monastrol-605 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the monastrol-605 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAMDC adipogenesis associated, Mth938 domain containing
ABCD4 ATP-binding cassette, sub-family D (ALD), member 4
AFF1 AF4/FMR2 family, member 1
AIM1L absent in melanoma 1-like
AK1 adenylate kinase 1
AP3B1 adaptor-related protein complex 3, beta 1 subunit
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ARRB1 arrestin, beta 1
ARRB2 arrestin, beta 2
ATXN8OS ATXN8 opposite strand (non-protein coding)
BIN1 bridging integrator 1
BTN2A3P butyrophilin, subfamily 2, member A3, pseudogene
BTN3A1 butyrophilin, subfamily 3, member A1
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit
CCDC40 coiled-coil domain containing 40
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CLEC11A C-type lectin domain family 11, member A
CRYAB crystallin, alpha B
CTAGE9 CTAGE family, member 9
DHRS9 dehydrogenase/reductase (SDR family) member 9
DVL2 dishevelled segment polarity protein 2
E2F1 E2F transcription factor 1
ERN2 endoplasmic reticulum to nucleus signaling 2
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
GFOD2 glucose-fructose oxidoreductase domain containing 2
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GPR19 G protein-coupled receptor 19
GPSM3 G-protein signaling modulator 3
GRM1 glutamate receptor, metabotropic 1
GYPB glycophorin B (MNS blood group)
HAPLN2 hyaluronan and proteoglycan link protein 2
HOXC5 homeobox C5
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
ICAM2 intercellular adhesion molecule 2
IL11 interleukin 11
IL9R interleukin 9 receptor
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIAA1614 KIAA1614
KLF6 Kruppel-like factor 6
LINC00574 long intergenic non-protein coding RNA 574
LMF2 lipase maturation factor 2
LPAR1 lysophosphatidic acid receptor 1
LTBP4 latent transforming growth factor beta binding protein 4
MARC1 mitochondrial amidoxime reducing component 1
MCHR1 melanin-concentrating hormone receptor 1
MGC2889 uncharacterized protein MGC2889
MIA3 melanoma inhibitory activity family, member 3
MPZL1 myelin protein zero-like 1
MTF1 metal-regulatory transcription factor 1
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MZF1 myeloid zinc finger 1
NAT6 N-acetyltransferase 6 (GCN5-related)
NCKIPSD NCK interacting protein with SH3 domain
NDRG2 NDRG family member 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRF1 nuclear respiratory factor 1
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
NUPL2 nucleoporin like 2
OR10H3 olfactory receptor, family 10, subfamily H, member 3
OR1F1 olfactory receptor, family 1, subfamily F, member 1
PADI2 peptidyl arginine deiminase, type II
PAX8 paired box 8
PCSK6 proprotein convertase subtilisin/kexin type 6
PCYT1B phosphate cytidylyltransferase 1, choline, beta
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa
PECAM1 platelet/endothelial cell adhesion molecule 1
PLD1 phospholipase D1, phosphatidylcholine-specific
PLK3 polo-like kinase 3
PMEL premelanosome protein
PRDM14 PR domain containing 14
PRPF18 pre-mRNA processing factor 18
PSD3 pleckstrin and Sec7 domain containing 3
PTGDS prostaglandin D2 synthase 21kDa (brain)
RASSF7 Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
RPS4Y1 ribosomal protein S4, Y-linked 1
SBNO2 strawberry notch homolog 2 (Drosophila)
SCYL3 SCY1-like 3 (S. cerevisiae)
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SLC38A7 solute carrier family 38, member 7
SLC45A2 solute carrier family 45, member 2
SLPI secretory leukocyte peptidase inhibitor
SRSF1 serine/arginine-rich splicing factor 1
STAB1 stabilin 1
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
TCP10 t-complex 10
TEX15 testis expressed 15
TLR5 toll-like receptor 5
TMPRSS5 transmembrane protease, serine 5
TPSAB1 tryptase alpha/beta 1
UBE4B ubiquitination factor E4B
ULK2 unc-51 like autophagy activating kinase 2
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae)
WDR48 WD repeat domain 48
ZC3H3 zinc finger CCCH-type containing 3
ZMYM6 zinc finger, MYM-type 6
ZNF446 zinc finger protein 446

decreased expression

Symbol Name
ACSF2 acyl-CoA synthetase family member 2
ACSL5 acyl-CoA synthetase long-chain family member 5
ADGRB1 adhesion G protein-coupled receptor B1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALX3 ALX homeobox 3
BAGE B melanoma antigen
BTBD2 BTB (POZ) domain containing 2
C1QTNF1 C1q and tumor necrosis factor related protein 1
C20ORF195 chromosome 20 open reading frame 195
CA7 carbonic anhydrase VII
CAV3 caveolin 3
CCDC70 coiled-coil domain containing 70
CCL25 chemokine (C-C motif) ligand 25
CCNJL cyclin J-like
CCNL2 cyclin L2
CD70 CD70 molecule
CEP41 centrosomal protein 41kDa
CHAT choline O-acetyltransferase
CHRM4 cholinergic receptor, muscarinic 4
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CUBN cubilin (intrinsic factor-cobalamin receptor)
DEPDC5 DEP domain containing 5
EFCAB1 EF-hand calcium binding domain 1
EFNA3 ephrin-A3
EPHA4 EPH receptor A4
ESPN espin
EVPL envoplakin
EYA4 EYA transcriptional coactivator and phosphatase 4
FBXO31 F-box protein 31
FOLR2 folate receptor 2 (fetal)
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GAS8-AS1 GAS8 antisense RNA 1
GDF2 growth differentiation factor 2
GJA1 gap junction protein, alpha 1, 43kDa
GPR15 G protein-coupled receptor 15
HDAC5 histone deacetylase 5
HIST1H3I histone cluster 1, H3i
HMX1 H6 family homeobox 1
HPX hemopexin
IFT81 intraflagellar transport 81
IL12RB1 interleukin 12 receptor, beta 1
IL13 interleukin 13
IL36RN interleukin 36 receptor antagonist
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5
KAT2B K(lysine) acetyltransferase 2B
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KLK1 kallikrein 1
KRT75 keratin 75, type II
LIAS lipoic acid synthetase
LOC730101 uncharacterized LOC730101
LRRC61 leucine rich repeat containing 61
LUZP2 leucine zipper protein 2
MAST3 microtubule associated serine/threonine kinase 3
MED17 mediator complex subunit 17
MEGF6 multiple EGF-like-domains 6
MIP major intrinsic protein of lens fiber
MMP3 matrix metallopeptidase 3
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NEMF nuclear export mediator factor
NLRP2 NLR family, pyrin domain containing 2
NPY6R neuropeptide Y receptor Y6 (pseudogene)
PCSK7 proprotein convertase subtilisin/kexin type 7
PDE8B phosphodiesterase 8B
PELP1 proline, glutamate and leucine rich protein 1
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PLCD1 phospholipase C, delta 1
PNOC prepronociceptin
PODNL1 podocan-like 1
POGLUT1 protein O-glucosyltransferase 1
PPCDC phosphopantothenoylcysteine decarboxylase
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RASL10A RAS-like, family 10, member A
RECQL4 RecQ protein-like 4
RLN1 relaxin 1
RPL10L ribosomal protein L10-like
SELL selectin L
SGK2 serum/glucocorticoid regulated kinase 2
SPRYD7 SPRY domain containing 7
STARD5 StAR-related lipid transfer (START) domain containing 5
SYNGR3 synaptogyrin 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
THBS2 thrombospondin 2
THRAP3 thyroid hormone receptor associated protein 3
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TOE1 target of EGR1, member 1 (nuclear)
TPM3 tropomyosin 3
TRAPPC12 trafficking protein particle complex 12
TRBV10-2 T cell receptor beta variable 10-2
TREM2 triggering receptor expressed on myeloid cells 2
USP6NL USP6 N-terminal like
VIPR1 vasoactive intestinal peptide receptor 1
WNT7A wingless-type MMTV integration site family, member 7A
ZBED1 zinc finger, BED-type containing 1
ZNF189 zinc finger protein 189
ZNF358 zinc finger protein 358
ZNF821 zinc finger protein 821