multiple sclerosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring. (Human Disease Ontology, DOID_2377)
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Genes

738 genes co-occuring with the disease multiple sclerosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
IFNB1 interferon, beta 1, fibroblast 3.5642
MBP myelin basic protein 3.23735
MOG myelin oligodendrocyte glycoprotein 3.04561
CD4 CD4 molecule 2.30293
AQP4 aquaporin 4 2.14942
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 1.83682
MBTPS1 membrane-bound transcription factor peptidase, site 1 1.82007
TNF tumor necrosis factor 1.79616
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 1.69496
S1PR1 sphingosine-1-phosphate receptor 1 1.68679
FOXP3 forkhead box P3 1.65789
PLP1 proteolipid protein 1 1.64936
MAG myelin associated glycoprotein 1.56622
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 1.54982
MX1 MX dynamin-like GTPase 1 1.53833
HLA-C major histocompatibility complex, class I, C 1.51325
CXCL10 chemokine (C-X-C motif) ligand 10 1.49262
CXCR3 chemokine (C-X-C motif) receptor 3 1.46847
IL7R interleukin 7 receptor 1.46407
IL17A interleukin 17A 1.44825
BDNF brain-derived neurotrophic factor 1.41446
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase 1.40132
CCL2 chemokine (C-C motif) ligand 2 1.39695
MMP9 matrix metallopeptidase 9 1.3952
IL10 interleukin 10 1.38952
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 1.38865
CD80 CD80 molecule 1.38254
IL2RA interleukin 2 receptor, alpha 1.35943
IL1B interleukin 1, beta 1.35899
OLIG2 oligodendrocyte lineage transcription factor 2 1.35333
CCR2 chemokine (C-C motif) receptor 2 1.35245
CCL3 chemokine (C-C motif) ligand 3 1.35202
ICAM1 intercellular adhesion molecule 1 1.35158
CD40 CD40 molecule, TNF receptor superfamily member 5 1.35158
ALB albumin 1.32629
CTLA4 cytotoxic T-lymphocyte-associated protein 4 1.32585
TGFB1 transforming growth factor, beta 1 1.32105
CLEC16A C-type lectin domain family 16, member A 1.31581
CCR1 chemokine (C-C motif) receptor 1 1.311
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.30751
CRYAB crystallin, alpha B 1.29833
CNR1 cannabinoid receptor 1 (brain) 1.2944
VCAM1 vascular cell adhesion molecule 1 1.2944
IL2 interleukin 2 1.28261
HLA-B major histocompatibility complex, class I, B 1.26909
RTN4 reticulon 4 1.26603
CD86 CD86 molecule 1.26081
LINGO1 leucine rich repeat and Ig domain containing 1 1.25471
TBX21 T-box 21 1.25384
CXCL13 chemokine (C-X-C motif) ligand 13 1.23169
CD52 CD52 molecule 1.22735
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 1.21565
S1PR5 sphingosine-1-phosphate receptor 5 1.20829
IL4 interleukin 4 1.20396
POMC proopiomelanocortin 1.20137
HLA-A major histocompatibility complex, class I, A 1.19402
CCL5 chemokine (C-C motif) ligand 5 1.17894
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.17164
MYOM3 myomesin 3 1.16778
IFNA1 interferon, alpha 1 1.1635
NFASC neurofascin 1.16307
CD276 CD276 molecule 1.16264
STAT1 signal transducer and activator of transcription 1, 91kDa 1.1605
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 1.15837
GFAP glial fibrillary acidic protein 1.149
BEAN1 brain expressed, associated with NEDD4, 1 1.14602
CCR7 chemokine (C-C motif) receptor 7 1.13543
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b 1.12066
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 1.11645
EVI5 ecotropic viral integration site 5 1.10216
APOE apolipoprotein E 1.08621
NGF nerve growth factor (beta polypeptide) 1.08286
SPP1 secreted phosphoprotein 1 1.07404
IFNAR1 interferon (alpha, beta and omega) receptor 1 1.06102
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 1.0606
CD79A CD79a molecule, immunoglobulin-associated alpha 1.04546
S1PR3 sphingosine-1-phosphate receptor 3 1.04377
SHPK sedoheptulokinase 1.0362
FASLG Fas ligand (TNF superfamily, member 6) 1.03493
GPC5 glypican 5 1.03325
IL6 interleukin 6 1.03282
NCAM1 neural cell adhesion molecule 1 1.0324
NELFCD negative elongation factor complex member C/D 1.02187
CNTF ciliary neurotrophic factor 1.01976
LTA lymphotoxin alpha 1.01891
CXCL12 chemokine (C-X-C motif) ligand 12 1.00794
SPHK2 sphingosine kinase 2 0.99697
OLIG1 oligodendrocyte transcription factor 1 0.993174
CD40LG CD40 ligand 0.989379
NEFH neurofilament, heavy polypeptide 0.983479
TIMP1 TIMP metallopeptidase inhibitor 1 0.97296
CCR6 chemokine (C-C motif) receptor 6 0.9717
NOS2 nitric oxide synthase 2, inducible 0.96918
CD1D CD1d molecule 0.959542
PRF1 perforin 1 (pore forming protein) 0.956614
RTN4R reticulon 4 receptor 0.954525
LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 0.948269
IL23A interleukin 23, alpha subunit p19 0.94369
HLA-DQB3 major histocompatibility complex, class II, DQ beta 3 0.940364
IFNAR2 interferon (alpha, beta and omega) receptor 2 0.926279
CXCL11 chemokine (C-X-C motif) ligand 11 0.925452
TRAC T cell receptor alpha constant 0.923387
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.920911
ERVW-1 endogenous retrovirus group W, member 1 0.918848
IFNG interferon, gamma 0.908965
PADI2 peptidyl arginine deiminase, type II 0.908142
CD46 CD46 molecule, complement regulatory protein 0.904032
CIITA class II, major histocompatibility complex, transactivator 0.902389
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 0.899103
STAT4 signal transducer and activator of transcription 4 0.897461
CD19 CD19 molecule 0.897051
TSPO translocator protein (18kDa) 0.89623
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.895
MMP2 matrix metallopeptidase 2 0.888438
MAPK14 mitogen-activated protein kinase 14 0.886389
PTPRC protein tyrosine phosphatase, receptor type, C 0.880243
CXCL9 chemokine (C-X-C motif) ligand 9 0.878605
CCR3 chemokine (C-C motif) receptor 3 0.8741
AIF1 allograft inflammatory factor 1 0.871643
CDR2 cerebellar degeneration-related protein 2, 62kDa 0.865093
KLRB1 killer cell lectin-like receptor subfamily B, member 1 0.862228
RANGRF RAN guanine nucleotide release factor 0.861818
CCL4 chemokine (C-C motif) ligand 4 0.861409
OMG oligodendrocyte myelin glycoprotein 0.852811
TYK2 tyrosine kinase 2 0.848716
IRF1 interferon regulatory factor 1 0.847898
TLR9 toll-like receptor 9 0.840934
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 0.834378
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.831099
CCL20 chemokine (C-C motif) ligand 20 0.829869
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.824948
CD27 CD27 molecule 0.822897
PPARG peroxisome proliferator-activated receptor gamma 0.821667
TLR4 toll-like receptor 4 0.819206
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.816334
CD200R1 CD200 receptor 1 0.816334
IL22 interleukin 22 0.815924
OCLN occludin 0.815104
CD58 CD58 molecule 0.814693
KLK6 kallikrein-related peptidase 6 0.812642
IDO1 indoleamine 2,3-dioxygenase 1 0.802385
GALC galactosylceramidase 0.799513
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.798692
CLDN11 claudin 11 0.795002
KIF21B kinesin family member 21B 0.795002
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 0.790492
PADI4 peptidyl arginine deiminase, type IV 0.787213
CLDN5 claudin 5 0.785165
HLA-E major histocompatibility complex, class I, E 0.784345
CD69 CD69 molecule 0.779432
RGS1 regulator of G-protein signaling 1 0.77575
HDGFRP2 hepatoma-derived growth factor-related protein 2 0.774932
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.768801
CXCR2 chemokine (C-X-C motif) receptor 2 0.76431
FAAH fatty acid amide hydrolase 0.761454
SH2D2A SH2 domain containing 2A 0.758601
CCL1 chemokine (C-C motif) ligand 1 0.757378
GC group-specific component (vitamin D binding protein) 0.755749
VIM vimentin 0.753713
CD200 CD200 molecule 0.750864
KIF1B kinesin family member 1B 0.748424
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.743547
METTL21B methyltransferase like 21B 0.742329
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase 0.737865
SOCS1 suppressor of cytokine signaling 1 0.737054
STAG3L2 stromal antigen 3-like 2 (pseudogene) 0.735027
STAG3L3 stromal antigen 3-like 3 (pseudogene) 0.735027
STAG3L1 stromal antigen 3-like 1 (pseudogene) 0.735027
CXCL2 chemokine (C-X-C motif) ligand 2 0.729357
NINJ1 ninjurin 1 0.729357
S1PR4 sphingosine-1-phosphate receptor 4 0.728547
DHODH dihydroorotate dehydrogenase (quinone) 0.728547
CARD17 caspase recruitment domain family, member 17 0.727738
SELPLG selectin P ligand 0.727333
MPHOSPH9 M-phase phosphoprotein 9 0.718846
HLA-G major histocompatibility complex, class I, G 0.718039
IL26 interleukin 26 0.716021
POLR1D polymerase (RNA) I polypeptide D, 16kDa 0.715215
SELL selectin L 0.714811
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 0.714408
EDA ectodysplasin A 0.709572
TALDO1 transaldolase 1 0.70434
HCRT hypocretin (orexin) neuropeptide precursor 0.699116
CX3CR1 chemokine (C-X3-C motif) receptor 1 0.698715
CRLF1 cytokine receptor-like factor 1 0.698313
CD83 CD83 molecule 0.697911
CXCR5 chemokine (C-X-C motif) receptor 5 0.697109
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 0.692296
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 0.691495
CAST calpastatin 0.686691
CCL19 chemokine (C-C motif) ligand 19 0.682693
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1 0.682294
IGF1 insulin-like growth factor 1 (somatomedin C) 0.682294
IL7 interleukin 7 0.676706
CD44 CD44 molecule (Indian blood group) 0.675909
S100B S100 calcium binding protein B 0.66914
CCL8 chemokine (C-C motif) ligand 8 0.6608
CTSS cathepsin S 0.659611
CD226 CD226 molecule 0.658026
HSPA4 heat shock 70kDa protein 4 0.65763
CD68 CD68 molecule 0.654858
TLR2 toll-like receptor 2 0.652089
HMOX1 heme oxygenase 1 0.651298
IL1RN interleukin 1 receptor antagonist 0.651298
IL22RA2 interleukin 22 receptor, alpha 2 0.650903
ICAM3 intercellular adhesion molecule 3 0.646559
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.64577
FAM49B family with sequence similarity 49, member B 0.645375
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.643797
GHR growth hormone receptor 0.643009
CCL11 chemokine (C-C motif) ligand 11 0.635921
ASIC1 acid sensing (proton gated) ion channel 1 0.634349
TBC1D2 TBC1 domain family, member 2 0.632777
B3GAT1 beta-1,3-glucuronyltransferase 1 0.632384
NPS neuropeptide S 0.631991
POLR2J polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa 0.63042
HVCN1 hydrogen voltage gated channel 1 0.630027
B2M beta-2-microglobulin 0.629242
IL12B interleukin 12B 0.628457
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.628065
PTPRD protein tyrosine phosphatase, receptor type, D 0.623359
VIP vasoactive intestinal peptide 0.620226
PPARA peroxisome proliferator-activated receptor alpha 0.618268
MADCAM1 mucosal vascular addressin cell adhesion molecule 1 0.618268
PDE7A phosphodiesterase 7A 0.615138
CCNDBP1 cyclin D-type binding-protein 1 0.615138
CCL13 chemokine (C-C motif) ligand 13 0.613183
CRH corticotropin releasing hormone 0.612401
TLR7 toll-like receptor 7 0.609666
PTGDS prostaglandin D2 synthase 21kDa (brain) 0.607714
MYD88 myeloid differentiation primary response 88 0.606933
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.605762
NTF3 neurotrophin 3 0.605372
IGBP1 immunoglobulin (CD79A) binding protein 1 0.604201
CCL7 chemokine (C-C motif) ligand 7 0.6003
MMP12 matrix metallopeptidase 12 0.597181
NOTCH1 notch 1 0.593674
NTF4 neurotrophin 4 0.592116
FN1 fibronectin 1 0.592116
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12 0.591337
MYT1 myelin transcription factor 1 0.589001
HLA-F major histocompatibility complex, class I, F 0.587054
HCG4P11 HLA complex group 4 pseudogene 11 0.587054
CD209 CD209 molecule 0.58433
CD5 CD5 molecule 0.582773
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 0.581996
TJP1 tight junction protein 1 0.578883
IL1A interleukin 1, alpha 0.576939
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 0.575772
ANKRD55 ankyrin repeat domain 55 0.571884
MMP3 matrix metallopeptidase 3 0.569163
CD6 CD6 molecule 0.569163
GPX5 glutathione peroxidase 5 0.565666
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 0.5645
CX3CL1 chemokine (C-X3-C motif) ligand 1 0.564112
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 0.562946
GPX4 glutathione peroxidase 4 0.562169
GPX1 glutathione peroxidase 1 0.560616
S1PR2 sphingosine-1-phosphate receptor 2 0.55712
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.553239
TMEM39A transmembrane protein 39A 0.551686
MMP7 matrix metallopeptidase 7 0.548195
PDE4A phosphodiesterase 4A, cAMP-specific 0.547419
TGFB2 transforming growth factor, beta 2 0.545868
CCR8 chemokine (C-C motif) receptor 8 0.544318
LGALS9 lectin, galactoside-binding, soluble, 9 0.54393
SELE selectin E 0.542767
TIMP2 TIMP metallopeptidase inhibitor 2 0.541605
ZFAT zinc finger and AT hook domain containing 0.53928
PML promyelocytic leukemia 0.53657
NGFR nerve growth factor receptor 0.535409
CD47 CD47 molecule 0.535409
NKX2-2 NK2 homeobox 2 0.532701
TLR3 toll-like receptor 3 0.531541
RORC RAR-related orphan receptor C 0.531541
NAPEPLD N-acyl phosphatidylethanolamine phospholipase D 0.530768
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 0.529994
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.526518
CST3 cystatin C 0.525746
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.525746
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.524202
CCL21 chemokine (C-C motif) ligand 21 0.524202
IL27 interleukin 27 0.522659
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.521888
JAG1 jagged 1 0.521117
SOD2 superoxide dismutase 2, mitochondrial 0.520731
ESAM endothelial cell adhesion molecule 0.517649
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 0.516494
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.514956
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 0.514186
GPR17 G protein-coupled receptor 17 0.510728
C20ORF57 chromosome 20 open reading frame 57 0.509192
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa 0.509192
EVI5L ecotropic viral integration site 5-like 0.509192
MROH2B maestro heat-like repeat family member 2B 0.509192
CHIT1 chitinase 1 (chitotriosidase) 0.508041
PNKD paroxysmal nonkinesigenic dyskinesia 0.507657
TMEM74B transmembrane protein 74B 0.507273
MGC45800 0.507273
MPO myeloperoxidase 0.501144
MEFV Mediterranean fever 0.498085
JUN jun proto-oncogene 0.498085
IFNE interferon, epsilon 0.496175
GATA3 GATA binding protein 3 0.495411
RPL7A ribosomal protein L7a 0.495411
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C 0.495411
MAPK1 mitogen-activated protein kinase 1 0.495411
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.495411
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.491978
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.491597
TSFM Ts translation elongation factor, mitochondrial 0.491215
FTL ferritin, light polypeptide 0.490072
GRM4 glutamate receptor, metabotropic 4 0.489691
IRF5 interferon regulatory factor 5 0.487407
SOCS3 suppressor of cytokine signaling 3 0.485885
SCN8A sodium channel, voltage gated, type VIII alpha subunit 0.483604
CSN1S2AP casein alpha s2-like A, pseudogene 0.480945
TUB tubby bipartite transcription factor 0.480186
CD34 CD34 molecule 0.478668
SPHK1 sphingosine kinase 1 0.477909
FTH1 ferritin, heavy polypeptide 1 0.476393
RPL5 ribosomal protein L5 0.474498
IL12RB1 interleukin 12 receptor, beta 1 0.471089
IFIH1 interferon induced with helicase C domain 1 0.470711
NES nestin 0.469197
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 0.467684
TTR transthyretin 0.467306
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 0.466928
CCL22 chemokine (C-C motif) ligand 22 0.466172
TRIM22 tripartite motif containing 22 0.465038
CXCR1 chemokine (C-X-C motif) receptor 1 0.464283
SCG2 secretogranin II 0.462016
CD24 CD24 molecule 0.461261
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 0.461261
ZNF433 zinc finger protein 433 0.458619
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.456732
PADI3 peptidyl arginine deiminase, type III 0.455601
LEP leptin 0.454093
CSF1R colony stimulating factor 1 receptor 0.452962
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa 0.452208
MDK midkine (neurite growth-promoting factor 2) 0.449947
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.447311
ADAM17 ADAM metallopeptidase domain 17 0.446558
ESR1 estrogen receptor 1 0.444676
TF transferrin 0.442418
RAG1 recombination activating gene 1 0.441666
C3AR1 complement component 3a receptor 1 0.440914
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 0.440162
FGF2 fibroblast growth factor 2 (basic) 0.440162
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.436026
ANPEP alanyl (membrane) aminopeptidase 0.435651
ARRB1 arrestin, beta 1 0.434524
KIF5A kinesin family member 5A 0.434524
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 0.434148
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.433397
BCHE butyrylcholinesterase 0.430393
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae) 0.42589
NCAN neurocan 0.424765
JAK2 Janus kinase 2 0.424389
FGF1 fibroblast growth factor 1 (acidic) 0.421765
CLIP1 CAP-GLY domain containing linker protein 1 0.421016
MMP25 matrix metallopeptidase 25 0.419142
NOTCH4 notch 4 0.416147
TYROBP TYRO protein tyrosine kinase binding protein 0.415398
MFSD4 major facilitator superfamily domain containing 4 0.41465
APOA1 apolipoprotein A-I 0.413901
IFNGR1 interferon gamma receptor 1 0.411657
MPLKIP M-phase specific PLK1 interacting protein 0.411283
CNTN2 contactin 2 (axonal) 0.408292
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1 0.406798
MMP15 matrix metallopeptidase 15 (membrane-inserted) 0.403811
CRP C-reactive protein, pentraxin-related 0.401945
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.400453
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.400453
MMP19 matrix metallopeptidase 19 0.397843
BDKRB1 bradykinin receptor B1 0.397843
NRG1 neuregulin 1 0.397471
TRBC2 T cell receptor beta constant 2 0.396725
IFNA16 interferon, alpha 16 0.396725
CAT catalase 0.394863
PTAFR platelet-activating factor receptor 0.394863
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.394491
MAPT microtubule-associated protein tau 0.394118
ACHE acetylcholinesterase (Yt blood group) 0.393001
NRP1 neuropilin 1 0.392257
ALCAM activated leukocyte cell adhesion molecule 0.392257
ANKFN1 ankyrin-repeat and fibronectin type III domain containing 1 0.391513
HSPE1 heat shock 10kDa protein 1 0.390397
CCL4L2 chemokine (C-C motif) ligand 4-like 2 0.389653
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 0.387794
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.387423
STIM2 stromal interaction molecule 2 0.387051
PADI1 peptidyl arginine deiminase, type I 0.387051
TREM2 triggering receptor expressed on myeloid cells 2 0.387051
CLEC3B C-type lectin domain family 3, member B 0.385565
BAX BCL2-associated X protein 0.385193
NCF1 neutrophil cytosolic factor 1 0.384822
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 0.384079
ESR2 estrogen receptor 2 (ER beta) 0.382966
KLRD1 killer cell lectin-like receptor subfamily D, member 1 0.382594
CCL4L1 chemokine (C-C motif) ligand 4-like 1 0.382594
OGFR opioid growth factor receptor 0.38111
FAM69A family with sequence similarity 69, member A 0.380368
KCNH7 potassium channel, voltage gated eag related subfamily H, member 7 0.379626
IL17RE interleukin 17 receptor E 0.378143
MMP24 matrix metallopeptidase 24 (membrane-inserted) 0.373698
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.371477
CDR1 cerebellar degeneration-related protein 1, 34kDa 0.370737
KLRK1 killer cell lectin-like receptor subfamily K, member 1 0.367779
MOBP myelin-associated oligodendrocyte basic protein 0.36704
CNTNAP1 contactin associated protein 1 0.366671
RTN4RL2 reticulon 4 receptor-like 2 0.366671
DARS aspartyl-tRNA synthetase 0.365193
SYN3 synapsin III 0.364824
TNR tenascin R 0.363716
JAK1 Janus kinase 1 0.36187
PTMS parathymosin 0.360026
EPHA4 EPH receptor A4 0.35892
METTL14 methyltransferase like 14 0.358551
GAP43 growth associated protein 43 0.357077
TNRC6A trinucleotide repeat containing 6A 0.352291
IFNA14 interferon, alpha 14 0.351187
NDUFS5 NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) 0.351187
NEFM neurofilament, medium polypeptide 0.350452
PDZRN4 PDZ domain containing ring finger 4 0.350452
CD300LF CD300 molecule-like family member f 0.347879
MAP2 microtubule-associated protein 2 0.347144
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.347144
STAT2 signal transducer and activator of transcription 2, 113kDa 0.346042
MGAM maltase-glucoamylase 0.346042
DNAH8 dynein, axonemal, heavy chain 8 0.344574
DPYSL2 dihydropyrimidinase-like 2 0.342739
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) 0.341639
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.338707
ZNF45 zinc finger protein 45 0.338341
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.338341
LCK LCK proto-oncogene, Src family tyrosine kinase 0.33651
COX5B cytochrome c oxidase subunit Vb 0.335778
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9 0.334681
C3 complement component 3 0.333949
ERV3-1 endogenous retrovirus group 3, member 1 0.332121
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D 0.331756
SPAG16 sperm associated antigen 16 0.331756
IL18 interleukin 18 0.331391
CD38 CD38 molecule 0.330295
ANXA1 annexin A1 0.329565
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 0.329565
NOTCH3 notch 3 0.32774
IRF7 interferon regulatory factor 7 0.326646
MICB MHC class I polypeptide-related sequence B 0.323365
LMNB1 lamin B1 0.323002
IGHV4-39 immunoglobulin heavy variable 4-39 0.322273
IL23R interleukin 23 receptor 0.321909
DEXI Dexi homolog (mouse) 0.316456
CNR2 cannabinoid receptor 2 (macrophage) 0.316092
ENO2 enolase 2 (gamma, neuronal) 0.316092
ERAP1 endoplasmic reticulum aminopeptidase 1 0.316092
OSM oncostatin M 0.315366
GDNF glial cell derived neurotrophic factor 0.313915
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa 0.312464
PLG plasminogen 0.312102
LAG3 lymphocyte-activation gene 3 0.311739
NCF1C neutrophil cytosolic factor 1C pseudogene 0.311014
TGM2 transglutaminase 2 0.311014
GRM2 glutamate receptor, metabotropic 2 0.311014
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.310652
ZC2HC1A zinc finger, C2HC-type containing 1A 0.310652
TRPV1 transient receptor potential cation channel, subfamily V, member 1 0.31029
METTL1 methyltransferase like 1 0.309566
ADRBK1 adrenergic, beta, receptor kinase 1 0.308118
GLS glutaminase 0.305226
IL6ST interleukin 6 signal transducer 0.304864
RSAD2 radical S-adenosyl methionine domain containing 2 0.304503
MICA MHC class I polypeptide-related sequence A 0.304142
MMEL1 membrane metallo-endopeptidase-like 1 0.303781
INS insulin 0.303781
MMP1 matrix metallopeptidase 1 0.300533
PON1 paraoxonase 1 0.300533
HBA2 hemoglobin, alpha 2 0.300173
CD72 CD72 molecule 0.299452
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 0.299452
HMGB1 high mobility group box 1 0.298371
CNST consortin, connexin sorting protein 0.298011
HCAR2 hydroxycarboxylic acid receptor 2 0.296211
HSPA8 heat shock 70kDa protein 8 0.293694
TAC1 tachykinin, precursor 1 0.293694
FYN FYN proto-oncogene, Src family tyrosine kinase 0.293694
SLC30A7 solute carrier family 30 (zinc transporter), member 7 0.293334
IFI6 interferon, alpha-inducible protein 6 0.291898
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa 0.29118
MRAP melanocortin 2 receptor accessory protein 0.290821
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 0.287235
STK17B serine/threonine kinase 17b 0.286877
GPR135 G protein-coupled receptor 135 0.285802
MYRF myelin regulatory factor 0.284013
OPALIN oligodendrocytic myelin paranodal and inner loop protein 0.283655
IL15 interleukin 15 0.283297
CXCR6 chemokine (C-X-C motif) receptor 6 0.282582
NLRP3 NLR family, pyrin domain containing 3 0.282582
ANXA5 annexin A5 0.280082
GJB6 gap junction protein, beta 6, 30kDa 0.280082
CNTN1 contactin 1 0.280082
SNPH syntaphilin 0.278297
IL10RA interleukin 10 receptor, alpha 0.277584
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 0.275801
PARP1 poly (ADP-ribose) polymerase 1 0.274021
VAMP7 vesicle-associated membrane protein 7 0.274021
MAEA macrophage erythroblast attacher 0.273664
CISH cytokine inducible SH2-containing protein 0.273308
TMPRSS13 transmembrane protease, serine 13 0.271886
MMP8 matrix metallopeptidase 8 0.269398
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase 0.268332
IL1R1 interleukin 1 receptor, type I 0.267622
KLHL2 kelch-like family member 2 0.266913
F11R F11 receptor 0.266203
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 0.265849
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.265494
SEPT1 septin 1 0.265494
MARCH3 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase 0.263014
CYCS cytochrome c, somatic 0.26266
HLA-DMB major histocompatibility complex, class II, DM beta 0.262306
SLC25A17 solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17 0.261952
LAMP1 lysosomal-associated membrane protein 1 0.261952
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.261245
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.260538
C4A complement component 4A (Rodgers blood group) 0.259477
SST somatostatin 0.25877
AGER advanced glycosylation end product-specific receptor 0.258417
PTH parathyroid hormone 0.257711
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.257711
MMP27 matrix metallopeptidase 27 0.257711
HACD2 3-hydroxyacyl-CoA dehydratase 2 0.257711
HBA1 hemoglobin, alpha 1 0.256652
CST7 cystatin F (leukocystatin) 0.256299
CCL17 chemokine (C-C motif) ligand 17 0.255946
SIRT1 sirtuin 1 0.255946
HP haptoglobin 0.255594
KEAP1 kelch-like ECH-associated protein 1 0.254888
SPIB Spi-B transcription factor (Spi-1/PU.1 related) 0.254536
LYZ lysozyme 0.254183
PHACTR2 phosphatase and actin regulator 2 0.253127
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 0.251366
RIPK2 receptor-interacting serine-threonine kinase 2 0.250311
HPR haptoglobin-related protein 0.24996
CXCL8 chemokine (C-X-C motif) ligand 8 0.24996
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.249257
FCRLB Fc receptor-like B 0.249257
APOD apolipoprotein D 0.247852
CCL15 chemokine (C-C motif) ligand 15 0.246098
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 0.245396
SP3 Sp3 transcription factor 0.245396
NOD2 nucleotide-binding oligomerization domain containing 2 0.245396
XCR1 chemokine (C motif) receptor 1 0.245046
IRF4 interferon regulatory factor 4 0.244696
IFI27 interferon, alpha-inducible protein 27 0.244345
FCRL3 Fc receptor-like 3 0.244345
IL17RC interleukin 17 receptor C 0.243295
CLEC4C C-type lectin domain family 4, member C 0.242945
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 0.242595
CLSTN2 calsyntenin 2 0.241895
GCA grancalcin, EF-hand calcium binding protein 0.241895
SWAP70 SWAP switching B-cell complex 70kDa subunit 0.240497
UBD ubiquitin D 0.240148
TSC22D3 TSC22 domain family, member 3 0.239799
HLA-DMA major histocompatibility complex, class II, DM alpha 0.238752
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 0.238403
EOMES eomesodermin 0.238403
PELO pelota homolog (Drosophila) 0.23788
GRM1 glutamate receptor, metabotropic 1 0.235616
KIAA0226 KIAA0226 0.234573
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 0.234225
GSN gelsolin 0.231795
DNTT DNA nucleotidylexotransferase 0.231448
ZBTB46 zinc finger and BTB domain containing 46 0.231102
ZFP57 ZFP57 zinc finger protein 0.231102
NCR1 natural cytotoxicity triggering receptor 1 0.229716
SHCBP1 SHC SH2-domain binding protein 1 0.229716
KLRC1 killer cell lectin-like receptor subfamily C, member 1 0.22937
LDLRAD4 low density lipoprotein receptor class A domain containing 4 0.229024
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.229024
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa 0.228333
COPS2 COP9 signalosome subunit 2 0.227988
SHH sonic hedgehog 0.227642
SCEL sciellin 0.227124
CA2 carbonic anhydrase II 0.225573
ETNPPL ethanolamine-phosphate phospho-lyase 0.225573
TMEM2 transmembrane protein 2 0.225229
ZFHX4 zinc finger homeobox 4 0.224712
FABP3 fatty acid binding protein 3, muscle and heart 0.22454
PGM3 phosphoglucomutase 3 0.223853
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3 0.222479
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 0.221793
APOC2 apolipoprotein C-II 0.221793
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7 0.220081
PLA2G1B phospholipase A2, group IB (pancreas) 0.219398
PLAT plasminogen activator, tissue 0.219398
CDC42 cell division cycle 42 0.218715
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B) 0.217352
GHRL ghrelin/obestatin prepropeptide 0.215992
IL2RB interleukin 2 receptor, beta 0.215314
LIFR leukemia inhibitory factor receptor alpha 0.215314
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 0.215314
FABP7 fatty acid binding protein 7, brain 0.214636
KCNK9 potassium channel, two pore domain subfamily K, member 9 0.213283
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.211597
SYN1 synapsin I 0.211597
TBATA thymus, brain and testes associated 0.210253
GLUL glutamate-ammonia ligase 0.210253
NKRF NFKB repressing factor 0.207745
SCAF11 SR-related CTD-associated factor 11 0.20658
SYK spleen tyrosine kinase 0.205916
CD1C CD1c molecule 0.204593
CD163 CD163 molecule 0.203275
GSR glutathione reductase 0.203275
CD70 CD70 molecule 0.202946
C10ORF88 chromosome 10 open reading frame 88 0.200656
DOK2 docking protein 2, 56kDa 0.200331
LPCAT2 lysophosphatidylcholine acyltransferase 2 0.199681
CD1E CD1e molecule 0.199356
SOX8 SRY (sex determining region Y)-box 8 0.199356
SOX10 SRY (sex determining region Y)-box 10 0.199356
C5 complement component 5 0.198386
SRPX2 sushi-repeat containing protein, X-linked 2 0.197742
IFNA17 interferon, alpha 17 0.196459
IGHM immunoglobulin heavy constant mu 0.196139
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.19582
BCL2L1 BCL2-like 1 0.195501
CD59 CD59 molecule, complement regulatory protein 0.194865
CD1B CD1b molecule 0.194548
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 0.193758
GLYAT glycine-N-acyltransferase 0.193285
IL21 interleukin 21 0.193285
KCNK3 potassium channel, two pore domain subfamily K, member 3 0.193285
HDAC9 histone deacetylase 9 0.192657
GAS6 growth arrest-specific 6 0.191408
PRL prolactin 0.191408
ADAD1 adenosine deaminase domain containing 1 (testis-specific) 0.191097
CXCL16 chemokine (C-X-C motif) ligand 16 0.190168
RBP7 retinol binding protein 7, cellular 0.189551
POU2AF1 POU class 2 associating factor 1 0.189244
GPER1 G protein-coupled estrogen receptor 1 0.188938
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.188632
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.187415
IFNA2 interferon, alpha 2 0.187415
GRIA3 glutamate receptor, ionotropic, AMPA 3 0.187415
AXL AXL receptor tyrosine kinase 0.186811
PRKCA protein kinase C, alpha 0.186811
HRH2 histamine receptor H2 0.18651
SATB2 SATB homeobox 2 0.18621
TPST1 tyrosylprotein sulfotransferase 1 0.18591
IFNLR1 interferon, lambda receptor 1 0.185612
MIR15B microRNA 15b 0.185016
NPAS1 neuronal PAS domain protein 1 0.184128
FCMR Fc fragment of IgM receptor 0.182957
CTSD cathepsin D 0.182666
GPR182 G protein-coupled receptor 182 0.182086
PLA2G10 phospholipase A2, group X 0.181798
KAZN kazrin, periplakin interacting protein 0.18151
RGCC regulator of cell cycle 0.18151
LTB lymphotoxin beta (TNF superfamily, member 3) 0.180084
DLL4 delta-like 4 (Drosophila) 0.178403
TRBC1 T cell receptor beta constant 1 0.178126
DARS2 aspartyl-tRNA synthetase 2, mitochondrial 0.177301
ERAP2 endoplasmic reticulum aminopeptidase 2 0.177029
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.177029
VCAN versican 0.176215
GJA1 gap junction protein, alpha 1, 43kDa 0.175947
NUMB numb homolog (Drosophila) 0.175947
DPP9 dipeptidyl-peptidase 9 0.175679
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.175679
MIR181C microRNA 181c 0.175146
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.175146
GLS2 glutaminase 2 (liver, mitochondrial) 0.174617
AVIL advillin 0.174617
TYRO3 TYRO3 protein tyrosine kinase 0.174354
KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 0.174093
LCN8 lipocalin 8 0.171785
ZNF175 zinc finger protein 175 0.171286
CREB1 cAMP responsive element binding protein 1 0.170299
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.170299
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 0.169812
SPAG1 sperm associated antigen 1 0.168617
FICD FIC domain containing 0.167915
IL31RA interleukin 31 receptor A 0.167682
WAPAL wings apart-like homolog (Drosophila) 0.167452
ARFGAP2 ADP-ribosylation factor GTPase activating protein 2 0.167224
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 0.166995
CP ceruloplasmin (ferroxidase) 0.166995
OLA1 Obg-like ATPase 1 0.166995
TFRC transferrin receptor 0.166768
APP amyloid beta (A4) precursor protein 0.166768
PADI6 peptidyl arginine deiminase, type VI 0.165874
GRIP1 glutamate receptor interacting protein 1 0.165874
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 0.165217
FOS FBJ murine osteosarcoma viral oncogene homolog 0.164571
TRIB2 tribbles pseudokinase 2 0.163938
STIM1 stromal interaction molecule 1 0.162908
MCAM melanoma cell adhesion molecule 0.162908
QPRT quinolinate phosphoribosyltransferase 0.162606
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) 0.162505
TRAPPC10 trafficking protein particle complex 10 0.162405
APOH apolipoprotein H (beta-2-glycoprotein I) 0.162306
BATF basic leucine zipper transcription factor, ATF-like 0.162109
NFIC nuclear factor I/C (CCAAT-binding transcription factor) 0.161716
SPAST spastin 0.161716
DRG2 developmentally regulated GTP binding protein 2 0.161523
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.160387
S100A9 S100 calcium binding protein A9 0.160387
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.160021
IFI44L interferon-induced protein 44-like 0.160021
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.159838
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.159658
IFI30 interferon, gamma-inducible protein 30 0.159302
MIR17 microRNA 17 0.151868
RPL3 ribosomal protein L3 0.150295
LRPPRC leucine-rich pentatricopeptide repeat containing 0.145363
IL17F interleukin 17F 0.145345
TTK TTK protein kinase 0.145235
FFAR2 free fatty acid receptor 2 0.145142
COPA coatomer protein complex, subunit alpha 0.144844
TRAF2 TNF receptor-associated factor 2 0.144382
MIRLET7D microRNA let-7d 0.144279
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.144147
MS4A1 membrane-spanning 4-domains, subfamily A, member 1 0.144121
AJAP1 adherens junctions associated protein 1 0.144044
CREM cAMP responsive element modulator 0.143969
NPAT nuclear protein, ataxia-telangiectasia locus 0.143892
GDF6 growth differentiation factor 6 0.143887
NOG noggin 0.143191
PTRF polymerase I and transcript release factor 0.143153
STARD13 StAR-related lipid transfer (START) domain containing 13 0.143153
NGDN neuroguidin, EIF4E binding protein 0.142885
HINT1 histidine triad nucleotide binding protein 1 0.142799
FADD Fas (TNFRSF6)-associated via death domain 0.142573
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.142509
DRD5 dopamine receptor D5 0.142501
ADAR adenosine deaminase, RNA-specific 0.141194
NPTXR neuronal pentraxin receptor 0.141149