nalbuphine-7177 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the nalbuphine-7177 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAM10 ADAM metallopeptidase domain 10
ADGRA2 adhesion G protein-coupled receptor A2
AK2 adenylate kinase 2
AKAP7 A kinase (PRKA) anchor protein 7
AKAP9 A kinase (PRKA) anchor protein 9
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
AQP3 aquaporin 3 (Gill blood group)
ARPIN actin-related protein 2/3 complex inhibitor
ATXN7L3B ataxin 7-like 3B
BCL3 B-cell CLL/lymphoma 3
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit
C19ORF73 chromosome 19 open reading frame 73
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CASP3 caspase 3, apoptosis-related cysteine peptidase
CD79B CD79b molecule, immunoglobulin-associated beta
CDK3 cyclin-dependent kinase 3
CFAP69 cilia and flagella associated protein 69
CPPED1 calcineurin-like phosphoesterase domain containing 1
CRAT carnitine O-acetyltransferase
CREBZF CREB/ATF bZIP transcription factor
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSE1L CSE1 chromosome segregation 1-like (yeast)
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DSCAM Down syndrome cell adhesion molecule
ERAP1 endoplasmic reticulum aminopeptidase 1
ESR1 estrogen receptor 1
ETV7 ets variant 7
FBLN1 fibulin 1
FBXL2 F-box and leucine-rich repeat protein 2
FLT4 fms-related tyrosine kinase 4
FN1 fibronectin 1
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GSK3A glycogen synthase kinase 3 alpha
HCRP1 hepatocellular carcinoma-related HCRP1
HDAC11 histone deacetylase 11
HEXA hexosaminidase A (alpha polypeptide)
HFE hemochromatosis
HIST1H2BC histone cluster 1, H2bc
HIST1H2BJ histone cluster 1, H2bj
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HP1BP3 heterochromatin protein 1, binding protein 3
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IQCC IQ motif containing C
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT19P2 keratin 19 pseudogene 2
LOC257152 uncharacterized LOC257152
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MBD3 methyl-CpG binding domain protein 3
MBNL2 muscleblind-like splicing regulator 2
MBNL3 muscleblind-like splicing regulator 3
METTL7A methyltransferase like 7A
MFN2 mitofusin 2
MSMB microseminoprotein, beta-
MTCP1 mature T-cell proliferation 1
NADK NAD kinase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NF2 neurofibromin 2 (merlin)
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
OVOL2 ovo-like zinc finger 2
PCM1 pericentriolar material 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PMFBP1 polyamine modulated factor 1 binding protein 1
POM121L2 POM121 transmembrane nucleoporin-like 2
PRDM9 PR domain containing 9
PTBP3 polypyrimidine tract binding protein 3
QKI QKI, KH domain containing, RNA binding
RABGAP1 RAB GTPase activating protein 1
RNF39 ring finger protein 39
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RPL7 ribosomal protein L7
RTEL1 regulator of telomere elongation helicase 1
RYK receptor-like tyrosine kinase
SAP30 Sin3A-associated protein, 30kDa
SDC2 syndecan 2
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
SKIL SKI-like proto-oncogene
SMC1A structural maintenance of chromosomes 1A
SNX13 sorting nexin 13
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
SPTAN1 spectrin, alpha, non-erythrocytic 1
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
THBD thrombomodulin
TMC7 transmembrane channel-like 7
TMEM120B transmembrane protein 120B
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TPD52 tumor protein D52
VIPR1 vasoactive intestinal peptide receptor 1
WSB1 WD repeat and SOCS box containing 1
ZDHHC17 zinc finger, DHHC-type containing 17
ZFP64 ZFP64 zinc finger protein
ZNF675 zinc finger protein 675

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
ARMC7 armadillo repeat containing 7
ATAD5 ATPase family, AAA domain containing 5
ATF3 activating transcription factor 3
AXIN1 axin 1
BATF basic leucine zipper transcription factor, ATF-like
C17ORF62 chromosome 17 open reading frame 62
C21ORF91 chromosome 21 open reading frame 91
C7ORF43 chromosome 7 open reading frame 43
CEP85 centrosomal protein 85kDa
CHKB choline kinase beta
CNGB3 cyclic nucleotide gated channel beta 3
COL9A2 collagen, type IX, alpha 2
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
CTSK cathepsin K
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DEAF1 DEAF1 transcription factor
DENND4B DENN/MADD domain containing 4B
DGKD diacylglycerol kinase, delta 130kDa
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38
EAF2 ELL associated factor 2
EHD3 EH-domain containing 3
EPHA2 EPH receptor A2
FAM189B family with sequence similarity 189, member B
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FOSL1 FOS-like antigen 1
FOXJ2 forkhead box J2
FZD2 frizzled class receptor 2
GAREM GRB2 associated, regulator of MAPK1
GPRC5C G protein-coupled receptor, class C, group 5, member C
GRWD1 glutamate-rich WD repeat containing 1
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HIST1H2AI histone cluster 1, H2ai
HOXC13 homeobox C13
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IMPACT impact RWD domain protein
INF2 inverted formin, FH2 and WH2 domain containing
IRF2BP1 interferon regulatory factor 2 binding protein 1
LIMA1 LIM domain and actin binding 1
LOC100272216 uncharacterized LOC100272216
LRP5 low density lipoprotein receptor-related protein 5
LRRC49 leucine rich repeat containing 49
LY6D lymphocyte antigen 6 complex, locus D
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAMLD1 mastermind-like domain containing 1
MANBA mannosidase, beta A, lysosomal
MDC1 mediator of DNA-damage checkpoint 1
MED24 mediator complex subunit 24
MORC3 MORC family CW-type zinc finger 3
MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MXD3 MAX dimerization protein 3
NCAM2 neural cell adhesion molecule 2
NDRG1 N-myc downstream regulated 1
NOL6 nucleolar protein 6 (RNA-associated)
PISD phosphatidylserine decarboxylase
PLA2G15 phospholipase A2, group XV
POR P450 (cytochrome) oxidoreductase
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTTG3P pituitary tumor-transforming 3, pseudogene
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RNF123 ring finger protein 123
RNF31 ring finger protein 31
RUFY2 RUN and FYVE domain containing 2
SAV1 salvador family WW domain containing protein 1
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SNHG3 small nucleolar RNA host gene 3
STARD13 StAR-related lipid transfer (START) domain containing 13
STRN4 striatin, calmodulin binding protein 4
TESK1 testis-specific kinase 1
THBS3 thrombospondin 3
THOP1 thimet oligopeptidase 1
TLN1 talin 1
TMEM127 transmembrane protein 127
TMEM254 transmembrane protein 254
TNS2 tensin 2
TRAIP TRAF interacting protein
TTC30A tetratricopeptide repeat domain 30A
UBIAD1 UbiA prenyltransferase domain containing 1
UBXN6 UBX domain protein 6
USP36 ubiquitin specific peptidase 36
VAV1 vav 1 guanine nucleotide exchange factor
WDR60 WD repeat domain 60
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZBED1 zinc finger, BED-type containing 1
ZBTB48 zinc finger and BTB domain containing 48
ZDHHC18 zinc finger, DHHC-type containing 18
ZNF219 zinc finger protein 219
ZNF813 zinc finger protein 813