naltrexone-2047 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the naltrexone-2047 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABR active BCR-related
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ANXA10 annexin A10
APOL2 apolipoprotein L, 2
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ATP10A ATPase, class V, type 10A
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
BCORL1 BCL6 corepressor-like 1
BIN1 bridging integrator 1
C9ORF156 chromosome 9 open reading frame 156
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CARD8 caspase recruitment domain family, member 8
CORO1A coronin, actin binding protein, 1A
CORO2A coronin, actin binding protein, 2A
DHODH dihydroorotate dehydrogenase (quinone)
DHRS2 dehydrogenase/reductase (SDR family) member 2
DTX2P1-UPK3BP1-PMS2P11 DTX2P1-UPK3BP1-PMS2P11 readthrough transcribed pseudogene
DXO decapping exoribonuclease
EGR2 early growth response 2
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
EMC3 ER membrane protein complex subunit 3
ESRRG estrogen-related receptor gamma
FAM184A family with sequence similarity 184, member A
FER fer (fps/fes related) tyrosine kinase
FOXA2 forkhead box A2
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GLP1R glucagon-like peptide 1 receptor
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GM2A GM2 ganglioside activator
GRAMD4 GRAM domain containing 4
HEG1 heart development protein with EGF-like domains 1
HIST1H4D histone cluster 1, H4d
HIST1H4E histone cluster 1, H4e
HLA-DOA major histocompatibility complex, class II, DO alpha
HMGN5 high mobility group nucleosome binding domain 5
HOMER3 homer scaffolding protein 3
HOXB5 homeobox B5
ICK intestinal cell (MAK-like) kinase
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
IQSEC2 IQ motif and Sec7 domain 2
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
IVD isovaleryl-CoA dehydrogenase
KDM4C lysine (K)-specific demethylase 4C
KDM5A lysine (K)-specific demethylase 5A
KIFC3 kinesin family member C3
LAMP1 lysosomal-associated membrane protein 1
LIN7B lin-7 homolog B (C. elegans)
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
LRRC37A3 leucine rich repeat containing 37, member A3
MBTPS2 membrane-bound transcription factor peptidase, site 2
MCTP1 multiple C2 domains, transmembrane 1
MED28 mediator complex subunit 28
MTAP methylthioadenosine phosphorylase
MXD4 MAX dimerization protein 4
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NAA38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NCKIPSD NCK interacting protein with SH3 domain
NEK1 NIMA-related kinase 1
NPFFR1 neuropeptide FF receptor 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PHF20L1 PHD finger protein 20-like 1
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PTPN21 protein tyrosine phosphatase, non-receptor type 21
RABGAP1 RAB GTPase activating protein 1
RALB v-ral simian leukemia viral oncogene homolog B
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RBM19 RNA binding motif protein 19
RHOBTB3 Rho-related BTB domain containing 3
RHOT2 ras homolog family member T2
S1PR1 sphingosine-1-phosphate receptor 1
SCAPER S-phase cyclin A-associated protein in the ER
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SH3BP2 SH3-domain binding protein 2
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD5 SMAD family member 5
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SPATA5L1 spermatogenesis associated 5-like 1
SPATS2L spermatogenesis associated, serine-rich 2-like
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
TBC1D22A TBC1 domain family, member 22A
TEX261 testis expressed 261
TGFA transforming growth factor, alpha
TGFB3 transforming growth factor, beta 3
THEMIS2 thymocyte selection associated family member 2
TLK1 tousled-like kinase 1
TLN2 talin 2
TMEM159 transmembrane protein 159
TRIM23 tripartite motif containing 23
TXLNG taxilin gamma
ULK2 unc-51 like autophagy activating kinase 2
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast)
ZFP30 ZFP30 zinc finger protein
ZNF286A zinc finger protein 286A
ZNF444 zinc finger protein 444

decreased expression

Symbol Name
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ARRB2 arrestin, beta 2
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BMP15 bone morphogenetic protein 15
C19ORF54 chromosome 19 open reading frame 54
C1QTNF1 C1q and tumor necrosis factor related protein 1
CCDC85C coiled-coil domain containing 85C
CLCN5 chloride channel, voltage-sensitive 5
CLDN1 claudin 1
CLIP2 CAP-GLY domain containing linker protein 2
CLK3 CDC-like kinase 3
CNGB3 cyclic nucleotide gated channel beta 3
COMMD10 COMM domain containing 10
CST4 cystatin S
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
DDIT3 DNA-damage-inducible transcript 3
DNAL4 dynein, axonemal, light chain 4
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EMP3 epithelial membrane protein 3
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
EVPL envoplakin
EXO1 exonuclease 1
FBXW12 F-box and WD repeat domain containing 12
FPGS folylpolyglutamate synthase
FURIN furin (paired basic amino acid cleaving enzyme)
GBX2 gastrulation brain homeobox 2
GLDC glycine dehydrogenase (decarboxylating)
GNA12 guanine nucleotide binding protein (G protein) alpha 12
GPATCH2L G patch domain containing 2-like
H2AFY2 H2A histone family, member Y2
HOXC13 homeobox C13
INPPL1 inositol polyphosphate phosphatase-like 1
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
ISYNA1 inositol-3-phosphate synthase 1
KIF13B kinesin family member 13B
KRT86 keratin 86, type II
LOC730101 uncharacterized LOC730101
LYPLA2P1 lysophospholipase II pseudogene 1
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MATN3 matrilin 3
MFSD11 major facilitator superfamily domain containing 11
MITF microphthalmia-associated transcription factor
MON1B MON1 secretory trafficking family member B
MOSPD3 motile sperm domain containing 3
MPC1 mitochondrial pyruvate carrier 1
MUM1 melanoma associated antigen (mutated) 1
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
NCS1 neuronal calcium sensor 1
NT5M 5',3'-nucleotidase, mitochondrial
NUBP2 nucleotide binding protein 2
OGFRL1 opioid growth factor receptor-like 1
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PDZK1 PDZ domain containing 1
PEX26 peroxisomal biogenesis factor 26
PGS1 phosphatidylglycerophosphate synthase 1
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLCD1 phospholipase C, delta 1
POLR1B polymerase (RNA) I polypeptide B, 128kDa
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
POMT1 protein-O-mannosyltransferase 1
POMT2 protein-O-mannosyltransferase 2
PRR15L proline rich 15-like
RAB8B RAB8B, member RAS oncogene family
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFWD3 ring finger and WD repeat domain 3
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SLC12A8 solute carrier family 12, member 8
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SPEG SPEG complex locus
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
STK16 serine/threonine kinase 16
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TBC1D12 TBC1 domain family, member 12
TEAD3 TEA domain family member 3
TESK1 testis-specific kinase 1
TM7SF2 transmembrane 7 superfamily member 2
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMCC2 transmembrane and coiled-coil domain family 2
TNRC6B trinucleotide repeat containing 6B
TPMT thiopurine S-methyltransferase
TPRA1 transmembrane protein, adipocyte asscociated 1
TRAPPC6A trafficking protein particle complex 6A
TRIM45 tripartite motif containing 45
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TSKU tsukushi, small leucine rich proteoglycan
TTBK2 tau tubulin kinase 2
TUBA3C tubulin, alpha 3c
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2
WDR76 WD repeat domain 76
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZNF211 zinc finger protein 211
ZNF580 zinc finger protein 580
ZNF8 zinc finger protein 8