multiple sclerosis Gene Set

Dataset DISEASES Experimental Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring. (Human Disease Ontology, DOID_2377)
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Genes

209 genes associated with the disease multiple sclerosis in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 2.00687
NOTCH4 notch 4 1.81461
TNXB tenascin XB 1.68372
AIF1 allograft inflammatory factor 1 1.50071
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 1.44218
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 1.39702
HLA-DOB major histocompatibility complex, class II, DO beta 1.35143
BAG6 BCL2-associated athanogene 6 1.33613
HLA-B major histocompatibility complex, class I, B 1.30486
HLA-C major histocompatibility complex, class I, C 1.2894
POU5F1 POU class 5 homeobox 1 1.2894
MICB MHC class I polypeptide-related sequence B 1.27521
MICA MHC class I polypeptide-related sequence A 1.25426
EHMT2 euchromatic histone-lysine N-methyltransferase 2 1.18942
GPR149 G protein-coupled receptor 149 1.11998
CFB complement factor B 1.02486
M6PR mannose-6-phosphate receptor (cation dependent) 0.982645
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 0.968307
AHI1 Abelson helper integration site 1 0.965481
IL22RA2 interleukin 22 receptor, alpha 2 0.910378
ZFP36L1 ZFP36 ring finger protein-like 1 0.820928
HLA-A major histocompatibility complex, class I, A 0.817078
CD86 CD86 molecule 0.817078
HLA-DMA major histocompatibility complex, class II, DM alpha 0.817078
IL12B interleukin 12B 0.817078
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.790827
BRD2 bromodomain containing 2 0.790827
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.774217
ATF6B activating transcription factor 6 beta 0.774217
MUC21 mucin 21, cell surface associated 0.774217
PSORS1C1 psoriasis susceptibility 1 candidate 1 0.752991
CDSN corneodesmosin 0.752991
METTL1 methyltransferase like 1 0.752991
SP140 SP140 nuclear body protein 0.69843
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase 0.69843
GPR65 G protein-coupled receptor 65 0.69843
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.69843
SLC30A7 solute carrier family 30 (zinc transporter), member 7 0.682635
KIF1B kinesin family member 1B 0.682635
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.682635
KLHL29 kelch-like family member 29 0.641775
IER3 immediate early response 3 0.641775
EOMES eomesodermin 0.63207
CD6 CD6 molecule 0.63207
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16 0.602429
MALT1 MALT1 paracaspase 0.58494
ZNF767P zinc finger family member 767, pseudogene 0.561725
DKKL1 dickkopf-like 1 0.561725
MAPK1 mitogen-activated protein kinase 1 0.561725
PTPRK protein tyrosine phosphatase, receptor type, K 0.552621
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 0.552621
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.537125
MERTK MER proto-oncogene, tyrosine kinase 0.52461
CLECL1 C-type lectin-like 1 0.52461
KIAA1456 KIAA1456 0.52461
MPV17L2 MPV17 mitochondrial membrane protein-like 2 0.52461
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2 0.486425
BATF basic leucine zipper transcription factor, ATF-like 0.486425
ODF3B outer dense fiber of sperm tails 3B 0.486425
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.486425
PRRT1 proline-rich transmembrane protein 1 0.486425
DENND3 DENN/MADD domain containing 3 0.464771
IL2RA interleukin 2 receptor, alpha 0.464771
MLANA melan-A 0.464771
EXTL2 exostosin-like glycosyltransferase 2 0.449873
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.449873
SOX17 SRY (sex determining region Y)-box 17 0.449873
RASSF9 Ras association (RalGDS/AF-6) domain family (N-terminal) member 9 0.429338
PCDH7 protocadherin 7 0.429338
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 0.408752
CD58 CD58 molecule 0.403461
ZBTB46 zinc finger and BTB domain containing 46 0.403461
CXCR4 chemokine (C-X-C motif) receptor 4 0.403461
TBKBP1 TBK1 binding protein 1 0.403461
PRRC2A proline-rich coiled-coil 2A 0.403461
PTGER4 prostaglandin E receptor 4 (subtype EP4) 0.403461
CD40 CD40 molecule, TNF receptor superfamily member 5 0.403461
MPHOSPH9 M-phase phosphoprotein 9 0.403461
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.403461
MANBA mannosidase, beta A, lysosomal 0.403461
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.368757
CLEC16A C-type lectin domain family 16, member A 0.368757
RASGEF1A RasGEF domain family, member 1A 0.368757
PLXNA2 plexin A2 0.368757
PLEK pleckstrin 0.368757
FAM69A family with sequence similarity 69, member A 0.368757
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1 0.368757
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 0.345945
CXCR5 chemokine (C-X-C motif) receptor 5 0.345945
ARL11 ADP-ribosylation factor-like 11 0.345945
C6ORF15 chromosome 6 open reading frame 15 0.345945
TAGAP T-cell activation RhoGTPase activating protein 0.327313
PPA2 pyrophosphatase (inorganic) 2 0.327313
USP31 ubiquitin specific peptidase 31 0.327313
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 0.327313
CDH5 cadherin 5, type 2 (vascular endothelium) 0.311576
RGS14 regulator of G-protein signaling 14 0.311576
FAM110D family with sequence similarity 110, member D 0.311576
SAE1 SUMO1 activating enzyme subunit 1 0.311576
MXD3 MAX dimerization protein 3 0.311576
DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding) 0.311576
TCF7 transcription factor 7 (T-cell specific, HMG-box) 0.297866
SUMF1 sulfatase modifying factor 1 0.297866
RMI2 RecQ mediated genome instability 2 0.297866
AK5 adenylate kinase 5 0.297866
MYNN myoneurin 0.285417
KIAA1211 KIAA1211 0.274608
RAD21L1 RAD21-like 1 (S. pombe) 0.274608
TMEM47 transmembrane protein 47 0.264872
SYK spleen tyrosine kinase 0.264872
DSG1 desmoglein 1 0.256228
TRIM31 tripartite motif containing 31 0.256228
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.256228
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.256228
VAV2 vav 2 guanine nucleotide exchange factor 0.256228
PVR poliovirus receptor 0.256228
SPRED2 sprouty-related, EVH1 domain containing 2 0.256228
GPC5 glypican 5 0.256228
ZNF433 zinc finger protein 433 0.256228
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.256228
RAB38 RAB38, member RAS oncogene family 0.197766
LEKR1 leucine, glutamate and lysine rich 1 0.197766
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.197766
MYB v-myb avian myeloblastosis viral oncogene homolog 0.197766
HLA-G major histocompatibility complex, class I, G 0.197766
LINC01551 long intergenic non-protein coding RNA 1551 0.197766
TAS1R2 taste receptor, type 1, member 2 0.197766
IL7R interleukin 7 receptor 0.197766
PDZRN4 PDZ domain containing ring finger 4 0.197766
MAMSTR MEF2 activating motif and SAP domain containing transcriptional regulator 0.197766
NDFIP1 Nedd4 family interacting protein 1 0.197766
RGS1 regulator of G-protein signaling 1 0.197766
ACYP2 acylphosphatase 2, muscle type 0.197766
DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11 0.197766
MRGPRE MAS-related GPR, member E 0.197766
ZMIZ1 zinc finger, MIZ-type containing 1 0.197766
CNKSR1 connector enhancer of kinase suppressor of Ras 1 0.197766
KANK1 KN motif and ankyrin repeat domains 1 0.197766
CUEDC1 CUE domain containing 1 0.197766
RPL5 ribosomal protein L5 0.15771
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 0.15771
RELN reelin 0.15771
TSPYL4 TSPY-like 4 0.15771
SPEF2 sperm flagellar 2 0.15771
SH3GL2 SH3-domain GRB2-like 2 0.15771
PDE9A phosphodiesterase 9A 0.15771
PTGFR prostaglandin F receptor (FP) 0.15771
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 0.15771
TRIM2 tripartite motif containing 2 0.126165
UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3 0.126165
BICD1 bicaudal D homolog 1 (Drosophila) 0.126165
GRXCR1 glutaredoxin, cysteine rich 1 0.126165
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 0.126165
CLRN3 clarin 3 0.126165
NLRP11 NLR family, pyrin domain containing 11 0.126165
WDR7 WD repeat domain 7 0.126165
LRRC16A leucine rich repeat containing 16A 0.126165
EGFL6 EGF-like-domain, multiple 6 0.126165
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 0.126165
AMY1A amylase, alpha 1A (salivary) 0.126165
PCSK5 proprotein convertase subtilisin/kexin type 5 0.100789
TRIM26 tripartite motif containing 26 0.100789
TLL1 tolloid-like 1 0.100789
TRAF3 TNF receptor-associated factor 3 0.100789
CTBP2 C-terminal binding protein 2 0.100789
GIMAP5 GTPase, IMAP family member 5 0.100789
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.080593
BUD13 BUD13 homolog (S. cerevisiae) 0.080593
AXDND1 axonemal dynein light chain domain containing 1 0.080593
NUBPL nucleotide binding protein-like 0.080593
IPP intracisternal A particle-promoted polypeptide 0.080593
MET MET proto-oncogene, receptor tyrosine kinase 0.080593
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.080593
JARID2 jumonji, AT rich interactive domain 2 0.080593
IL12A interleukin 12A 0.080593
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 0.064973
IGF2R insulin-like growth factor 2 receptor 0.064973
ASB3 ankyrin repeat and SOCS box containing 3 0.064973
CPAMD8 C3 and PZP-like, alpha-2-macroglobulin domain containing 8 0.064973
RUFY2 RUN and FYVE domain containing 2 0.064973
NWD2 NACHT and WD repeat domain containing 2 0.064973
SCG5 secretogranin V 0.064973
NCKAP5 NCK-associated protein 5 0.064973
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 0.064973
EN1 engrailed homeobox 1 0.064973
FOXO3 forkhead box O3 0.064973
COL27A1 collagen, type XXVII, alpha 1 0.064973
ADGRG1 adhesion G protein-coupled receptor G1 0.064973
FHIT fragile histidine triad 0.052255
BVES-AS1 BVES antisense RNA 1 0.052255
MXI1 MAX interactor 1, dimerization protein 0.052255
SVIL supervillin 0.052255
KPNB1 karyopherin (importin) beta 1 0.052255
AACS acetoacetyl-CoA synthetase 0.052255
SAMD12 sterile alpha motif domain containing 12 0.052255
POPDC3 popeye domain containing 3 0.052255
ALDH18A1 aldehyde dehydrogenase 18 family, member A1 0.052255
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.052255
POU2F3 POU class 2 homeobox 3 0.052255
ADRA1A adrenoceptor alpha 1A 0.043246
ACP5 acid phosphatase 5, tartrate resistant 0.043246
CALR3 calreticulin 3 0.043246
SLC35E1 solute carrier family 35, member E1 0.043246
KCNIP1 Kv channel interacting protein 1 0.043246
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.043246
EDN2 endothelin 2 0.043246
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.043246
ADGRG6 adhesion G protein-coupled receptor G6 0.035343
RASSF2 Ras association (RalGDS/AF-6) domain family member 2 0.035343