mood disorder Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A cognitive disorder that involves an excessive, irrational dread of everyday situations. (Human Disease Ontology, DOID_3324)
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Genes

310 genes co-occuring with the disease mood disorder in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
BPI bactericidal/permeability-increasing protein 2.3959
GADL1 glutamate decarboxylase-like 1 2.02794
TRH thyrotropin-releasing hormone 1.88297
MAOA monoamine oxidase A 1.52072
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 1.5014
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 1.41183
CRH corticotropin releasing hormone 1.39564
BDNF brain-derived neurotrophic factor 1.37381
POMC proopiomelanocortin 1.37076
MAATS1 MYCBP-associated, testis expressed 1 1.3241
DISC1 disrupted in schizophrenia 1 1.3062
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 1.26909
COMT catechol-O-methyltransferase 1.1635
NPEPPS aminopeptidase puromycin sensitive 1.1541
ALG9 ALG9, alpha-1,2-mannosyltransferase 1.15198
DEFB107B defensin, beta 107B 1.13543
PCDHB4 protocadherin beta 4 1.12151
CDH12 cadherin 12, type 2 (N-cadherin 2) 1.10889
DTNBP1 dystrobrevin binding protein 1 1.08412
DEFB1 defensin, beta 1 1.05976
SYT4 synaptotagmin IV 1.03198
CINP cyclin-dependent kinase 2 interacting protein 1.02945
PI4K2B phosphatidylinositol 4-kinase type 2 beta 1.00921
PRL prolactin 0.993174
PCDH12 protocadherin 12 0.939119
CDH18 cadherin 18, type 2 0.936629
TSNAX translin-associated factor X 0.935385
CLOCK clock circadian regulator 0.910199
KATNB1 katanin p80 (WD repeat containing) subunit B 1 0.909376
GOLPH3 golgi phosphoprotein 3 (coat-protein) 0.906086
ZNF80 zinc finger protein 80 0.888438
NRG1 neuregulin 1 0.857724
GSK3B glycogen synthase kinase 3 beta 0.855268
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 0.854449
CDH10 cadherin 10, type 2 (T2-cadherin) 0.819206
CCBL2 cysteine conjugate-beta lyase 2 0.817155
TUBA8 tubulin, alpha 8 0.81018
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5 0.80936
RNF123 ring finger protein 123 0.779841
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D 0.778613
CRHBP corticotropin releasing hormone binding protein 0.773705
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) 0.773296
INPP1 inositol polyphosphate-1-phosphatase 0.763086
SLC4A10 solute carrier family 4, sodium bicarbonate transporter, member 10 0.748017
RGS4 regulator of G-protein signaling 4 0.741111
GRID1 glutamate receptor, ionotropic, delta 1 0.716828
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1 0.713601
TPH2 tryptophan hydroxylase 2 0.699919
MAOB monoamine oxidase B 0.699116
CDH9 cadherin 9, type 2 (T1-cadherin) 0.695905
FLNA filamin A, alpha 0.687091
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.684292
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 0.671925
DRD2 dopamine receptor D2 0.671527
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1 0.670732
DRD3 dopamine receptor D3 0.669936
CDH15 cadherin 15, type 1, M-cadherin (myotubule) 0.669936
KCNH7 potassium channel, voltage gated eag related subfamily H, member 7 0.664769
ADARB1 adenosine deaminase, RNA-specific, B1 0.663975
RORB RAR-related orphan receptor B 0.653276
GRIK3 glutamate receptor, ionotropic, kainate 3 0.648533
FEZ1 fasciculation and elongation protein zeta 1 (zygin I) 0.641039
CDH8 cadherin 8, type 2 0.634742
KCTD12 potassium channel tetramerization domain containing 12 0.624143
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 0.618268
EPHA6 EPH receptor A6 0.616312
PDCD2 programmed cell death 2 0.61162
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 0.608885
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) 0.606152
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 0.605372
NTF4 neurotrophin 4 0.60186
HPS6 Hermansky-Pudlak syndrome 6 0.58939
PTPN7 protein tyrosine phosphatase, non-receptor type 7 0.582384
ARNTL aryl hydrocarbon receptor nuclear translocator-like 0.580439
PDE4B phosphodiesterase 4B, cAMP-specific 0.569941
CDK14 cyclin-dependent kinase 14 0.566443
EGR3 early growth response 3 0.565666
TRPC3 transient receptor potential cation channel, subfamily C, member 3 0.563723
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled 0.561392
KAT6B K(lysine) acetyltransferase 6B 0.561392
ALDH4A1 aldehyde dehydrogenase 4 family, member A1 0.556732
SLC16A8 solute carrier family 16 (monocarboxylate transporter), member 8 0.555568
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) 0.554791
DEAF1 DEAF1 transcription factor 0.548583
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 0.544705
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 0.541992
CHRM2 cholinergic receptor, muscarinic 2 0.541217
MFGE8 milk fat globule-EGF factor 8 protein 0.537344
CHD1L chromodomain helicase DNA binding protein 1-like 0.533475
CORT cortistatin 0.527676
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.52729
EGOT eosinophil granule ontogeny transcript (non-protein coding) 0.526904
DRD4 dopamine receptor D4 0.523045
DAO D-amino-acid oxidase 0.518805
GRIA1 glutamate receptor, ionotropic, AMPA 1 0.508808
AVPR1B arginine vasopressin receptor 1B 0.508808
SRPX2 sushi-repeat containing protein, X-linked 2 0.500379
SNAP25 synaptosomal-associated protein, 25kDa 0.486266
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit 0.480945
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 0.480945
PURA purine-rich element binding protein A 0.480186
MARCKS myristoylated alanine-rich protein kinase C substrate 0.477909
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 0.474119
DPYSL3 dihydropyrimidinase-like 3 0.471846
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 0.468063
INS insulin 0.468063
GRIA2 glutamate receptor, ionotropic, AMPA 2 0.465416
KPNA1 karyopherin alpha 1 (importin alpha 5) 0.461639
ANKK1 ankyrin repeat and kinase domain containing 1 0.461639
EGR4 early growth response 4 0.454093
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.440162
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.438282
TOR1A torsin family 1, member A (torsin A) 0.433397
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1 0.425139
SULT4A1 sulfotransferase family 4A, member 1 0.421016
NGF nerve growth factor (beta polypeptide) 0.419142
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 0.403811
NRXN3 neurexin 3 0.402318
AUTS2 autism susceptibility candidate 2 0.401199
AK2 adenylate kinase 2 0.398216
PRG4 proteoglycan 4 0.397098
IDO1 indoleamine 2,3-dioxygenase 1 0.396353
SP8 Sp8 transcription factor 0.396353
TP73 tumor protein p73 0.39598
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.393001
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 0.393001
LDB1 LIM domain binding 1 0.389281
AHRR aryl-hydrocarbon receptor repressor 0.386679
PCDH10 protocadherin 10 0.380368
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 0.379626
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.377773
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 0.37592
DNAH8 dynein, axonemal, heavy chain 8 0.375179
SRCIN1 SRC kinase signaling inhibitor 1 0.374068
CARS cysteinyl-tRNA synthetase 0.373698
UBD ubiquitin D 0.370368
IL6 interleukin 6 0.365562
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase) 0.360026
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) 0.357446
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 0.356709
GHRH growth hormone releasing hormone 0.352659
AMY1C amylase, alpha 1C (salivary) 0.350452
AMY1B amylase, alpha 1B (salivary) 0.350452
AMY1A amylase, alpha 1A (salivary) 0.350452
NPAS2 neuronal PAS domain protein 2 0.349717
CRP C-reactive protein, pentraxin-related 0.348614
XG Xg blood group 0.348246
PIR pirin (iron-binding nuclear protein) 0.346777
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 0.343473
KIF1A kinesin family member 1A 0.342006
DRD1 dopamine receptor D1 0.339073
DIO1 deiodinase, iodothyronine, type I 0.33651
PTPRG protein tyrosine phosphatase, receptor type, G 0.33066
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 0.328834
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.328469
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 0.328105
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 0.328105
MIER1 mesoderm induction early response 1, transcriptional regulator 0.326646
IL2RB interleukin 2 receptor, beta 0.321909
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 0.321909
PER2 period circadian clock 2 0.318999
PRRC2A proline-rich coiled-coil 2A 0.318635
RAP1GAP RAP1 GTPase activating protein 0.317909
GRM3 glutamate receptor, metabotropic 3 0.316456
DAOA D-amino acid oxidase activator 0.315003
AANAT aralkylamine N-acetyltransferase 0.31464
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.313915
PER1 period circadian clock 1 0.313189
GSK3A glycogen synthase kinase 3 alpha 0.309928
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.308842
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 0.305587
EEF2 eukaryotic translation elongation factor 2 0.294772
CYP2D7 cytochrome P450, family 2, subfamily D, polypeptide 7 (gene/pseudogene) 0.291539
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 0.288668
BSN bassoon presynaptic cytomatrix protein 0.287235
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 0.281868
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) 0.278297
NDEL1 nudE neurodevelopment protein 1-like 1 0.275445
NR1I2 nuclear receptor subfamily 1, group I, member 2 0.273308
POLG polymerase (DNA directed), gamma 0.270819
FEV FEV (ETS oncogene family) 0.268687
HOMER1 homer scaffolding protein 1 0.264077
ZNF436 zinc finger protein 436 0.260184
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 0.257711
GRM4 glutamate receptor, metabotropic 4 0.248203
TES testin LIM domain protein 0.247501
PCNT pericentrin 0.24715
HRH1 histamine receptor H1 0.243295
IFI30 interferon, gamma-inducible protein 30 0.239799
OXT oxytocin/neurophysin I prepropeptide 0.238054
CRY1 cryptochrome circadian clock 1 0.231102
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 0.231102
NTF3 neurotrophin 3 0.230409
TPH1 tryptophan hydroxylase 1 0.225229
PGRMC1 progesterone receptor membrane component 1 0.225229
TH tyrosine hydroxylase 0.222822
GH1 growth hormone 1 0.222479
SEPT2 septin 2 0.220424
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 0.218715
STYK1 serine/threonine/tyrosine kinase 1 0.214636
TMTC1 transmembrane and tetratricopeptide repeat containing 1 0.214636
NPS neuropeptide S 0.212945
NRCAM neuronal cell adhesion molecule 0.206248
PNP purine nucleoside phosphorylase 0.204593
PEG10 paternally expressed 10 0.20229
CLPS colipase, pancreatic 0.201308
NKX2-2 NK2 homeobox 2 0.199356
SGSH N-sulfoglucosamine sulfohydrolase 0.199033
MC2R melanocortin 2 receptor (adrenocorticotropic hormone) 0.198064
SYNE1 spectrin repeat containing, nuclear envelope 1 0.189244
HP haptoglobin 0.188326
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.188022
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 0.186811
HPR haptoglobin-related protein 0.183541
VIT vitrin 0.181798
BCO1 beta-carotene oxygenase 1 0.181798
DPYSL2 dihydropyrimidinase-like 2 0.179802
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.17952
ENDOG endonuclease G 0.177576
CCK cholecystokinin 0.174093
PCSK7 proprotein convertase subtilisin/kexin type 7 0.172544
NPY neuropeptide Y 0.171535
PTH parathyroid hormone 0.164359
LCT lactase 0.163729
AGPS alkylglycerone phosphate synthase 0.163317
FGA fibrinogen alpha chain 0.162306
FXYD1 FXYD domain containing ion transport regulator 1 0.161139
FGD1 FYVE, RhoGEF and PH domain containing 1 0.161139
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 0.159838
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 0.140171
EFS embryonal Fyn-associated substrate 0.139272
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.138511
PRSS21 protease, serine, 21 (testisin) 0.138432
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 0.135282
ALAS1 5'-aminolevulinate synthase 1 0.134432
PMEL premelanosome protein 0.133457
HNMT histamine N-methyltransferase 0.132745
MGAM maltase-glucoamylase 0.130993
MGP matrix Gla protein 0.130517
SOX10 SRY (sex determining region Y)-box 10 0.130508
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 0.130508
TF transferrin 0.130349
PHYH phytanoyl-CoA 2-hydroxylase 0.130131
NSF N-ethylmaleimide-sensitive factor 0.129769
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.129703
MMP12 matrix metallopeptidase 12 0.129694
ACHE acetylcholinesterase (Yt blood group) 0.12912
PER3 period circadian clock 3 0.128392
TRPC1 transient receptor potential cation channel, subfamily C, member 1 0.128147
EPGN epithelial mitogen 0.128051
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.127841
PRODH proline dehydrogenase (oxidase) 1 0.127484
CCL11 chemokine (C-C motif) ligand 11 0.126716
MIXL1 Mix paired-like homeobox 0.126619
EGR2 early growth response 2 0.126449
EP300 E1A binding protein p300 0.126364
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 0.126165
PNPLA2 patatin-like phospholipase domain containing 2 0.12604
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.125201
GPR162 G protein-coupled receptor 162 0.125013
PADI4 peptidyl arginine deiminase, type IV 0.12387
NCR3 natural cytotoxicity triggering receptor 3 0.123756
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.123342
GAST gastrin 0.121884
TKT transketolase 0.12177
LAX1 lymphocyte transmembrane adaptor 1 0.121057
GLS glutaminase 0.120353
RRM1 ribonucleotide reductase M1 0.118831
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein 0.116213
LEP leptin 0.114967
GLS2 glutaminase 2 (liver, mitochondrial) 0.112394
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 0.106828
FOXP2 forkhead box P2 0.104131
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 0.09847
DCTN1 dynactin 1 0.096915
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type 0.096744
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.095882
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 0.095043
CCL5 chemokine (C-C motif) ligand 5 0.094014
KAT5 K(lysine) acetyltransferase 5 0.093298
ATXN7 ataxin 7 0.093225
S100B S100 calcium binding protein B 0.092934
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2 0.092571
MID2 midline 2 0.092535
B3GAT2 beta-1,3-glucuronyltransferase 2 0.091582
IVD isovaleryl-CoA dehydrogenase 0.091324
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide 0.091213
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 0.090471
HEXA hexosaminidase A (alpha polypeptide) 0.090207
FADS1 fatty acid desaturase 1 0.089907
NOS2 nitric oxide synthase 2, inducible 0.089644
HRAS Harvey rat sarcoma viral oncogene homolog 0.087547
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 0.087391
ELANE elastase, neutrophil expressed 0.087042
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.087004
IARS isoleucyl-tRNA synthetase 0.086771
CCL2 chemokine (C-C motif) ligand 2 0.086771
HK1 hexokinase 1 0.086267
CRYZ crystallin, zeta (quinone reductase) 0.085519
PNOC prepronociceptin 0.085401
CREBBP CREB binding protein 0.085323
SP6 Sp6 transcription factor 0.085008
FBP1 fructose-1,6-bisphosphatase 1 0.083736
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 0.083696
DCXR dicarbonyl/L-xylulose reductase 0.083056
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 0.08241
CDH13 cadherin 13 0.08233
HAND1 heart and neural crest derivatives expressed 1 0.082047
XBP1 X-box binding protein 1 0.082007
TACR1 tachykinin receptor 1 0.080949