monastrol-668 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the monastrol-668 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAN aggrecan
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
ALPK1 alpha-kinase 1
BIK BCL2-interacting killer (apoptosis-inducing)
BMP7 bone morphogenetic protein 7
BMP8A bone morphogenetic protein 8a
C11ORF80 chromosome 11 open reading frame 80
C17ORF70 chromosome 17 open reading frame 70
CCNT1 cyclin T1
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
CLCN7 chloride channel, voltage-sensitive 7
CRYM crystallin, mu
DCLRE1A DNA cross-link repair 1A
DCN decorin
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DUS2 dihydrouridine synthase 2
EDA ectodysplasin A
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3
ERCC4 excision repair cross-complementation group 4
FA2H fatty acid 2-hydroxylase
FCGRT Fc fragment of IgG, receptor, transporter, alpha
GK glycerol kinase
GLRX3 glutaredoxin 3
GM2A GM2 ganglioside activator
GPSM2 G-protein signaling modulator 2
H2AFY2 H2A histone family, member Y2
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
HAP1 huntingtin-associated protein 1
HIST1H1D histone cluster 1, H1d
HOXA4 homeobox A4
HOXD9 homeobox D9
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
ICA1 islet cell autoantigen 1, 69kDa
IGFALS insulin-like growth factor binding protein, acid labile subunit
IL13RA1 interleukin 13 receptor, alpha 1
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
INTS7 integrator complex subunit 7
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KLHL24 kelch-like family member 24
KYNU kynureninase
LRRN2 leucine rich repeat neuronal 2
LZTS3 leucine zipper, putative tumor suppressor family member 3
MED1 mediator complex subunit 1
METTL2B methyltransferase like 2B
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MNS1 meiosis-specific nuclear structural 1
MXD4 MAX dimerization protein 4
MYL10 myosin, light chain 10, regulatory
MZF1 myeloid zinc finger 1
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NPFFR1 neuropeptide FF receptor 1
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2
PCSK7 proprotein convertase subtilisin/kexin type 7
PDZD3 PDZ domain containing 3
PHLDB1 pleckstrin homology-like domain, family B, member 1
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLCE1 phospholipase C, epsilon 1
PLCL2 phospholipase C-like 2
PLSCR3 phospholipid scramblase 3
PON3 paraoxonase 3
POTEKP POTE ankyrin domain family, member K, pseudogene
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PRDM11 PR domain containing 11
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
REC8 REC8 meiotic recombination protein
RGS16 regulator of G-protein signaling 16
RGS3 regulator of G-protein signaling 3
RNF141 ring finger protein 141
RPL37A ribosomal protein L37a
RPS2 ribosomal protein S2
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RUNDC3A RUN domain containing 3A
S1PR4 sphingosine-1-phosphate receptor 4
SPN sialophorin
SYT2 synaptotagmin II
SZRD1 SUZ RNA binding domain containing 1
TBC1D2B TBC1 domain family, member 2B
TCF4 transcription factor 4
TSKU tsukushi, small leucine rich proteoglycan
TSPAN8 tetraspanin 8
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
TTLL4 tubulin tyrosine ligase-like family member 4
TXNRD3 thioredoxin reductase 3
UBQLN4 ubiquilin 4
UNC93B1 unc-93 homolog B1 (C. elegans)
WDR18 WD repeat domain 18
WNK1 WNK lysine deficient protein kinase 1
ZGPAT zinc finger, CCCH-type with G patch domain
ZNF189 zinc finger protein 189
ZNF318 zinc finger protein 318
ZNF821 zinc finger protein 821

decreased expression

Symbol Name
AATF apoptosis antagonizing transcription factor
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADORA3 adenosine A3 receptor
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ART1 ADP-ribosyltransferase 1
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BACE1 beta-site APP-cleaving enzyme 1
BATF3 basic leucine zipper transcription factor, ATF-like 3
BDH1 3-hydroxybutyrate dehydrogenase, type 1
C1ORF105 chromosome 1 open reading frame 105
C9ORF78 chromosome 9 open reading frame 78
CA5BP1 carbonic anhydrase VB pseudogene 1
CAMKV CaM kinase-like vesicle-associated
CASD1 CAS1 domain containing 1
CCNA1 cyclin A1
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CHN1 chimerin 1
CIC capicua transcriptional repressor
CLEC16A C-type lectin domain family 16, member A
CPOX coproporphyrinogen oxidase
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CTNNBIP1 catenin, beta interacting protein 1
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DYSF dysferlin
EPN3 epsin 3
ERF Ets2 repressor factor
EXOSC9 exosome component 9
FAM192A family with sequence similarity 192, member A
FAM63A family with sequence similarity 63, member A
FDXR ferredoxin reductase
FGD6 FYVE, RhoGEF and PH domain containing 6
FMO4 flavin containing monooxygenase 4
GEM GTP binding protein overexpressed in skeletal muscle
HAGH hydroxyacylglutathione hydrolase
HAS2 hyaluronan synthase 2
HDAC5 histone deacetylase 5
HDAC7 histone deacetylase 7
HIST1H3G histone cluster 1, H3g
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HMHA1 histocompatibility (minor) HA-1
HOXC11 homeobox C11
KIFC3 kinesin family member C3
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
KLHL25 kelch-like family member 25
KLK8 kallikrein-related peptidase 8
LINC00216 long intergenic non-protein coding RNA 216
LRRC15 leucine rich repeat containing 15
LRRC8E leucine rich repeat containing 8 family, member E
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAPK3 mitogen-activated protein kinase 3
MED23 mediator complex subunit 23
METTL22 methyltransferase like 22
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit
NELL2 NEL-like 2 (chicken)
NOL6 nucleolar protein 6 (RNA-associated)
NUAK1 NUAK family, SNF1-like kinase, 1
NVL nuclear VCP-like
OVGP1 oviductal glycoprotein 1, 120kDa
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PAK1IP1 PAK1 interacting protein 1
PARP16 poly (ADP-ribose) polymerase family, member 16
PBX3 pre-B-cell leukemia homeobox 3
PC pyruvate carboxylase
PLEKHO2 pleckstrin homology domain containing, family O member 2
PMEL premelanosome protein
PMM2 phosphomannomutase 2
POU5F1B POU class 5 homeobox 1B
PRR16 proline rich 16
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PYROXD1 pyridine nucleotide-disulphide oxidoreductase domain 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RASL11B RAS-like, family 11, member B
RNF39 ring finger protein 39
SASH3 SAM and SH3 domain containing 3
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13
SNAI2 snail family zinc finger 2
SPON2 spondin 2, extracellular matrix protein
SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1
TARBP1 TAR (HIV-1) RNA binding protein 1
TFB2M transcription factor B2, mitochondrial
TGS1 trimethylguanosine synthase 1
TMOD3 tropomodulin 3 (ubiquitous)
TMPRSS11D transmembrane protease, serine 11D
TRIP10 thyroid hormone receptor interactor 10
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN32 tetraspanin 32
VRK2 vaccinia related kinase 2
XPA xeroderma pigmentosum, complementation group A
ZNF408 zinc finger protein 408
ZNF432 zinc finger protein 432
ZNF557 zinc finger protein 557
ZNF696 zinc finger protein 696
ZNF8 zinc finger protein 8