monocrotaline-2749 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the monocrotaline-2749 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ARTN artemin
BAX BCL2-associated X protein
BLZF1 basic leucine zipper nuclear factor 1
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CAPN5 calpain 5
CCDC121 coiled-coil domain containing 121
CCR2 chemokine (C-C motif) receptor 2
CD70 CD70 molecule
CDC14B cell division cycle 14B
CDK18 cyclin-dependent kinase 18
CFHR4 complement factor H-related 4
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CRMP1 collapsin response mediator protein 1
CSF1R colony stimulating factor 1 receptor
CTSF cathepsin F
DCAF15 DDB1 and CUL4 associated factor 15
DMTN dematin actin binding protein
DOK4 docking protein 4
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
FBLN1 fibulin 1
FGFR1 fibroblast growth factor receptor 1
FH fumarate hydratase
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GABRD gamma-aminobutyric acid (GABA) A receptor, delta
GLIPR1 GLI pathogenesis-related 1
GM2A GM2 ganglioside activator
GRB7 growth factor receptor-bound protein 7
GSTA3 glutathione S-transferase alpha 3
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HYAL1 hyaluronoglucosaminidase 1
IGLV3-19 immunoglobulin lambda variable 3-19
IL11 interleukin 11
IL1B interleukin 1, beta
KDM5A lysine (K)-specific demethylase 5A
KLHL28 kelch-like family member 28
LAMC2 laminin, gamma 2
MED16 mediator complex subunit 16
METTL16 methyltransferase like 16
MFN2 mitofusin 2
MFSD7 major facilitator superfamily domain containing 7
MR1 major histocompatibility complex, class I-related
MYL10 myosin, light chain 10, regulatory
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OLFML2A olfactomedin-like 2A
PACS1 phosphofurin acidic cluster sorting protein 1
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PDE4C phosphodiesterase 4C, cAMP-specific
PHLDB1 pleckstrin homology-like domain, family B, member 1
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
POM121L2 POM121 transmembrane nucleoporin-like 2
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PSD4 pleckstrin and Sec7 domain containing 4
PVR poliovirus receptor
QPCTL glutaminyl-peptide cyclotransferase-like
RAB6B RAB6B, member RAS oncogene family
RFX2 regulatory factor X, 2 (influences HLA class II expression)
RPL35A ribosomal protein L35a
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RTN2 reticulon 2
RYR2 ryanodine receptor 2 (cardiac)
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SEC14L5 SEC14-like 5 (S. cerevisiae)
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SH2D2A SH2 domain containing 2A
SH3GL3 SH3-domain GRB2-like 3
SIGLEC8 sialic acid binding Ig-like lectin 8
SIX2 SIX homeobox 2
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SOX10 SRY (sex determining region Y)-box 10
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SRD5A3 steroid 5 alpha-reductase 3
STMN1 stathmin 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THAP9 THAP domain containing 9
THBD thrombomodulin
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRIM3 tripartite motif containing 3
TRIO trio Rho guanine nucleotide exchange factor
TROVE2 TROVE domain family, member 2
UCN urocortin
UTRN utrophin
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
XDH xanthine dehydrogenase
YIPF4 Yip1 domain family, member 4
ZC2HC1C zinc finger, C2HC-type containing 1C
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ACSL4 acyl-CoA synthetase long-chain family member 4
ACTL8 actin-like 8
AHDC1 AT hook, DNA binding motif, containing 1
ANXA2P3 annexin A2 pseudogene 3
ATAD5 ATPase family, AAA domain containing 5
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
BCORL1 BCL6 corepressor-like 1
BRPF1 bromodomain and PHD finger containing, 1
C19ORF40 chromosome 19 open reading frame 40
C1ORF159 chromosome 1 open reading frame 159
CBX8 chromobox homolog 8
CCNO cyclin O
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHKB choline kinase beta
CLCN2 chloride channel, voltage-sensitive 2
CNGB3 cyclic nucleotide gated channel beta 3
CORT cortistatin
CPTP ceramide-1-phosphate transfer protein
CRELD1 cysteine-rich with EGF-like domains 1
CTNNBIP1 catenin, beta interacting protein 1
CXADR coxsackie virus and adenovirus receptor
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DBF4B DBF4 zinc finger B
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DSCAM Down syndrome cell adhesion molecule
FAM189A2 family with sequence similarity 189, member A2
FBRS fibrosin
FLNB filamin B, beta
FURIN furin (paired basic amino acid cleaving enzyme)
FYCO1 FYVE and coiled-coil domain containing 1
GAB2 GRB2-associated binding protein 2
GFOD1 glucose-fructose oxidoreductase domain containing 1
H1F0 H1 histone family, member 0
HIST1H2AI histone cluster 1, H2ai
HIST1H2AJ histone cluster 1, H2aj
HPS6 Hermansky-Pudlak syndrome 6
HYI hydroxypyruvate isomerase (putative)
IFT22 intraflagellar transport 22
IRF6 interferon regulatory factor 6
KDM5C lysine (K)-specific demethylase 5C
L2HGDH L-2-hydroxyglutarate dehydrogenase
LAMA3 laminin, alpha 3
LHX6 LIM homeobox 6
LRP3 low density lipoprotein receptor-related protein 3
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MBIP MAP3K12 binding inhibitory protein 1
MITF microphthalmia-associated transcription factor
MNX1 motor neuron and pancreas homeobox 1
MOSPD3 motile sperm domain containing 3
MXD3 MAX dimerization protein 3
NCALD neurocalcin delta
NECAB3 N-terminal EF-hand calcium binding protein 3
NIPAL2 NIPA-like domain containing 2
NOL12 nucleolar protein 12
NPIPB3 nuclear pore complex interacting protein family, member B3
ONECUT2 one cut homeobox 2
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PARP16 poly (ADP-ribose) polymerase family, member 16
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PLEKHO2 pleckstrin homology domain containing, family O member 2
PROS1 protein S (alpha)
PSKH1 protein serine kinase H1
RAB20 RAB20, member RAS oncogene family
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RNF126P1 ring finger protein 126 pseudogene 1
RPL10L ribosomal protein L10-like
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
SCMH1 sex comb on midleg homolog 1 (Drosophila)
SCN1B sodium channel, voltage gated, type I beta subunit
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SMAD7 SMAD family member 7
SPAG4 sperm associated antigen 4
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TAOK1 TAO kinase 1
TCP10 t-complex 10
TMSB15A thymosin beta 15a
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSPAN1 tetraspanin 1
VAX2 ventral anterior homeobox 2
VEZT vezatin, adherens junctions transmembrane protein
VGF VGF nerve growth factor inducible
XKR8 XK, Kell blood group complex subunit-related family, member 8
ZFAND3 zinc finger, AN1-type domain 3
ZNF205 zinc finger protein 205
ZNF34 zinc finger protein 34
ZNF574 zinc finger protein 574
ZNF639 zinc finger protein 639
ZNF747 zinc finger protein 747