myopia Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
Description A refractive error characterized by the inability to see farther objects clearly. (Human Disease Ontology, DOID_11830)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:11830
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Genes

341 genes associated with the disease myopia in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 2.17705
MIPEP mitochondrial intermediate peptidase 1.86468
ASPA aspartoacylase 1.85286
ATOH7 atonal homolog 7 (Drosophila) 1.82268
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 1.80795
VIPR2 vasoactive intestinal peptide receptor 2 1.74243
RSPO1 R-spondin 1 1.71314
ZNF536 zinc finger protein 536 1.67004
DENND1A DENN/MADD domain containing 1A 1.62029
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 1.62029
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 1.60174
CMSS1 cms1 ribosomal small subunit homolog (yeast) 1.59609
ZEB2 zinc finger E-box binding homeobox 2 1.52524
LOC100129620 uncharacterized LOC100129620 1.50906
LOC646021 1.43537
LAMA2 laminin, alpha 2 1.42467
DCLK1 doublecortin-like kinase 1 1.42467
CHEK2 checkpoint kinase 2 1.42467
FLI1 Fli-1 proto-oncogene, ETS transcription factor 1.39396
BCAS3 breast carcinoma amplified sequence 3 1.37327
PML promyelocytic leukemia 1.34719
RERE arginine-glutamic acid dipeptide (RE) repeats 1.33878
FILIP1L filamin A interacting protein 1-like 1.31765
TMEM30C transmembrane protein 30C 1.29707
MIR100HG mir-100-let-7a-2 cluster host gene 1.28906
RFTN1 raftlin, lipid raft linker 1 1.28906
TACC2 transforming, acidic coiled-coil containing protein 2 1.28906
SRPK2 SRSF protein kinase 2 1.28906
MYPN myopalladin 1.28906
SPTBN1 spectrin, beta, non-erythrocytic 1 1.26953
LRP1B low density lipoprotein receptor-related protein 1B 1.26953
ARID3A AT rich interactive domain 3A (BRIGHT-like) 1.26953
BMP6 bone morphogenetic protein 6 1.25477
CLSTN2 calsyntenin 2 1.25477
TIMELESS timeless circadian clock 1.25477
LOC729305 uncharacterized LOC729305 1.21996
PPP1R3B protein phosphatase 1, regulatory subunit 3B 1.20482
PTPRD protein tyrosine phosphatase, receptor type, D 1.20161
DOCK9 dedicator of cytokinesis 9 1.18062
SCFD2 sec1 family domain containing 2 1.14463
GYLTL1B glycosyltransferase-like 1B 1.14463
RPTOR regulatory associated protein of MTOR, complex 1 1.14463
MIP major intrinsic protein of lens fiber 1.12853
FHIT fragile histidine triad 1.10764
CDH4 cadherin 4, type 1, R-cadherin (retinal) 1.10764
DNAH9 dynein, axonemal, heavy chain 9 1.10764
TECRL trans-2,3-enoyl-CoA reductase-like 1.10764
ERI1 exoribonuclease 1 1.10764
ADGRA2 adhesion G protein-coupled receptor A2 1.10764
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 1.09284
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 1.08665
TSHR thyroid stimulating hormone receptor 1.07599
DENND2A DENN/MADD domain containing 2A 1.07599
GATA4 GATA binding protein 4 1.07599
PARP8 poly (ADP-ribose) polymerase family, member 8 1.07599
LOC100506085 uncharacterized LOC100506085 1.07599
CNTN5 contactin 5 1.07599
PEX16 peroxisomal biogenesis factor 16 1.04539
PRRC2C proline-rich coiled-coil 2C 1.03788
CHD4 chromodomain helicase DNA binding protein 4 1.02476
WDR34 WD repeat domain 34 1.02476
IGSF9 immunoglobulin superfamily, member 9 1.00925
CAPN9 calpain 9 1.00407
PEX14 peroxisomal biogenesis factor 14 1.00407
ESRRG estrogen-related receptor gamma 1.00407
BMP2 bone morphogenetic protein 2 1.00003
PHF21A PHD finger protein 21A 0.993697
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 0.993169
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4 0.986376
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.986376
CTNND2 catenin (cadherin-associated protein), delta 2 0.986376
STAU2 staufen double-stranded RNA binding protein 2 0.971169
MYH9 myosin, heavy chain 9, non-muscle 0.971169
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 0.96005
SLC44A2 solute carrier family 44 (choline transporter), member 2 0.916706
ZMAT4 zinc finger, matrin-type 4 0.909246
VAV2 vav 2 guanine nucleotide exchange factor 0.903565
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.900854
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase) 0.89953
BICC1 BicC family RNA binding protein 1 0.894421
CEP85L centrosomal protein 85kDa-like 0.884
ARHGAP24 Rho GTPase activating protein 24 0.863433
LY6K lymphocyte antigen 6 complex, locus K 0.859982
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 0.842929
GLIS1 GLIS family zinc finger 1 0.842041
LOC100288181 uncharacterized LOC100288181 0.828571
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.816443
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.814931
ST5 suppression of tumorigenicity 5 0.800256
MEGF11 multiple EGF-like-domains 11 0.798096
MSRA methionine sulfoxide reductase A 0.79774
RAB3C RAB3C, member RAS oncogene family 0.794591
ALPK1 alpha-kinase 1 0.790534
KRT26 keratin 26, type I 0.789545
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.787593
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.783178
PARVB parvin, beta 0.778649
ZNF717 zinc finger protein 717 0.760692
CTIF CBP80/20-dependent translation initiation factor 0.759036
PXYLP1 2-phosphoxylose phosphatase 1 0.747865
PEMT phosphatidylethanolamine N-methyltransferase 0.747128
GPR180 G protein-coupled receptor 180 0.746884
SORCS3 sortilin-related VPS10 domain containing receptor 3 0.744948
UBASH3A ubiquitin associated and SH3 domain containing A 0.74049
DENND1C DENN/MADD domain containing 1C 0.737547
C19ORF81 chromosome 19 open reading frame 81 0.736436
XYLT1 xylosyltransferase I 0.731685
MPZL1 myelin protein zero-like 1 0.730518
PAX6 paired box 6 0.730285
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) 0.726862
FAM45A family with sequence similarity 45, member A 0.715357
LHX6 LIM homeobox 6 0.715155
ADGRV1 adhesion G protein-coupled receptor V1 0.714552
MOCS1 molybdenum cofactor synthesis 1 0.712564
CDH13 cadherin 13 0.710614
LOC100652770 0.709269
RNF125 ring finger protein 125, E3 ubiquitin protein ligase 0.706258
RSU1 Ras suppressor protein 1 0.706073
PTGER3 prostaglandin E receptor 3 (subtype EP3) 0.698585
ZMYND11 zinc finger, MYND-type containing 11 0.697901
PRR5 proline rich 5 (renal) 0.691138
PDE11A phosphodiesterase 11A 0.690343
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae) 0.685698
LOC440704 uncharacterized LOC440704 0.681256
DNHD1 dynein heavy chain domain 1 0.680391
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 0.67742
LY86-AS1 LY86 antisense RNA 1 0.668836
AKAP12 A kinase (PRKA) anchor protein 12 0.666845
GPC5 glypican 5 0.665868
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.664902
TMTC1 transmembrane and tetratricopeptide repeat containing 1 0.663947
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.654978
SLIT3 slit homolog 3 (Drosophila) 0.654134
TENM4 teneurin transmembrane protein 4 0.644215
RBMS3 RNA binding motif, single stranded interacting protein 3 0.64313
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase 0.642063
OR10J1 olfactory receptor, family 10, subfamily J, member 1 0.641015
APOH apolipoprotein H (beta-2-glycoprotein I) 0.636031
COL18A1 collagen, type XVIII, alpha 1 0.635554
TMEM132D transmembrane protein 132D 0.634147
ECE1 endothelin converting enzyme 1 0.632771
SDK1 sidekick cell adhesion molecule 1 0.632771
DMGDH dimethylglycine dehydrogenase 0.630552
HDAC11 histone deacetylase 11 0.628481
SMAD9 SMAD family member 9 0.627273
MIPEPP3 mitochondrial intermediate peptidase pseudogene 3 0.626482
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.623051
NPAS3 neuronal PAS domain protein 3 0.616096
SH2D4B SH2 domain containing 4B 0.61577
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.606572
MUSK muscle, skeletal, receptor tyrosine kinase 0.605359
PDZRN4 PDZ domain containing ring finger 4 0.603005
CAPN14 calpain 14 0.601861
BBS2 Bardet-Biedl syndrome 2 0.601298
SLC39A11 solute carrier family 39, member 11 0.60074
OTX2-AS1 OTX2 antisense RNA 1 (head to head) 0.600463
DKFZP451B082 uncharacterized LOC401282 0.599913
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.59964
SNX9 sorting nexin 9 0.597094
WDR62 WD repeat domain 62 0.596808
ASB17 ankyrin repeat and SOCS box containing 17 0.596242
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.594847
COL22A1 collagen, type XXII, alpha 1 0.594571
LPPR1 lipid phosphate phosphatase-related protein type 1 0.593752
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 0.593212
C10ORF11 chromosome 10 open reading frame 11 0.587807
EPAS1 endothelial PAS domain protein 1 0.586586
IL31RA interleukin 31 receptor A 0.585865
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.585389
GPM6A glycoprotein M6A 0.585389
NFASC neurofascin 0.58352
CD96 CD96 molecule 0.581931
PRKCE protein kinase C, epsilon 0.581707
MTUS2 microtubule associated tumor suppressor candidate 2 0.58124
LAMC3 laminin, gamma 3 0.580999
MTMR7 myotubularin related protein 7 0.58076
PIEZO2 piezo-type mechanosensitive ion channel component 2 0.58076
KIF16B kinesin family member 16B 0.577723
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.577268
LAMA1 laminin, alpha 1 0.574821
GALC galactosylceramidase 0.574169
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 0.573738
ZNF578 zinc finger protein 578 0.573738
ZBTB20 zinc finger and BTB domain containing 20 0.573738
C1QTNF9B C1q and tumor necrosis factor related protein 9B 0.572673
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.572043
THRB thyroid hormone receptor, beta 0.571418
C12ORF42 chromosome 12 open reading frame 42 0.571005
METTL24 methyltransferase like 24 0.57039
FLJ45831 0.567598
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.566629
BOLA3 bolA family member 3 0.566055
CCDC184 coiled-coil domain containing 184 0.563434
LYPD6B LY6/PLAUR domain containing 6B 0.563041
IGSF21 immunoglobin superfamily, member 21 0.561491
NME8 NME/NM23 family member 8 0.559415
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.558127
AJAP1 adherens junctions associated protein 1 0.556685
PARVA parvin, alpha 0.556329
THSD4 thrombospondin, type I, domain containing 4 0.555448
PLEKHA7 pleckstrin homology domain containing, family A member 7 0.554925
TNIK TRAF2 and NCK interacting kinase 0.554062
PELI2 pellino E3 ubiquitin protein ligase family member 2 0.552536
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34 0.551045
PCDH15 protocadherin-related 15 0.550555
PLXNA4 plexin A4 0.550555
KSR2 kinase suppressor of ras 2 0.550231
ABHD17C abhydrolase domain containing 17C 0.548949
SOX5 SRY (sex determining region Y)-box 5 0.548632
WIPI2 WD repeat domain, phosphoinositide interacting 2 0.547847
STRN striatin, calmodulin binding protein 0.546
LYPD6 LY6/PLAUR domain containing 6 0.542744
SEC63 SEC63 homolog (S. cerevisiae) 0.542589
ERICH6B glutamate-rich 6B 0.542281
SV2B synaptic vesicle glycoprotein 2B 0.539714
C5ORF42 chromosome 5 open reading frame 42 0.539566
C16ORF62 chromosome 16 open reading frame 62 0.539271
CHD2 chromodomain helicase DNA binding protein 2 0.538685
MCPH1 microcephalin 1 0.537815
BDNF-AS BDNF antisense RNA 0.537671
CPNE5 copine V 0.537384
UNC5C unc-5 homolog C (C. elegans) 0.537241
HEATR4 HEAT repeat containing 4 0.537098
PCDH7 protocadherin 7 0.536671
MSH4 mutS homolog 4 0.53653
SFXN4 sideroflexin 4 0.536107
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 0.536107
THAP8 THAP domain containing 8 0.534578
TNNI3K TNNI3 interacting kinase 0.534304
RBM19 RNA binding motif protein 19 0.533623
INADL InaD-like (Drosophila) 0.533487
FREM1 FRAS1 related extracellular matrix 1 0.533217
ETV6 ets variant 6 0.532948
DZIP3 DAZ interacting zinc finger protein 3 0.532681
EML1 echinoderm microtubule associated protein like 1 0.532281
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 0.532016
KCNK9 potassium channel, two pore domain subfamily K, member 9 0.530576
BRE brain and reproductive organ-expressed (TNFRSF1A modulator) 0.530576
SLC1A6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 0.529547
CABP7 calcium binding protein 7 0.529293
PRKG1 protein kinase, cGMP-dependent, type I 0.529293
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3 0.529039
EXOC2 exocyst complex component 2 0.528535
CNTN3 contactin 3 (plasmacytoma associated) 0.528284
MTUS1 microtubule associated tumor suppressor 1 0.528284
FOXO1 forkhead box O1 0.528034
PROM1 prominin 1 0.527661
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.527166
CNTN4 contactin 4 0.52427
ANKRD30B ankyrin repeat domain 30B 0.523916
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.523564
NCKAP5L NCK-associated protein 5-like 0.523097
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 0.522634
ARHGAP18 Rho GTPase activating protein 18 0.522634
STARD13 StAR-related lipid transfer (START) domain containing 13 0.522288
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1 0.522174
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.521489
CNIH3 cornichon family AMPA receptor auxiliary protein 3 0.52115
ATXN1 ataxin 1 0.520031
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.519149
MACROD2 MACRO domain containing 2 0.519149
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.518495
MAPRE2 microtubule-associated protein, RP/EB family, member 2 0.518495
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial 0.518386
RARS arginyl-tRNA synthetase 0.518386
MYO18B myosin XVIIIB 0.518063
ARSB arylsulfatase B 0.517955
PCDHGA1 protocadherin gamma subfamily A, 1 0.516994
FBXO36 F-box protein 36 0.516571
MYH13 myosin, heavy chain 13, skeletal muscle 0.515734
SMIM23 small integral membrane protein 23 0.51563
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa 0.51532
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) 0.5146
DPYD dihydropyrimidine dehydrogenase 0.514295
NETO1 neuropilin (NRP) and tolloid (TLL)-like 1 0.514193
UBE2L3 ubiquitin-conjugating enzyme E2L 3 0.512985
ABI3BP ABI family, member 3 (NESH) binding protein 0.512786
CASP6 caspase 6, apoptosis-related cysteine peptidase 0.512588
SGCE sarcoglycan, epsilon 0.511996
PRDM10 PR domain containing 10 0.510925
RELN reelin 0.510636
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 0.510252
COX7B2 cytochrome c oxidase subunit VIIb2 0.509966
ACSL5 acyl-CoA synthetase long-chain family member 5 0.509776
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.508927
MYO3B myosin IIIB 0.508647
RGL1 ral guanine nucleotide dissociation stimulator-like 1 0.508368
FANCI Fanconi anemia, complementation group I 0.507905
TARBP1 TAR (HIV-1) RNA binding protein 1 0.507721
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0.507539
CSMD1 CUB and Sushi multiple domains 1 0.507539
MTCL1 microtubule crosslinking factor 1 0.507105
ICAM3 intercellular adhesion molecule 3 0.506961
CPEB3 cytoplasmic polyadenylation element binding protein 3 0.506889
FRAS1 Fraser extracellular matrix complex subunit 1 0.506817
VAV3 vav 3 guanine nucleotide exchange factor 0.506531
PLD5 phospholipase D family, member 5 0.506247
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 0.505894
GPATCH2L G patch domain containing 2-like 0.505264
ERBB4 erb-b2 receptor tyrosine kinase 4 0.505194
IRX2 iroquois homeobox 2 0.504986
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 0.504986
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.503958
GRM7 glutamate receptor, metabotropic 7 0.502949
ITGA11 integrin, alpha 11 0.502816
AIM1 absent in melanoma 1 0.50275
MOB1A MOB kinase activator 1A 0.502683
MAP3K13 mitogen-activated protein kinase kinase kinase 13 0.502683
ZNF727 zinc finger protein 727 0.502683
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.502617
CHURC1-FNTB CHURC1-FNTB readthrough 0.502551
NCALD neurocalcin delta 0.502353
HS3ST4 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 0.502353
FAM169A family with sequence similarity 169, member A 0.502222
ASIC2 acid sensing (proton gated) ion channel 2 0.502091
BPIFC BPI fold containing family C 0.501764
UNC80 unc-80 homolog (C. elegans) 0.501634
FBXO41 F-box protein 41 0.501634
DLEU2 deleted in lymphocytic leukemia 2 (non-protein coding) 0.501246
CHURC1 churchill domain containing 1 0.500733
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.500542
EXD2 exonuclease 3'-5' domain containing 2 0.500478
GRM4 glutamate receptor, metabotropic 4 0.500415
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5 0.500351
SLC26A9 solute carrier family 26 (anion exchanger), member 9 0.500351
LDLRAD3 low density lipoprotein receptor class A domain containing 3 0.500162
CNTN6 contactin 6 0.499973
AGBL4 ATP/GTP binding protein-like 4 0.499659
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide 0.499534
ABLIM2 actin binding LIM protein family, member 2 0.498914
TMEM244 transmembrane protein 244 0.497998
PDGFD platelet derived growth factor D 0.497998
TSPAN5 tetraspanin 5 0.497937
C4ORF19 chromosome 4 open reading frame 19 0.497696
ROCK1P1 Rho-associated, coiled-coil containing protein kinase 1 pseudogene 1 0.497576
MN1 meningioma (disrupted in balanced translocation) 1 0.497336
CASD1 CAS1 domain containing 1 0.497276
USH2A Usher syndrome 2A (autosomal recessive, mild) 0.497038
CCSER1 coiled-coil serine-rich protein 1 0.496742
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.496565
ZNF462 zinc finger protein 462 0.496271