nadolol-4139 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the nadolol-4139 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM15 ADAM metallopeptidase domain 15
ADAM22 ADAM metallopeptidase domain 22
ADGRL1 adhesion G protein-coupled receptor L1
ADRB3 adrenoceptor beta 3
AGFG1 ArfGAP with FG repeats 1
AHNAK2 AHNAK nucleoprotein 2
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALK anaplastic lymphoma receptor tyrosine kinase
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ATN1 atrophin 1
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
C11ORF16 chromosome 11 open reading frame 16
C21ORF2 chromosome 21 open reading frame 2
C22ORF46 chromosome 22 open reading frame 46
C9ORF116 chromosome 9 open reading frame 116
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CCDC68 coiled-coil domain containing 68
CD58 CD58 molecule
CDC14A cell division cycle 14A
CEP112 centrosomal protein 112kDa
CLCN6 chloride channel, voltage-sensitive 6
CLGN calmegin
CPT2 carnitine palmitoyltransferase 2
CYB561 cytochrome b561
DTX2 deltex 2, E3 ubiquitin ligase
EPOR erythropoietin receptor
FAM149B1 family with sequence similarity 149, member B1
FAM89B family with sequence similarity 89, member B
FBXO21 F-box protein 21
FJX1 four jointed box 1 (Drosophila)
FLOT1 flotillin 1
GALR3 galanin receptor 3
GK glycerol kinase
GPR137 G protein-coupled receptor 137
GRK5 G protein-coupled receptor kinase 5
H2AFX H2A histone family, member X
HIST1H4E histone cluster 1, H4e
HNMT histamine N-methyltransferase
HPX hemopexin
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
HSPG2 heparan sulfate proteoglycan 2
ICA1 islet cell autoantigen 1, 69kDa
IL17RC interleukin 17 receptor C
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3
KIAA0319L KIAA0319-like
KIAA1107 KIAA1107
KLHDC4 kelch domain containing 4
KRIT1 KRIT1, ankyrin repeat containing
LEPR leptin receptor
LIMCH1 LIM and calponin homology domains 1
LY6G6C lymphocyte antigen 6 complex, locus G6C
MAPK7 mitogen-activated protein kinase 7
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MED25 mediator complex subunit 25
METTL16 methyltransferase like 16
MOB1A MOB kinase activator 1A
MR1 major histocompatibility complex, class I-related
MTMR8 myotubularin related protein 8
N4BP2L1 NEDD4 binding protein 2-like 1
NCOR2 nuclear receptor corepressor 2
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa
NF1 neurofibromin 1
NPC1 Niemann-Pick disease, type C1
NRTN neurturin
PCNX pecanex homolog (Drosophila)
PEG10 paternally expressed 10
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PROS1 protein S (alpha)
PTGDR2 prostaglandin D2 receptor 2
RBM12 RNA binding motif protein 12
RHBG Rh family, B glycoprotein (gene/pseudogene)
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RRN3P1 RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 1
RSU1 Ras suppressor protein 1
SAG S-antigen; retina and pineal gland (arrestin)
SAYSD1 SAYSVFN motif domain containing 1
SEPP1 selenoprotein P, plasma, 1
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SKI SKI proto-oncogene
SLC35E2 solute carrier family 35, member E2
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SOAT1 sterol O-acyltransferase 1
STYK1 serine/threonine/tyrosine kinase 1
TDRD12 tudor domain containing 12
TGFB2 transforming growth factor, beta 2
THAP9 THAP domain containing 9
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TMEM5 transmembrane protein 5
TP53I11 tumor protein p53 inducible protein 11
TRIM23 tripartite motif containing 23
ZBTB33 zinc finger and BTB domain containing 33
ZDHHC17 zinc finger, DHHC-type containing 17
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF155 zinc finger protein 155
ZNF350 zinc finger protein 350
ZNF609 zinc finger protein 609

decreased expression

Symbol Name
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ACSL5 acyl-CoA synthetase long-chain family member 5
ADAM23 ADAM metallopeptidase domain 23
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALG12 ALG12, alpha-1,6-mannosyltransferase
ALPK1 alpha-kinase 1
AMPH amphiphysin
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1
ARSE arylsulfatase E (chondrodysplasia punctata 1)
ART1 ADP-ribosyltransferase 1
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
CCRL2 chemokine (C-C motif) receptor-like 2
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD82 CD82 molecule
CFAP45 cilia and flagella associated protein 45
CFHR4 complement factor H-related 4
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CHST4 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CRYBB2P1 crystallin, beta B2 pseudogene 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DPF1 D4, zinc and double PHD fingers family 1
DPF3 D4, zinc and double PHD fingers, family 3
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3
EPYC epiphycan
ETNK2 ethanolamine kinase 2
FLCN folliculin
FSTL1 follistatin-like 1
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GNG13 guanine nucleotide binding protein (G protein), gamma 13
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPRC5D G protein-coupled receptor, class C, group 5, member D
GRIP2 glutamate receptor interacting protein 2
HAS2 hyaluronan synthase 2
HHAT hedgehog acyltransferase
HIST1H2AK histone cluster 1, H2ak
HLA-DMB major histocompatibility complex, class II, DM beta
HMOX1 heme oxygenase 1
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
IBSP integrin-binding sialoprotein
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
IQCA1 IQ motif containing with AAA domain 1
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIAA1456 KIAA1456
KLF13 Kruppel-like factor 13
LEFTY2 left-right determination factor 2
LOC100131510 uncharacterized LOC100131510
LOC79999 uncharacterized LOC79999
LPAR4 lysophosphatidic acid receptor 4
LRRC48 leucine rich repeat containing 48
MFGE8 milk fat globule-EGF factor 8 protein
MYO15A myosin XVA
NAG18 NAG18 mRNA
NELL2 NEL-like 2 (chicken)
NEUROD1 neuronal differentiation 1
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
NPY6R neuropeptide Y receptor Y6 (pseudogene)
OCA2 oculocutaneous albinism II
PCDHB13 protocadherin beta 13
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PICK1 protein interacting with PRKCA 1
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLCD1 phospholipase C, delta 1
POLH polymerase (DNA directed), eta
POLL polymerase (DNA directed), lambda
PRDM14 PR domain containing 14
PTPRM protein tyrosine phosphatase, receptor type, M
PXDC1 PX domain containing 1
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RGS9 regulator of G-protein signaling 9
RHBDD3 rhomboid domain containing 3
RIMBP2 RIMS binding protein 2
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RPL10L ribosomal protein L10-like
RPL34 ribosomal protein L34
SCGB2A2 secretoglobin, family 2A, member 2
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC14A2 solute carrier family 14 (urea transporter), member 2
SLC16A4 solute carrier family 16, member 4
SLC22A14 solute carrier family 22, member 14
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SPRR1B small proline-rich protein 1B
TAGLN3 transgelin 3
TAOK1 TAO kinase 1
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TEP1 telomerase-associated protein 1
UBQLN4 ubiquilin 4
UCN urocortin
ZDHHC11 zinc finger, DHHC-type containing 11
ZFHX4 zinc finger homeobox 4
ZMAT4 zinc finger, matrin-type 4