naltrexone-6241 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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195 genes differentially expressed following the naltrexone-6241 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1
ACOX1 acyl-CoA oxidase 1, palmitoyl
AMT aminomethyltransferase
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit
APOL2 apolipoprotein L, 2
AQP9 aquaporin 9
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATN1 atrophin 1
ATP9A ATPase, class II, type 9A
AZGP1 alpha-2-glycoprotein 1, zinc-binding
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BAIAP2 BAI1-associated protein 2
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BMP4 bone morphogenetic protein 4
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
C14ORF1 chromosome 14 open reading frame 1
CD40 CD40 molecule, TNF receptor superfamily member 5
CEP135 centrosomal protein 135kDa
CEP162 centrosomal protein 162kDa
CNN1 calponin 1, basic, smooth muscle
COL4A1 collagen, type IV, alpha 1
CRYGC crystallin, gamma C
CTSF cathepsin F
CUL4B cullin 4B
CXCR4 chemokine (C-X-C motif) receptor 4
DOK4 docking protein 4
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
ERMAP erythroblast membrane-associated protein (Scianna blood group)
FST follistatin
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GRM1 glutamate receptor, metabotropic 1
HBS1L HBS1-like translational GTPase
HIGD2A HIG1 hypoxia inducible domain family, member 2A
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HOXC8 homeobox C8
HPSE2 heparanase 2 (inactive)
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
ICK intestinal cell (MAK-like) kinase
IDUA iduronidase, alpha-L-
IL5RA interleukin 5 receptor, alpha
INPP5J inositol polyphosphate-5-phosphatase J
IQCA1 IQ motif containing with AAA domain 1
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITGA8 integrin, alpha 8
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KANSL3 KAT8 regulatory NSL complex subunit 3
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KLK12 kallikrein-related peptidase 12
LUZP1 leucine zipper protein 1
MAST3 microtubule associated serine/threonine kinase 3
MEF2D myocyte enhancer factor 2D
MYBPC3 myosin binding protein C, cardiac
NGLY1 N-glycanase 1
NIPAL2 NIPA-like domain containing 2
NR2C1 nuclear receptor subfamily 2, group C, member 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PAQR6 progestin and adipoQ receptor family member VI
PART1 prostate androgen-regulated transcript 1 (non-protein coding)
PBX2 pre-B-cell leukemia homeobox 2
PLSCR3 phospholipid scramblase 3
POLL polymerase (DNA directed), lambda
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
QKI QKI, KH domain containing, RNA binding
RAD54L2 RAD54-like 2 (S. cerevisiae)
RASAL2 RAS protein activator like 2
RPLP2 ribosomal protein, large, P2
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SHARPIN SHANK-associated RH domain interactor
SLC35F5 solute carrier family 35, member F5
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SOS2 son of sevenless homolog 2 (Drosophila)
SPPL2B signal peptide peptidase like 2B
SPTAN1 spectrin, alpha, non-erythrocytic 1
SYMPK symplekin
SYNC syncoilin, intermediate filament protein
TCF3 transcription factor 3
THRA thyroid hormone receptor, alpha
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast)
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TPD52 tumor protein D52
TRAK1 trafficking protein, kinesin binding 1
TRIB2 tribbles pseudokinase 2
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TSNAXIP1 translin-associated factor X interacting protein 1
TSSK2 testis-specific serine kinase 2
TTC28 tetratricopeptide repeat domain 28
TXNL4A thioredoxin-like 4A
UBOX5 U-box domain containing 5
UBTD1 ubiquitin domain containing 1
VASH2 vasohibin 2
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)
WDR25 WD repeat domain 25
WSCD1 WSC domain containing 1
YY1 YY1 transcription factor

decreased expression

Symbol Name
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
AKAP12 A kinase (PRKA) anchor protein 12
AKR1C3 aldo-keto reductase family 1, member C3
ARL15 ADP-ribosylation factor-like 15
ARMC6 armadillo repeat containing 6
ASB7 ankyrin repeat and SOCS box containing 7
AXIN1 axin 1
BAHD1 bromo adjacent homology domain containing 1
BAK1 BCL2-antagonist/killer 1
BCOR BCL6 corepressor
C16ORF45 chromosome 16 open reading frame 45
C17ORF80 chromosome 17 open reading frame 80
C1ORF35 chromosome 1 open reading frame 35
C5 complement component 5
C5ORF45 chromosome 5 open reading frame 45
CBR4 carbonyl reductase 4
CFD complement factor D (adipsin)
CIDEC cell death-inducing DFFA-like effector c
DCTN4 dynactin 4 (p62)
DNMBP dynamin binding protein
EDC3 enhancer of mRNA decapping 3
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
EXOC5 exocyst complex component 5
F3 coagulation factor III (thromboplastin, tissue factor)
FADS3 fatty acid desaturase 3
FAM114A2 family with sequence similarity 114, member A2
FAM160B2 family with sequence similarity 160, member B2
FBRS fibrosin
FNTB farnesyltransferase, CAAX box, beta
FURIN furin (paired basic amino acid cleaving enzyme)
FUZ fuzzy planar cell polarity protein
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B
GDAP1 ganglioside induced differentiation associated protein 1
GLS2 glutaminase 2 (liver, mitochondrial)
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPX2 glutathione peroxidase 2
HIST1H2BC histone cluster 1, H2bc
HPSE heparanase
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IL12RB1 interleukin 12 receptor, beta 1
IL17RA interleukin 17 receptor A
INO80D INO80 complex subunit D
LAMA3 laminin, alpha 3
LYRM9 LYR motif containing 9
MBIP MAP3K12 binding inhibitory protein 1
MBTD1 mbt domain containing 1
MBTPS2 membrane-bound transcription factor peptidase, site 2
METTL16 methyltransferase like 16
MIS18BP1 MIS18 binding protein 1
MORC4 MORC family CW-type zinc finger 4
MOSPD3 motile sperm domain containing 3
MTHFS 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
MTMR11 myotubularin related protein 11
MUTYH mutY homolog
NCAM2 neural cell adhesion molecule 2
NECAB3 N-terminal EF-hand calcium binding protein 3
NES nestin
NR1H2 nuclear receptor subfamily 1, group H, member 2
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
OSMR oncostatin M receptor
PARD6A par-6 family cell polarity regulator alpha
PARPBP PARP1 binding protein
PCSK7 proprotein convertase subtilisin/kexin type 7
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PLD3 phospholipase D family, member 3
PLEKHO1 pleckstrin homology domain containing, family O member 1
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
QTRT1 queuine tRNA-ribosyltransferase 1
RBM41 RNA binding motif protein 41
RFTN1 raftlin, lipid raft linker 1
SECTM1 secreted and transmembrane 1
SETD8 SET domain containing (lysine methyltransferase) 8
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SND1-IT1 SND1 intronic transcript 1
SNRPC small nuclear ribonucleoprotein polypeptide C
SPIDR scaffolding protein involved in DNA repair
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)
SYTL2 synaptotagmin-like 2
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa
TCTA T-cell leukemia translocation altered
TCTN2 tectonic family member 2
THOP1 thimet oligopeptidase 1
TLN1 talin 1
TOE1 target of EGR1, member 1 (nuclear)
TPST2 tyrosylprotein sulfotransferase 2
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TSPAN1 tetraspanin 1
TXLNG taxilin gamma
ZDHHC14 zinc finger, DHHC-type containing 14
ZFP30 ZFP30 zinc finger protein
ZNF211 zinc finger protein 211
ZNF586 zinc finger protein 586
ZNF747 zinc finger protein 747
ZNF767P zinc finger family member 767, pseudogene