nefopam-3730 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the nefopam-3730 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACE angiotensin I converting enzyme
ACTA1 actin, alpha 1, skeletal muscle
AKAP13 A kinase (PRKA) anchor protein 13
AMPD3 adenosine monophosphate deaminase 3
ANGPTL2 angiopoietin-like 2
ANKRD26 ankyrin repeat domain 26
ARTN artemin
ATF7 activating transcription factor 7
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BAIAP2 BAI1-associated protein 2
BBC3 BCL2 binding component 3
BCAT2 branched chain amino-acid transaminase 2, mitochondrial
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
CCDC57 coiled-coil domain containing 57
CD33 CD33 molecule
CEMIP cell migration inducing protein, hyaluronan binding
CHRNG cholinergic receptor, nicotinic, gamma (muscle)
CNR2 cannabinoid receptor 2 (macrophage)
COBLL1 cordon-bleu WH2 repeat protein-like 1
CPZ carboxypeptidase Z
CRAT carnitine O-acetyltransferase
CREB3L1 cAMP responsive element binding protein 3-like 1
CRHR2 corticotropin releasing hormone receptor 2
CRTC1 CREB regulated transcription coactivator 1
DKFZP434C153 DKFZP434C153 protein
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DOCK6 dedicator of cytokinesis 6
DSCC1 DNA replication and sister chromatid cohesion 1
DTNA dystrobrevin, alpha
EBF2 early B-cell factor 2
EGR1 early growth response 1
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EPB41L5 erythrocyte membrane protein band 4.1 like 5
ESR1 estrogen receptor 1
FAM212B family with sequence similarity 212, member B
FANCA Fanconi anemia, complementation group A
FBXO22 F-box protein 22
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GJA4 gap junction protein, alpha 4, 37kDa
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
GPER1 G protein-coupled estrogen receptor 1
GPR19 G protein-coupled receptor 19
GRM1 glutamate receptor, metabotropic 1
GSTM5 glutathione S-transferase mu 5
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
IL10RA interleukin 10 receptor, alpha
IL1RN interleukin 1 receptor antagonist
INO80D INO80 complex subunit D
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3
JAK3 Janus kinase 3
KAT8 K(lysine) acetyltransferase 8
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA1109 KIAA1109
KLF13 Kruppel-like factor 13
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LIMD1 LIM domains containing 1
LIMK2 LIM domain kinase 2
LIPG lipase, endothelial
LOC100294391 uncharacterized LOC100294391
LTB4R leukotriene B4 receptor
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MC5R melanocortin 5 receptor
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MMP10 matrix metallopeptidase 10
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MST1L macrophage stimulating 1-like
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC13 mucin 13, cell surface associated
MYEF2 myelin expression factor 2
NRP1 neuropilin 1
ONECUT2 one cut homeobox 2
OR3A3 olfactory receptor, family 3, subfamily A, member 3
PALM paralemmin
PCDHB3 protocadherin beta 3
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PLEKHS1 pleckstrin homology domain containing, family S member 1
PLK4 polo-like kinase 4
POU2F3 POU class 2 homeobox 3
PRKCE protein kinase C, epsilon
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RAB6B RAB6B, member RAS oncogene family
RASA3 RAS p21 protein activator 3
RASL11B RAS-like, family 11, member B
REM1 RAS (RAD and GEM)-like GTP-binding 1
RPH3A rabphilin 3A
SAYSD1 SAYSVFN motif domain containing 1
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SLC30A4 solute carrier family 30 (zinc transporter), member 4
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
SYNGR4 synaptogyrin 4
TAOK2 TAO kinase 2
TET3 tet methylcytosine dioxygenase 3
TLDC1 TBC/LysM-associated domain containing 1
TLK1 tousled-like kinase 1
VPS9D1 VPS9 domain containing 1
ZBTB6 zinc finger and BTB domain containing 6
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF287 zinc finger protein 287

decreased expression

Symbol Name
AATK apoptosis-associated tyrosine kinase
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
AHSG alpha-2-HS-glycoprotein
AK5 adenylate kinase 5
ALPK3 alpha-kinase 3
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
ARHGAP24 Rho GTPase activating protein 24
ASB13 ankyrin repeat and SOCS box containing 13
ATAT1 alpha tubulin acetyltransferase 1
AURKC aurora kinase C
C17ORF70 chromosome 17 open reading frame 70
C3 complement component 3
C9ORF40 chromosome 9 open reading frame 40
CARD8 caspase recruitment domain family, member 8
CCDC7 coiled-coil domain containing 7
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CDH19 cadherin 19, type 2
CES3 carboxylesterase 3
CFAP69 cilia and flagella associated protein 69
CHRM3 cholinergic receptor, muscarinic 3
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CLCA1 chloride channel accessory 1
CNPY4 canopy FGF signaling regulator 4
CNTN1 contactin 1
COLGALT2 collagen beta(1-O)galactosyltransferase 2
CYB5R2 cytochrome b5 reductase 2
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNM3 dynamin 3
EGFL7 EGF-like-domain, multiple 7
EPN1 epsin 1
ERCC4 excision repair cross-complementation group 4
FAM120C family with sequence similarity 120C
FAM189A2 family with sequence similarity 189, member A2
FBXO46 F-box protein 46
FKRP fukutin related protein
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPRIN2 G protein regulated inducer of neurite outgrowth 2
HAO2 hydroxyacid oxidase 2 (long chain)
HIST1H1D histone cluster 1, H1d
HPN hepsin
HYI hydroxypyruvate isomerase (putative)
IL2 interleukin 2
IL22 interleukin 22
INE1 inactivation escape 1 (non-protein coding)
KLF3 Kruppel-like factor 3 (basic)
KRT9 keratin 9, type I
LIME1 Lck interacting transmembrane adaptor 1
LMO7 LIM domain 7
LMTK2 lemur tyrosine kinase 2
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LY86 lymphocyte antigen 86
LYPD3 LY6/PLAUR domain containing 3
MARK1 MAP/microtubule affinity-regulating kinase 1
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MDM4 MDM4, p53 regulator
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1
MLYCD malonyl-CoA decarboxylase
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MYOZ3 myozenin 3
NFIX nuclear factor I/X (CCAAT-binding transcription factor)
NT5M 5',3'-nucleotidase, mitochondrial
NTSR1 neurotensin receptor 1 (high affinity)
PC pyruvate carboxylase
PCDHA9 protocadherin alpha 9
PIN1P1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 pseudogene 1
POLL polymerase (DNA directed), lambda
PRAMEF10 PRAME family member 10
PRF1 perforin 1 (pore forming protein)
RNF126P1 ring finger protein 126 pseudogene 1
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
SCARA3 scavenger receptor class A, member 3
SCD5 stearoyl-CoA desaturase 5
SCIN scinderin
SIX3 SIX homeobox 3
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC16A6 solute carrier family 16, member 6
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SLMO1 slowmo homolog 1 (Drosophila)
SNRPN small nuclear ribonucleoprotein polypeptide N
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TCP10 t-complex 10
TESPA1 thymocyte expressed, positive selection associated 1
TEX15 testis expressed 15
TIGD6 tigger transposable element derived 6
TMEM74B transmembrane protein 74B
TRAC T cell receptor alpha constant
TRIM25 tripartite motif containing 25
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSC22D4 TSC22 domain family, member 4
VGF VGF nerve growth factor inducible
VGLL3 vestigial-like family member 3
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF197 zinc finger protein 197
ZNF574 zinc finger protein 574
ZNF747 zinc finger protein 747