nalidixic acid-4691 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the nalidixic acid-4691 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
AGFG1 ArfGAP with FG repeats 1
AMPD3 adenosine monophosphate deaminase 3
ANGEL2 angel homolog 2 (Drosophila)
ANGPT4 angiopoietin 4
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BMP5 bone morphogenetic protein 5
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CDC14A cell division cycle 14A
CEP76 centrosomal protein 76kDa
CLDN17 claudin 17
CLSTN2 calsyntenin 2
CNTN1 contactin 1
CTNS cystinosin, lysosomal cystine transporter
CXCR4 chemokine (C-X-C motif) receptor 4
DCBLD2 discoidin, CUB and LCCL domain containing 2
DCN decorin
DCX doublecortin
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DGKE diacylglycerol kinase, epsilon 64kDa
DIXDC1 DIX domain containing 1
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
ELAC2 elaC ribonuclease Z 2
FBLN1 fibulin 1
FBXO11 F-box protein 11
GAS7 growth arrest-specific 7
GNRHR gonadotropin-releasing hormone receptor
GRM8 glutamate receptor, metabotropic 8
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
GTPBP1 GTP binding protein 1
HIST1H2AJ histone cluster 1, H2aj
HIST1H4A histone cluster 1, H4a
HSPG2 heparan sulfate proteoglycan 2
IDI2-AS1 IDI2 antisense RNA 1
KAZALD1 Kazal-type serine peptidase inhibitor domain 1
KCNIP1 Kv channel interacting protein 1
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLF2 Kruppel-like factor 2
KLHL20 kelch-like family member 20
KRAS Kirsten rat sarcoma viral oncogene homolog
KRIT1 KRIT1, ankyrin repeat containing
LIMK2 LIM domain kinase 2
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAPK7 mitogen-activated protein kinase 7
METTL7A methyltransferase like 7A
MORC1 MORC family CW-type zinc finger 1
MUSK muscle, skeletal, receptor tyrosine kinase
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
NOP16 NOP16 nucleolar protein
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
NUP188 nucleoporin 188kDa
PARD6B par-6 family cell polarity regulator beta
PCDHB3 protocadherin beta 3
PCM1 pericentriolar material 1
PHLDB1 pleckstrin homology-like domain, family B, member 1
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2
PLEKHS1 pleckstrin homology domain containing, family S member 1
PLK4 polo-like kinase 4
PSG4 pregnancy specific beta-1-glycoprotein 4
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PVR poliovirus receptor
RAB6B RAB6B, member RAS oncogene family
RAI2 retinoic acid induced 2
RFPL1 ret finger protein-like 1
RGS6 regulator of G-protein signaling 6
RHBG Rh family, B glycoprotein (gene/pseudogene)
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RPL10L ribosomal protein L10-like
RPS3A ribosomal protein S3A
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
RXRB retinoid X receptor, beta
SCAND2P SCAN domain containing 2 pseudogene
SCD5 stearoyl-CoA desaturase 5
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SLPI secretory leukocyte peptidase inhibitor
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRCAP Snf2-related CREBBP activator protein
SRD5A3 steroid 5 alpha-reductase 3
SRSF7 serine/arginine-rich splicing factor 7
STRN3 striatin, calmodulin binding protein 3
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TAOK3 TAO kinase 3
TAPBP TAP binding protein (tapasin)
TESC tescalcin
TLE2 transducin-like enhancer of split 2
TMEM242 transmembrane protein 242
TOP3A topoisomerase (DNA) III alpha
VDAC3 voltage-dependent anion channel 3
XYLB xylulokinase homolog (H. influenzae)
ZNF204P zinc finger protein 204, pseudogene
ZNF286A zinc finger protein 286A
ZNF652 zinc finger protein 652
ZNF675 zinc finger protein 675
ZNF682 zinc finger protein 682
ZNF750 zinc finger protein 750

decreased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12
ACSL4 acyl-CoA synthetase long-chain family member 4
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ALPK1 alpha-kinase 1
ANKZF1 ankyrin repeat and zinc finger domain containing 1
BFSP1 beaded filament structural protein 1, filensin
C22ORF46 chromosome 22 open reading frame 46
C5 complement component 5
C7ORF69 chromosome 7 open reading frame 69
CAMK1 calcium/calmodulin-dependent protein kinase I
CCP110 centriolar coiled coil protein 110kDa
CD79B CD79b molecule, immunoglobulin-associated beta
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CIR1 corepressor interacting with RBPJ, 1
CORO1A coronin, actin binding protein, 1A
CRY2 cryptochrome circadian clock 2
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DEAF1 DEAF1 transcription factor
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DNAL4 dynein, axonemal, light chain 4
DNALI1 dynein, axonemal, light intermediate chain 1
DSCAM Down syndrome cell adhesion molecule
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
ELSPBP1 epididymal sperm binding protein 1
ERN2 endoplasmic reticulum to nucleus signaling 2
ETNK2 ethanolamine kinase 2
EYA3 EYA transcriptional coactivator and phosphatase 3
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FLJ21369 uncharacterized protein FLJ21369
FLJ22184
GADD45G growth arrest and DNA-damage-inducible, gamma
GLS2 glutaminase 2 (liver, mitochondrial)
GPC3 glypican 3
GPR87 G protein-coupled receptor 87
HIRA histone cell cycle regulator
HIST1H2BN histone cluster 1, H2bn
HMG20A high mobility group 20A
HSPB6 heat shock protein, alpha-crystallin-related, B6
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL4R interleukin 4 receptor
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KCNK12 potassium channel, two pore domain subfamily K, member 12
KDM7A lysine (K)-specific demethylase 7A
KDM8 lysine (K)-specific demethylase 8
KLK5 kallikrein-related peptidase 5
KPNA5 karyopherin alpha 5 (importin alpha 6)
KRT8P12 keratin 8 pseudogene 12
LIN7A lin-7 homolog A (C. elegans)
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MRPL52 mitochondrial ribosomal protein L52
MYLK myosin light chain kinase
NEUROD1 neuronal differentiation 1
NPIPB3 nuclear pore complex interacting protein family, member B3
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PAIP2B poly(A) binding protein interacting protein 2B
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PODXL2 podocalyxin-like 2
POLL polymerase (DNA directed), lambda
PPT2 palmitoyl-protein thioesterase 2
PRF1 perforin 1 (pore forming protein)
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
SAA3P serum amyloid A3 pseudogene
SCAI suppressor of cancer cell invasion
SETD8 SET domain containing (lysine methyltransferase) 8
SH2D4A SH2 domain containing 4A
SLC12A8 solute carrier family 12, member 8
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SLIT2 slit homolog 2 (Drosophila)
SND1-IT1 SND1 intronic transcript 1
SP1 Sp1 transcription factor
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINK5 serine peptidase inhibitor, Kazal type 5
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
STX1A syntaxin 1A (brain)
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TET3 tet methylcytosine dioxygenase 3
TLN1 talin 1
TMEM132A transmembrane protein 132A
TMEM212 transmembrane protein 212
TRAIP TRAF interacting protein
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TUBA3D tubulin, alpha 3d
TUBB2B tubulin, beta 2B class IIb
UPK2 uroplakin 2
USB1 U6 snRNA biogenesis 1
VLDLR very low density lipoprotein receptor
XAB2 XPA binding protein 2
ZBTB22 zinc finger and BTB domain containing 22