multiple system atrophy Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description OMIM mapping confirmed by DO. [LS]. (Human Disease Ontology, DOID_4752)
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Genes

187 genes co-occuring with the disease multiple system atrophy in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
TPPP tubulin polymerization promoting protein 1.94266
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase 1.88021
SNCA synuclein, alpha (non A4 component of amyloid precursor) 1.67141
ATXN3 ataxin 3 1.59742
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 1.47725
KIAA0101 KIAA0101 1.45968
SNCB synuclein, beta 1.40701
SNCG synuclein, gamma (breast cancer-specific protein 1) 1.33152
TH tyrosine hydroxylase 1.32017
IGKV1-17 immunoglobulin kappa variable 1-17 1.311
CBS cystathionine-beta-synthase 1.20223
MAPT microtubule-associated protein tau 1.18669
BEAN1 brain expressed, associated with NEDD4, 1 1.09251
CALB1 calbindin 1, 28kDa 1.08579
LRRK2 leucine-rich repeat kinase 2 1.07992
STRN striatin, calmodulin binding protein 1.05765
TPH1 tryptophan hydroxylase 1 1.03704
ATG4C autophagy related 4C, cysteine peptidase 1.03282
SNCAIP synuclein, alpha interacting protein 1.00161
RGS14 regulator of G-protein signaling 14 0.961216
TAC1 tachykinin, precursor 1 0.957868
C10ORF2 chromosome 10 open reading frame 2 0.941196
DRD2 dopamine receptor D2 0.935385
C9ORF72 chromosome 9 open reading frame 72 0.906498
CDK13 cyclin-dependent kinase 13 0.852402
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.843802
PDYN prodynorphin 0.829869
CRYAB crystallin, alpha B 0.816745
HDAC6 histone deacetylase 6 0.807718
FXYD3 FXYD domain containing ion transport regulator 3 0.803616
RAB29 RAB29, member RAS oncogene family 0.802795
AVP arginine vasopressin 0.801974
PSPC1 paraspeckle component 1 0.792951
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa 0.781479
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.781069
GRN granulin 0.778204
SEPT8 septin 8 0.765535
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 0.762678
FBXO7 F-box protein 7 0.733811
FMR1 fragile X mental retardation 1 0.727333
MBP myelin basic protein 0.724098
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 0.723694
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 0.718039
SQSTM1 sequestosome 1 0.711989
REN renin 0.707559
GCH1 GTP cyclohydrolase 1 0.696707
ATXN2 ataxin 2 0.690694
RABEP1 rabaptin, RAB GTPase binding effector protein 1 0.680297
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 0.672324
MAP2 microtubule-associated protein 2 0.667947
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 0.649718
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.646165
MT3 metallothionein 3 0.63042
CHAT choline O-acetyltransferase 0.629242
SGSH N-sulfoglucosamine sulfohydrolase 0.626888
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 0.623359
CHMP2B charged multivesicular body protein 2B 0.622967
GLUD2 glutamate dehydrogenase 2 0.619834
NEFH neurofilament, heavy polypeptide 0.612401
TCTA T-cell leukemia translocation altered 0.60225
GLUD1 glutamate dehydrogenase 1 0.60147
NBR1 neighbor of BRCA1 gene 1 0.592116
MAP1B microtubule-associated protein 1B 0.591337
ATP13A2 ATPase type 13A2 0.590558
SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae) 0.582384
NUP62 nucleoporin 62kDa 0.580828
GPAA1 glycosylphosphatidylinositol anchor attachment 1 0.562169
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 0.562169
FTL ferritin, light polypeptide 0.561781
FTH1 ferritin, heavy polypeptide 1 0.561392
SND1 staphylococcal nuclease and tudor domain containing 1 0.54393
MIR148B microRNA 148b 0.538893
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 0.538506
TGOLN2 trans-golgi network protein 2 0.535022
MMRN1 multimerin 1 0.534248
GDNF glial cell derived neurotrophic factor 0.528449
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 0.518034
POLG polymerase (DNA directed), gamma 0.513033
HCRT hypocretin (orexin) neuropeptide precursor 0.511112
ACHE acetylcholinesterase (Yt blood group) 0.508808
GHRH growth hormone releasing hormone 0.508041
SEPT7 septin 7 0.506507
SST somatostatin 0.501909
PACRG PARK2 co-regulated 0.496557
ATXN1 ataxin 1 0.493122
TMEM106B transmembrane protein 106B 0.482464
PRNP prion protein 0.474498
SEPT6 septin 6 0.469576
PORCN porcupine homolog (Drosophila) 0.465794
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 0.463905
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 0.462772
PRKCG protein kinase C, gamma 0.452962
MAOB monoamine oxidase B 0.451454
CTBS chitobiase, di-N-acetyl- 0.4443
PPP2R2B protein phosphatase 2, regulatory subunit B, beta 0.44129
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like 0.43753
CDK5 cyclin-dependent kinase 5 0.431519
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.430393
MAP4 microtubule-associated protein 4 0.426265
GLG1 golgi glycoprotein 1 0.42289
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.416896
HTT huntingtin 0.415398
GYPE glycophorin E (MNS blood group) 0.411283
ADRA1B adrenoceptor alpha 1B 0.410535
PARK7 parkinson protein 7 0.403064
GBA glucosidase, beta, acid 0.400453
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.40008
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide 0.393374
PENK proenkephalin 0.382594
RARG retinoic acid receptor, gamma 0.378885
BSN bassoon presynaptic cytomatrix protein 0.375179
FUS FUS RNA binding protein 0.36704
TBP TATA box binding protein 0.357077
HSPA4 heat shock 70kDa protein 4 0.352659
MDK midkine (neurite growth-promoting factor 2) 0.344941
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) 0.344574
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 0.34384
BDNF brain-derived neurotrophic factor 0.335412
RAB3A RAB3A, member RAS oncogene family 0.331391
CYP2D7 cytochrome P450, family 2, subfamily D, polypeptide 7 (gene/pseudogene) 0.325916
SPG11 spastic paraplegia 11 (autosomal recessive) 0.32373
UBQLN1 ubiquilin 1 0.321545
PLEKHG4 pleckstrin homology domain containing, family G (with RhoGef domain) member 4 0.321181
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B 0.312464
MIR96 microRNA 96 0.311739
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 0.30848
IGF1 insulin-like growth factor 1 (somatomedin C) 0.299812
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 0.297291
MYRF myelin regulatory factor 0.293334
PLD2 phospholipase D2 0.292257
HRH3 histamine receptor H3 0.288668
GFAP glial fibrillary acidic protein 0.286519
PARK2 parkin RBR E3 ubiquitin protein ligase 0.285086
SIAH1 siah E3 ubiquitin protein ligase 1 0.282582
DST dystonin 0.277227
FRY furry homolog (Drosophila) 0.276514
SEPT4 septin 4 0.274732
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 0.267977
FANCB Fanconi anemia, complementation group B 0.265494
MTSS1 metastasis suppressor 1 0.263722
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.263368
INS insulin 0.253831
FRS2 fibroblast growth factor receptor substrate 2 0.251718
APTX aprataxin 0.250311
COMT catechol-O-methyltransferase 0.248203
CHGB chromogranin B 0.235268
SYP synaptophysin 0.233183
OMD osteomodulin 0.230409
NPY neuropeptide Y 0.228679
SCAI suppressor of cancer cell invasion 0.228679
TRH thyrotropin-releasing hormone 0.223165
REXO1L1P REX1, RNA exonuclease 1 homolog (S. cerevisiae)-like 1, pseudogene 0.221108
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 0.217352
PVALB parvalbumin 0.214636
FXN frataxin 0.209918
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 0.207245
ATN1 atrophin 1 0.203275
SBDS Shwachman-Bodian-Diamond syndrome 0.202618
FXYD1 FXYD domain containing ion transport regulator 1 0.202618
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.200493
CYLD cylindromatosis (turban tumor syndrome) 0.197742
ADRBK1 adrenergic, beta, receptor kinase 1 0.197099
SEPT5 septin 5 0.193285
TARDBP TAR DNA binding protein 0.190786
MCF2 MCF.2 cell line derived transforming sequence 0.188022
HTN3 histatin 3 0.183835
WNT10A wingless-type MMTV integration site family, member 10A 0.182086
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.181798
CALCA calcitonin-related polypeptide alpha 0.181222
NEFM neurofilament, medium polypeptide 0.180084
DCTN1 dynactin 1 0.17896
TTPA tocopherol (alpha) transfer protein 0.177029
PANK2 pantothenate kinase 2 0.176215
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 0.175411
SHMT1 serine hydroxymethyltransferase 1 (soluble) 0.173314
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.172799
ATXN7 ataxin 7 0.167682
CAPN2 calpain 2, (m/II) large subunit 0.166995
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) 0.163938
SETD1A SET domain containing 1A 0.163111
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 0.162707
NPS neuropeptide S 0.161912
SACS sacsin molecular chaperone 0.160574
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.146782
VIM vimentin 0.145703
PTER phosphotriesterase related 0.14493
PTPRC protein tyrosine phosphatase, receptor type, C 0.144855