moxisylyte-7255 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the moxisylyte-7255 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ANOS1 anosmin 1
AP1M2 adaptor-related protein complex 1, mu 2 subunit
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCR breakpoint cluster region
BNIP1 BCL2/adenovirus E1B 19kDa interacting protein 1
BTBD7 BTB (POZ) domain containing 7
C1ORF116 chromosome 1 open reading frame 116
CA9 carbonic anhydrase IX
CALB1 calbindin 1, 28kDa
CARD10 caspase recruitment domain family, member 10
CCZ1 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)
CDC14B cell division cycle 14B
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
COX15 cytochrome c oxidase assembly homolog 15 (yeast)
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CTGF connective tissue growth factor
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CXCL3 chemokine (C-X-C motif) ligand 3
CYR61 cysteine-rich, angiogenic inducer, 61
DENND3 DENN/MADD domain containing 3
DGKQ diacylglycerol kinase, theta 110kDa
DHRS12 dehydrogenase/reductase (SDR family) member 12
DIAPH1 diaphanous-related formin 1
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
EGR4 early growth response 4
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
EPHB2 EPH receptor B2
ERP44 endoplasmic reticulum protein 44
FAM69A family with sequence similarity 69, member A
FGF2 fibroblast growth factor 2 (basic)
FLT1 fms-related tyrosine kinase 1
GNS glucosamine (N-acetyl)-6-sulfatase
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HOMER3 homer scaffolding protein 3
KLHL20 kelch-like family member 20
KLHL22 kelch-like family member 22
KRT34 keratin 34, type I
LIME1 Lck interacting transmembrane adaptor 1
LRRC41 leucine rich repeat containing 41
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAPK14 mitogen-activated protein kinase 14
MAPK7 mitogen-activated protein kinase 7
MBNL2 muscleblind-like splicing regulator 2
MCF2L MCF.2 cell line derived transforming sequence-like
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MR1 major histocompatibility complex, class I-related
MYOF myoferlin
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NPAS1 neuronal PAS domain protein 1
NPY6R neuropeptide Y receptor Y6 (pseudogene)
NRF1 nuclear respiratory factor 1
NRP1 neuropilin 1
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PDLIM5 PDZ and LIM domain 5
PELI1 pellino E3 ubiquitin protein ligase 1
POU5F1B POU class 5 homeobox 1B
PRF1 perforin 1 (pore forming protein)
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RARG retinoic acid receptor, gamma
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNF126P1 ring finger protein 126 pseudogene 1
RNF6 ring finger protein (C3H2C3 type) 6
RPL7 ribosomal protein L7
RUSC2 RUN and SH3 domain containing 2
SBNO2 strawberry notch homolog 2 (Drosophila)
SCN10A sodium channel, voltage gated, type X alpha subunit
SIPA1L3 signal-induced proliferation-associated 1 like 3
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SPATA2L spermatogenesis associated 2-like
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
STIM1 stromal interaction molecule 1
TGFB2 transforming growth factor, beta 2
TMCC1 transmembrane and coiled-coil domain family 1
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TMEM70 transmembrane protein 70
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TSC22D2 TSC22 domain family, member 2
TTLL7 tubulin tyrosine ligase-like family member 7
USP20 ubiquitin specific peptidase 20
WNT7A wingless-type MMTV integration site family, member 7A
WWC1 WW and C2 domain containing 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZBTB22 zinc finger and BTB domain containing 22
ZNF276 zinc finger protein 276
ZNF93 zinc finger protein 93

decreased expression

Symbol Name
ANKFY1 ankyrin repeat and FYVE domain containing 1
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
AUH AU RNA binding protein/enoyl-CoA hydratase
AXIN1 axin 1
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BBS4 Bardet-Biedl syndrome 4
BPHL biphenyl hydrolase-like (serine hydrolase)
CADPS2 Ca++-dependent secretion activator 2
CBR4 carbonyl reductase 4
CCDC88C coiled-coil domain containing 88C
CHKB choline kinase beta
CNTNAP1 contactin associated protein 1
COMMD10 COMM domain containing 10
DDIT4 DNA-damage-inducible transcript 4
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EFCAB2 EF-hand calcium binding domain 2
EGLN2 egl-9 family hypoxia-inducible factor 2
EN1 engrailed homeobox 1
ERCC5 excision repair cross-complementation group 5
EVPL envoplakin
FAM155A family with sequence similarity 155, member A
FBXO2 F-box protein 2
FBXO46 F-box protein 46
FCHO1 FCH domain only 1
FHOD1 formin homology 2 domain containing 1
FXN frataxin
GALE UDP-galactose-4-epimerase
GCA grancalcin, EF-hand calcium binding protein
GLCE glucuronic acid epimerase
GLI3 GLI family zinc finger 3
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
GTPBP6 GTP binding protein 6 (putative)
GYS1 glycogen synthase 1 (muscle)
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HSPB8 heat shock 22kDa protein 8
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
IP6K2 inositol hexakisphosphate kinase 2
ITM2C integral membrane protein 2C
KIAA0894 KIAA0894 protein
KIF18A kinesin family member 18A
KLF7 Kruppel-like factor 7 (ubiquitous)
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LZTR1 leucine-zipper-like transcription regulator 1
MBIP MAP3K12 binding inhibitory protein 1
MFGE8 milk fat globule-EGF factor 8 protein
MORC3 MORC family CW-type zinc finger 3
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma
NDE1 nudE neurodevelopment protein 1
NMB neuromedin B
NTSR1 neurotensin receptor 1 (high affinity)
NUPL2 nucleoporin like 2
OPLAH 5-oxoprolinase (ATP-hydrolysing)
ORAI3 ORAI calcium release-activated calcium modulator 3
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PALMD palmdelphin
PARP16 poly (ADP-ribose) polymerase family, member 16
PEX12 peroxisomal biogenesis factor 12
PID1 phosphotyrosine interaction domain containing 1
PILRB paired immunoglobin-like type 2 receptor beta
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PRKCD protein kinase C, delta
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
RANBP17 RAN binding protein 17
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RBL1 retinoblastoma-like 1
RPGR retinitis pigmentosa GTPase regulator
RPL13P5 ribosomal protein L13 pseudogene 5
RPL23AP32 ribosomal protein L23a pseudogene 32
SERINC5 serine incorporator 5
SESN1 sestrin 1
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SMU1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)
SOX12 SRY (sex determining region Y)-box 12
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
TCTN2 tectonic family member 2
TGFB3 transforming growth factor, beta 3
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM132A transmembrane protein 132A
TPST2 tyrosylprotein sulfotransferase 2
TRAIP TRAF interacting protein
TRAPPC11 trafficking protein particle complex 11
TRIM21 tripartite motif containing 21
TSC1 tuberous sclerosis 1
TTC17 tetratricopeptide repeat domain 17
UBTD1 ubiquitin domain containing 1
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
ZFYVE16 zinc finger, FYVE domain containing 16
ZNF14 zinc finger protein 14
ZNF230 zinc finger protein 230
ZNF33B zinc finger protein 33B
ZNF415 zinc finger protein 415
ZNF562 zinc finger protein 562
ZNF85 zinc finger protein 85