morphological abnormality of the pyramidal tract Gene Set

Dataset HPO Gene-Disease Associations
Category disease or phenotype associations
Type phenotype
Description Any structural abnormality of the pyramidal tract, whose chief element, the corticospinal tract, is the only direct connection between the brain and the spinal cord. In addition to the corticospinal tract, the pyramidal system includes the corticobulbar, corticomesencephalic, and corticopontine tracts. (Human Phenotype Ontology, HP_0002062)
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28 genes associated with the morphological abnormality of the pyramidal tract phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.

Symbol Name
ALS2 amyotrophic lateral sclerosis 2 (juvenile)
ATL1 atlastin GTPase 1
ATXN10 ataxin 10
ATXN8 ataxin 8
ATXN8OS ATXN8 opposite strand (non-protein coding)
CTC1 CTS telomere maintenance complex component 1
DPYS dihydropyrimidinase
FKTN fukutin
GAN gigaxonin
KCNC3 potassium channel, voltage gated Shaw related subfamily C, member 3
KIAA0196 KIAA0196
L1CAM L1 cell adhesion molecule
L2HGDH L-2-hydroxyglutarate dehydrogenase
MAPT microtubule-associated protein tau
NIPA1 non imprinted in Prader-Willi/Angelman syndrome 1
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLP1 proteolipid protein 1
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator
SLC19A3 solute carrier family 19 (thiamine transporter), member 3
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SOD1 superoxide dismutase 1, soluble
SPAST spastin
SPG11 spastic paraplegia 11 (autosomal recessive)
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive)
TREX1 three prime repair exonuclease 1
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C