motor neuron degeneration Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description retrogressive impairment of function or destruction of the cells that innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses (Mammalian Phenotype Ontology, MP_0000938)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0000938
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Genes

26 gene mutations causing the motor neuron degeneration phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
APAF1 apoptotic peptidase activating factor 1
AR androgen receptor
ATCAY ataxia, cerebellar, Cayman type
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2
BCL2 B-cell CLL/lymphoma 2
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
CLP1 cleavage and polyadenylation factor I subunit 1
CNTF ciliary neurotrophic factor
CTF1 cardiotrophin 1
DCTN1 dynactin 1
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
ERBB3 erb-b2 receptor tyrosine kinase 3
GIGYF2 GRB10 interacting GYF protein 2
GPHN gephyrin
HTRA2 HtrA serine peptidase 2
IGHMBP2 immunoglobulin mu binding protein 2
LTN1 listerin E3 ubiquitin protein ligase 1
SCYL1 SCY1-like 1 (S. cerevisiae)
SOX10 SRY (sex determining region Y)-box 10
SOX2 SRY (sex determining region Y)-box 2
TBCE tubulin folding cofactor E
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCP valosin containing protein
VEGFA vascular endothelial growth factor A
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)