monastrol-627 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the monastrol-627 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
API5 apoptosis inhibitor 5
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASMTL acetylserotonin O-methyltransferase-like
ATXN2 ataxin 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
C1ORF115 chromosome 1 open reading frame 115
CANT1 calcium activated nucleotidase 1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHD3 chromodomain helicase DNA binding protein 3
CHIC2 cysteine-rich hydrophobic domain 2
CLDN4 claudin 4
CLK3 CDC-like kinase 3
CNPPD1 cyclin Pas1/PHO80 domain containing 1
CSNK1A1 casein kinase 1, alpha 1
DDIT3 DNA-damage-inducible transcript 3
DGCR2 DiGeorge syndrome critical region gene 2
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13
EHD4 EH-domain containing 4
EML3 echinoderm microtubule associated protein like 3
ENOSF1 enolase superfamily member 1
EPS8L1 EPS8-like 1
ERI3 ERI1 exoribonuclease family member 3
FAM134A family with sequence similarity 134, member A
FAM134C family with sequence similarity 134, member C
FBXO9 F-box protein 9
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
HEATR1 HEAT repeat containing 1
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H3G histone cluster 1, H3g
HLA-B major histocompatibility complex, class I, B
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
ITCH itchy E3 ubiquitin protein ligase
KRIT1 KRIT1, ankyrin repeat containing
KRT86 keratin 86, type II
LPPR2 lipid phosphate phosphatase-related protein type 2
MACF1 microtubule-actin crosslinking factor 1
MAN2A2 mannosidase, alpha, class 2A, member 2
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2
MED9 mediator complex subunit 9
MNAT1 MNAT CDK-activating kinase assembly factor 1
MOB4 MOB family member 4, phocein
MORC2 MORC family CW-type zinc finger 2
MT1HL1 metallothionein 1H-like 1
MUC1 mucin 1, cell surface associated
MUC3A mucin 3A, cell surface associated
NPM3 nucleophosmin/nucleoplasmin 3
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
NQO1 NAD(P)H dehydrogenase, quinone 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
ORAI3 ORAI calcium release-activated calcium modulator 3
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PFDN4 prefoldin subunit 4
PHLDB1 pleckstrin homology-like domain, family B, member 1
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLD3 phospholipase D family, member 3
PLXNA1 plexin A1
PMEPA1 prostate transmembrane protein, androgen induced 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPCS phosphopantothenoylcysteine synthetase
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PRKCH protein kinase C, eta
PSD4 pleckstrin and Sec7 domain containing 4
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
RAB32 RAB32, member RAS oncogene family
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2
RPL18 ribosomal protein L18
SCD5 stearoyl-CoA desaturase 5
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SFXN1 sideroflexin 1
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive)
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
STX6 syntaxin 6
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TBC1D22A TBC1 domain family, member 22A
TBCC tubulin folding cofactor C
TCF3 transcription factor 3
TESK1 testis-specific kinase 1
TGFB3 transforming growth factor, beta 3
THOC1 THO complex 1
TMEM132A transmembrane protein 132A
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TOM1L1 target of myb1 (chicken)-like 1
TRIB3 tribbles pseudokinase 3
TRMT61A tRNA methyltransferase 61A
TXNDC15 thioredoxin domain containing 15
USF2 upstream transcription factor 2, c-fos interacting
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae)
ZNF212 zinc finger protein 212
ZNF22 zinc finger protein 22

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
AKIRIN1 akirin 1
ASNSD1 asparagine synthetase domain containing 1
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ASUN asunder spermatogenesis regulator
BYSL bystin-like
CA2 carbonic anhydrase II
CASC3 cancer susceptibility candidate 3
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CCDC71 coiled-coil domain containing 71
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
COA7 cytochrome c oxidase assembly factor 7 (putative)
CRABP2 cellular retinoic acid binding protein 2
CSK c-src tyrosine kinase
DCAF6 DDB1 and CUL4 associated factor 6
DENND4B DENN/MADD domain containing 4B
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DPF2 D4, zinc and double PHD fingers family 2
EDC4 enhancer of mRNA decapping 4
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM46A family with sequence similarity 46, member A
FAM57A family with sequence similarity 57, member A
FDXR ferredoxin reductase
FNDC3B fibronectin type III domain containing 3B
FOXC1 forkhead box C1
FSD1 fibronectin type III and SPRY domain containing 1
GCH1 GTP cyclohydrolase 1
GCHFR GTP cyclohydrolase I feedback regulator
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GUSB glucuronidase, beta
HELLS helicase, lymphoid-specific
IMPAD1 inositol monophosphatase domain containing 1
IRS1 insulin receptor substrate 1
IRX5 iroquois homeobox 5
KAT2A K(lysine) acetyltransferase 2A
KCTD2 potassium channel tetramerization domain containing 2
KEAP1 kelch-like ECH-associated protein 1
KIF1BP KIF1 binding protein
LMNB1 lamin B1
LOXL1 lysyl oxidase-like 1
MAP7D1 MAP7 domain containing 1
MCM10 minichromosome maintenance complex component 10
MON1B MON1 secretory trafficking family member B
MREG melanoregulin
MRPL19 mitochondrial ribosomal protein L19
MRPS10 mitochondrial ribosomal protein S10
MSL1 male-specific lethal 1 homolog (Drosophila)
MTPAP mitochondrial poly(A) polymerase
MVD mevalonate (diphospho) decarboxylase
MYNN myoneurin
NFE2L2 nuclear factor, erythroid 2-like 2
NIPA2 non imprinted in Prader-Willi/Angelman syndrome 2
NSL1 NSL1, MIS12 kinetochore complex component
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PALM paralemmin
PBX3 pre-B-cell leukemia homeobox 3
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
POLB polymerase (DNA directed), beta
PPAN peter pan homolog (Drosophila)
PPT2 palmitoyl-protein thioesterase 2
PRKRIR protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
PRPSAP2 phosphoribosyl pyrophosphate synthetase-associated protein 2
PWP2 PWP2 periodic tryptophan protein homolog (yeast)
PXMP2 peroxisomal membrane protein 2, 22kDa
QDPR quinoid dihydropteridine reductase
RAB4B RAB4B, member RAS oncogene family
RAI14 retinoic acid induced 14
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RBBP8 retinoblastoma binding protein 8
RGS16 regulator of G-protein signaling 16
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RSRC1 arginine/serine-rich coiled-coil 1
SCFD1 sec1 family domain containing 1
SIL1 SIL1 nucleotide exchange factor
SLC10A3 solute carrier family 10, member 3
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SLC25A46 solute carrier family 25, member 46
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
STYXL1 serine/threonine/tyrosine interacting-like 1
TMEM180 transmembrane protein 180
TP53BP2 tumor protein p53 binding protein 2
TPSD1 tryptase delta 1
TSC1 tuberous sclerosis 1
TSPAN1 tetraspanin 1
TSPYL4 TSPY-like 4
TYK2 tyrosine kinase 2
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UBQLN2 ubiquilin 2
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
WDR37 WD repeat domain 37
WDR43 WD repeat domain 43
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
ZBTB5 zinc finger and BTB domain containing 5
ZNF263 zinc finger protein 263
ZNF747 zinc finger protein 747