nalidixic acid-2297 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the nalidixic acid-2297 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ADGRF5 adhesion G protein-coupled receptor F5
AHSP alpha hemoglobin stabilizing protein
AKAP6 A kinase (PRKA) anchor protein 6
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
AQP7 aquaporin 7
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BCL2 B-cell CLL/lymphoma 2
BTG2 BTG family, member 2
C17ORF59 chromosome 17 open reading frame 59
C19ORF66 chromosome 19 open reading frame 66
C22ORF46 chromosome 22 open reading frame 46
C2ORF27A chromosome 2 open reading frame 27A
CA9 carbonic anhydrase IX
CCZ1 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)
CD48 CD48 molecule
CD80 CD80 molecule
CD82 CD82 molecule
CLIP2 CAP-GLY domain containing linker protein 2
CTNNA2 catenin (cadherin-associated protein), alpha 2
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
DGAT1 diacylglycerol O-acyltransferase 1
DGCR8 DGCR8 microprocessor complex subunit
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EGR4 early growth response 4
ELAVL3 ELAV like neuron-specific RNA binding protein 3
ERCC2 excision repair cross-complementation group 2
ESR1 estrogen receptor 1
FADS2 fatty acid desaturase 2
FAM212B family with sequence similarity 212, member B
FBXL7 F-box and leucine-rich repeat protein 7
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FGFR4 fibroblast growth factor receptor 4
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2
GLS glutaminase
HIC2 hypermethylated in cancer 2
HNMT histamine N-methyltransferase
HPR haptoglobin-related protein
IDS iduronate 2-sulfatase
IL21 interleukin 21
IMPG2 interphotoreceptor matrix proteoglycan 2
KLK13 kallikrein-related peptidase 13
KRT31 keratin 31, type I
KRT8 keratin 8, type II
KRTAP5-9 keratin associated protein 5-9
LBP lipopolysaccharide binding protein
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
LOXL2 lysyl oxidase-like 2
LOXL3 lysyl oxidase-like 3
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1
MAGOH2P mago-nashi homolog 2, pseudogene
MAN1C1 mannosidase, alpha, class 1C, member 1
MED25 mediator complex subunit 25
MLXIP MLX interacting protein
MOGAT2 monoacylglycerol O-acyltransferase 2
MST1 macrophage stimulating 1
MST1L macrophage stimulating 1-like
MT4 metallothionein 4
NEFM neurofilament, medium polypeptide
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PCDH1 protocadherin 1
PDE4C phosphodiesterase 4C, cAMP-specific
PI3 peptidase inhibitor 3, skin-derived
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PMFBP1 polyamine modulated factor 1 binding protein 1
POMT2 protein-O-mannosyltransferase 2
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PRB1 proline-rich protein BstNI subfamily 1
PRKCA protein kinase C, alpha
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PSAT1 phosphoserine aminotransferase 1
PSD3 pleckstrin and Sec7 domain containing 3
PYHIN1 pyrin and HIN domain family, member 1
RABEP2 rabaptin, RAB GTPase binding effector protein 2
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RGS2 regulator of G-protein signaling 2
RNF126P1 ring finger protein 126 pseudogene 1
RPS3A ribosomal protein S3A
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC2 syndecan 2
SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
SPP1 secreted phosphoprotein 1
SYT5 synaptotagmin V
TBL1Y transducin (beta)-like 1, Y-linked
TCHH trichohyalin
TFCP2L1 transcription factor CP2-like 1
TKTL1 transketolase-like 1
TMEM8B transmembrane protein 8B
TPMT thiopurine S-methyltransferase
VIPR1 vasoactive intestinal peptide receptor 1
WNT1 wingless-type MMTV integration site family, member 1
ZC3H7B zinc finger CCCH-type containing 7B
ZNF518A zinc finger protein 518A

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ADCY7 adenylate cyclase 7
ADM adrenomedullin
AFAP1 actin filament associated protein 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATP13A2 ATPase type 13A2
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BBS7 Bardet-Biedl syndrome 7
BFSP1 beaded filament structural protein 1, filensin
BTF3P12 basic transcription factor 3 pseudogene 12
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C7ORF43 chromosome 7 open reading frame 43
CA5BP1 carbonic anhydrase VB pseudogene 1
CCDC85C coiled-coil domain containing 85C
CD83 CD83 molecule
CGA glycoprotein hormones, alpha polypeptide
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLCN6 chloride channel, voltage-sensitive 6
CTSV cathepsin V
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DCAF13 DDB1 and CUL4 associated factor 13
DCLRE1A DNA cross-link repair 1A
DZANK1 double zinc ribbon and ankyrin repeat domains 1
EDEM2 ER degradation enhancer, mannosidase alpha-like 2
ELOVL4 ELOVL fatty acid elongase 4
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EPHX2 epoxide hydrolase 2, cytoplasmic
ERMAP erythroblast membrane-associated protein (Scianna blood group)
EVPL envoplakin
FAAH fatty acid amide hydrolase
FKBP14 FK506 binding protein 14, 22 kDa
FOXI1 forkhead box I1
GFI1 growth factor independent 1 transcription repressor
GPRIN2 G protein regulated inducer of neurite outgrowth 2
HDAC4 histone deacetylase 4
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
HP1BP3 heterochromatin protein 1, binding protein 3
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IFT140 intraflagellar transport 140
IFT22 intraflagellar transport 22
IL22 interleukin 22
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
JMJD4 jumonji domain containing 4
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KEL Kell blood group, metallo-endopeptidase
LOC390998 ribosomal protein L10 pseudogene
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3
MAGEB2 melanoma antigen family B2
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MON1B MON1 secretory trafficking family member B
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NLRX1 NLR family member X1
NPFFR1 neuropeptide FF receptor 1
ODF2 outer dense fiber of sperm tails 2
OLFML3 olfactomedin-like 3
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
PALM paralemmin
PARP12 poly (ADP-ribose) polymerase family, member 12
PCDHB13 protocadherin beta 13
PHEX phosphate regulating endopeptidase homolog, X-linked
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PRF1 perforin 1 (pore forming protein)
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PTK6 protein tyrosine kinase 6
RAB3A RAB3A, member RAS oncogene family
RAB3D RAB3D, member RAS oncogene family
RASA2 RAS p21 protein activator 2
RPL10L ribosomal protein L10-like
RPL23AP32 ribosomal protein L23a pseudogene 32
SCGB2A2 secretoglobin, family 2A, member 2
SDC3 syndecan 3
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC46A3 solute carrier family 46, member 3
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SP1 Sp1 transcription factor
SREK1IP1 SREK1-interacting protein 1
STARD5 StAR-related lipid transfer (START) domain containing 5
SYCP2 synaptonemal complex protein 2
TBKBP1 TBK1 binding protein 1
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TMEM242 transmembrane protein 242
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRAPPC2 trafficking protein particle complex 2
TRIM68 tripartite motif containing 68
TSPYL2 TSPY-like 2
USP27X ubiquitin specific peptidase 27, X-linked
XK X-linked Kx blood group
ZBTB48 zinc finger and BTB domain containing 48
ZFP69B ZFP69 zinc finger protein B
ZMAT5 zinc finger, matrin-type 5
ZNF254 zinc finger protein 254
ZNF574 zinc finger protein 574
ZNF668 zinc finger protein 668