negative regulation of canonical wnt signaling pathway Gene Set

Dataset GO Biological Process Annotations
Category structural or functional annotations
Type biological process
Description Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. (Gene Ontology, GO_0090090)
External Link http://amigo.geneontology.org/amigo/term/GO:0090090
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Genes

152 genes participating in the negative regulation of canonical wnt signaling pathway biological process from the curated GO Biological Process Annotations dataset.

Symbol Name
AES amino-terminal enhancer of split
AMER1 APC membrane recruitment protein 1
AMER2 APC membrane recruitment protein 2
ANKRD6 ankyrin repeat domain 6
APC adenomatous polyposis coli
APC2 adenomatosis polyposis coli 2
AXIN1 axin 1
AXIN2 axin 2
BICC1 BicC family RNA binding protein 1
BMP2 bone morphogenetic protein 2
CAV1 caveolin 1, caveolae protein, 22kDa
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CHD8 chromodomain helicase DNA binding protein 8
CTHRC1 collagen triple helix repeat containing 1
CTNND1 catenin (cadherin-associated protein), delta 1
CUL3 cullin 3
CYLD cylindromatosis (turban tumor syndrome)
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DAB2IP DAB2 interacting protein
DACT1 dishevelled-binding antagonist of beta-catenin 1
DACT3 dishevelled-binding antagonist of beta-catenin 3
DDIT3 DNA-damage-inducible transcript 3
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK2 dickkopf WNT signaling pathway inhibitor 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
DRAXIN dorsal inhibitory axon guidance protein
DVL1 dishevelled segment polarity protein 1
DVL2 dishevelled segment polarity protein 2
DVL3 dishevelled segment polarity protein 3
EGR1 early growth response 1
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FRZB frizzled-related protein
FUZ fuzzy planar cell polarity protein
FZD1 frizzled class receptor 1
FZD6 frizzled class receptor 6
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GLI1 GLI family zinc finger 1
GLI3 GLI family zinc finger 3
GPC3 glypican 3
GREM1 gremlin 1, DAN family BMP antagonist
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
HDAC2 histone deacetylase 2
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
INVS inversin
ISL1 ISL LIM homeobox 1
KLHL12 kelch-like family member 12
KREMEN2 kringle containing transmembrane protein 2
LATS1 large tumor suppressor kinase 1
LATS2 large tumor suppressor kinase 2
LEF1 lymphoid enhancer-binding factor 1
LIMD1 LIM domains containing 1
LRP4 low density lipoprotein receptor-related protein 4
LRP6 low density lipoprotein receptor-related protein 6
LZTS2 leucine zipper, putative tumor suppressor 2
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast)
MAPK14 mitogen-activated protein kinase 14
MCC mutated in colorectal cancers
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
NKD1 naked cuticle homolog 1 (Drosophila)
NKD2 naked cuticle homolog 2 (Drosophila)
NKX2-5 NK2 homeobox 5
NOG noggin
NOTCH1 notch 1
NPHP3 nephronophthisis 3 (adolescent)
NPHP4 nephronophthisis 4
PFDN5 prefoldin subunit 5
PRICKLE1 prickle homolog 1 (Drosophila)
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PSMB11 proteasome (prosome, macropain) subunit, beta type, 11
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PSME4 proteasome (prosome, macropain) activator subunit 4
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
PTPRO protein tyrosine phosphatase, receptor type, O
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1
RBX1 ring-box 1, E3 ubiquitin protein ligase
ROR2 receptor tyrosine kinase-like orphan receptor 2
RPS27A ribosomal protein S27a
SCYL2 SCY1-like 2 (S. cerevisiae)
SDHAF2 succinate dehydrogenase complex assembly factor 2
SFRP1 secreted frizzled-related protein 1
SFRP2 secreted frizzled-related protein 2
SFRP4 secreted frizzled-related protein 4
SFRP5 secreted frizzled-related protein 5
SHH sonic hedgehog
SIAH2 siah E3 ubiquitin protein ligase 2
SNAI2 snail family zinc finger 2
SOST sclerostin
SOSTDC1 sclerostin domain containing 1
SOX10 SRY (sex determining region Y)-box 10
SOX17 SRY (sex determining region Y)-box 17
SOX2 SRY (sex determining region Y)-box 2
SOX9 SRY (sex determining region Y)-box 9
STK3 serine/threonine kinase 3
STK4 serine/threonine kinase 4
TBX18 T-box 18
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TLE2 transducin-like enhancer of split 2
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBB ubiquitin B
UBC ubiquitin C
WIF1 WNT inhibitory factor 1
WNT11 wingless-type MMTV integration site family, member 11
WNT3A wingless-type MMTV integration site family, member 3A
WNT4 wingless-type MMTV integration site family, member 4
WNT5A wingless-type MMTV integration site family, member 5A
WNT5B wingless-type MMTV integration site family, member 5B
WNT9A wingless-type MMTV integration site family, member 9A
WWTR1 WW domain containing transcription regulator 1
ZNRF3 zinc and ring finger 3