negative regulation of hydrolase activity Gene Set

Dataset GO Biological Process Annotations
Category structural or functional annotations
Type biological process
Description Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds. (Gene Ontology, GO_0051346)
External Link http://amigo.geneontology.org/amigo/term/GO:0051346
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Genes

346 genes participating in the negative regulation of hydrolase activity biological process from the curated GO Biological Process Annotations dataset.

Symbol Name
A2M alpha-2-macroglobulin
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHSG alpha-2-HS-glycoprotein
AIP aryl hydrocarbon receptor interacting protein
AKT1 v-akt murine thymoma viral oncogene homolog 1
AMBP alpha-1-microglobulin/bikunin precursor
AMOT angiomotin
ANGPTL3 angiopoietin-like 3
ANGPTL4 angiopoietin-like 4
ANOS1 anosmin 1
ANXA1 annexin A1
APCS amyloid P component, serum
APLP2 amyloid beta (A4) precursor-like protein 2
APOA1 apolipoprotein A-I
APOA2 apolipoprotein A-II
APOC1 apolipoprotein C-I
APOC3 apolipoprotein C-III
APP amyloid beta (A4) precursor protein
AQP1 aquaporin 1 (Colton blood group)
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
ARFGEF3 ARFGEF family member 3
ARL2 ADP-ribosylation factor-like 2
ARRB1 arrestin, beta 1
ARRB2 arrestin, beta 2
ATPIF1 ATPase inhibitory factor 1
AVP arginine vasopressin
BAG4 BCL2-associated athanogene 4
BCAS3 breast carcinoma amplified sequence 3
BCL2L12 BCL2-like 12 (proline rich)
BICD1 bicaudal D homolog 1 (Drosophila)
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BIRC5 baculoviral IAP repeat containing 5
BIRC6 baculoviral IAP repeat containing 6
BIRC7 baculoviral IAP repeat containing 7
BIRC8 baculoviral IAP repeat containing 8
BST2 bone marrow stromal cell antigen 2
C3 complement component 3
C5 complement component 5
CAMSAP3 calmodulin regulated spectrin-associated protein family, member 3
CARD16 caspase recruitment domain family, member 16
CARD17 caspase recruitment domain family, member 17
CARD18 caspase recruitment domain family, member 18
CASC5 cancer susceptibility candidate 5
CAST calpastatin
CCDC8 coiled-coil domain containing 8
CD109 CD109 molecule
CD27 CD27 molecule
CD2BP2 CD2 (cytoplasmic tail) binding protein 2
CD44 CD44 molecule (Indian blood group)
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CHP1 calcineurin-like EF-hand protein 1
CMYA5 cardiomyopathy associated 5
CNST consortin, connexin sorting protein
COL28A1 collagen, type XXVIII, alpha 1
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COL6A3 collagen, type VI, alpha 3
COL7A1 collagen, type VII, alpha 1
CPAMD8 C3 and PZP-like, alpha-2-macroglobulin domain containing 8
CPEB2 cytoplasmic polyadenylation element binding protein 2
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CRB2 crumbs family member 2
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CRY2 cryptochrome circadian clock 2
CRYAB crystallin, alpha B
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSRNP2 cysteine-serine-rich nuclear protein 2
CSRNP3 cysteine-serine-rich nuclear protein 3
CST1 cystatin SN
CST11 cystatin 11
CST2 cystatin SA
CST3 cystatin C
CST4 cystatin S
CST5 cystatin D
CST6 cystatin E/M
CST7 cystatin F (leukocystatin)
CST8 cystatin 8 (cystatin-related epididymal specific)
CST9 cystatin 9 (testatin)
CST9L cystatin 9-like
CSTA cystatin A (stefin A)
CSTB cystatin B (stefin B)
CSTL1 cystatin-like 1
DAB2IP DAB2 interacting protein
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DHCR24 24-dehydrocholesterol reductase
DLG2 discs, large homolog 2 (Drosophila)
DLG3 discs, large homolog 3 (Drosophila)
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DPEP1 dipeptidase 1 (renal)
ECM1 extracellular matrix protein 1
EGLN1 egl-9 family hypoxia-inducible factor 1
ELFN1 extracellular leucine-rich repeat and fibronectin type III domain containing 1
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2
ELL elongation factor RNA polymerase II
F11R F11 receptor
FABP1 fatty acid binding protein 1, liver
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FETUB fetuin B
FICD FIC domain containing
FKBP15 FK506 binding protein 15, 133kDa
FKBP1A FK506 binding protein 1A, 12kDa
FKBP1B FK506 binding protein 1B, 12.6 kDa
FNIP1 folliculin interacting protein 1
FURIN furin (paired basic amino acid cleaving enzyme)
FZD10 frizzled class receptor 10
GAS6 growth arrest-specific 6
GCHFR GTP cyclohydrolase I feedback regulator
GMIP GEM interacting protein
GNAT1 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1
GPATCH2 G patch domain containing 2
GPC3 glypican 3
GPI glucose-6-phosphate isomerase
GPX1 glutathione peroxidase 1
GRXCR1 glutaredoxin, cysteine rich 1
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HMSD histocompatibility (minor) serpin domain containing
HPN hepsin
HRAS Harvey rat sarcoma viral oncogene homolog
HRG histidine-rich glycoprotein
IFI16 interferon, gamma-inducible protein 16
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IL24 interleukin 24
IL6 interleukin 6
INTS1 integrator complex subunit 1
ITIH1 inter-alpha-trypsin inhibitor heavy chain 1
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5
ITIH6 inter-alpha-trypsin inhibitor heavy chain family, member 6
KDM5A lysine (K)-specific demethylase 5A
KIAA0430 KIAA0430
KLF4 Kruppel-like factor 4 (gut)
KNG1 kininogen 1
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
LCN1 lipocalin 1
LEF1 lymphoid enhancer-binding factor 1
LEPR leptin receptor
LMTK3 lemur tyrosine kinase 3
LRRK2 leucine-rich repeat kinase 2
LTF lactotransferrin
LXN latexin
MAP2K5 mitogen-activated protein kinase kinase 5
MAPK7 mitogen-activated protein kinase 7
MASTL microtubule associated serine/threonine kinase-like
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MKL1 megakaryoblastic leukemia (translocation) 1
MMP9 matrix metallopeptidase 9
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)
MT3 metallothionein 3
MYO1D myosin ID
NAIP NLR family, apoptosis inhibitory protein
NCKAP1L NCK-associated protein 1-like
NEIL1 nei endonuclease VIII-like 1 (E. coli)
NGF nerve growth factor (beta polypeptide)
NIFK nucleolar protein interacting with the FHA domain of MKI67
NLE1 notchless homolog 1 (Drosophila)
NLRC4 NLR family, CARD domain containing 4
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NOS1 nitric oxide synthase 1 (neuronal)
NOS3 nitric oxide synthase 3 (endothelial cell)
OXA1L oxidase (cytochrome c) assembly 1-like
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae)
PAPLN papilin, proteoglycan-like sulfated glycoprotein
PARK7 parkinson protein 7
PAX2 paired box 2
PCDH11X protocadherin 11 X-linked
PCID2 PCI domain containing 2
PCIF1 PDX1 C-terminal inhibiting factor 1
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PEBP1 phosphatidylethanolamine binding protein 1
PI15 peptidase inhibitor 15
PI16 peptidase inhibitor 16
PI3 peptidase inhibitor 3, skin-derived
PICALM phosphatidylinositol binding clathrin assembly protein
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1
PLA2R1 phospholipase A2 receptor 1, 180kDa
PLAUR plasminogen activator, urokinase receptor
PLIN5 perilipin 5
PLN phospholamban
PLXNB3 plexin B3
POR P450 (cytochrome) oxidoreductase
PPIF peptidylprolyl isomerase F
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP1R26 protein phosphatase 1, regulatory subunit 26
PPP1R27 protein phosphatase 1, regulatory subunit 27
PPP1R35 protein phosphatase 1, regulatory subunit 35
PPP1R36 protein phosphatase 1, regulatory subunit 36
PPP1R37 protein phosphatase 1, regulatory subunit 37
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4
PPP4R4 protein phosphatase 4, regulatory subunit 4
PRDX3 peroxiredoxin 3
PRDX5 peroxiredoxin 5
PRKCZ protein kinase C, zeta
PROL1 proline rich, lacrimal 1
PROS1 protein S (alpha)
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PTTG1 pituitary tumor-transforming 1
PTX3 pentraxin 3, long
PXK PX domain containing serine/threonine kinase
R3HDML R3H domain containing-like
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RAG1 recombination activating gene 1
RASA4 RAS p21 protein activator 4
RBM26 RNA binding motif protein 26
RCC2 regulator of chromosome condensation 2
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RENBP renin binding protein
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
RGS2 regulator of G-protein signaling 2
RIMBP2 RIMS binding protein 2
RNF34 ring finger protein 34, E3 ubiquitin protein ligase
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RRP1B ribosomal RNA processing 1B
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
SERPINA11 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
SERPINA9 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB10 serpin peptidase inhibitor, clade B (ovalbumin), member 10
SERPINB11 serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene)
SERPINB12 serpin peptidase inhibitor, clade B (ovalbumin), member 12
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINE3 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SFN stratifin
SFRP2 secreted frizzled-related protein 2
SH2D4A SH2 domain containing 4A
SH3BP4 SH3-domain binding protein 4
SH3RF1 SH3 domain containing ring finger 1
SH3RF2 SH3 domain containing ring finger 2
SIAH2 siah E3 ubiquitin protein ligase 2
SIRT1 sirtuin 1
SLC7A14 solute carrier family 7, member 14
SLPI secretory leukocyte peptidase inhibitor
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SORT1 sortilin 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative)
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative)
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPINK4 serine peptidase inhibitor, Kazal type 4
SPINK5 serine peptidase inhibitor, Kazal type 5
SPINK6 serine peptidase inhibitor, Kazal type 6
SPINK7 serine peptidase inhibitor, Kazal type 7 (putative)
SPINK8 serine peptidase inhibitor, Kazal type 8 (putative)
SPINK9 serine peptidase inhibitor, Kazal type 9
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPINT3 serine peptidase inhibitor, Kunitz type, 3
SPINT4 serine peptidase inhibitor, Kunitz type 4
SPOCD1 SPOC domain containing 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
SPP2 secreted phosphoprotein 2, 24kDa
SPRED1 sprouty-related, EVH1 domain containing 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SSPO SCO-spondin
SYTL2 synaptotagmin-like 2
TERF2 telomeric repeat binding factor 2
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGFB2 transforming growth factor, beta 2
THBS1 thrombospondin 1
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP2 TIMP metallopeptidase inhibitor 2
TIMP3 TIMP metallopeptidase inhibitor 3
TIMP4 TIMP metallopeptidase inhibitor 4
TIPRL TOR signaling pathway regulator
TLR9 toll-like receptor 9
TMBIM6 transmembrane BAX inhibitor motif containing 6
TMED2 transmembrane emp24 domain trafficking protein 2
TMEM132D transmembrane protein 132D
TMEM225 transmembrane protein 225
TNF tumor necrosis factor
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TNNI3 troponin I type 3 (cardiac)
TNNT2 troponin T type 2 (cardiac)
TP53 tumor protein p53
TRIAP1 TP53 regulated inhibitor of apoptosis 1
TSKS testis-specific serine kinase substrate
UBN1 ubinuclein 1
UCHL5 ubiquitin carboxyl-terminal hydrolase L5
UMODL1 uromodulin-like 1
URI1 URI1, prefoldin-like chaperone
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
USP17L2 ubiquitin specific peptidase 17-like family member 2
USP47 ubiquitin specific peptidase 47
VEGFA vascular endothelial growth factor A
VIL1 villin 1
VTN vitronectin
WDR81 WD repeat domain 81
WFDC1 WAP four-disulfide core domain 1
WFDC10A WAP four-disulfide core domain 10A
WFDC10B WAP four-disulfide core domain 10B
WFDC12 WAP four-disulfide core domain 12
WFDC13 WAP four-disulfide core domain 13
WFDC2 WAP four-disulfide core domain 2
WFDC3 WAP four-disulfide core domain 3
WFDC5 WAP four-disulfide core domain 5
WFDC8 WAP four-disulfide core domain 8
WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
WNK1 WNK lysine deficient protein kinase 1
WNT9A wingless-type MMTV integration site family, member 9A
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZCCHC9 zinc finger, CCHC domain containing 9
ZFYVE1 zinc finger, FYVE domain containing 1