nalidixic acid-3668 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the nalidixic acid-3668 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTC1 actin, alpha, cardiac muscle 1
ACVR1B activin A receptor, type IB
ADAM23 ADAM metallopeptidase domain 23
AGO4 argonaute RISC catalytic component 4
ANXA10 annexin A10
ARMC4 armadillo repeat containing 4
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2
BMP7 bone morphogenetic protein 7
BRS3 bombesin-like receptor 3
BTF3P11 basic transcription factor 3 pseudogene 11
C1ORF95 chromosome 1 open reading frame 95
C5AR2 complement component 5a receptor 2
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CCDC132 coiled-coil domain containing 132
CCDC40 coiled-coil domain containing 40
CD53 CD53 molecule
CHI3L2 chitinase 3-like 2
CHRNG cholinergic receptor, nicotinic, gamma (muscle)
CLCN1 chloride channel, voltage-sensitive 1
CLTC clathrin, heavy chain (Hc)
CNGB3 cyclic nucleotide gated channel beta 3
CTNND2 catenin (cadherin-associated protein), delta 2
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYTH3 cytohesin 3
DGCR5 DiGeorge syndrome critical region gene 5 (non-protein coding)
DNAAF1 dynein, axonemal, assembly factor 1
ECM2 extracellular matrix protein 2, female organ and adipocyte specific
FAM182B family with sequence similarity 182, member B
FGF8 fibroblast growth factor 8 (androgen-induced)
FGFR1 fibroblast growth factor receptor 1
FSHB follicle stimulating hormone, beta polypeptide
FZD1 frizzled class receptor 1
GAB1 GRB2-associated binding protein 1
GLYAT glycine-N-acyltransferase
GPR137 G protein-coupled receptor 137
HHAT hedgehog acyltransferase
HHIPL2 HHIP-like 2
HRG histidine-rich glycoprotein
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
IGLJ3 immunoglobulin lambda joining 3
IL2RG interleukin 2 receptor, gamma
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGB7 integrin, beta 7
KIAA1109 KIAA1109
KIAA1456 KIAA1456
KLHL18 kelch-like family member 18
KLHL29 kelch-like family member 29
KRT85 keratin 85, type II
LINC00474 long intergenic non-protein coding RNA 474
LRRC15 leucine rich repeat containing 15
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MRC2 mannose receptor, C type 2
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MUC3B mucin 3B, cell surface associated
MYEF2 myelin expression factor 2
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle
MZF1 myeloid zinc finger 1
NEURL1 neuralized E3 ubiquitin protein ligase 1
NFASC neurofascin
OR2B6 olfactory receptor, family 2, subfamily B, member 6
OSGIN2 oxidative stress induced growth inhibitor family member 2
PAX2 paired box 2
PDE3B phosphodiesterase 3B, cGMP-inhibited
PLEKHS1 pleckstrin homology domain containing, family S member 1
PLXND1 plexin D1
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRAF2 PRA1 domain family, member 2
PRPH2 peripherin 2 (retinal degeneration, slow)
PSORS1C2 psoriasis susceptibility 1 candidate 2
RAP1GAP RAP1 GTPase activating protein
RORA RAR-related orphan receptor A
RUNX1 runt-related transcription factor 1
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SERHL2 serine hydrolase-like 2
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
SH2D3A SH2 domain containing 3A
SH3BP2 SH3-domain binding protein 2
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC45A2 solute carrier family 45, member 2
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SPINK5 serine peptidase inhibitor, Kazal type 5
STARD8 StAR-related lipid transfer (START) domain containing 8
TAT tyrosine aminotransferase
THRB thyroid hormone receptor, beta
TMEM246 transmembrane protein 246
TNNT2 troponin T type 2 (cardiac)
TRD T cell receptor delta locus
TRIM14 tripartite motif containing 14
TRIM23 tripartite motif containing 23
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCN urocortin
UNC5B unc-5 homolog B (C. elegans)
VIPR2 vasoactive intestinal peptide receptor 2
WNT16 wingless-type MMTV integration site family, member 16
WNT2B wingless-type MMTV integration site family, member 2B
ZSCAN2 zinc finger and SCAN domain containing 2

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ANP32A-IT1 ANP32A intronic transcript 1
AP4M1 adaptor-related protein complex 4, mu 1 subunit
BLMH bleomycin hydrolase
C14ORF79 chromosome 14 open reading frame 79
C16ORF59 chromosome 16 open reading frame 59
C17ORF80 chromosome 17 open reading frame 80
C1ORF105 chromosome 1 open reading frame 105
CA9 carbonic anhydrase IX
CD70 CD70 molecule
CDK20 cyclin-dependent kinase 20
CDK6 cyclin-dependent kinase 6
CENPO centromere protein O
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
ERN2 endoplasmic reticulum to nucleus signaling 2
FBXL7 F-box and leucine-rich repeat protein 7
FLJ21369 uncharacterized protein FLJ21369
FRS3 fibroblast growth factor receptor substrate 3
FUZ fuzzy planar cell polarity protein
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GAL3ST4 galactose-3-O-sulfotransferase 4
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GLB1L galactosidase, beta 1-like
GPR176 G protein-coupled receptor 176
GPR19 G protein-coupled receptor 19
HAUS4 HAUS augmin-like complex, subunit 4
HIST1H3C histone cluster 1, H3c
HSPA1L heat shock 70kDa protein 1-like
IFT81 intraflagellar transport 81
IQCC IQ motif containing C
IRF2BP1 interferon regulatory factor 2 binding protein 1
KCTD20 potassium channel tetramerization domain containing 20
KDM7A lysine (K)-specific demethylase 7A
LINC00341 long intergenic non-protein coding RNA 341
LIPG lipase, endothelial
LMCD1 LIM and cysteine-rich domains 1
LRRC37A3 leucine rich repeat containing 37, member A3
LY6G5C lymphocyte antigen 6 complex, locus G5C
MEGF8 multiple EGF-like-domains 8
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MMP3 matrix metallopeptidase 3
MOXD1 monooxygenase, DBH-like 1
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
NEK11 NIMA-related kinase 11
OLFML2A olfactomedin-like 2A
ORAI3 ORAI calcium release-activated calcium modulator 3
PCSK7 proprotein convertase subtilisin/kexin type 7
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PDZK1 PDZ domain containing 1
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PICK1 protein interacting with PRKCA 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PODNL1 podocan-like 1
POLM polymerase (DNA directed), mu
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PTGES2 prostaglandin E synthase 2
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAB4B RAB4B, member RAS oncogene family
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RHBDD3 rhomboid domain containing 3
ROM1 retinal outer segment membrane protein 1
SAYSD1 SAYSVFN motif domain containing 1
SCAMP5 secretory carrier membrane protein 5
SDC3 syndecan 3
SERGEF secretion regulating guanine nucleotide exchange factor
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SETD8 SET domain containing (lysine methyltransferase) 8
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2
SLC4A3 solute carrier family 4 (anion exchanger), member 3
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TBC1D19 TBC1 domain family, member 19
TM7SF2 transmembrane 7 superfamily member 2
TPRA1 transmembrane protein, adipocyte asscociated 1
TSC22D4 TSC22 domain family, member 4
TSPAN8 tetraspanin 8
UBQLN4 ubiquilin 4
WDR33 WD repeat domain 33
ZFP30 ZFP30 zinc finger protein
ZNF10 zinc finger protein 10
ZNF276 zinc finger protein 276
ZNF32 zinc finger protein 32
ZNF428 zinc finger protein 428
ZNF528 zinc finger protein 528
ZNF639 zinc finger protein 639