monastrol-681 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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199 genes differentially expressed following the monastrol-681 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACOT9 acyl-CoA thioesterase 9
ACTA2 actin, alpha 2, smooth muscle, aorta
AKT3 v-akt murine thymoma viral oncogene homolog 3
AMDHD2 amidohydrolase domain containing 2
ANAPC10 anaphase promoting complex subunit 10
APH1B APH1B gamma secretase subunit
ARFRP1 ADP-ribosylation factor related protein 1
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BECN1 beclin 1, autophagy related
C12ORF49 chromosome 12 open reading frame 49
C1ORF115 chromosome 1 open reading frame 115
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2
CDK17 cyclin-dependent kinase 17
CIDEC cell death-inducing DFFA-like effector c
CLIC4 chloride intracellular channel 4
CRNKL1 crooked neck pre-mRNA splicing factor 1
CRYAB crystallin, alpha B
CTNNBIP1 catenin, beta interacting protein 1
CTTN cortactin
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11
DCP1A decapping mRNA 1A
DDIT4 DNA-damage-inducible transcript 4
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52
DGCR2 DiGeorge syndrome critical region gene 2
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DUSP13 dual specificity phosphatase 13
DXO decapping exoribonuclease
EPS8L1 EPS8-like 1
ERCC6L excision repair cross-complementation group 6-like
FAM153A family with sequence similarity 153, member A
FGD1 FYVE, RhoGEF and PH domain containing 1
FGFR1 fibroblast growth factor receptor 1
FOSL1 FOS-like antigen 1
GBAP1 glucosidase, beta, acid pseudogene 1
GRK5 G protein-coupled receptor kinase 5
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-G major histocompatibility complex, class I, G
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFRD1 interferon-related developmental regulator 1
INO80B INO80 complex subunit B
INSIG1 insulin induced gene 1
IRF6 interferon regulatory factor 6
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KREMEN2 kringle containing transmembrane protein 2
LIG3 ligase III, DNA, ATP-dependent
MOB3B MOB kinase activator 3B
MYL10 myosin, light chain 10, regulatory
MYO1A myosin IA
NADK NAD kinase
NCAPH non-SMC condensin I complex, subunit H
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
NKIRAS2 NFKB inhibitor interacting Ras-like 2
NOC4L nucleolar complex associated 4 homolog (S. cerevisiae)
NXPH3 neurexophilin 3
OSGEP O-sialoglycoprotein endopeptidase
PCDH12 protocadherin 12
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta
PLCG1 phospholipase C, gamma 1
PON2 paraoxonase 2
PRELP proline/arginine-rich end leucine-rich repeat protein
PRIM2 primase, DNA, polypeptide 2 (58kDa)
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PTK2B protein tyrosine kinase 2 beta
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RNF24 ring finger protein 24
RPS2 ribosomal protein S2
S100P S100 calcium binding protein P
SBNO1 strawberry notch homolog 1 (Drosophila)
SETD2 SET domain containing 2
SH3PXD2A SH3 and PX domains 2A
SIL1 SIL1 nucleotide exchange factor
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC22A18 solute carrier family 22, member 18
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC35F2 solute carrier family 35, member F2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SRR serine racemase
STX7 syntaxin 7
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
TBXA2R thromboxane A2 receptor
TPCN1 two pore segment channel 1
TRAC T cell receptor alpha constant
TRIM3 tripartite motif containing 3
TRIO trio Rho guanine nucleotide exchange factor
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast)
UST uronyl-2-sulfotransferase
VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae)
VRK3 vaccinia related kinase 3
VWA5A von Willebrand factor A domain containing 5A
ZBTB40 zinc finger and BTB domain containing 40
ZNF236 zinc finger protein 236
ZNF771 zinc finger protein 771

decreased expression

Symbol Name
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACKR3 atypical chemokine receptor 3
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ARRB2 arrestin, beta 2
ATG7 autophagy related 7
AVPR1B arginine vasopressin receptor 1B
BCCIP BRCA2 and CDKN1A interacting protein
BTBD2 BTB (POZ) domain containing 2
C16ORF62 chromosome 16 open reading frame 62
C6ORF47 chromosome 6 open reading frame 47
CA2 carbonic anhydrase II
CASC3 cancer susceptibility candidate 3
CCP110 centriolar coiled coil protein 110kDa
CDC42BPB CDC42 binding protein kinase beta (DMPK-like)
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit
CMTR1 cap methyltransferase 1
CPTP ceramide-1-phosphate transfer protein
CRTAC1 cartilage acidic protein 1
DENND1B DENN/MADD domain containing 1B
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
ECHDC1 ethylmalonyl-CoA decarboxylase 1
EDAR ectodysplasin A receptor
EGLN1 egl-9 family hypoxia-inducible factor 1
EGLN2 egl-9 family hypoxia-inducible factor 2
EPM2AIP1 EPM2A (laforin) interacting protein 1
ETV7 ets variant 7
EVL Enah/Vasp-like
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM193A family with sequence similarity 193, member A
FAM46A family with sequence similarity 46, member A
FOLR2 folate receptor 2 (fetal)
FOXD1 forkhead box D1
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GPATCH3 G patch domain containing 3
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3
HOOK2 hook microtubule-tethering protein 2
IL17RA interleukin 17 receptor A
IRS1 insulin receptor substrate 1
ITGA10 integrin, alpha 10
KIF3B kinesin family member 3B
KLHL25 kelch-like family member 25
LTBP3 latent transforming growth factor beta binding protein 3
LYRM2 LYR motif containing 2
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MON1B MON1 secretory trafficking family member B
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NOTCH1 notch 1
NUP62 nucleoporin 62kDa
PAK1IP1 PAK1 interacting protein 1
PELP1 proline, glutamate and leucine rich protein 1
PFAS phosphoribosylformylglycinamidine synthase
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLD2 phospholipase D2
PNRC1 proline-rich nuclear receptor coactivator 1
PODXL podocalyxin-like
PRAF2 PRA1 domain family, member 2
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBBP5 retinoblastoma binding protein 5
RBM47 RNA binding motif protein 47
RNF141 ring finger protein 141
RNF220 ring finger protein 220
RNF38 ring finger protein 38
RNH1 ribonuclease/angiogenin inhibitor 1
RPAP1 RNA polymerase II associated protein 1
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SLC10A3 solute carrier family 10, member 3
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC22A14 solute carrier family 22, member 14
SLN sarcolipin
SMAD7 SMAD family member 7
SREBF1 sterol regulatory element binding transcription factor 1
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
STK16 serine/threonine kinase 16
SYT2 synaptotagmin II
TNRC6B trinucleotide repeat containing 6B
TSC22D4 TSC22 domain family, member 4
TUBA3C tubulin, alpha 3c
UBQLN4 ubiquilin 4
UGDH UDP-glucose 6-dehydrogenase
VIM vimentin
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WDR46 WD repeat domain 46
ZBED1 zinc finger, BED-type containing 1
ZBTB22 zinc finger and BTB domain containing 22
ZNF185 zinc finger protein 185 (LIM domain)
ZNF408 zinc finger protein 408
ZNF574 zinc finger protein 574
ZNF587 zinc finger protein 587
ZNF611 zinc finger protein 611
ZNF652 zinc finger protein 652
ZNF669 zinc finger protein 669
ZNF710 zinc finger protein 710
ZNF74 zinc finger protein 74