myopia Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A refractive error characterized by the inability to see farther objects clearly. (Human Disease Ontology, DOID_11830)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0000545
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Genes

357 genes associated with the myopia phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 2.12703
MIPEP mitochondrial intermediate peptidase 1.79316
ASPA aspartoacylase 1.76992
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 1.72215
VIPR2 vasoactive intestinal peptide receptor 2 1.63535
RSPO1 R-spondin 1 1.59332
ZNF536 zinc finger protein 536 1.53903
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 1.48419
DENND1A DENN/MADD domain containing 1A 1.48419
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 1.46277
CMSS1 cms1 ribosomal small subunit homolog (yeast) 1.45654
ZEB2 zinc finger E-box binding homeobox 2 1.37339
LOC100129620 uncharacterized LOC100129620 1.35521
LOC646021 1.25845
DCLK1 doublecortin-like kinase 1 1.24751
LAMA2 laminin, alpha 2 1.24751
CHEK2 checkpoint kinase 2 1.24751
FLI1 Fli-1 proto-oncogene, ETS transcription factor 1.21853
BCAS3 breast carcinoma amplified sequence 3 1.19958
PML promyelocytic leukemia 1.1784
RERE arginine-glutamic acid dipeptide (RE) repeats 1.17192
FILIP1L filamin A interacting protein 1-like 1.15465
GPC6 glypican 6 1.15352
TMEM30C transmembrane protein 30C 1.13523
SRPK2 SRSF protein kinase 2 1.12851
TACC2 transforming, acidic coiled-coil containing protein 2 1.12851
MIR100HG mir-100-let-7a-2 cluster host gene 1.12851
ARID3A AT rich interactive domain 3A (BRIGHT-like) 1.11203
NKAIN2 Na+/K+ transporting ATPase interacting 2 1.11203
SPTBN1 spectrin, beta, non-erythrocytic 1 1.11203
CLSTN2 calsyntenin 2 1.09906
TIMELESS timeless circadian clock 1.09906
BMP6 bone morphogenetic protein 6 1.09906
LOC729305 uncharacterized LOC729305 1.0674
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 1.0674
PPP1R3B protein phosphatase 1, regulatory subunit 3B 1.05359
PTPRD protein tyrosine phosphatase, receptor type, D 1.05066
DOCK9 dedicator of cytokinesis 9 1.03165
RPTOR regulatory associated protein of MTOR, complex 1 1.00059
GYLTL1B glycosyltransferase-like 1B 1.00059
PDE4D phosphodiesterase 4D, cAMP-specific 1.00059
MIP major intrinsic protein of lens fiber 0.986868
FHIT fragile histidine triad 0.969142
TECRL trans-2,3-enoyl-CoA reductase-like 0.969142
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.969142
ERI1 exoribonuclease 1 0.969142
ADGRA2 adhesion G protein-coupled receptor A2 0.969142
DNAH9 dynein, axonemal, heavy chain 9 0.969142
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.95642
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 0.951078
LOC100506085 uncharacterized LOC100506085 0.942765
PARP8 poly (ADP-ribose) polymerase family, member 8 0.942765
GATA4 GATA binding protein 4 0.942765
CNTN5 contactin 5 0.942765
PTN pleiotrophin 0.923916
PEX16 peroxisomal biogenesis factor 16 0.917338
PRRC2C proline-rich coiled-coil 2C 0.910869
WDR34 WD repeat domain 34 0.899912
CHD4 chromodomain helicase DNA binding protein 4 0.899912
FLJ45872 0.899912
IGSF9 immunoglobulin superfamily, member 9 0.887424
CAPN9 calpain 9 0.882984
NXPH1 neurexophilin 1 0.882984
BMP2 bone morphogenetic protein 2 0.879522
PHF21A PHD finger protein 21A 0.87428
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 0.873845
CTNND2 catenin (cadherin-associated protein), delta 2 0.868241
TMPRSS9 transmembrane protease, serine 9 0.868241
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4 0.868241
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.868241
STAU2 staufen double-stranded RNA binding protein 2 0.855449
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 0.845725
LRP1B low density lipoprotein receptor-related protein 1B 0.843198
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.839148
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 0.812214
SLC44A2 solute carrier family 44 (choline transporter), member 2 0.806402
ZMAT4 zinc finger, matrin-type 4 0.799669
VAV2 vav 2 guanine nucleotide exchange factor 0.794657
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.792263
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase) 0.791087
BICC1 BicC family RNA binding protein 1 0.786
CEP85L centrosomal protein 85kDa-like 0.776085
ARHGAP24 Rho GTPase activating protein 24 0.756753
LY6K lymphocyte antigen 6 complex, locus K 0.753299
PRICKLE2 prickle homolog 2 (Drosophila) 0.742794
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 0.737679
GLIS1 GLIS family zinc finger 1 0.73677
LOC100288181 uncharacterized LOC100288181 0.723288
STX8 syntaxin 8 0.713947
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.712186
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.710801
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.703538
ST5 suppression of tumorigenicity 5 0.696021
MEGF11 multiple EGF-like-domains 11 0.694067
MSRA methionine sulfoxide reductase A 0.693745
RAB3C RAB3C, member RAS oncogene family 0.690896
RFX8 RFX family member 8, lacking RFX DNA binding domain 0.687825
ALPK1 alpha-kinase 1 0.687222
KRT26 keratin 26, type I 0.686325
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.684556
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.680552
PARVB parvin, beta 0.676017
IFIH1 interferon induced with helicase C domain 1 0.670488
AATF apoptosis antagonizing transcription factor 0.66338
ZNF717 zinc finger protein 717 0.658738
CTIF CBP80/20-dependent translation initiation factor 0.657238
SNTG1 syntrophin, gamma 1 0.648629
PXYLP1 2-phosphoxylose phosphatase 1 0.646866
PEMT phosphatidylethanolamine N-methyltransferase 0.646119
GPR180 G protein-coupled receptor 180 0.645871
SORCS3 sortilin-related VPS10 domain containing receptor 3 0.643909
UBASH3A ubiquitin associated and SH3 domain containing A 0.639391
DENND1C DENN/MADD domain containing 1C 0.636409
C19ORF81 chromosome 19 open reading frame 81 0.635284
XYLT1 xylosyltransferase I 0.630903
MPZL1 myelin protein zero-like 1 0.629837
PAX6 paired box 6 0.629625
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) 0.626496
DSP desmoplakin 0.626086
FAM45A family with sequence similarity 45, member A 0.615926
LHX6 LIM homeobox 6 0.615734
ADGRV1 adhesion G protein-coupled receptor V1 0.61516
MOCS1 molybdenum cofactor synthesis 1 0.613269
CDH13 cadherin 13 0.611413
LOC100652770 0.610133
RNF125 ring finger protein 125, E3 ubiquitin protein ligase 0.607266
RSU1 Ras suppressor protein 1 0.60709
PTGER3 prostaglandin E receptor 3 (subtype EP3) 0.599941
ZMYND11 zinc finger, MYND-type containing 11 0.599285
PRR5 proline rich 5 (renal) 0.592807
PDE11A phosphodiesterase 11A 0.592045
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae) 0.587592
LOC440704 uncharacterized LOC440704 0.583665
DNHD1 dynein heavy chain domain 1 0.582939
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 0.580444
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 0.578018
PXDNL peroxidasin-like 0.576102
LY86-AS1 LY86 antisense RNA 1 0.572823
AKAP12 A kinase (PRKA) anchor protein 12 0.570703
GPC5 glypican 5 0.569663
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.568635
TMTC1 transmembrane and tetratricopeptide repeat containing 1 0.56762
CNBD1 cyclic nucleotide binding domain containing 1 0.562717
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.558686
SLIT3 slit homolog 3 (Drosophila) 0.558007
TRIM67 tripartite motif containing 67 0.55536
TENM4 teneurin transmembrane protein 4 0.549174
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila) 0.549174
RBMS3 RNA binding motif, single stranded interacting protein 3 0.548004
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase 0.546854
OR10J1 olfactory receptor, family 10, subfamily J, member 1 0.545725
APOH apolipoprotein H (beta-2-glycoprotein I) 0.540725
COL18A1 collagen, type XVIII, alpha 1 0.540309
TMEM132D transmembrane protein 132D 0.539082
ECE1 endothelin converting enzyme 1 0.537883
SDK1 sidekick cell adhesion molecule 1 0.537883
DMGDH dimethylglycine dehydrogenase 0.535942
HDAC11 histone deacetylase 11 0.53407
SMAD9 SMAD family member 9 0.532978
MIPEPP3 mitochondrial intermediate peptidase pseudogene 3 0.532262
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.529158
NPAS3 neuronal PAS domain protein 3 0.522995
SH2D4B SH2 domain containing 4B 0.522707
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.515252
MUSK muscle, skeletal, receptor tyrosine kinase 0.514254
PDZRN4 PDZ domain containing ring finger 4 0.512253
CAPN14 calpain 14 0.511281
BBS2 Bardet-Biedl syndrome 2 0.510802
SLC39A11 solute carrier family 39, member 11 0.510327
OTX2-AS1 OTX2 antisense RNA 1 (head to head) 0.510092
DKFZP451B082 uncharacterized LOC401282 0.509623
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.509391
SNX9 sorting nexin 9 0.507344
WDR62 WD repeat domain 62 0.507122
ASB17 ankyrin repeat and SOCS box containing 17 0.50668
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.505592
COL22A1 collagen, type XXII, alpha 1 0.505377
ADAM18 ADAM metallopeptidase domain 18 0.50495
LPPR1 lipid phosphate phosphatase-related protein type 1 0.504738
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 0.504316
C10ORF11 chromosome 10 open reading frame 11 0.500023
EPAS1 endothelial PAS domain protein 1 0.498995
IL31RA interleukin 31 receptor A 0.498388
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.497987
GPM6A glycoprotein M6A 0.497987
NFASC neurofascin 0.496412
CD96 CD96 molecule 0.495071
PRKCE protein kinase C, epsilon 0.494882
MTUS2 microtubule associated tumor suppressor candidate 2 0.494506
LAMC3 laminin, gamma 3 0.49432
PIEZO2 piezo-type mechanosensitive ion channel component 2 0.494133
MTMR7 myotubularin related protein 7 0.494133
KIF16B kinesin family member 16B 0.491771
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.491417
LAMA1 laminin, alpha 1 0.489511
GALC galactosylceramidase 0.489002
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 0.488666
ZNF578 zinc finger protein 578 0.488666
ZBTB20 zinc finger and BTB domain containing 20 0.488666
C1QTNF9B C1q and tumor necrosis factor related protein 9B 0.487836
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.487343
THRB thyroid hormone receptor, beta 0.486856
C12ORF42 chromosome 12 open reading frame 42 0.486516
METTL24 methyltransferase like 24 0.485988
FLJ45831 0.483588
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.482756
BOLA3 bolA family member 3 0.482262
CCDC184 coiled-coil domain containing 184 0.480014
LYPD6B LY6/PLAUR domain containing 6B 0.4797
CSMD1 CUB and Sushi multiple domains 1 0.479543
IGSF21 immunoglobin superfamily, member 21 0.478461
NME8 NME/NM23 family member 8 0.476802
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.475772
AJAP1 adherens junctions associated protein 1 0.474617
PARVA parvin, alpha 0.474332
THSD4 thrombospondin, type I, domain containing 4 0.473626
PLEKHA7 pleckstrin homology domain containing, family A member 7 0.473207
TNIK TRAF2 and NCK interacting kinase 0.472515
PELI2 pellino E3 ubiquitin protein ligase family member 2 0.471263
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34 0.469948
PLXNA4 plexin A4 0.469516
PCDH15 protocadherin-related 15 0.469516
KSR2 kinase suppressor of ras 2 0.46923
ABHD17C abhydrolase domain containing 17C 0.468099
SOX5 SRY (sex determining region Y)-box 5 0.467819
WIPI2 WD repeat domain, phosphoinositide interacting 2 0.467126
STRN striatin, calmodulin binding protein 0.465496
LYPD6 LY6/PLAUR domain containing 6 0.462746
SEC63 SEC63 homolog (S. cerevisiae) 0.462619
ERICH6B glutamate-rich 6B 0.462364
SV2B synaptic vesicle glycoprotein 2B 0.460243
C5ORF42 chromosome 5 open reading frame 42 0.46012
C16ORF62 chromosome 16 open reading frame 62 0.459876
CHD2 chromodomain helicase DNA binding protein 2 0.459391
MCPH1 microcephalin 1 0.458671
BDNF-AS BDNF antisense RNA 0.458552
CPNE5 copine V 0.458315
UNC5C unc-5 homolog C (C. elegans) 0.458196
HEATR4 HEAT repeat containing 4 0.458078
PCDH7 protocadherin 7 0.457725
MSH4 mutS homolog 4 0.457608
SFXN4 sideroflexin 4 0.457258
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 0.457258
THAP8 THAP domain containing 8 0.455991
TNNI3K TNNI3 interacting kinase 0.455764
RBM19 RNA binding motif protein 19 0.45519
INADL InaD-like (Drosophila) 0.455075
FREM1 FRAS1 related extracellular matrix 1 0.454845
ETV6 ets variant 6 0.454616
DZIP3 DAZ interacting zinc finger protein 3 0.454387
EML1 echinoderm microtubule associated protein like 1 0.454047
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 0.45382
BRE brain and reproductive organ-expressed (TNFRSF1A modulator) 0.452592
KCNK9 potassium channel, two pore domain subfamily K, member 9 0.452592
SLC1A6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 0.451714
CABP7 calcium binding protein 7 0.451497
PRKG1 protein kinase, cGMP-dependent, type I 0.451497
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3 0.45128
EXOC2 exocyst complex component 2 0.45085
MTUS1 microtubule associated tumor suppressor 1 0.450636
CNTN3 contactin 3 (plasmacytoma associated) 0.450636
FOXO1 forkhead box O1 0.450422
PROM1 prominin 1 0.450103
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.449681
CASS4 Cas scaffolding protein family member 4 0.448846
CNTN4 contactin 4 0.44721
ANKRD30B ankyrin repeat domain 30B 0.446909
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.446609
NCKAP5L NCK-associated protein 5-like 0.446211
ARHGAP18 Rho GTPase activating protein 18 0.445816
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 0.445816
STARD13 StAR-related lipid transfer (START) domain containing 13 0.445522
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1 0.445424
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.44484
CNIH3 cornichon family AMPA receptor auxiliary protein 3 0.444551
ATXN1 ataxin 1 0.443596
MACROD2 MACRO domain containing 2 0.442843
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.442843
MAPRE2 microtubule-associated protein, RP/EB family, member 2 0.442285
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.442285
RARS arginyl-tRNA synthetase 0.442192
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial 0.442192
MYO18B myosin XVIIIB 0.441916
ARSB arylsulfatase B 0.441824
PCDHGA1 protocadherin gamma subfamily A, 1 0.441003
FBXO36 F-box protein 36 0.440642
MYH13 myosin, heavy chain 13, skeletal muscle 0.439927
SMIM23 small integral membrane protein 23 0.439838
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa 0.439578
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) 0.439043
DPYD dihydropyrimidine dehydrogenase 0.438815
NETO1 neuropilin (NRP) and tolloid (TLL)-like 1 0.438739
UBE2L3 ubiquitin-conjugating enzyme E2L 3 0.43784
ABI3BP ABI family, member 3 (NESH) binding protein 0.437691
CASP6 caspase 6, apoptosis-related cysteine peptidase 0.437543
SGCE sarcoglycan, epsilon 0.437102
PRDM10 PR domain containing 10 0.436303
RELN reelin 0.436087
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 0.435801
COX7B2 cytochrome c oxidase subunit VIIb2 0.435588
ACSL5 acyl-CoA synthetase long-chain family member 5 0.435446
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.434812
MYO3B myosin IIIB 0.434603
RGL1 ral guanine nucleotide dissociation stimulator-like 1 0.434394
FANCI Fanconi anemia, complementation group I 0.434048
TARBP1 TAR (HIV-1) RNA binding protein 1 0.433911
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0.433773
MTCL1 microtubule crosslinking factor 1 0.433364
ICAM3 intercellular adhesion molecule 3 0.433228
CPEB3 cytoplasmic polyadenylation element binding protein 3 0.43316
FRAS1 Fraser extracellular matrix complex subunit 1 0.433093
VAV3 vav 3 guanine nucleotide exchange factor 0.432823
PLD5 phospholipase D family, member 5 0.432555
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 0.432221
GPATCH2L G patch domain containing 2-like 0.431627
ERBB4 erb-b2 receptor tyrosine kinase 4 0.431561
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 0.431365
IRX2 iroquois homeobox 2 0.431365
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.430395
GRM7 glutamate receptor, metabotropic 7 0.429443
ITGA11 integrin, alpha 11 0.429318
AIM1 absent in melanoma 1 0.429255
ZNF727 zinc finger protein 727 0.429193
MAP3K13 mitogen-activated protein kinase kinase kinase 13 0.429193
MOB1A MOB kinase activator 1A 0.429193
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.42913
CHURC1-FNTB CHURC1-FNTB readthrough 0.429068
HS3ST4 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 0.428881
NCALD neurocalcin delta 0.428881
FAM169A family with sequence similarity 169, member A 0.428757
ASIC2 acid sensing (proton gated) ion channel 2 0.428633
BPIFC BPI fold containing family C 0.428325
FBXO41 F-box protein 41 0.428202
UNC80 unc-80 homolog (C. elegans) 0.428202
DLEU2 deleted in lymphocytic leukemia 2 (non-protein coding) 0.427836
CHURC1 churchill domain containing 1 0.427352
TCF4 transcription factor 4 0.427171
EXD2 exonuclease 3'-5' domain containing 2 0.427111
GRM4 glutamate receptor, metabotropic 4 0.427051
SLC26A9 solute carrier family 26 (anion exchanger), member 9 0.426992
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5 0.426992
LDLRAD3 low density lipoprotein receptor class A domain containing 3 0.426812
CNTN6 contactin 6 0.426634
AGBL4 ATP/GTP binding protein-like 4 0.426338
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide 0.426221
ABLIM2 actin binding LIM protein family, member 2 0.425822
TMEM244 transmembrane protein 244 0.425233
PDGFD platelet derived growth factor D 0.425233
TSPAN5 tetraspanin 5 0.425194
C4ORF19 chromosome 4 open reading frame 19 0.425039
ROCK1P1 Rho-associated, coiled-coil containing protein kinase 1 pseudogene 1 0.424962
MN1 meningioma (disrupted in balanced translocation) 1 0.424807
CASD1 CAS1 domain containing 1 0.424769
USH2A Usher syndrome 2A (autosomal recessive, mild) 0.424616
CCSER1 coiled-coil serine-rich protein 1 0.424425
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.424311
ZNF462 zinc finger protein 462 0.424122