nalidixic acid-2336 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the nalidixic acid-2336 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
APOM apolipoprotein M
ARHGAP44 Rho GTPase activating protein 44
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ATP11A ATPase, class VI, type 11A
AVL9 AVL9 homolog (S. cerevisiase)
B9D2 B9 protein domain 2
BMP7 bone morphogenetic protein 7
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CAMSAP1 calmodulin regulated spectrin-associated protein 1
CAND2 cullin-associated and neddylation-dissociated 2 (putative)
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CCDC57 coiled-coil domain containing 57
CCND1 cyclin D1
CFAP69 cilia and flagella associated protein 69
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
COQ7 coenzyme Q7 homolog, ubiquinone (yeast)
CREB1 cAMP responsive element binding protein 1
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8
CYSLTR2 cysteinyl leukotriene receptor 2
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DZANK1 double zinc ribbon and ankyrin repeat domains 1
ELL2 elongation factor, RNA polymerase II, 2
EML2 echinoderm microtubule associated protein like 2
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GBAP1 glucosidase, beta, acid pseudogene 1
GK glycerol kinase
GNS glucosamine (N-acetyl)-6-sulfatase
GOSR2 golgi SNAP receptor complex member 2
GPSM3 G-protein signaling modulator 3
HAMP hepcidin antimicrobial peptide
HDAC11 histone deacetylase 11
HOXB6 homeobox B6
IL22 interleukin 22
IL27RA interleukin 27 receptor, alpha
IL6R interleukin 6 receptor
IRX5 iroquois homeobox 5
KDM4B lysine (K)-specific demethylase 4B
KDM7A lysine (K)-specific demethylase 7A
KLF11 Kruppel-like factor 11
LIMD2 LIM domain containing 2
LINC00597 long intergenic non-protein coding RNA 597
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
MAP2K2 mitogen-activated protein kinase kinase 2
MAP4 microtubule-associated protein 4
MAX MYC associated factor X
MBTPS2 membrane-bound transcription factor peptidase, site 2
MECP2 methyl CpG binding protein 2
METTL7A methyltransferase like 7A
MFAP3 microfibrillar-associated protein 3
MON2 MON2 homolog (S. cerevisiae)
MR1 major histocompatibility complex, class I-related
MVK mevalonate kinase
NCALD neurocalcin delta
NCOA3 nuclear receptor coactivator 3
NUMB numb homolog (Drosophila)
ONECUT1 one cut homeobox 1
ORAI2 ORAI calcium release-activated calcium modulator 2
PAQR6 progestin and adipoQ receptor family member VI
PCM1 pericentriolar material 1
PDLIM5 PDZ and LIM domain 5
PI4KB phosphatidylinositol 4-kinase, catalytic, beta
PLCG1 phospholipase C, gamma 1
PRB1 proline-rich protein BstNI subfamily 1
RAB11B RAB11B, member RAS oncogene family
RABGAP1L RAB GTPase activating protein 1-like
SALL2 spalt-like transcription factor 2
SCAMP5 secretory carrier membrane protein 5
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SLC16A6 solute carrier family 16, member 6
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC35E1 solute carrier family 35, member E1
SLC35F6 solute carrier family 35, member F6
SPHK2 sphingosine kinase 2
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
SSBP2 single-stranded DNA binding protein 2
STC2 stanniocalcin 2
STEAP4 STEAP family member 4
SYT13 synaptotagmin XIII
SZT2 seizure threshold 2 homolog (mouse)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TECPR2 tectonin beta-propeller repeat containing 2
TMEM194A transmembrane protein 194A
TRAPPC2 trafficking protein particle complex 2
TRD T cell receptor delta locus
VGF VGF nerve growth factor inducible
WDR59 WD repeat domain 59
WFDC2 WAP four-disulfide core domain 2
WNT6 wingless-type MMTV integration site family, member 6
WSB1 WD repeat and SOCS box containing 1
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZNF43 zinc finger protein 43
ZNF510 zinc finger protein 510
ZNF783 zinc finger family member 783

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ACAD10 acyl-CoA dehydrogenase family, member 10
ADAM15 ADAM metallopeptidase domain 15
ALG12 ALG12, alpha-1,6-mannosyltransferase
ALPK1 alpha-kinase 1
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ANXA2P2 annexin A2 pseudogene 2
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
AVPI1 arginine vasopressin-induced 1
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BAHD1 bromo adjacent homology domain containing 1
C11ORF68 chromosome 11 open reading frame 68
C16ORF59 chromosome 16 open reading frame 59
CCDC25 coiled-coil domain containing 25
CCDC85C coiled-coil domain containing 85C
CHMP7 charged multivesicular body protein 7
CLCN6 chloride channel, voltage-sensitive 6
CLEC16A C-type lectin domain family 16, member A
CLEC7A C-type lectin domain family 7, member A
CPTP ceramide-1-phosphate transfer protein
CX3CR1 chemokine (C-X3-C motif) receptor 1
DBF4B DBF4 zinc finger B
DGAT1 diacylglycerol O-acyltransferase 1
DHRS11 dehydrogenase/reductase (SDR family) member 11
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
E4F1 E4F transcription factor 1
EDAR ectodysplasin A receptor
EDC3 enhancer of mRNA decapping 3
EXD3 exonuclease 3'-5' domain containing 3
FANCC Fanconi anemia, complementation group C
FBXL6 F-box and leucine-rich repeat protein 6
FBXO46 F-box protein 46
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FKBPL FK506 binding protein like
FLJ21369 uncharacterized protein FLJ21369
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GLTP glycolipid transfer protein
GMEB1 glucocorticoid modulatory element binding protein 1
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
IRF2 interferon regulatory factor 2
ITPKB inositol-trisphosphate 3-kinase B
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
LAX1 lymphocyte transmembrane adaptor 1
LIMA1 LIM domain and actin binding 1
LOC729164 hCG1732469
LUZP1 leucine zipper protein 1
MAGEF1 melanoma antigen family F1
MED15 mediator complex subunit 15
METTL2B methyltransferase like 2B
MILR1 mast cell immunoglobulin-like receptor 1
MNS1 meiosis-specific nuclear structural 1
NAG18 NAG18 mRNA
NAT6 N-acetyltransferase 6 (GCN5-related)
NCS1 neuronal calcium sensor 1
NHEJ1 nonhomologous end-joining factor 1
NIPAL2 NIPA-like domain containing 2
NT5M 5',3'-nucleotidase, mitochondrial
NTSR1 neurotensin receptor 1 (high affinity)
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PDZD7 PDZ domain containing 7
POLM polymerase (DNA directed), mu
PPDPF pancreatic progenitor cell differentiation and proliferation factor
PROSER1 proline and serine rich 1
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
RAB3A RAB3A, member RAS oncogene family
RECQL4 RecQ protein-like 4
RETN resistin
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
SHARPIN SHANK-associated RH domain interactor
SHPK sedoheptulokinase
SMR3A submaxillary gland androgen regulated protein 3A
SPATA2L spermatogenesis associated 2-like
SPIDR scaffolding protein involved in DNA repair
SSBP3 single stranded DNA binding protein 3
STAG3 stromal antigen 3
TBXAS1 thromboxane A synthase 1 (platelet)
TIGD6 tigger transposable element derived 6
TLN1 talin 1
TMC7 transmembrane channel-like 7
TMEM110 transmembrane protein 110
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM212 transmembrane protein 212
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TSPAN13 tetraspanin 13
TUBGCP5 tubulin, gamma complex associated protein 5
UNC119 unc-119 homolog (C. elegans)
URM1 ubiquitin related modifier 1
VILL villin-like
XAB2 XPA binding protein 2
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZBTB5 zinc finger and BTB domain containing 5
ZDHHC18 zinc finger, DHHC-type containing 18
ZHX2 zinc fingers and homeoboxes 2
ZNF324 zinc finger protein 324
ZNF552 zinc finger protein 552
ZNHIT2 zinc finger, HIT-type containing 2