol polyphosphate-5-phosphatase K
INS insulin
IRAK3 interleukin-1 receptor-associated kinase 3
ITCH itchy E3 ubiquitin protein ligase
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB1BP1 integrin beta 1 binding protein 1
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
IVNS1ABP influenza virus NS1A binding protein
KANK1 KN motif and ankyrin repeat domains 1
KCTD13 potassium channel tetramerization domain containing 13
KDM1A lysine (K)-specific demethylase 1A
KLF4 Kruppel-like factor 4 (gut)
LAX1 lymphocyte transmembrane adaptor 1
LEMD2 LEM domain containing 2
LEPROT leptin receptor overlapping transcript
LIF leukemia inhibitory factor
LIMD1 LIM domains containing 1
LITAF lipopolysaccharide-induced TNF factor
LMBRD1 LMBR1 domain containing 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LRRK2 leucine-rich repeat kinase 2
LYN LYN proto-oncogene, Src family tyrosine kinase
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MAPK7 mitogen-activated protein kinase 7
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MAPKAP1 mitogen-activated protein kinase associated protein 1
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MARVELD3 MARVEL domain containing 3
MBIP MAP3K12 binding inhibitory protein 1
MCL1 myeloid cell leukemia 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MECOM MDS1 and EVI1 complex locus
MEN1 multiple endocrine neoplasia I
MFN2 mitofusin 2
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MSTN myostatin
MUC1 mucin 1, cell surface associated
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MYADM myeloid-associated differentiation marker
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NCOR1 nuclear receptor corepressor 1
NDRG2 NDRG family member 2
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)
NEUROD1 neuronal differentiation 1
NF1 neurofibromin 1
NF2 neurofibromin 2 (merlin)
NFE2L2 nuclear factor, erythroid 2-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
NLRC3 NLR family, CARD domain containing 3
NLRP12 NLR family, pyrin domain containing 12
NLRP3 NLR family, pyrin domain containing 3
NLRP6 NLR family, pyrin domain containing 6
NLRX1 NLR family member X1
NME5 NME/NM23 family member 5
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae)
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NONO non-POU domain containing, octamer-binding
NUAK1 NUAK family, SNF1-like kinase, 1
NUAK2 NUAK family, SNF1-like kinase, 2
NUP62 nucleoporin 62kDa
OLFM4 olfactomedin 4
OPA1 optic atrophy 1 (autosomal dominant)
OPTN optineurin
OTUD7B OTU deubiquitinase 7B
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PAQR3 progestin and adipoQ receptor family member III
PARK2 parkin RBR E3 ubiquitin protein ligase
PARK7 parkinson protein 7
PARL presenilin associated, rhomboid-like
PBK PDZ binding kinase
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDCD6 programmed cell death 6
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDX1 pancreatic and duodenal homeobox 1
PER1 period circadian clock 1
PGAP2 post-GPI attachment to proteins 2
PHLDA3 pleckstrin homology-like domain, family A, member 3
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PINK1 PTEN induced putative kinase 1
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive)
PLAUR plasminogen activator, urokinase receptor
PLEK pleckstrin
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
PPEF2 protein phosphatase, EF-hand calcium binding domain 2
PPIF peptidylprolyl isomerase F
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKCA protein kinase C, alpha
PRKCD protein kinase C, delta
PRKCDBP protein kinase C, delta binding protein
PRNP prion protein
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PTEN phosphatase and tensin homolog
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRJ protein tyrosine phosphatase, receptor type, J
PTPRR protein tyrosine phosphatase, receptor type, R
PYCARD PYD and CARD domain containing
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1
RANBP9 RAN binding protein 9
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RASA2 RAS p21 protein activator 2
RASA3 RAS p21 protein activator 3
RASA4 RAS p21 protein activator 4
RASAL1 RAS protein activator like 1 (GAP1 like)
RASAL2 RAS protein activator like 2
RASAL3 RAS protein activator like 3
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
RGS14 regulator of G-protein signaling 14
RGS2 regulator of G-protein signaling 2
RGS3 regulator of G-protein signaling 3
RGS4 regulator of G-protein signaling 4
RHOH ras homolog family member H
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF149 ring finger protein 149
RNF34 ring finger protein 34, E3 ubiquitin protein ligase
RORA RAR-related orphan receptor A
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
RRM2B ribonucleotide reductase M2 B (TP53 inducible)
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
SCAI suppressor of cancer cell invasion
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SFRP2 secreted frizzled-related protein 2
SFRP5 secreted frizzled-related protein 5
SH3BP4 SH3-domain binding protein 4
SIRT1 sirtuin 1
SLA2 Src-like-adaptor 2
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SLIT2 slit homolog 2 (Drosophila)
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SNAI1 snail family zinc finger 1
SNAI2 snail family zinc finger 2
SOCS1 suppressor of cytokine signaling 1
SOCS2 suppressor of cytokine signaling 2
SOCS3 suppressor of cytokine signaling 3
SOCS4 suppressor of cytokine signaling 4
SOCS5 suppressor of cytokine signaling 5
SOCS6 suppressor of cytokine signaling 6
SOCS7 suppressor of cytokine signaling 7
SOD2 superoxide dismutase 2, mitochondrial
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRED1 sprouty-related, EVH1 domain containing 1
SPRED2 sprouty-related, EVH1 domain containing 2
SPRED3 sprouty-related, EVH1 domain containing 3
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
ST20 suppressor of tumorigenicity 20
STAMBP STAM binding protein
STAT1 signal transducer and activator of transcription 1, 91kDa
STK38 serine/threonine kinase 38
STMN3 stathmin-like 3
SYNGAP1 synaptic Ras GTPase activating protein 1
SYVN1 synovial apoptosis inhibitor 1, synoviolin
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
TAOK3 TAO kinase 3
TBC1D10C TBC1 domain family, member 10C
TBC1D7 TBC1 domain family, member 7
THBS1 thrombospondin 1
TIMP2 TIMP metallopeptidase inhibitor 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLR4 toll-like receptor 4
TMBIM6 transmembrane BAX inhibitor motif containing 6
TMEM127 transmembrane protein 127
TMEM161A transmembrane protein 161A
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP8L1 tumor necrosis factor, alpha-induced protein 8-like 1
TNIP1 TNFAIP3 interacting protein 1
TNIP3 TNFAIP3 interacting protein 3
TNK1 tyrosine kinase, non-receptor, 1
TP73 tumor protein p73
TPT1 tumor protein, translationally-controlled 1
TRAP1 TNF receptor-associated protein 1
TRIAP1 TP53 regulated inhibitor of apoptosis 1
TRIM32 tripartite motif containing 32
TRIM40 tripartite motif containing 40
TRIM59 tripartite motif containing 59
TRIM67 tripartite motif containing 67
TSC1 tuberous sclerosis 1
TSC2 tuberous sclerosis 2
TSPAN6 tetraspanin 6
TWIST1 twist family bHLH transcription factor 1
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats
UBE2B ubiquitin-conjugating enzyme E2B
UBR1 ubiquitin protein ligase E3 component n-recognin 1
UBR2 ubiquitin protein ligase E3 component n-recognin 2
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
URI1 URI1, prefoldin-like chaperone
USP47 ubiquitin specific peptidase 47
VDAC2 voltage-dependent anion channel 2
VIMP VCP-interacting membrane selenoprotein
VNN1 vanin 1
VRK3 vaccinia related kinase 3
WFS1 Wolfram syndrome 1 (wolframin)
WNK2 WNK lysine deficient protein kinase 2
WTIP Wilms tumor 1 interacting protein
WWC1 WW and C2 domain containing 1
WWC2 WW and C2 domain containing 2
WWC3 WWC family member 3
XBP1 X-box binding protein 1
XDH xanthine dehydrogenase
YBX3 Y box binding protein 3
ZMYND11 zinc finger, MYND-type containing 11
ZNF385A zinc finger protein 385A
ZNF675 zinc finger protein 675