moxonidine-7343 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the moxonidine-7343 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADORA1 adenosine A1 receptor
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ALS2CL ALS2 C-terminal like
AR androgen receptor
ARC activity-regulated cytoskeleton-associated protein
ARRB1 arrestin, beta 1
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATXN2L ataxin 2-like
BIN1 bridging integrator 1
C9ORF9 chromosome 9 open reading frame 9
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CAMK1 calcium/calmodulin-dependent protein kinase I
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCDC57 coiled-coil domain containing 57
CDC25C cell division cycle 25C
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CES3 carboxylesterase 3
CHKB choline kinase beta
CHST10 carbohydrate sulfotransferase 10
CLCN7 chloride channel, voltage-sensitive 7
COL11A2 collagen, type XI, alpha 2
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CRY2 cryptochrome circadian clock 2
CTAGE5 CTAGE family, member 5
CYR61 cysteine-rich, angiogenic inducer, 61
DGKE diacylglycerol kinase, epsilon 64kDa
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DSCAM Down syndrome cell adhesion molecule
DTNA dystrobrevin, alpha
EFNA3 ephrin-A3
EPHA1 EPH receptor A1
EPN1 epsin 1
ERN1 endoplasmic reticulum to nucleus signaling 1
FAM114A2 family with sequence similarity 114, member A2
FAM184A family with sequence similarity 184, member A
FAM65A family with sequence similarity 65, member A
FGFR1 fibroblast growth factor receptor 1
FLRT2 fibronectin leucine rich transmembrane protein 2
FRK fyn-related Src family tyrosine kinase
GRIK5 glutamate receptor, ionotropic, kainate 5
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
HPS4 Hermansky-Pudlak syndrome 4
HSF1 heat shock transcription factor 1
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
IDS iduronate 2-sulfatase
IGSF6 immunoglobulin superfamily, member 6
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL11 interleukin 11
LOC390998 ribosomal protein L10 pseudogene
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MIIP migration and invasion inhibitory protein
MNDA myeloid cell nuclear differentiation antigen
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MRPL41 mitochondrial ribosomal protein L41
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
NEUROD4 neuronal differentiation 4
NF1 neurofibromin 1
NME5 NME/NM23 family member 5
ORAI2 ORAI calcium release-activated calcium modulator 2
PADI1 peptidyl arginine deiminase, type I
PBX2 pre-B-cell leukemia homeobox 2
PDGFA platelet-derived growth factor alpha polypeptide
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
POFUT1 protein O-fucosyltransferase 1
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PRKCA protein kinase C, alpha
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
RAB40C RAB40C, member RAS oncogene family
RASAL2 RAS protein activator like 2
RASL11B RAS-like, family 11, member B
RGS12 regulator of G-protein signaling 12
RIMS3 regulating synaptic membrane exocytosis 3
RPL7 ribosomal protein L7
RTEL1 regulator of telomere elongation helicase 1
SCRN3 secernin 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SFTPB surfactant protein B
SIT1 signaling threshold regulating transmembrane adaptor 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SNX13 sorting nexin 13
SSPN sarcospan
SSX1 synovial sarcoma, X breakpoint 1
SYMPK symplekin
TBC1D30 TBC1 domain family, member 30
TGFB2 transforming growth factor, beta 2
TMEM63A transmembrane protein 63A
UBOX5 U-box domain containing 5
VPS13B vacuolar protein sorting 13 homolog B (yeast)
VPS9D1 VPS9 domain containing 1
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZNF710 zinc finger protein 710

decreased expression

Symbol Name
ABHD4 abhydrolase domain containing 4
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATF3 activating transcription factor 3
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BAGE B melanoma antigen
C1ORF35 chromosome 1 open reading frame 35
C9ORF91 chromosome 9 open reading frame 91
CAPN5 calpain 5
CARD8 caspase recruitment domain family, member 8
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCDC85C coiled-coil domain containing 85C
CCNT1 cyclin T1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CINP cyclin-dependent kinase 2 interacting protein
CIR1 corepressor interacting with RBPJ, 1
CLCF1 cardiotrophin-like cytokine factor 1
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
COQ6 coenzyme Q6 monooxygenase
CPPED1 calcineurin-like phosphoesterase domain containing 1
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DDIT3 DNA-damage-inducible transcript 3
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24
DNAL4 dynein, axonemal, light chain 4
EFCAB2 EF-hand calcium binding domain 2
ENO2 enolase 2 (gamma, neuronal)
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
ESRP2 epithelial splicing regulatory protein 2
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GPC3 glypican 3
HIST1H1D histone cluster 1, H1d
HIST1H4F histone cluster 1, H4f
HIST2H2AA3 histone cluster 2, H2aa3
HYI hydroxypyruvate isomerase (putative)
IRF2BP1 interferon regulatory factor 2 binding protein 1
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
KAT2B K(lysine) acetyltransferase 2B
KREMEN2 kringle containing transmembrane protein 2
KRI1 KRI1 homolog (S. cerevisiae)
LIG4 ligase IV, DNA, ATP-dependent
LOC100287590 uncharacterized LOC100287590
LOC642236 FSHD region gene 1 pseudogene
LRRC37A2 leucine rich repeat containing 37, member A2
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAPK12 mitogen-activated protein kinase 12
MCOLN3 mucolipin 3
MMD monocyte to macrophage differentiation-associated
MXD3 MAX dimerization protein 3
NACA2 nascent polypeptide-associated complex alpha subunit 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEK11 NIMA-related kinase 11
NPIPB15 nuclear pore complex interacting protein family, member B15
NRSN2 neurensin 2
NUP62CL nucleoporin 62kDa C-terminal like
ONECUT2 one cut homeobox 2
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
OTUD3 OTU deubiquitinase 3
PCDHB3 protocadherin beta 3
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
RANBP17 RAN binding protein 17
RIC8B RIC8 guanine nucleotide exchange factor B
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF170 ring finger protein 170
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SDC3 syndecan 3
SOWAHC sosondowah ankyrin repeat domain family member C
SREK1IP1 SREK1-interacting protein 1
SUSD6 sushi domain containing 6
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TBC1D17 TBC1 domain family, member 17
THOP1 thimet oligopeptidase 1
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TMC7 transmembrane channel-like 7
TMEM121 transmembrane protein 121
TMEM180 transmembrane protein 180
TMEM209 transmembrane protein 209
TRAIP TRAF interacting protein
TRIM25 tripartite motif containing 25
TSPAN5 tetraspanin 5
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1
USB1 U6 snRNA biogenesis 1
VASH2 vasohibin 2
VAX2 ventral anterior homeobox 2
WDR62 WD repeat domain 62
WDR76 WD repeat domain 76
ZBTB39 zinc finger and BTB domain containing 39
ZNF14 zinc finger protein 14
ZNF248 zinc finger protein 248
ZNF254 zinc finger protein 254
ZNF273 zinc finger protein 273
ZNF571 zinc finger protein 571
ZNF816 zinc finger protein 816