monocrotaline-7127 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the monocrotaline-7127 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALAD aminolevulinate dehydratase
ANKZF1 ankyrin repeat and zinc finger domain containing 1
APH1B APH1B gamma secretase subunit
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ARG2 arginase 2
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARPIN actin-related protein 2/3 complex inhibitor
ASF1A anti-silencing function 1A histone chaperone
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
BAHCC1 BAH domain and coiled-coil containing 1
BIN1 bridging integrator 1
BRD4 bromodomain containing 4
C14ORF79 chromosome 14 open reading frame 79
C1ORF105 chromosome 1 open reading frame 105
C2ORF68 chromosome 2 open reading frame 68
C9ORF156 chromosome 9 open reading frame 156
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCNJ cyclin J
CEP295 centrosomal protein 295kDa
CFLAR CASP8 and FADD-like apoptosis regulator
CIB2 calcium and integrin binding family member 2
COL13A1 collagen, type XIII, alpha 1
CTSK cathepsin K
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DDN dendrin
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DENND2A DENN/MADD domain containing 2A
DHRS9 dehydrogenase/reductase (SDR family) member 9
DIAPH1 diaphanous-related formin 1
DMTN dematin actin binding protein
E2F3 E2F transcription factor 3
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
ERAP2 endoplasmic reticulum aminopeptidase 2
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GAS8 growth arrest-specific 8
GATA2 GATA binding protein 2
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GNL1 guanine nucleotide binding protein-like 1
GPR137 G protein-coupled receptor 137
GRAMD4 GRAM domain containing 4
GTF2A1 general transcription factor IIA, 1, 19/37kDa
H2AFX H2A histone family, member X
HLX H2.0-like homeobox
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
INPP5K inositol polyphosphate-5-phosphatase K
KANK2 KN motif and ankyrin repeat domains 2
KIAA0922 KIAA0922
KIF5C kinesin family member 5C
KIRREL kin of IRRE like (Drosophila)
KLF7 Kruppel-like factor 7 (ubiquitous)
KRIT1 KRIT1, ankyrin repeat containing
LIMK2 LIM domain kinase 2
LIN7B lin-7 homolog B (C. elegans)
LRP5L low density lipoprotein receptor-related protein 5-like
LRRC61 leucine rich repeat containing 61
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAOA monoamine oxidase A
MAPT microtubule-associated protein tau
MFN2 mitofusin 2
MFSD6 major facilitator superfamily domain containing 6
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MRPS14 mitochondrial ribosomal protein S14
MTAP methylthioadenosine phosphorylase
MVK mevalonate kinase
N4BP1 NEDD4 binding protein 1
NME5 NME/NM23 family member 5
NOLC1 nucleolar and coiled-body phosphoprotein 1
ORAI2 ORAI calcium release-activated calcium modulator 2
PAX9 paired box 9
PCDHGB5 protocadherin gamma subfamily B, 5
PDK3 pyruvate dehydrogenase kinase, isozyme 3
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PHLDB1 pleckstrin homology-like domain, family B, member 1
PPCDC phosphopantothenoylcysteine decarboxylase
RAB2A RAB2A, member RAS oncogene family
RAB31 RAB31, member RAS oncogene family
RAD50 RAD50 homolog (S. cerevisiae)
RNF216 ring finger protein 216
RUNX3 runt-related transcription factor 3
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SLC48A1 solute carrier family 48 (heme transporter), member 1
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
SMG5 SMG5 nonsense mediated mRNA decay factor
STAG3 stromal antigen 3
STAG3L4 stromal antigen 3-like 4 (pseudogene)
TLDC1 TBC/LysM-associated domain containing 1
TM2D1 TM2 domain containing 1
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TRADD TNFRSF1A-associated via death domain
TRIM21 tripartite motif containing 21
TTC38 tetratricopeptide repeat domain 38
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
YIPF2 Yip1 domain family, member 2
ZNF839 zinc finger protein 839

decreased expression

Symbol Name
ADGRF1 adhesion G protein-coupled receptor F1
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
APLP1 amyloid beta (A4) precursor-like protein 1
BAHD1 bromo adjacent homology domain containing 1
BAK1 BCL2-antagonist/killer 1
BANK1 B-cell scaffold protein with ankyrin repeats 1
BBS10 Bardet-Biedl syndrome 10
C17ORF80 chromosome 17 open reading frame 80
C1R complement component 1, r subcomponent
CAPN5 calpain 5
CCNA1 cyclin A1
CDC45 cell division cycle 45
CFAP44 cilia and flagella associated protein 44
CHML choroideremia-like (Rab escort protein 2)
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CLCN2 chloride channel, voltage-sensitive 2
CTNNBIP1 catenin, beta interacting protein 1
CUL9 cullin 9
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DOLPP1 dolichyldiphosphatase 1
EVPL envoplakin
FAM155A family with sequence similarity 155, member A
FAM188A family with sequence similarity 188, member A
FAM86C1 family with sequence similarity 86, member C1
FGF2 fibroblast growth factor 2 (basic)
GALE UDP-galactose-4-epimerase
GCA grancalcin, EF-hand calcium binding protein
HDAC5 histone deacetylase 5
HIRA histone cell cycle regulator
HS1BP3 HCLS1 binding protein 3
IFT81 intraflagellar transport 81
IL4R interleukin 4 receptor
IL7R interleukin 7 receptor
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
JADE1 jade family PHD finger 1
KCTD15 potassium channel tetramerization domain containing 15
KIAA0894 KIAA0894 protein
KIF18A kinesin family member 18A
L2HGDH L-2-hydroxyglutarate dehydrogenase
LRRC37A3 leucine rich repeat containing 37, member A3
MANEA mannosidase, endo-alpha
MCMBP minichromosome maintenance complex binding protein
MCTP1 multiple C2 domains, transmembrane 1
MED24 mediator complex subunit 24
METRN meteorin, glial cell differentiation regulator
MNX1 motor neuron and pancreas homeobox 1
MTG1 mitochondrial ribosome-associated GTPase 1
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MXD3 MAX dimerization protein 3
NCAPH non-SMC condensin I complex, subunit H
NECAB3 N-terminal EF-hand calcium binding protein 3
NPY1R neuropeptide Y receptor Y1
ODF2 outer dense fiber of sperm tails 2
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PBLD phenazine biosynthesis-like protein domain containing
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLD3 phospholipase D family, member 3
PLEKHO2 pleckstrin homology domain containing, family O member 2
POLH polymerase (DNA directed), eta
PTGFR prostaglandin F receptor (FP)
PTPN14 protein tyrosine phosphatase, non-receptor type 14
QTRT1 queuine tRNA-ribosyltransferase 1
RAB3A RAB3A, member RAS oncogene family
RABGGTA Rab geranylgeranyltransferase, alpha subunit
RAD9A RAD9 homolog A (S. pombe)
RBM38 RNA binding motif protein 38
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
RPL13P5 ribosomal protein L13 pseudogene 5
RPP25 ribonuclease P/MRP 25kDa subunit
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
SCML2 sex comb on midleg-like 2 (Drosophila)
SETD1B SET domain containing 1B
SETD6 SET domain containing 6
SKA1 spindle and kinetochore associated complex subunit 1
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SOX12 SRY (sex determining region Y)-box 12
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
STK25 serine/threonine kinase 25
STRN4 striatin, calmodulin binding protein 4
SUGCT succinyl-CoA:glutarate-CoA transferase
TGS1 trimethylguanosine synthase 1
TM7SF2 transmembrane 7 superfamily member 2
TMEM2 transmembrane protein 2
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TROAP trophinin associated protein
UBL4A ubiquitin-like 4A
UBXN2B UBX domain protein 2B
USP6NL USP6 N-terminal like
USP8 ubiquitin specific peptidase 8
WLS wntless Wnt ligand secretion mediator
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZFP36 ZFP36 ring finger protein
ZNF180 zinc finger protein 180
ZNF282 zinc finger protein 282