naproxen-6096 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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194 genes differentially expressed following the naproxen-6096 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAA2 acetyl-CoA acyltransferase 2
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADCK4 aarF domain containing kinase 4
ADCY7 adenylate cyclase 7
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
ADRA1D adrenoceptor alpha 1D
AKAP1 A kinase (PRKA) anchor protein 1
AMPD1 adenosine monophosphate deaminase 1
ANXA2P3 annexin A2 pseudogene 3
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ASB1 ankyrin repeat and SOCS box containing 1
C10ORF10 chromosome 10 open reading frame 10
C4BPA complement component 4 binding protein, alpha
CA5B carbonic anhydrase VB, mitochondrial
CD4 CD4 molecule
CD6 CD6 molecule
CDHR2 cadherin-related family member 2
CEP112 centrosomal protein 112kDa
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COMP cartilage oligomeric matrix protein
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
EDN1 endothelin 1
EPN1 epsin 1
FBXO24 F-box protein 24
FBXO4 F-box protein 4
FOXF1 forkhead box F1
FSHB follicle stimulating hormone, beta polypeptide
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
GBP2 guanylate binding protein 2, interferon-inducible
GLP1R glucagon-like peptide 1 receptor
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HR hair growth associated
IL11 interleukin 11
IL2RB interleukin 2 receptor, beta
KCNK10 potassium channel, two pore domain subfamily K, member 10
KLHL11 kelch-like family member 11
KLHL35 kelch-like family member 35
KRT75 keratin 75, type II
LAG3 lymphocyte-activation gene 3
LAMP1 lysosomal-associated membrane protein 1
LEF1 lymphoid enhancer-binding factor 1
LIF leukemia inhibitory factor
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LRRC23 leucine rich repeat containing 23
LY9 lymphocyte antigen 9
MED25 mediator complex subunit 25
MFSD6 major facilitator superfamily domain containing 6
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MUC6 mucin 6, oligomeric mucus/gel-forming
MYF5 myogenic factor 5
NCOR2 nuclear receptor corepressor 2
NKX6-1 NK6 homeobox 1
NPC1 Niemann-Pick disease, type C1
NR6A1 nuclear receptor subfamily 6, group A, member 1
NRG1 neuregulin 1
NSUN6 NOP2/Sun domain family, member 6
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
PDPN podoplanin
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PTPRJ protein tyrosine phosphatase, receptor type, J
PTTG2 pituitary tumor-transforming 2
RAB3B RAB3B, member RAS oncogene family
RGS12 regulator of G-protein signaling 12
RHBG Rh family, B glycoprotein (gene/pseudogene)
RPH3A rabphilin 3A
RPL35A ribosomal protein L35a
RPS4Y1 ribosomal protein S4, Y-linked 1
SH3BP2 SH3-domain binding protein 2
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SPTAN1 spectrin, alpha, non-erythrocytic 1
SPTB spectrin, beta, erythrocytic
SPTBN5 spectrin, beta, non-erythrocytic 5
SRF serum response factor (c-fos serum response element-binding transcription factor)
TAGLN3 transgelin 3
TM4SF5 transmembrane 4 L six family member 5
TP63 tumor protein p63
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRPM3 transient receptor potential cation channel, subfamily M, member 3
TSPAN2 tetraspanin 2
UBA6 ubiquitin-like modifier activating enzyme 6
VIPR1 vasoactive intestinal peptide receptor 1
WFDC8 WAP four-disulfide core domain 8
ZNF484 zinc finger protein 484
ZNF639 zinc finger protein 639
ZNF646 zinc finger protein 646
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
AMT aminomethyltransferase
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
BAHCC1 BAH domain and coiled-coil containing 1
BHLHE41 basic helix-loop-helix family, member e41
C2ORF54 chromosome 2 open reading frame 54
C3ORF18 chromosome 3 open reading frame 18
CA5BP1 carbonic anhydrase VB pseudogene 1
CAPRIN2 caprin family member 2
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4
CFAP69 cilia and flagella associated protein 69
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CORO7 coronin 7
CRMP1 collapsin response mediator protein 1
CRYGC crystallin, gamma C
CUL9 cullin 9
DBF4B DBF4 zinc finger B
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DGAT1 diacylglycerol O-acyltransferase 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DRD1 dopamine receptor D1
DUSP9 dual specificity phosphatase 9
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
FAM189A2 family with sequence similarity 189, member A2
FGD1 FYVE, RhoGEF and PH domain containing 1
FGGY FGGY carbohydrate kinase domain containing
FLJ11710 uncharacterized protein FLJ11710
GAMT guanidinoacetate N-methyltransferase
GPATCH2L G patch domain containing 2-like
GRB7 growth factor receptor-bound protein 7
HAO2 hydroxyacid oxidase 2 (long chain)
HDAC11 histone deacetylase 11
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST1H2BJ histone cluster 1, H2bj
HOXB2 homeobox B2
HOXC8 homeobox C8
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
INO80D INO80 complex subunit D
INPP5J inositol polyphosphate-5-phosphatase J
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KDM8 lysine (K)-specific demethylase 8
KLHL28 kelch-like family member 28
KREMEN2 kringle containing transmembrane protein 2
LAX1 lymphocyte transmembrane adaptor 1
LENEP lens epithelial protein
LOC729164 hCG1732469
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MYLK myosin light chain kinase
NDOR1 NADPH dependent diflavin oxidoreductase 1
NECAB2 N-terminal EF-hand calcium binding protein 2
NKX3-2 NK3 homeobox 2
NPTX1 neuronal pentraxin I
NR1H2 nuclear receptor subfamily 1, group H, member 2
NT5E 5'-nucleotidase, ecto (CD73)
OSMR oncostatin M receptor
PCDH12 protocadherin 12
PCSK7 proprotein convertase subtilisin/kexin type 7
PDE12 phosphodiesterase 12
PDGFD platelet derived growth factor D
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PLEKHA6 pleckstrin homology domain containing, family A member 6
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
PORCN porcupine homolog (Drosophila)
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
RAB40AL RAB40A, member RAS oncogene family-like
RAB40C RAB40C, member RAS oncogene family
RAPSN receptor-associated protein of the synapse
RFXAP regulatory factor X-associated protein
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
RPL10L ribosomal protein L10-like
SCGB2A2 secretoglobin, family 2A, member 2
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SLPI secretory leukocyte peptidase inhibitor
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
STAB2 stabilin 2
STEAP1 six transmembrane epithelial antigen of the prostate 1
TIGD6 tigger transposable element derived 6
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM242 transmembrane protein 242
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRIM36 tripartite motif containing 36
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UPP1 uridine phosphorylase 1
XDH xanthine dehydrogenase
ZNF10 zinc finger protein 10
ZNF205 zinc finger protein 205
ZNF219 zinc finger protein 219
ZNF329 zinc finger protein 329
ZNF350 zinc finger protein 350
ZNF532 zinc finger protein 532