nalidixic acid-7367 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

193 genes differentially expressed following the nalidixic acid-7367 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM5 ADAM metallopeptidase domain 5 (pseudogene)
ADGRG1 adhesion G protein-coupled receptor G1
ANGEL2 angel homolog 2 (Drosophila)
ANKRD6 ankyrin repeat domain 6
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
CA9 carbonic anhydrase IX
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CAMSAP1 calmodulin regulated spectrin-associated protein 1
CASKIN2 CASK interacting protein 2
CCNT2 cyclin T2
CDHR2 cadherin-related family member 2
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
CIB2 calcium and integrin binding family member 2
CLCN6 chloride channel, voltage-sensitive 6
CLDN11 claudin 11
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
COL8A1 collagen, type VIII, alpha 1
CSRNP3 cysteine-serine-rich nuclear protein 3
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
CYSLTR1 cysteinyl leukotriene receptor 1
DOC2B double C2-like domains, beta
DPYS dihydropyrimidinase
DRD2 dopamine receptor D2
EDRF1 erythroid differentiation regulatory factor 1
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)
ESR1 estrogen receptor 1
ETV1 ets variant 1
ETV5 ets variant 5
EXOC6B exocyst complex component 6B
FAM120C family with sequence similarity 120C
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FGF1 fibroblast growth factor 1 (acidic)
FN1 fibronectin 1
FURIN furin (paired basic amino acid cleaving enzyme)
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GRM1 glutamate receptor, metabotropic 1
GZMK granzyme K (granzyme 3; tryptase II)
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
IL15 interleukin 15
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KRTAP1-3 keratin associated protein 1-3
KYNU kynureninase
LARP4B La ribonucleoprotein domain family, member 4B
LCT lactase
LEF1 lymphoid enhancer-binding factor 1
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
MYO5A myosin VA (heavy chain 12, myoxin)
NAGLU N-acetylglucosaminidase, alpha
NLGN1 neuroligin 1
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
OR12D3 olfactory receptor, family 12, subfamily D, member 3
OVGP1 oviductal glycoprotein 1, 120kDa
PAPOLA poly(A) polymerase alpha
PDE11A phosphodiesterase 11A
PDGFB platelet-derived growth factor beta polypeptide
PER3 period circadian clock 3
PFKL phosphofructokinase, liver
PLEKHO2 pleckstrin homology domain containing, family O member 2
PODNL1 podocan-like 1
POU5F1B POU class 5 homeobox 1B
PPARD peroxisome proliferator-activated receptor delta
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRDM2 PR domain containing 2, with ZNF domain
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
PXMP4 peroxisomal membrane protein 4, 24kDa
RGS12 regulator of G-protein signaling 12
RUNDC3B RUN domain containing 3B
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
S1PR1 sphingosine-1-phosphate receptor 1
SCG2 secretogranin II
SCNN1D sodium channel, non voltage gated 1 delta subunit
SEC14L4 SEC14-like 4 (S. cerevisiae)
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
SNX13 sorting nexin 13
SPTAN1 spectrin, alpha, non-erythrocytic 1
STK24 serine/threonine kinase 24
SUGP1 SURP and G patch domain containing 1
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TAOK3 TAO kinase 3
TENM4 teneurin transmembrane protein 4
TG thyroglobulin
TRPC3 transient receptor potential cation channel, subfamily C, member 3
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TXNRD3 thioredoxin reductase 3
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
ZNF222 zinc finger protein 222
ZNF276 zinc finger protein 276
ZNF358 zinc finger protein 358
ZNF391 zinc finger protein 391
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
AGBL5 ATP/GTP binding protein-like 5
ANG angiogenin, ribonuclease, RNase A family, 5
ASB7 ankyrin repeat and SOCS box containing 7
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide
BCL9 B-cell CLL/lymphoma 9
BSPRY B-box and SPRY domain containing
C1ORF159 chromosome 1 open reading frame 159
C4ORF19 chromosome 4 open reading frame 19
C7ORF43 chromosome 7 open reading frame 43
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CCDC106 coiled-coil domain containing 106
CCDC68 coiled-coil domain containing 68
CDH7 cadherin 7, type 2
CENPJ centromere protein J
CENPO centromere protein O
CENPT centromere protein T
CEP112 centrosomal protein 112kDa
CINP cyclin-dependent kinase 2 interacting protein
CLEC10A C-type lectin domain family 10, member A
CNKSR1 connector enhancer of kinase suppressor of Ras 1
CRYBB2P1 crystallin, beta B2 pseudogene 1
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
ELP6 elongator acetyltransferase complex subunit 6
ENO2 enolase 2 (gamma, neuronal)
FAM178A family with sequence similarity 178, member A
FBXL4 F-box and leucine-rich repeat protein 4
FBXW12 F-box and WD repeat domain containing 12
GLDC glycine dehydrogenase (decarboxylating)
HDAC4 histone deacetylase 4
HIST1H2AJ histone cluster 1, H2aj
HIST1H2AM histone cluster 1, H2am
HIST1H3B histone cluster 1, H3b
ICK intestinal cell (MAK-like) kinase
IMPAD1 inositol monophosphatase domain containing 1
IQCG IQ motif containing G
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KLF7 Kruppel-like factor 7 (ubiquitous)
LRP5L low density lipoprotein receptor-related protein 5-like
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MFGE8 milk fat globule-EGF factor 8 protein
MITF microphthalmia-associated transcription factor
MOXD1 monooxygenase, DBH-like 1
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
NOL12 nucleolar protein 12
NOTCH1 notch 1
NR1H3 nuclear receptor subfamily 1, group H, member 3
NT5M 5',3'-nucleotidase, mitochondrial
NUBPL nucleotide binding protein-like
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
OSMR oncostatin M receptor
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic)
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLCD1 phospholipase C, delta 1
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PRICKLE3 prickle homolog 3 (Drosophila)
RASA2 RAS p21 protein activator 2
SCRN3 secernin 3
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC25A40 solute carrier family 25, member 40
SLITRK5 SLIT and NTRK-like family, member 5
SMG9 SMG9 nonsense mediated mRNA decay factor
SNHG3 small nucleolar RNA host gene 3
SNIP1 Smad nuclear interacting protein 1
ST20 suppressor of tumorigenicity 20
STAC SH3 and cysteine rich domain
STAG3 stromal antigen 3
STARD5 StAR-related lipid transfer (START) domain containing 5
SUGCT succinyl-CoA:glutarate-CoA transferase
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TLR2 toll-like receptor 2
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMC7 transmembrane channel-like 7
TMEM132A transmembrane protein 132A
TMEM57 transmembrane protein 57
TMEM62 transmembrane protein 62
TNNI3 troponin I type 3 (cardiac)
TNRC6B trinucleotide repeat containing 6B
TTLL7 tubulin tyrosine ligase-like family member 7
USP6 ubiquitin specific peptidase 6
WDR19 WD repeat domain 19
WWC2 WW and C2 domain containing 2
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF112 zinc finger protein 112
ZNF189 zinc finger protein 189
ZNF84 zinc finger protein 84
ZNHIT2 zinc finger, HIT-type containing 2